PMC:7565665 / 56317-56634 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T384","span":{"begin":187,"end":189},"obj":"Body_part"},{"id":"T385","span":{"begin":210,"end":212},"obj":"Body_part"}],"attributes":[{"id":"A384","pred":"fma_id","subj":"T384","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A385","pred":"fma_id","subj":"T385","obj":"http://purl.org/sig/ont/fma/fma284995"}],"text":"Moreover, the mechanistic confirmation of the role of acquired CFTR dysfunction in COPD pathogenesis comes from studies which showed that the pharmacological rescue of mutant CFTR to the PM was able to correct CS-induced inflammatory-oxidative stress, autophagy impairment, and COPD-emphysema pathogenesis [14,42,62]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T411","span":{"begin":83,"end":87},"obj":"Disease"},{"id":"T412","span":{"begin":278,"end":282},"obj":"Disease"},{"id":"T413","span":{"begin":283,"end":292},"obj":"Disease"}],"attributes":[{"id":"A411","pred":"mondo_id","subj":"T411","obj":"http://purl.obolibrary.org/obo/MONDO_0005002"},{"id":"A412","pred":"mondo_id","subj":"T412","obj":"http://purl.obolibrary.org/obo/MONDO_0005002"},{"id":"A413","pred":"mondo_id","subj":"T413","obj":"http://purl.obolibrary.org/obo/MONDO_0004849"}],"text":"Moreover, the mechanistic confirmation of the role of acquired CFTR dysfunction in COPD pathogenesis comes from studies which showed that the pharmacological rescue of mutant CFTR to the PM was able to correct CS-induced inflammatory-oxidative stress, autophagy impairment, and COPD-emphysema pathogenesis [14,42,62]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T672","span":{"begin":63,"end":67},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T673","span":{"begin":175,"end":179},"obj":"http://purl.obolibrary.org/obo/PR_000001044"}],"text":"Moreover, the mechanistic confirmation of the role of acquired CFTR dysfunction in COPD pathogenesis comes from studies which showed that the pharmacological rescue of mutant CFTR to the PM was able to correct CS-induced inflammatory-oxidative stress, autophagy impairment, and COPD-emphysema pathogenesis [14,42,62]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T52316","span":{"begin":187,"end":189},"obj":"Chemical"},{"id":"T37185","span":{"begin":210,"end":212},"obj":"Chemical"}],"attributes":[{"id":"A47635","pred":"chebi_id","subj":"T52316","obj":"http://purl.obolibrary.org/obo/CHEBI_141444"},{"id":"A79472","pred":"chebi_id","subj":"T52316","obj":"http://purl.obolibrary.org/obo/CHEBI_16410"},{"id":"A8169","pred":"chebi_id","subj":"T52316","obj":"http://purl.obolibrary.org/obo/CHEBI_53551"},{"id":"A7723","pred":"chebi_id","subj":"T37185","obj":"http://purl.obolibrary.org/obo/CHEBI_73462"}],"text":"Moreover, the mechanistic confirmation of the role of acquired CFTR dysfunction in COPD pathogenesis comes from studies which showed that the pharmacological rescue of mutant CFTR to the PM was able to correct CS-induced inflammatory-oxidative stress, autophagy impairment, and COPD-emphysema pathogenesis [14,42,62]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1411","span":{"begin":175,"end":179},"obj":"Gene"},{"id":"1426","span":{"begin":210,"end":212},"obj":"Gene"},{"id":"1461","span":{"begin":63,"end":79},"obj":"Disease"},{"id":"1462","span":{"begin":83,"end":87},"obj":"Disease"},{"id":"1463","span":{"begin":278,"end":292},"obj":"Disease"}],"attributes":[{"id":"A1411","pred":"tao:has_database_id","subj":"1411","obj":"Gene:1080"},{"id":"A1426","pred":"tao:has_database_id","subj":"1426","obj":"Gene:1431"},{"id":"A1461","pred":"tao:has_database_id","subj":"1461","obj":"MESH:D009461"},{"id":"A1462","pred":"tao:has_database_id","subj":"1462","obj":"MESH:D029424"},{"id":"A1463","pred":"tao:has_database_id","subj":"1463","obj":"MESH:D029424"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Moreover, the mechanistic confirmation of the role of acquired CFTR dysfunction in COPD pathogenesis comes from studies which showed that the pharmacological rescue of mutant CFTR to the PM was able to correct CS-induced inflammatory-oxidative stress, autophagy impairment, and COPD-emphysema pathogenesis [14,42,62]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T173","span":{"begin":83,"end":87},"obj":"Phenotype"},{"id":"T174","span":{"begin":234,"end":250},"obj":"Phenotype"},{"id":"T175","span":{"begin":278,"end":282},"obj":"Phenotype"},{"id":"T176","span":{"begin":283,"end":292},"obj":"Phenotype"}],"attributes":[{"id":"A173","pred":"hp_id","subj":"T173","obj":"http://purl.obolibrary.org/obo/HP_0006510"},{"id":"A174","pred":"hp_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/HP_0025464"},{"id":"A175","pred":"hp_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/HP_0006510"},{"id":"A176","pred":"hp_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/HP_0002097"}],"text":"Moreover, the mechanistic confirmation of the role of acquired CFTR dysfunction in COPD pathogenesis comes from studies which showed that the pharmacological rescue of mutant CFTR to the PM was able to correct CS-induced inflammatory-oxidative stress, autophagy impairment, and COPD-emphysema pathogenesis [14,42,62]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T759","span":{"begin":63,"end":67},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T760","span":{"begin":88,"end":100},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T761","span":{"begin":175,"end":179},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T762","span":{"begin":252,"end":261},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T763","span":{"begin":252,"end":261},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T764","span":{"begin":293,"end":305},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"Moreover, the mechanistic confirmation of the role of acquired CFTR dysfunction in COPD pathogenesis comes from studies which showed that the pharmacological rescue of mutant CFTR to the PM was able to correct CS-induced inflammatory-oxidative stress, autophagy impairment, and COPD-emphysema pathogenesis [14,42,62]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T298","span":{"begin":0,"end":317},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Moreover, the mechanistic confirmation of the role of acquired CFTR dysfunction in COPD pathogenesis comes from studies which showed that the pharmacological rescue of mutant CFTR to the PM was able to correct CS-induced inflammatory-oxidative stress, autophagy impairment, and COPD-emphysema pathogenesis [14,42,62]."}