PMC:7565665 / 49670-50003 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T347","span":{"begin":25,"end":27},"obj":"Body_part"},{"id":"T348","span":{"begin":117,"end":119},"obj":"Body_part"},{"id":"T349","span":{"begin":176,"end":178},"obj":"Body_part"},{"id":"T350","span":{"begin":187,"end":198},"obj":"Body_part"},{"id":"T351","span":{"begin":261,"end":274},"obj":"Body_part"}],"attributes":[{"id":"A347","pred":"fma_id","subj":"T347","obj":"http://purl.org/sig/ont/fma/fma284995"},{"id":"A348","pred":"fma_id","subj":"T348","obj":"http://purl.org/sig/ont/fma/fma284995"},{"id":"A349","pred":"fma_id","subj":"T349","obj":"http://purl.org/sig/ont/fma/fma284995"},{"id":"A350","pred":"fma_id","subj":"T350","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A351","pred":"fma_id","subj":"T351","obj":"http://purl.org/sig/ont/fma/fma0326100"}],"text":"As previously mentioned, CS exposure can also cause CFTR dysfunction, where a recent investigation demonstrated that CS exposure decreased CFTR expression while a treatment of CS-exposed macrophages with the autophagy inducer fisetin, which works by modulating autophagosome degradation, significantly recovered CFTR expression [35]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T577","span":{"begin":52,"end":56},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T578","span":{"begin":76,"end":77},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T579","span":{"begin":139,"end":143},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T580","span":{"begin":161,"end":162},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T581","span":{"begin":312,"end":316},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T582","span":{"begin":329,"end":331},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"}],"text":"As previously mentioned, CS exposure can also cause CFTR dysfunction, where a recent investigation demonstrated that CS exposure decreased CFTR expression while a treatment of CS-exposed macrophages with the autophagy inducer fisetin, which works by modulating autophagosome degradation, significantly recovered CFTR expression [35]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T43074","span":{"begin":25,"end":27},"obj":"Chemical"},{"id":"T8893","span":{"begin":117,"end":119},"obj":"Chemical"},{"id":"T58026","span":{"begin":176,"end":178},"obj":"Chemical"},{"id":"T21089","span":{"begin":208,"end":225},"obj":"Chemical"},{"id":"T13491","span":{"begin":226,"end":233},"obj":"Chemical"}],"attributes":[{"id":"A57641","pred":"chebi_id","subj":"T43074","obj":"http://purl.obolibrary.org/obo/CHEBI_73462"},{"id":"A34275","pred":"chebi_id","subj":"T8893","obj":"http://purl.obolibrary.org/obo/CHEBI_73462"},{"id":"A99446","pred":"chebi_id","subj":"T58026","obj":"http://purl.obolibrary.org/obo/CHEBI_73462"},{"id":"A74960","pred":"chebi_id","subj":"T21089","obj":"http://purl.obolibrary.org/obo/CHEBI_138880"},{"id":"A72342","pred":"chebi_id","subj":"T13491","obj":"http://purl.obolibrary.org/obo/CHEBI_42567"}],"text":"As previously mentioned, CS exposure can also cause CFTR dysfunction, where a recent investigation demonstrated that CS exposure decreased CFTR expression while a treatment of CS-exposed macrophages with the autophagy inducer fisetin, which works by modulating autophagosome degradation, significantly recovered CFTR expression [35]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1206","span":{"begin":139,"end":143},"obj":"Gene"},{"id":"1207","span":{"begin":312,"end":316},"obj":"Gene"},{"id":"1219","span":{"begin":52,"end":68},"obj":"Disease"}],"attributes":[{"id":"A1206","pred":"tao:has_database_id","subj":"1206","obj":"Gene:1080"},{"id":"A1207","pred":"tao:has_database_id","subj":"1207","obj":"Gene:1080"},{"id":"A1219","pred":"tao:has_database_id","subj":"1219","obj":"MESH:D009461"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"As previously mentioned, CS exposure can also cause CFTR dysfunction, where a recent investigation demonstrated that CS exposure decreased CFTR expression while a treatment of CS-exposed macrophages with the autophagy inducer fisetin, which works by modulating autophagosome degradation, significantly recovered CFTR expression [35]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T661","span":{"begin":52,"end":56},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T662","span":{"begin":139,"end":143},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T663","span":{"begin":208,"end":217},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T664","span":{"begin":208,"end":217},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T665","span":{"begin":275,"end":286},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T666","span":{"begin":312,"end":316},"obj":"http://purl.obolibrary.org/obo/GO_0005260"}],"text":"As previously mentioned, CS exposure can also cause CFTR dysfunction, where a recent investigation demonstrated that CS exposure decreased CFTR expression while a treatment of CS-exposed macrophages with the autophagy inducer fisetin, which works by modulating autophagosome degradation, significantly recovered CFTR expression [35]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T264","span":{"begin":0,"end":333},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"As previously mentioned, CS exposure can also cause CFTR dysfunction, where a recent investigation demonstrated that CS exposure decreased CFTR expression while a treatment of CS-exposed macrophages with the autophagy inducer fisetin, which works by modulating autophagosome degradation, significantly recovered CFTR expression [35]."}