PMC:7565665 / 58686-65877
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T395 | 105-109 | Body_part | denotes | Lung | http://purl.org/sig/ont/fma/fma7195 |
| T396 | 239-243 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T397 | 559-563 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T398 | 744-748 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T399 | 830-834 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T400 | 835-841 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T401 | 1061-1063 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T402 | 1115-1117 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T403 | 1386-1399 | Body_part | denotes | autophagosome | http://purl.org/sig/ont/fma/fma0326100 |
| T404 | 1457-1459 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T405 | 1562-1566 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T406 | 1783-1785 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T407 | 2120-2127 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T408 | 2608-2612 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T409 | 2750-2752 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T410 | 3037-3039 | Body_part | denotes | PM | http://purl.org/sig/ont/fma/fma63841 |
| T411 | 3137-3139 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T412 | 3144-3146 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T413 | 3184-3193 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T414 | 3329-3337 | Body_part | denotes | alveolar | http://purl.org/sig/ont/fma/fma264783 |
| T415 | 3565-3567 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T416 | 3750-3758 | Body_part | denotes | lysosome | http://purl.org/sig/ont/fma/fma63836 |
| T417 | 3798-3800 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T418 | 3886-3888 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T419 | 4146-4157 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T420 | 4338-4340 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T421 | 4655-4659 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T422 | 4810-4814 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T423 | 4940-4944 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T424 | 5020-5028 | Body_part | denotes | Thymosin | http://purl.org/sig/ont/fma/fma67128 |
| T425 | 5151-5153 | Body_part | denotes | PM | http://purl.org/sig/ont/fma/fma63841 |
| T426 | 6059-6061 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T427 | 6141-6146 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T428 | 6678-6688 | Body_part | denotes | fibroblast | http://purl.org/sig/ont/fma/fma63877 |
| T429 | 6717-6742 | Body_part | denotes | alveolar epithelial cells | http://purl.org/sig/ont/fma/fma62499 |
| T430 | 6737-6742 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T431 | 6801-6803 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T432 | 6858-6866 | Body_part | denotes | collagen | http://purl.org/sig/ont/fma/fma63891 |
| T433 | 6888-6893 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T434 | 7051-7055 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T101 | 105-109 | Body_part | denotes | Lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T102 | 239-243 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T103 | 559-563 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T104 | 744-748 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T105 | 830-834 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T106 | 835-841 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T107 | 1562-1566 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T108 | 2608-2612 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T109 | 4655-4659 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T110 | 4810-4814 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T111 | 4940-4944 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T112 | 7051-7055 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T437 | 85-118 | Disease | denotes | Chronic Obstructive Lung Diseases | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T438 | 219-252 | Disease | denotes | chronic obstructive lung diseases | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T439 | 287-297 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T440 | 539-572 | Disease | denotes | chronic obstructive lung diseases | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T441 | 744-757 | Disease | denotes | lung diseases | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T442 | 867-883 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T443 | 1161-1170 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T444 | 1567-1573 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T445 | 1579-1583 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T446 | 1584-1593 | Disease | denotes | emphysema | http://purl.obolibrary.org/obo/MONDO_0004849 |
| T447 | 2436-2440 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T448 | 2441-2450 | Disease | denotes | emphysema | http://purl.obolibrary.org/obo/MONDO_0004849 |
| T449 | 2596-2620 | Disease | denotes | obstructive lung disease | http://purl.obolibrary.org/obo/MONDO_0002267 |
| T450 | 2608-2620 | Disease | denotes | lung disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T451 | 2820-2824 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T452 | 2825-2834 | Disease | denotes | emphysema | http://purl.obolibrary.org/obo/MONDO_0004849 |
| T453 | 3079-3083 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T454 | 3084-3093 | Disease | denotes | emphysema | http://purl.obolibrary.org/obo/MONDO_0004849 |
| T455 | 4514-4518 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T456 | 4519-4528 | Disease | denotes | emphysema | http://purl.obolibrary.org/obo/MONDO_0004849 |
| T457 | 4652-4654 | Disease | denotes | CF | http://purl.obolibrary.org/obo/MONDO_0009061 |
| T458 | 4655-4667 | Disease | denotes | lung disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T459 | 4693-4702 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T460 | 4799-4801 | Disease | denotes | CF | http://purl.obolibrary.org/obo/MONDO_0009061 |
| T461 | 4815-4825 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T462 | 5091-5093 | Disease | denotes | CF | http://purl.obolibrary.org/obo/MONDO_0009061 |
| T463 | 5428-5430 | Disease | denotes | CF | http://purl.obolibrary.org/obo/MONDO_0009061 |
| T464 | 5594-5596 | Disease | denotes | CF | http://purl.obolibrary.org/obo/MONDO_0009061 |
| T465 | 5983-5985 | Disease | denotes | CF | http://purl.obolibrary.org/obo/MONDO_0009061 |
| T466 | 6210-6214 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T467 | 6219-6221 | Disease | denotes | CF | http://purl.obolibrary.org/obo/MONDO_0009061 |
| T468 | 6230-6240 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T469 | 6324-6337 | Disease | denotes | infections in | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T470 | 6338-6342 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T471 | 6347-6349 | Disease | denotes | CF | http://purl.obolibrary.org/obo/MONDO_0009061 |
| T472 | 6444-6447 | Disease | denotes | IPF | http://purl.obolibrary.org/obo/MONDO_0002429|http://purl.obolibrary.org/obo/MONDO_0008345 |
| T474 | 6555-6558 | Disease | denotes | IPF | http://purl.obolibrary.org/obo/MONDO_0002429|http://purl.obolibrary.org/obo/MONDO_0008345 |
| T476 | 6643-6646 | Disease | denotes | IPF | http://purl.obolibrary.org/obo/MONDO_0002429|http://purl.obolibrary.org/obo/MONDO_0008345 |
| T478 | 6841-6853 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T479 | 7031-7063 | Disease | denotes | chronic obstructive lung disease | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T480 | 7039-7063 | Disease | denotes | obstructive lung disease | http://purl.obolibrary.org/obo/MONDO_0002267 |
| T481 | 7051-7063 | Disease | denotes | lung disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T701 | 105-109 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | Lung |
| T702 | 105-109 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | Lung |
| T703 | 149-153 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T704 | 172-173 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T705 | 239-243 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T706 | 239-243 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T707 | 469-473 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T708 | 495-496 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T709 | 559-563 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T710 | 559-563 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T711 | 744-748 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T712 | 744-748 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T713 | 830-834 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T714 | 830-834 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T715 | 998-1002 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T716 | 1015-1018 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T717 | 1203-1209 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T718 | 1263-1264 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T719 | 1328-1329 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T720 | 1562-1566 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T721 | 1562-1566 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T722 | 1741-1745 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T723 | 1803-1807 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T724 | 1896-1902 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airway |
| T725 | 2397-2398 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T726 | 2608-2612 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T727 | 2608-2612 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T728 | 2761-2765 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T729 | 2940-2950 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T730 | 3025-3029 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T731 | 3065-3066 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T732 | 3224-3228 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T733 | 3406-3412 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airway |
| T734 | 3523-3529 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T735 | 3533-3534 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T736 | 3576-3580 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T737 | 3640-3646 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T738 | 3750-3758 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosome |
| T739 | 4052-4054 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 34 |
| T740 | 4060-4061 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T741 | 4161-4162 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T742 | 4409-4411 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T743 | 4595-4598 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T744 | 4655-4659 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T745 | 4655-4659 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T746 | 4810-4814 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T747 | 4810-4814 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T748 | 4940-4944 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T749 | 4940-4944 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T750 | 5011-5018 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T751 | 5139-5143 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T752 | 5155-5162 | http://purl.obolibrary.org/obo/CLO_0009381 | denotes | 203]. T |
| T753 | 5304-5308 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T754 | 5507-5508 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T755 | 5568-5571 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T756 | 5584-5590 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T757 | 5670-5675 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T758 | 5719-5720 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T759 | 5778-5782 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T760 | 5805-5806 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T761 | 5834-5838 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T762 | 6141-6146 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T763 | 6148-6150 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T764 | 6386-6389 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T765 | 6418-6419 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T766 | 6678-6688 | http://purl.obolibrary.org/obo/CL_0000057 | denotes | fibroblast |
| T767 | 6726-6736 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T768 | 6737-6742 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T769 | 6760-6761 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T770 | 6858-6866 | http://purl.obolibrary.org/obo/CHEBI_3815 | denotes | collagen |
| T771 | 6888-6893 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T772 | 7001-7002 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T773 | 7051-7055 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T774 | 7051-7055 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T73 | 1061-1063 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T91727 | 1115-1117 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T38305 | 1251-1261 | Chemical | denotes | cysteamine | http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029 |
| T134 | 1457-1459 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T56457 | 1618-1628 | Chemical | denotes | cysteamine | http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029 |
| T80 | 1678-1689 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T73677 | 1705-1714 | Chemical | denotes | mucolytic | http://purl.obolibrary.org/obo/CHEBI_77034 |
| T72726 | 1783-1785 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T49800 | 1972-1981 | Chemical | denotes | dendrimer | http://purl.obolibrary.org/obo/CHEBI_51338|http://purl.obolibrary.org/obo/CHEBI_61483 |
| T62899 | 2139-2148 | Chemical | denotes | dendrimer | http://purl.obolibrary.org/obo/CHEBI_51338|http://purl.obolibrary.org/obo/CHEBI_61483 |
| T47656 | 2155-2160 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T15350 | 2346-2356 | Chemical | denotes | cysteamine | http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029 |
| T54058 | 2369-2378 | Chemical | denotes | dendrimer | http://purl.obolibrary.org/obo/CHEBI_51338|http://purl.obolibrary.org/obo/CHEBI_61483 |
| T77653 | 2656-2660 | Chemical | denotes | GSNO | http://purl.obolibrary.org/obo/CHEBI_50091 |
| T90481 | 2688-2706 | Chemical | denotes | nitric oxide donor | http://purl.obolibrary.org/obo/CHEBI_50566 |
| T28575 | 2688-2700 | Chemical | denotes | nitric oxide | http://purl.obolibrary.org/obo/CHEBI_16480 |
| T41830 | 2695-2700 | Chemical | denotes | oxide | http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356 |
| T97 | 2701-2706 | Chemical | denotes | donor | http://purl.obolibrary.org/obo/CHEBI_17891 |
| T18880 | 2750-2752 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T99 | 2883-2887 | Chemical | denotes | GSNO | http://purl.obolibrary.org/obo/CHEBI_50091 |
| T100 | 2936-2939 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T38467 | 3037-3039 | Chemical | denotes | PM | http://purl.obolibrary.org/obo/CHEBI_141444|http://purl.obolibrary.org/obo/CHEBI_16410|http://purl.obolibrary.org/obo/CHEBI_53551 |
| T23686 | 3137-3139 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T105 | 3144-3146 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T44313 | 3413-3417 | Chemical | denotes | GSNO | http://purl.obolibrary.org/obo/CHEBI_50091 |
| T97111 | 3488-3492 | Chemical | denotes | GSNO | http://purl.obolibrary.org/obo/CHEBI_50091 |
| T108 | 3565-3567 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T109 | 3611-3621 | Chemical | denotes | cysteamine | http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029 |
| T111 | 3626-3630 | Chemical | denotes | GSNO | http://purl.obolibrary.org/obo/CHEBI_50091 |
| T112 | 3702-3707 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T54131 | 3717-3728 | Chemical | denotes | gemfibrozil | http://purl.obolibrary.org/obo/CHEBI_5296 |
| T17954 | 3730-3733 | Chemical | denotes | GEM | http://purl.obolibrary.org/obo/CHEBI_5296 |
| T48946 | 3774-3781 | Chemical | denotes | fisetin | http://purl.obolibrary.org/obo/CHEBI_42567 |
| T116 | 3798-3800 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T117 | 3886-3888 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T16262 | 4020-4023 | Chemical | denotes | GEM | http://purl.obolibrary.org/obo/CHEBI_5296 |
| T83227 | 4024-4031 | Chemical | denotes | fisetin | http://purl.obolibrary.org/obo/CHEBI_42567 |
| T14089 | 4294-4305 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T9718 | 4306-4313 | Chemical | denotes | fisetin | http://purl.obolibrary.org/obo/CHEBI_42567 |
| T93835 | 4338-4340 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T87765 | 4589-4594 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T5256 | 4774-4783 | Chemical | denotes | rapamycin | http://purl.obolibrary.org/obo/CHEBI_9168 |
| T13696 | 5011-5018 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T67833 | 5151-5153 | Chemical | denotes | PM | http://purl.obolibrary.org/obo/CHEBI_141444|http://purl.obolibrary.org/obo/CHEBI_16410|http://purl.obolibrary.org/obo/CHEBI_53551 |
| T129 | 5495-5505 | Chemical | denotes | cysteamine | http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029 |
| T27730 | 5516-5527 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T79502 | 5528-5532 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T133 | 5853-5863 | Chemical | denotes | cysteamine | http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029 |
| T17243 | 6028-6038 | Chemical | denotes | cysteamine | http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_58029 |
| T137 | 6059-6061 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T8987 | 6109-6117 | Chemical | denotes | ceramide | http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639 |
| T140 | 6292-6300 | Chemical | denotes | ceramide | http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639 |
| T96107 | 6801-6803 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T144 | 6823-6832 | Chemical | denotes | bleomycin | http://purl.obolibrary.org/obo/CHEBI_22907 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1477 | 85-118 | Disease | denotes | Chronic Obstructive Lung Diseases | MESH:D029424 |
| 1500 | 1741-1745 | Gene | denotes | CFTR | Gene:1080 |
| 1501 | 627-633 | Species | denotes | murine | Tax:10090 |
| 1502 | 1098-1104 | Species | denotes | murine | Tax:10090 |
| 1503 | 1251-1261 | Chemical | denotes | cysteamine | MESH:D003543 |
| 1504 | 1298-1308 | Chemical | denotes | aminothiol | |
| 1505 | 1618-1628 | Chemical | denotes | cysteamine | MESH:D003543 |
| 1506 | 2346-2356 | Chemical | denotes | cysteamine | MESH:D003543 |
| 1507 | 149-165 | Disease | denotes | CFTR dysfunction | MESH:D009461 |
| 1508 | 219-252 | Disease | denotes | chronic obstructive lung diseases | MESH:D029424 |
| 1509 | 287-297 | Disease | denotes | infections | MESH:D007239 |
| 1510 | 363-372 | Disease | denotes | mortality | MESH:D003643 |
| 1511 | 469-485 | Disease | denotes | CFTR dysfunction | MESH:D009461 |
| 1512 | 539-572 | Disease | denotes | chronic obstructive lung diseases | MESH:D029424 |
| 1513 | 744-757 | Disease | denotes | lung diseases | MESH:D008171 |
| 1514 | 867-883 | Disease | denotes | viral infections | MESH:D001102 |
| 1515 | 998-1014 | Disease | denotes | CFTR dysfunction | MESH:D009461 |
| 1516 | 1147-1170 | Disease | denotes | aeruginosa co-infection | MESH:D060085 |
| 1517 | 1562-1573 | Disease | denotes | lung injury | MESH:D055370 |
| 1518 | 1579-1593 | Disease | denotes | COPD-emphysema | MESH:D029424 |
| 1519 | 1803-1819 | Disease | denotes | CFTR dysfunction | MESH:D009461 |
| 1520 | 2436-2450 | Disease | denotes | COPD-emphysema | MESH:D029424 |
| 1521 | 2596-2620 | Disease | denotes | obstructive lung disease | MESH:D008173 |
| 1550 | 3025-3029 | Gene | denotes | CFTR | Gene:1080 |
| 1551 | 3224-3228 | Gene | denotes | CFTR | Gene:12638 |
| 1552 | 3576-3580 | Gene | denotes | CFTR | Gene:12638 |
| 1553 | 3901-3905 | Gene | denotes | TFEB | Gene:7942 |
| 1554 | 4036-4040 | Gene | denotes | TFEB | Gene:7942 |
| 1555 | 2750-2752 | Gene | denotes | CS | Gene:1431 |
| 1556 | 2898-2913 | Gene | denotes | cigarette smoke | Gene:1431 |
| 1557 | 3094-3100 | Species | denotes | murine | Tax:10090 |
| 1558 | 4248-4261 | Species | denotes | P. aeruginosa | Tax:287 |
| 1559 | 4384-4397 | Species | denotes | P. aeruginosa | Tax:287 |
| 1560 | 2656-2660 | Chemical | denotes | GSNO | |
| 1561 | 2688-2700 | Chemical | denotes | nitric oxide | MESH:D009569 |
| 1562 | 2883-2887 | Chemical | denotes | GSNO | |
| 1563 | 3413-3417 | Chemical | denotes | GSNO | |
| 1564 | 3488-3492 | Chemical | denotes | GSNO | |
| 1565 | 3611-3621 | Chemical | denotes | cysteamine | MESH:D003543 |
| 1566 | 3626-3630 | Chemical | denotes | GSNO | |
| 1567 | 3717-3728 | Chemical | denotes | gemfibrozil | MESH:D015248 |
| 1568 | 3730-3733 | Chemical | denotes | GEM | MESH:D015248 |
| 1569 | 4020-4023 | Chemical | denotes | GEM | MESH:D015248 |
| 1570 | 4024-4031 | Chemical | denotes | fisetin | MESH:C017875 |
| 1571 | 4306-4313 | Chemical | denotes | fisetin | MESH:C017875 |
| 1572 | 2761-2777 | Disease | denotes | CFTR dysfunction | MESH:D009461 |
| 1573 | 2820-2834 | Disease | denotes | COPD-emphysema | MESH:D029424 |
| 1574 | 3079-3093 | Disease | denotes | COPD-emphysema | MESH:D029424 |
| 1575 | 4185-4205 | Disease | denotes | phagocytosis defects | MESH:D000014 |
| 1576 | 4349-4368 | Disease | denotes | phagocytosis defect | MESH:D000014 |
| 1577 | 4514-4528 | Disease | denotes | COPD-emphysema | MESH:D029424 |
| 1602 | 5034-5037 | Gene | denotes | Tα1 | Gene:134864 |
| 1603 | 5139-5143 | Gene | denotes | CFTR | Gene:1080 |
| 1604 | 5161-5164 | Gene | denotes | Tα1 | Gene:134864 |
| 1605 | 5304-5308 | Gene | denotes | CFTR | Gene:1080 |
| 1606 | 5778-5782 | Gene | denotes | CFTR | Gene:1080 |
| 1607 | 5834-5838 | Gene | denotes | CFTR | Gene:1080 |
| 1608 | 5670-5675 | Species | denotes | human | Tax:9606 |
| 1609 | 5754-5762 | Species | denotes | patients | Tax:9606 |
| 1610 | 6134-6140 | Species | denotes | murine | Tax:10090 |
| 1611 | 4774-4783 | Chemical | denotes | rapamycin | MESH:D020123 |
| 1612 | 5495-5505 | Chemical | denotes | cysteamine | MESH:D003543 |
| 1613 | 5853-5863 | Chemical | denotes | cysteamine | MESH:D003543 |
| 1614 | 5921-5931 | Chemical | denotes | cysteamine | MESH:D003543 |
| 1615 | 6028-6038 | Chemical | denotes | cysteamine | MESH:D003543 |
| 1616 | 6109-6117 | Chemical | denotes | ceramide | MESH:D002518 |
| 1617 | 6292-6300 | Chemical | denotes | ceramide | MESH:D002518 |
| 1618 | 4644-4667 | Disease | denotes | chronic CF lung disease | MESH:D003550 |
| 1619 | 4683-4702 | Disease | denotes | pulmonary infection | MESH:D012141 |
| 1620 | 4810-4825 | Disease | denotes | lung infections | MESH:D012141 |
| 1621 | 4940-4953 | Disease | denotes | lung toxicity | MESH:D008171 |
| 1622 | 6210-6214 | Disease | denotes | COPD | MESH:D029424 |
| 1623 | 6219-6240 | Disease | denotes | CF-related infections | MESH:D003550 |
| 1624 | 6314-6334 | Disease | denotes | pulmonary infections | MESH:D012141 |
| 1625 | 6338-6342 | Disease | denotes | COPD | MESH:D029424 |
| 1630 | 6908-6916 | Gene | denotes | Beclin-1 | Gene:56208 |
| 1631 | 6881-6887 | Species | denotes | murine | Tax:10090 |
| 1632 | 6823-6832 | Chemical | denotes | bleomycin | MESH:D001761 |
| 1633 | 6841-6853 | Disease | denotes | inflammation | MESH:D007249 |
| 1637 | 7162-7169 | Species | denotes | patient | Tax:9606 |
| 1638 | 7031-7063 | Disease | denotes | chronic obstructive lung disease | MESH:D029424 |
| 1639 | 7170-7179 | Disease | denotes | mortality | MESH:D003643 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T188 | 93-118 | Phenotype | denotes | Obstructive Lung Diseases | http://purl.obolibrary.org/obo/HP_0006536 |
| T189 | 227-252 | Phenotype | denotes | obstructive lung diseases | http://purl.obolibrary.org/obo/HP_0006536 |
| T190 | 277-297 | Phenotype | denotes | recurrent infections | http://purl.obolibrary.org/obo/HP_0002719 |
| T191 | 547-572 | Phenotype | denotes | obstructive lung diseases | http://purl.obolibrary.org/obo/HP_0006536 |
| T192 | 736-757 | Phenotype | denotes | chronic lung diseases | http://purl.obolibrary.org/obo/HP_0006528 |
| T193 | 780-796 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T194 | 1492-1508 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T195 | 1579-1583 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T196 | 1584-1593 | Phenotype | denotes | emphysema | http://purl.obolibrary.org/obo/HP_0002097 |
| T197 | 2436-2440 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T198 | 2441-2450 | Phenotype | denotes | emphysema | http://purl.obolibrary.org/obo/HP_0002097 |
| T199 | 2596-2620 | Phenotype | denotes | obstructive lung disease | http://purl.obolibrary.org/obo/HP_0006536 |
| T200 | 2820-2824 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T201 | 2825-2834 | Phenotype | denotes | emphysema | http://purl.obolibrary.org/obo/HP_0002097 |
| T202 | 3079-3083 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T203 | 3084-3093 | Phenotype | denotes | emphysema | http://purl.obolibrary.org/obo/HP_0002097 |
| T204 | 3941-3957 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T205 | 4514-4518 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T206 | 4519-4528 | Phenotype | denotes | emphysema | http://purl.obolibrary.org/obo/HP_0002097 |
| T207 | 4655-4667 | Phenotype | denotes | lung disease | http://purl.obolibrary.org/obo/HP_0002088 |
| T208 | 4683-4702 | Phenotype | denotes | pulmonary infection | http://purl.obolibrary.org/obo/HP_0006532 |
| T209 | 6210-6214 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T210 | 6314-6334 | Phenotype | denotes | pulmonary infections | http://purl.obolibrary.org/obo/HP_0006532 |
| T211 | 6338-6342 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T212 | 7039-7063 | Phenotype | denotes | obstructive lung disease | http://purl.obolibrary.org/obo/HP_0006536 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T791 | 3-12 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | Autophagy |
| T792 | 3-12 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | Autophagy |
| T793 | 53-65 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | Pathogenesis |
| T794 | 139-148 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T795 | 139-148 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T796 | 149-153 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T797 | 203-215 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T798 | 459-468 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T799 | 459-468 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T800 | 469-473 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T801 | 573-585 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T802 | 672-681 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T803 | 672-681 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T804 | 798-807 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T805 | 798-807 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T806 | 809-828 | http://purl.obolibrary.org/obo/GO_0090398 | denotes | cellular senescence |
| T807 | 867-883 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T808 | 988-997 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T809 | 988-997 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T810 | 998-1002 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T811 | 1353-1362 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T812 | 1353-1362 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T813 | 1386-1409 | http://purl.obolibrary.org/obo/GO_0000045 | denotes | autophagosome formation |
| T814 | 1400-1409 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T815 | 1465-1470 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
| T816 | 1510-1519 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T817 | 1510-1519 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T818 | 1521-1540 | http://purl.obolibrary.org/obo/GO_0090398 | denotes | cellular senescence |
| T819 | 1741-1745 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T820 | 1803-1807 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T821 | 2761-2765 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T822 | 2786-2795 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T823 | 2786-2795 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T824 | 2835-2847 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T825 | 2955-2964 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T826 | 2955-2964 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T827 | 3025-3029 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T828 | 3213-3222 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T829 | 3224-3228 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T830 | 3239-3251 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
| T831 | 3287-3296 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T832 | 3287-3296 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T833 | 3576-3580 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T834 | 3581-3590 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T835 | 3581-3590 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T836 | 3683-3692 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T837 | 3683-3692 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T838 | 3759-3768 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T839 | 3809-3818 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T840 | 3809-3818 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T841 | 3906-3915 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T842 | 3906-3915 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T843 | 3959-3968 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T844 | 3959-3968 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T845 | 4121-4130 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T846 | 4121-4130 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T847 | 4185-4197 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
| T848 | 4275-4284 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T849 | 4275-4284 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T850 | 4349-4361 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
| T851 | 4442-4451 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T852 | 4442-4451 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T853 | 4568-4577 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T854 | 4568-4577 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T855 | 5139-5143 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T856 | 5232-5241 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T857 | 5232-5241 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T858 | 5304-5308 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T859 | 5439-5448 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T860 | 5439-5448 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T861 | 5538-5547 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T862 | 5538-5547 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T863 | 5778-5782 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T864 | 5834-5838 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T865 | 6070-6079 | http://purl.obolibrary.org/obo/GO_0061724 | denotes | lipophagy |
| T866 | 6364-6373 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T867 | 6364-6373 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T868 | 6480-6489 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T869 | 6480-6489 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T870 | 6559-6571 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T871 | 6623-6632 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T872 | 6623-6632 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T873 | 6647-6659 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T874 | 6663-6698 | http://purl.obolibrary.org/obo/GO_2000269 | denotes | regulating the fibroblast apoptosis |
| T875 | 6678-6698 | http://purl.obolibrary.org/obo/GO_0044346 | denotes | fibroblast apoptosis |
| T876 | 6689-6698 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T877 | 6689-6698 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T878 | 6841-6853 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T879 | 6927-6936 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T880 | 6927-6936 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T881 | 6955-6964 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T882 | 6955-6964 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T883 | 7064-7076 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T308 | 0-2 | Sentence | denotes | 8. |
| T309 | 3-118 | Sentence | denotes | Autophagy Augmentation Strategies to Mitigate the Pathogenesis and Progression of Chronic Obstructive Lung Diseases |
| T310 | 119-373 | Sentence | denotes | As discussed above, autophagy-CFTR dysfunction plays a vital role in regulating the pathogenesis of chronic obstructive lung diseases, including facilitating recurrent infections leading to severe disease exacerbations and an increased risk of mortality. |
| T311 | 374-586 | Sentence | denotes | Therefore, it is apparent that pharmacological interventions targeted to correct the autophagy-CFTR dysfunction provides a lucrative therapeutic strategy to control chronic obstructive lung diseases pathogenesis. |
| T312 | 587-916 | Sentence | denotes | Indeed, using in vitro and pre-clinical murine models, we and others have shown that autophagy augmentation mitigates several pathogenic features of chronic lung diseases, such as inflammatory-oxidative stress, apoptosis, cellular senescence, lung tissue damage, and bacterial or viral infections [22,35,42,45,58,62,149,151,153]. |
| T313 | 917-1182 | Sentence | denotes | The utility of pharmacological or natural compounds that can alleviate autophagy-CFTR dysfunction has been comprehensively investigated in both CS-induced in vitro and pre-clinical murine models of CS exposure, with or without P. aeruginosa co-infection [34,35,42]. |
| T314 | 1183-1605 | Sentence | denotes | We have extensively tested the pre-clinical therapeutic efficacy of cysteamine, a naturally occurring FDA-approved aminothiol compound, which is a known proteostasis and autophagy regulator that induces autophagosome formation, in controlling various pathogenic features of CS- and aging-induced inflammatory-oxidative stress, apoptosis, cellular senescence, pathogen clearance, lung injury, and COPD-emphysema [22,33,94]. |
| T315 | 1606-1920 | Sentence | denotes | Even though cysteamine offers several beneficial attributes such as its antioxidant, bactericidal, mucolytic, and, the most promising, CFTR-rescuing potential that corrects the CS-induced acquired CFTR dysfunction, there are some limitations such as the optimization of beneficial dose and airway delivery methods. |
| T316 | 1921-2078 | Sentence | denotes | We and others have devised strategies such as nano/dendrimer-based formulations which can be efficiently delivered through intranasal inhalation [42,45,149]. |
| T317 | 2079-2329 | Sentence | denotes | The more specific targeting of pulmonary tissues using nano/dendrimer-based drugs improves the therapeutic potential while mitigating some system-wide side effects that may be associated with systemic and nontargeted delivery methods [42,45,149,201]. |
| T318 | 2330-2621 | Sentence | denotes | We believe that cysteamine or its nano/dendrimer formulations have a significant potential of controlling COPD-emphysema pathogenic features, including recurrent exacerbations, based on its known pre-clinical efficacy and ongoing clinical evaluations in controlling obstructive lung disease. |
| T319 | 2622-2848 | Sentence | denotes | Our relatively recent study using GSNO, an endogenously occurring nitric oxide donor, highlights the biological significance of CS-induced CFTR dysfunction-related autophagy impairment in mediating COPD-emphysema pathogenesis. |
| T320 | 2849-3045 | Sentence | denotes | We showed that an augmentation of GSNO decreases cigarette smoke extract (CSE)-induced ROS activation and autophagy-flux impairment by rescuing the aggresome-bound perinuclear CFTR to the PM [62]. |
| T321 | 3046-3430 | Sentence | denotes | Furthermore, using a preclinical COPD-emphysema murine model, we demonstrated that chronic CS (Ch-CS) induced an increase in inflammatory cytokines in BALF, aggresome formation, CFTR-aggresome localization, oxidative/nitrosative stress, and apoptosis, and the emphysematous changes (alveolar airspace enlargement) were significantly improved by augmenting the airway GSNO levels [62]. |
| T322 | 3431-3599 | Sentence | denotes | Thus, this study provides proof-of-concept evidence that GSNO augmentation could be further tested as a potential strategy to correct CS-induced CFTR-autophagy defects. |
| T323 | 3600-3863 | Sentence | denotes | Apart from cysteamine and GSNO, we also tested the potential of other FDA-approved autophagy-inducing drugs, such as gemfibrozil (GEM), which induces lysosome formation, and fisetin, in controlling CS-induced autophagy dysfunction and hampered pathogen clearance. |
| T324 | 3864-4056 | Sentence | denotes | Our study showed that CS/CSE-induced TFEB/autophagy impairment, inflammatory-oxidative stress, apoptosis, and senescence can be mitigated by treatment with GEM/fisetin via TFEB induction [34]. |
| T325 | 4057-4270 | Sentence | denotes | In a subsequent investigation, we demonstrated that CSE-induced autophagy dysfunction in macrophages is a critical mechanism of phagocytosis defects and the resulting diminished clearance of P. aeruginosa [33,35]. |
| T326 | 4271-4538 | Sentence | denotes | The autophagy-inducing antioxidant fisetin was able to restore the CS-induced phagocytosis defect and facilitate P. aeruginosa clearance [35], suggesting the potential of autophagy-inducing strategies in controlling exacerbations prevalent in COPD-emphysema subjects. |
| T327 | 4539-4725 | Sentence | denotes | The therapeutic potential of autophagy augmenting drugs has been extensively investigated in controlling chronic CF lung disease and associated pulmonary infection-related exacerbations. |
| T328 | 4726-4975 | Sentence | denotes | There have been extensive studies on the use of rapamycin in controlling CF-related lung infections, but its clinical use is hampered due to its potent immunosuppressive property and certain reports of significant lung toxicity [5,6,44,151,153,202]. |
| T329 | 4976-5160 | Sentence | denotes | Lately, the efficacy of the thymic peptide, Thymosin α-1 (Tα1), was demonstrated in correcting the basic defect in CF, which is the restoration of misfolded ΔF508-CFTR to the PM [203]. |
| T330 | 5161-5309 | Sentence | denotes | Tα1 possesses anti-inflammatory properties and is also known to induce autophagy [204], which could be its mechanism of action to rescue ΔF508-CFTR. |
| T331 | 5310-5479 | Sentence | denotes | Nonetheless, future pre-clinical and clinical studies will be essential before it could be any therapeutic benefit in CF-related autophagy dysfunction and exacerbations. |
| T332 | 5480-5709 | Sentence | denotes | The utility of cysteamine, a potent antioxidant drug with autophagy-inducing potential, has been widely tested in CF in vitro, in vivo models, and is currently being investigated in phase 2 human clinical trials [58,205,206,207]. |
| T333 | 5710-5880 | Sentence | denotes | However, a previously completed study of 10 patients with the ΔF508-CFTR mutation demonstrated a significant improvement in CFTR function with cysteamine treatment [208]. |
| T334 | 5881-6152 | Sentence | denotes | Similarly, our recent studies validated cysteamine’s extensive repertoire of protective mechanisms in CF, and demonstrated for the first time that cysteamine was able to control CS-induced lipophagy impairment and the resulting ceramide accumulation in murine lungs [22]. |
| T335 | 6153-6350 | Sentence | denotes | This finding might have implications in controlling both COPD and CF-related infections and exacerbations, knowing the deleterious role of ceramide in promoting pulmonary infections in COPD and CF. |
| T336 | 6351-6578 | Sentence | denotes | In addition, autophagy dysfunction has been now widely accepted as a pathogenic mechanism in IPF, and thus strategies to augment autophagy are justified as relevant potential interventions in controlling IPF pathogenesis [209]. |
| T337 | 6579-6749 | Sentence | denotes | Indeed, some recent studies have shown that autophagy mitigates IPF pathogenesis by regulating the fibroblast apoptosis and senescence of alveolar epithelial cells [209]. |
| T338 | 6750-6943 | Sentence | denotes | Moreover, a recent report describes the utility of IL-37 in reducing the bleomycin-induced inflammation and collagen deposition in murine lungs by increasing Beclin-1-dependent autophagy [158]. |
| T339 | 6944-7191 | Sentence | denotes | Therefore, autophagy augmentation strategies likely have a strong potential to control chronic obstructive lung disease pathogenesis, including suppressing the severe pulmonary exacerbations which frequently result in patient mortality (Figure 2). |