PMC:7565665 / 54534-54831 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T374","span":{"begin":45,"end":47},"obj":"Body_part"},{"id":"T375","span":{"begin":89,"end":97},"obj":"Body_part"}],"attributes":[{"id":"A374","pred":"fma_id","subj":"T374","obj":"http://purl.org/sig/ont/fma/fma284995"},{"id":"A375","pred":"fma_id","subj":"T375","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"In a relatively recent study, we showed that CS-induced accumulation or trapping of TFEB proteins into perinuclear aggresome bodies prevents it from entering the nucleus and performing its function as an autophagy regulating transcription factor, thereby culminating in autophagy dysfunction [34]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T650","span":{"begin":3,"end":4},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T651","span":{"begin":293,"end":295},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"}],"text":"In a relatively recent study, we showed that CS-induced accumulation or trapping of TFEB proteins into perinuclear aggresome bodies prevents it from entering the nucleus and performing its function as an autophagy regulating transcription factor, thereby culminating in autophagy dysfunction [34]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T67128","span":{"begin":45,"end":47},"obj":"Chemical"},{"id":"T28","span":{"begin":89,"end":97},"obj":"Chemical"},{"id":"T29","span":{"begin":162,"end":169},"obj":"Chemical"}],"attributes":[{"id":"A71128","pred":"chebi_id","subj":"T67128","obj":"http://purl.obolibrary.org/obo/CHEBI_73462"},{"id":"A40326","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A49965","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"}],"text":"In a relatively recent study, we showed that CS-induced accumulation or trapping of TFEB proteins into perinuclear aggresome bodies prevents it from entering the nucleus and performing its function as an autophagy regulating transcription factor, thereby culminating in autophagy dysfunction [34]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1403","span":{"begin":84,"end":88},"obj":"Gene"},{"id":"1428","span":{"begin":45,"end":47},"obj":"Gene"}],"attributes":[{"id":"A1403","pred":"tao:has_database_id","subj":"1403","obj":"Gene:7942"},{"id":"A1428","pred":"tao:has_database_id","subj":"1428","obj":"Gene:1431"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In a relatively recent study, we showed that CS-induced accumulation or trapping of TFEB proteins into perinuclear aggresome bodies prevents it from entering the nucleus and performing its function as an autophagy regulating transcription factor, thereby culminating in autophagy dysfunction [34]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T743","span":{"begin":204,"end":213},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T744","span":{"begin":204,"end":213},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T745","span":{"begin":225,"end":245},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T746","span":{"begin":225,"end":238},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T747","span":{"begin":270,"end":279},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T748","span":{"begin":270,"end":279},"obj":"http://purl.obolibrary.org/obo/GO_0006914"}],"text":"In a relatively recent study, we showed that CS-induced accumulation or trapping of TFEB proteins into perinuclear aggresome bodies prevents it from entering the nucleus and performing its function as an autophagy regulating transcription factor, thereby culminating in autophagy dysfunction [34]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T291","span":{"begin":0,"end":297},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In a relatively recent study, we showed that CS-induced accumulation or trapping of TFEB proteins into perinuclear aggresome bodies prevents it from entering the nucleus and performing its function as an autophagy regulating transcription factor, thereby culminating in autophagy dysfunction [34]."}