PMC:7565665 / 55543-55917 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7565665","sourcedb":"PMC","sourceid":"7565665","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7565665","text":"Specifically, a decrease in/loss of WT-CFTR is causally related to increased ROS-mediated inflammatory-oxidative stress, mucus hypersecretion, elevated ceramide levels, and hampered mucociliary clearance resulting in an increased incident of recurrent and chronic pulmonary infections, all of which result in chronic obstructive pathologies in CF airways [15,51,53,110,194].","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T381","span":{"begin":121,"end":126},"obj":"Body_part"}],"attributes":[{"id":"A381","pred":"fma_id","subj":"T381","obj":"http://purl.org/sig/ont/fma/fma66938"},{"subj":"T381","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T97","span":{"begin":121,"end":126},"obj":"Body_part"}],"attributes":[{"id":"A97","pred":"uberon_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/UBERON_0000912"},{"subj":"T97","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T407","span":{"begin":274,"end":284},"obj":"Disease"},{"id":"T408","span":{"begin":344,"end":346},"obj":"Disease"}],"attributes":[{"id":"A407","pred":"mondo_id","subj":"T407","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A408","pred":"mondo_id","subj":"T408","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"subj":"T407","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T408","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T663","span":{"begin":14,"end":15},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T664","span":{"begin":39,"end":43},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T665","span":{"begin":347,"end":354},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"}],"attributes":[{"subj":"T663","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T664","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T665","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T35","span":{"begin":36,"end":38},"obj":"Chemical"},{"id":"T36","span":{"begin":77,"end":80},"obj":"Chemical"},{"id":"T15409","span":{"begin":152,"end":160},"obj":"Chemical"}],"attributes":[{"id":"A85038","pred":"chebi_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_141450"},{"id":"A90917","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A83766","pred":"chebi_id","subj":"T15409","obj":"http://purl.obolibrary.org/obo/CHEBI_17761"},{"id":"A62949","pred":"chebi_id","subj":"T15409","obj":"http://purl.obolibrary.org/obo/CHEBI_52639"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T15409","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1409","span":{"begin":39,"end":43},"obj":"Gene"},{"id":"1436","span":{"begin":77,"end":80},"obj":"Chemical"},{"id":"1437","span":{"begin":152,"end":160},"obj":"Chemical"},{"id":"1457","span":{"begin":264,"end":284},"obj":"Disease"}],"attributes":[{"id":"A1409","pred":"tao:has_database_id","subj":"1409","obj":"Gene:1080"},{"id":"A1436","pred":"tao:has_database_id","subj":"1436","obj":"MESH:D017382"},{"id":"A1437","pred":"tao:has_database_id","subj":"1437","obj":"MESH:D002518"},{"id":"A1457","pred":"tao:has_database_id","subj":"1457","obj":"MESH:D012141"},{"subj":"1409","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1436","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1437","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1457","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T169","span":{"begin":103,"end":119},"obj":"Phenotype"},{"id":"T170","span":{"begin":264,"end":284},"obj":"Phenotype"}],"attributes":[{"id":"A169","pred":"hp_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/HP_0025464"},{"id":"A170","pred":"hp_id","subj":"T170","obj":"http://purl.obolibrary.org/obo/HP_0006532"},{"subj":"T169","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T170","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T754","span":{"begin":39,"end":43},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T755","span":{"begin":182,"end":203},"obj":"http://purl.obolibrary.org/obo/GO_0120197"}],"attributes":[{"subj":"T754","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T755","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T295","span":{"begin":0,"end":374},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T295","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d0ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec93ea"},{"id":"LitCovid-PD-MONDO","color":"#93ecd3"},{"id":"LitCovid-PD-CLO","color":"#ecb993"},{"id":"LitCovid-PD-CHEBI","color":"#9f93ec"},{"id":"LitCovid-PubTator","color":"#a0ec93"},{"id":"LitCovid-PD-HP","color":"#ec93ba"},{"id":"LitCovid-PD-GO-BP","color":"#93d4ec"},{"id":"LitCovid-sentences","color":"#ecea93"}]}]}}