PMC:7565665 / 37666-38018 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T241","span":{"begin":91,"end":94},"obj":"Body_part"},{"id":"T242","span":{"begin":175,"end":186},"obj":"Body_part"},{"id":"T243","span":{"begin":251,"end":256},"obj":"Body_part"},{"id":"T244","span":{"begin":340,"end":345},"obj":"Body_part"}],"attributes":[{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A243","pred":"fma_id","subj":"T243","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A244","pred":"fma_id","subj":"T244","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Using the technique of reduced representation bisulfite sequencing (RRBS) to determine the DNA methylation profile, the authors found that the promoter regions of Atg12 in CF macrophages are significantly more methylated as compared to the control WT cells, thereby elucidating a novel mechanism for reduced autophagy activity in CF immune cells [154]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T311","span":{"begin":172,"end":174},"obj":"Disease"},{"id":"T312","span":{"begin":330,"end":332},"obj":"Disease"}],"attributes":[{"id":"A311","pred":"mondo_id","subj":"T311","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A312","pred":"mondo_id","subj":"T312","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"}],"text":"Using the technique of reduced representation bisulfite sequencing (RRBS) to determine the DNA methylation profile, the authors found that the promoter regions of Atg12 in CF macrophages are significantly more methylated as compared to the control WT cells, thereby elucidating a novel mechanism for reduced autophagy activity in CF immune cells [154]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T411","span":{"begin":251,"end":256},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T412","span":{"begin":278,"end":279},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T413","span":{"begin":318,"end":326},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T414","span":{"begin":340,"end":345},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Using the technique of reduced representation bisulfite sequencing (RRBS) to determine the DNA methylation profile, the authors found that the promoter regions of Atg12 in CF macrophages are significantly more methylated as compared to the control WT cells, thereby elucidating a novel mechanism for reduced autophagy activity in CF immune cells [154]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T193","span":{"begin":46,"end":55},"obj":"Chemical"},{"id":"T194","span":{"begin":91,"end":94},"obj":"Chemical"},{"id":"T195","span":{"begin":248,"end":250},"obj":"Chemical"}],"attributes":[{"id":"A193","pred":"chebi_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/CHEBI_17137"},{"id":"A194","pred":"chebi_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A195","pred":"chebi_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/CHEBI_141450"}],"text":"Using the technique of reduced representation bisulfite sequencing (RRBS) to determine the DNA methylation profile, the authors found that the promoter regions of Atg12 in CF macrophages are significantly more methylated as compared to the control WT cells, thereby elucidating a novel mechanism for reduced autophagy activity in CF immune cells [154]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"929","span":{"begin":163,"end":168},"obj":"Gene"}],"attributes":[{"id":"A929","pred":"tao:has_database_id","subj":"929","obj":"Gene:9140"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Using the technique of reduced representation bisulfite sequencing (RRBS) to determine the DNA methylation profile, the authors found that the promoter regions of Atg12 in CF macrophages are significantly more methylated as compared to the control WT cells, thereby elucidating a novel mechanism for reduced autophagy activity in CF immune cells [154]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T498","span":{"begin":91,"end":106},"obj":"http://purl.obolibrary.org/obo/GO_0006306"},{"id":"T499","span":{"begin":95,"end":106},"obj":"http://purl.obolibrary.org/obo/GO_0032259"},{"id":"T500","span":{"begin":308,"end":317},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T501","span":{"begin":308,"end":317},"obj":"http://purl.obolibrary.org/obo/GO_0006914"}],"text":"Using the technique of reduced representation bisulfite sequencing (RRBS) to determine the DNA methylation profile, the authors found that the promoter regions of Atg12 in CF macrophages are significantly more methylated as compared to the control WT cells, thereby elucidating a novel mechanism for reduced autophagy activity in CF immune cells [154]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T197","span":{"begin":0,"end":352},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Using the technique of reduced representation bisulfite sequencing (RRBS) to determine the DNA methylation profile, the authors found that the promoter regions of Atg12 in CF macrophages are significantly more methylated as compared to the control WT cells, thereby elucidating a novel mechanism for reduced autophagy activity in CF immune cells [154]."}