PMC:7565665 / 30605-31839
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T179 | 29-33 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T180 | 392-401 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T181 | 432-440 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T182 | 527-532 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T183 | 664-688 | Body_part | denotes | gastrointestinal systems | http://purl.org/sig/ont/fma/fma71132 |
| T184 | 859-864 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T185 | 875-888 | Body_part | denotes | organ systems | http://purl.org/sig/ont/fma/fma7149 |
| T186 | 875-880 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T187 | 970-974 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T51 | 29-33 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T52 | 875-880 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T53 | 970-974 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T261 | 29-42 | Disease | denotes | lung diseases | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T262 | 94-102 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T263 | 186-194 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T264 | 303-311 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T265 | 330-338 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T266 | 537-541 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T267 | 558-566 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T268 | 975-987 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T269 | 1093-1102 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T270 | 1171-1179 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T336 | 29-33 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T337 | 29-33 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T338 | 352-362 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T339 | 455-456 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T340 | 527-532 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T341 | 859-864 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T342 | 875-888 | http://purl.obolibrary.org/obo/UBERON_0000467 | denotes | organ systems |
| T343 | 935-938 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T344 | 970-974 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T345 | 970-974 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T346 | 1004-1005 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T347 | 1104-1107 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 776 | 94-104 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 777 | 303-313 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 778 | 29-42 | Disease | denotes | lung diseases | MESH:D008171 |
| 779 | 186-194 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 780 | 330-338 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 781 | 537-541 | Disease | denotes | ARDS | MESH:D012128 |
| 782 | 558-566 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 783 | 664-688 | Disease | denotes | gastrointestinal systems | MESH:D005767 |
| 784 | 970-987 | Disease | denotes | lung inflammation | MESH:D011014 |
| 785 | 1093-1102 | Disease | denotes | infection | MESH:D007239 |
| 786 | 1171-1179 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 787 | 1210-1219 | Disease | denotes | mortality | MESH:D003643 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T104 | 29-42 | Phenotype | denotes | lung diseases | http://purl.obolibrary.org/obo/HP_0002088 |
| T105 | 432-446 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T412 | 54-63 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T413 | 54-63 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T414 | 142-151 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T415 | 142-151 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T416 | 245-267 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
| T417 | 287-299 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T418 | 573-594 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T419 | 809-818 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T420 | 809-818 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T421 | 826-847 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T422 | 915-924 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T423 | 915-924 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T424 | 975-987 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T425 | 1022-1031 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T426 | 1022-1031 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T427 | 1055-1076 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T161 | 0-268 | Sentence | denotes | As discussed above for other lung diseases, targeting autophagy to prevent the replication of SARS-CoV-2 is not the only potential benefit of autophagy augmentation for the treatment of COVID-19, but it may also allow the fine-tuning of optimal inflammatory responses. |
| T162 | 269-488 | Sentence | denotes | As now known, the pathogenesis of SARS-CoV-2-mediated severe COVID-19 involves the activation of numerous pro-inflammatory cytokines as part of the aforementioned cytokine storm causing a hyper-inflammatory state [142]. |
| T163 | 489-750 | Sentence | denotes | In addition to the destruction of the lungs and ARDS associated with COVID-19, this inflammatory response can cause damage to the cardiovascular, nervous, renal, hepatic, and gastrointestinal systems with wide ranging immediate and long-term consequences [142]. |
| T164 | 751-894 | Sentence | denotes | In support of this, studies have demonstrated the role of autophagy in the inflammatory response within the lungs and other organ systems [61]. |
| T165 | 895-1015 | Sentence | denotes | As mentioned above, autophagy induction has been demonstrated to attenuate lung inflammation when exposed to a pathogen. |
| T166 | 1016-1234 | Sentence | denotes | Thus, autophagy induction to limit the inflammatory response, in addition to infection, has an immense therapeutic potential as an effective treatment for COVID-19 and decreasing the associated mortality and morbidity. |