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PMC:7565665 / 61308-63224 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T409 128-130 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T410 415-417 Body_part denotes PM http://purl.org/sig/ont/fma/fma63841
T411 515-517 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T412 522-524 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T413 562-571 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T414 707-715 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T415 943-945 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T416 1128-1136 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T417 1176-1178 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T418 1264-1266 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T419 1524-1535 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T420 1716-1718 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T451 198-202 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T452 203-212 Disease denotes emphysema http://purl.obolibrary.org/obo/MONDO_0004849
T453 457-461 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T454 462-471 Disease denotes emphysema http://purl.obolibrary.org/obo/MONDO_0004849
T455 1892-1896 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T456 1897-1906 Disease denotes emphysema http://purl.obolibrary.org/obo/MONDO_0004849

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T728 139-143 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T729 318-328 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T730 403-407 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T731 443-444 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T732 602-606 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T733 784-790 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T734 901-907 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T735 911-912 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T736 954-958 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T737 1018-1024 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T738 1128-1136 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T739 1430-1432 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T740 1438-1439 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T741 1539-1540 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T742 1787-1789 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T77653 34-38 Chemical denotes GSNO http://purl.obolibrary.org/obo/CHEBI_50091
T90481 66-84 Chemical denotes nitric oxide donor http://purl.obolibrary.org/obo/CHEBI_50566
T28575 66-78 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T41830 73-78 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T97 79-84 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T18880 128-130 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T99 261-265 Chemical denotes GSNO http://purl.obolibrary.org/obo/CHEBI_50091
T100 314-317 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T38467 415-417 Chemical denotes PM http://purl.obolibrary.org/obo/CHEBI_141444|http://purl.obolibrary.org/obo/CHEBI_16410|http://purl.obolibrary.org/obo/CHEBI_53551
T23686 515-517 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T105 522-524 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T44313 791-795 Chemical denotes GSNO http://purl.obolibrary.org/obo/CHEBI_50091
T97111 866-870 Chemical denotes GSNO http://purl.obolibrary.org/obo/CHEBI_50091
T108 943-945 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T109 989-999 Chemical denotes cysteamine http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029
T111 1004-1008 Chemical denotes GSNO http://purl.obolibrary.org/obo/CHEBI_50091
T112 1080-1085 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T54131 1095-1106 Chemical denotes gemfibrozil http://purl.obolibrary.org/obo/CHEBI_5296
T17954 1108-1111 Chemical denotes GEM http://purl.obolibrary.org/obo/CHEBI_5296
T48946 1152-1159 Chemical denotes fisetin http://purl.obolibrary.org/obo/CHEBI_42567
T116 1176-1178 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T117 1264-1266 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T16262 1398-1401 Chemical denotes GEM http://purl.obolibrary.org/obo/CHEBI_5296
T83227 1402-1409 Chemical denotes fisetin http://purl.obolibrary.org/obo/CHEBI_42567
T14089 1672-1683 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T9718 1684-1691 Chemical denotes fisetin http://purl.obolibrary.org/obo/CHEBI_42567
T93835 1716-1718 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1550 403-407 Gene denotes CFTR Gene:1080
1551 602-606 Gene denotes CFTR Gene:12638
1552 954-958 Gene denotes CFTR Gene:12638
1553 1279-1283 Gene denotes TFEB Gene:7942
1554 1414-1418 Gene denotes TFEB Gene:7942
1555 128-130 Gene denotes CS Gene:1431
1556 276-291 Gene denotes cigarette smoke Gene:1431
1557 472-478 Species denotes murine Tax:10090
1558 1626-1639 Species denotes P. aeruginosa Tax:287
1559 1762-1775 Species denotes P. aeruginosa Tax:287
1560 34-38 Chemical denotes GSNO
1561 66-78 Chemical denotes nitric oxide MESH:D009569
1562 261-265 Chemical denotes GSNO
1563 791-795 Chemical denotes GSNO
1564 866-870 Chemical denotes GSNO
1565 989-999 Chemical denotes cysteamine MESH:D003543
1566 1004-1008 Chemical denotes GSNO
1567 1095-1106 Chemical denotes gemfibrozil MESH:D015248
1568 1108-1111 Chemical denotes GEM MESH:D015248
1569 1398-1401 Chemical denotes GEM MESH:D015248
1570 1402-1409 Chemical denotes fisetin MESH:C017875
1571 1684-1691 Chemical denotes fisetin MESH:C017875
1572 139-155 Disease denotes CFTR dysfunction MESH:D009461
1573 198-212 Disease denotes COPD-emphysema MESH:D029424
1574 457-471 Disease denotes COPD-emphysema MESH:D029424
1575 1563-1583 Disease denotes phagocytosis defects MESH:D000014
1576 1727-1746 Disease denotes phagocytosis defect MESH:D000014
1577 1892-1906 Disease denotes COPD-emphysema MESH:D029424

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T200 198-202 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T201 203-212 Phenotype denotes emphysema http://purl.obolibrary.org/obo/HP_0002097
T202 457-461 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T203 462-471 Phenotype denotes emphysema http://purl.obolibrary.org/obo/HP_0002097
T204 1319-1335 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T205 1892-1896 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T206 1897-1906 Phenotype denotes emphysema http://purl.obolibrary.org/obo/HP_0002097

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T821 139-143 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T822 164-173 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T823 164-173 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T824 213-225 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T825 333-342 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T826 333-342 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T827 403-407 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T828 591-600 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T829 602-606 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T830 617-629 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T831 665-674 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T832 665-674 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T833 954-958 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T834 959-968 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T835 959-968 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T836 1061-1070 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T837 1061-1070 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T838 1137-1146 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T839 1187-1196 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T840 1187-1196 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T841 1284-1293 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T842 1284-1293 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T843 1337-1346 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T844 1337-1346 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T845 1499-1508 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T846 1499-1508 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T847 1563-1575 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T848 1653-1662 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T849 1653-1662 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T850 1727-1739 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T851 1820-1829 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T852 1820-1829 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T319 0-226 Sentence denotes Our relatively recent study using GSNO, an endogenously occurring nitric oxide donor, highlights the biological significance of CS-induced CFTR dysfunction-related autophagy impairment in mediating COPD-emphysema pathogenesis.
T320 227-423 Sentence denotes We showed that an augmentation of GSNO decreases cigarette smoke extract (CSE)-induced ROS activation and autophagy-flux impairment by rescuing the aggresome-bound perinuclear CFTR to the PM [62].
T321 424-808 Sentence denotes Furthermore, using a preclinical COPD-emphysema murine model, we demonstrated that chronic CS (Ch-CS) induced an increase in inflammatory cytokines in BALF, aggresome formation, CFTR-aggresome localization, oxidative/nitrosative stress, and apoptosis, and the emphysematous changes (alveolar airspace enlargement) were significantly improved by augmenting the airway GSNO levels [62].
T322 809-977 Sentence denotes Thus, this study provides proof-of-concept evidence that GSNO augmentation could be further tested as a potential strategy to correct CS-induced CFTR-autophagy defects.
T323 978-1241 Sentence denotes Apart from cysteamine and GSNO, we also tested the potential of other FDA-approved autophagy-inducing drugs, such as gemfibrozil (GEM), which induces lysosome formation, and fisetin, in controlling CS-induced autophagy dysfunction and hampered pathogen clearance.
T324 1242-1434 Sentence denotes Our study showed that CS/CSE-induced TFEB/autophagy impairment, inflammatory-oxidative stress, apoptosis, and senescence can be mitigated by treatment with GEM/fisetin via TFEB induction [34].
T325 1435-1648 Sentence denotes In a subsequent investigation, we demonstrated that CSE-induced autophagy dysfunction in macrophages is a critical mechanism of phagocytosis defects and the resulting diminished clearance of P. aeruginosa [33,35].
T326 1649-1916 Sentence denotes The autophagy-inducing antioxidant fisetin was able to restore the CS-induced phagocytosis defect and facilitate P. aeruginosa clearance [35], suggesting the potential of autophagy-inducing strategies in controlling exacerbations prevalent in COPD-emphysema subjects.