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PMC:7565665 / 68143-69313 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T438 218-225 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T439 242-257 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T489 725-727 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T490 863-876 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T491 877-879 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T492 888-890 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T493 1007-1027 Disease denotes respiratory diseases http://purl.obolibrary.org/obo/MONDO_0005087
T494 1148-1158 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T789 180-184 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T790 242-248 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T791 249-257 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T792 336-340 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T793 432-436 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T794 476-480 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T795 644-645 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T796 830-833 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T797 1049-1053 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T85472 18-28 Chemical denotes cysteamine http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029
T158 115-125 Chemical denotes cysteamine http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029
T55491 218-225 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T7519 348-358 Chemical denotes cysteamine http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029
T44863 608-618 Chemical denotes cysteamine http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029
T28868 742-751 Chemical denotes dendrimer http://purl.obolibrary.org/obo/CHEBI_51338|http://purl.obolibrary.org/obo/CHEBI_61483
T31667 1103-1114 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T19153 1143-1146 Chemical denotes MDR http://purl.obolibrary.org/obo/CHEBI_53218

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1699 180-184 Gene denotes CFTR Gene:1080
1700 336-340 Gene denotes CFTR Gene:1080
1701 432-436 Gene denotes CFTR Gene:1080
1702 476-480 Gene denotes CFTR Gene:1080
1703 561-574 Species denotes P. aeruginosa Tax:287
1704 806-819 Species denotes P. aeruginosa Tax:287
1705 891-899 Species denotes patients Tax:9606
1706 18-28 Chemical denotes cysteamine MESH:D003543
1707 115-125 Chemical denotes cysteamine MESH:D003543
1708 608-618 Chemical denotes cysteamine MESH:D003543
1709 729-739 Chemical denotes Cysteamine MESH:D003543
1710 863-873 Disease denotes infections MESH:D007239
1711 1007-1027 Disease denotes respiratory diseases MESH:D012140
1712 1049-1065 Disease denotes CFTR dysfunction MESH:D009461
1713 1148-1158 Disease denotes infections MESH:D007239

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T904 180-184 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T905 336-340 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T906 385-394 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T907 385-394 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T908 432-436 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T909 476-480 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T910 481-490 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T911 481-490 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T912 1049-1053 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T355 0-70 Sentence denotes Studies exploring cysteamine-dendrimers have revealed similar results.
T356 71-278 Sentence denotes Two of our recent studies demonstrated that cysteamine-based dendrimers were able to not only decrease ΔF508-CFTR aggregation, but also rescue the protein to increase the plasma membrane expression [45,149].
T357 279-455 Sentence denotes Moreover, these investigations showed that this recue of CFTR by the cysteamine-dendrimers alleviated the autophagy impairment associated with the ΔF508-CFTR mutation [45,149].
T358 456-600 Sentence denotes This alleviation of CFTR-autophagy impairment was further shown to increase the clearance and killing of P. aeruginosa in both studies [45,149].
T359 601-728 Sentence denotes Hence, cysteamine-based dendrimers provide a therapeutic option in the treatment of both acute and chronic exacerbations in CF.
T360 729-931 Sentence denotes Cysteamine’s dendrimer-based formulation also proved beneficial for clearing P. aeruginosa, and thus has potential for treating other infections in CF and non-CF patients who are prone to exacerbations.
T361 932-1170 Sentence denotes The added advantage of this intervention strategy is that exacerbations in respiratory diseases including those with CFTR dysfunction may be treated and prevented without antibiotics, where multidrug-resistant (MDR) infections are common.