PMC:7565665 / 6539-7342
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T36 | 55-57 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T37 | 118-122 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T38 | 212-216 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T39 | 500-504 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T11 | 118-122 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T12 | 212-216 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T13 | 500-504 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T70 | 190-203 | Disease | denotes | infections in | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T71 | 212-224 | Disease | denotes | lung disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T72 | 312-322 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T73 | 368-370 | Disease | denotes | PN | http://purl.obolibrary.org/obo/MONDO_0011405 |
| T74 | 505-518 | Disease | denotes | infections in | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T75 | 748-752 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T76 | 753-762 | Disease | denotes | emphysema | http://purl.obolibrary.org/obo/MONDO_0004849 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T53 | 118-122 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T54 | 118-122 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T55 | 212-216 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T56 | 212-216 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T57 | 448-449 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T58 | 500-504 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T59 | 500-504 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T20 | 55-57 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T21 | 368-370 | Chemical | denotes | PN | http://purl.obolibrary.org/obo/CHEBI_74754 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 131 | 368-370 | Gene | denotes | PN | Gene:79650 |
| 132 | 55-57 | Gene | denotes | CS | Gene:1431 |
| 133 | 190-200 | Disease | denotes | infections | MESH:D007239 |
| 134 | 212-224 | Disease | denotes | lung disease | MESH:D008171 |
| 135 | 302-322 | Disease | denotes | pulmonary infections | MESH:D012141 |
| 136 | 500-515 | Disease | denotes | lung infections | MESH:D012141 |
| 137 | 748-762 | Disease | denotes | COPD-emphysema | MESH:D029424 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T31 | 204-224 | Phenotype | denotes | chronic lung disease | http://purl.obolibrary.org/obo/HP_0006528 |
| T32 | 302-322 | Phenotype | denotes | pulmonary infections | http://purl.obolibrary.org/obo/HP_0006532 |
| T33 | 748-752 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T34 | 753-762 | Phenotype | denotes | emphysema | http://purl.obolibrary.org/obo/HP_0002097 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T64 | 123-128 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
| T65 | 249-254 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
| T66 | 375-384 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T67 | 375-384 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T68 | 698-707 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T69 | 698-707 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T70 | 763-775 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T30 | 0-239 | Sentence | denotes | In addition, we recently demonstrated that exposure to CS and other noxious environmental agents promotes accelerated lung aging, which is another important factor contributing to increased infections in chronic lung disease subjects [33]. |
| T31 | 240-354 | Sentence | denotes | In fact, aging per se is responsible for an increased risk of pulmonary infections due to the decline of immunity. |
| T32 | 355-592 | Sentence | denotes | Notably, the PN and autophagy are known to decrease over time with age, and therefore, serve a crucial role in determining the increased risk of lung infections in the elderly, by virtue of hampered pathogen clearance mechanisms [13,41]. |
| T33 | 593-803 | Sentence | denotes | Therefore, several studies, including our recent reports, demonstrate the therapeutic potential of novel autophagy augmentation strategies for controlling COPD-emphysema pathogenesis and progression [22,42,43]. |