PMC:7565665 / 57175-57520
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T389 | 68-70 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T390 | 320-324 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T98 | 320-324 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T419 | 157-161 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T420 | 162-171 | Disease | denotes | emphysema | http://purl.obolibrary.org/obo/MONDO_0004849 |
| T421 | 320-333 | Disease | denotes | lung diseases | http://purl.obolibrary.org/obo/MONDO_0005275 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T680 | 79-83 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T681 | 186-188 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T682 | 229-233 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T683 | 320-324 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T684 | 320-324 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T56 | 68-70 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T23892 | 97-105 | Chemical | denotes | ceramide | http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1415 | 229-233 | Gene | denotes | CFTR | Gene:1080 |
| 1424 | 68-70 | Gene | denotes | CS | Gene:1431 |
| 1443 | 97-105 | Chemical | denotes | ceramide | MESH:D002518 |
| 1466 | 79-95 | Disease | denotes | CFTR dysfunction | MESH:D009461 |
| 1467 | 157-171 | Disease | denotes | COPD-emphysema | MESH:D029424 |
| 1468 | 320-333 | Disease | denotes | lung diseases | MESH:D008171 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T181 | 157-161 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T182 | 162-171 | Phenotype | denotes | emphysema | http://purl.obolibrary.org/obo/HP_0002097 |
| T183 | 312-333 | Phenotype | denotes | chronic lung diseases | http://purl.obolibrary.org/obo/HP_0006528 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T771 | 34-43 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T772 | 34-43 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T773 | 79-83 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T774 | 120-129 | http://purl.obolibrary.org/obo/GO_0061724 | denotes | lipophagy |
| T775 | 172-184 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T776 | 215-224 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T777 | 215-224 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T778 | 229-233 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T301 | 0-345 | Sentence | denotes | Lately, we also demonstrated that autophagy augmentation alleviates CS-induced CFTR dysfunction, ceramide accumulation (lipophagy impairment), and resulting COPD-emphysema pathogenesis [22], thus demonstrating that autophagy and CFTR share an interconnected biology crucial for the initiation and progression of chronic lung diseases (Figure 1). |