> top > docs > PMC:7565665 > spans > 28541-30604 > annotations

PMC:7565665 / 28541-30604 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T176 201-205 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T177 1647-1655 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T178 1719-1723 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T50 1719-1723 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T243 113-129 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T244 478-486 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T245 682-690 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T246 767-771 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T247 860-868 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T248 1072-1092 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T249 1083-1092 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T250 1094-1101 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T251 1281-1289 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T252 1345-1353 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T253 1626-1630 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T254 1636-1645 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T255 1694-1698 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T256 1704-1712 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T257 1719-1731 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T258 1815-1819 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T259 1890-1898 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T260 1901-1911 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T322 19-26 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T323 72-75 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T324 100-101 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T325 159-164 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T326 165-168 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T327 201-205 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T328 322-323 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T329 653-654 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T330 921-922 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T331 1305-1308 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T332 1719-1723 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T333 1719-1723 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T334 1755-1756 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T335 2057-2062 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T156 418-423 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T157 425-435 Chemical denotes spermidine http://purl.obolibrary.org/obo/CHEBI_16610|http://purl.obolibrary.org/obo/CHEBI_57834
T159 992-997 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T160 1007-1025 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T161 1610-1615 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
741 478-488 Species denotes SARS-CoV-2 Tax:2697049
742 767-776 Species denotes SARS-COV2 Tax:2697049
743 1474-1525 Species denotes Middle East respiratory syndrome (MERS) coronavirus Tax:1335626
744 1626-1635 Species denotes SARS-COV2 Tax:2697049
745 425-435 Chemical denotes spermidine MESH:D013095
746 437-444 Chemical denotes MK02206
747 450-461 Chemical denotes niclosamide MESH:D009534
748 1007-1025 Chemical denotes hydroxychloroquine MESH:D006886
749 1027-1030 Chemical denotes HCQ MESH:D006886
750 1245-1248 Chemical denotes HCQ MESH:D006886
751 113-129 Disease denotes viral infections MESH:D001102
752 682-690 Disease denotes COVID-19 MESH:C000657245
753 860-868 Disease denotes COVID-19 MESH:C000657245
754 1072-1092 Disease denotes rheumatoid arthritis MESH:D001172
755 1094-1101 Disease denotes malaria MESH:D008288
756 1281-1289 Disease denotes COVID-19 MESH:C000657245
757 1345-1353 Disease denotes COVID-19 MESH:C000657245
758 1636-1645 Disease denotes infection MESH:D007239
759 1694-1698 Disease denotes ARDS MESH:D012128
760 1704-1712 Disease denotes COVID-19 MESH:C000657245
761 1719-1731 Disease denotes lung disease MESH:D008171
762 1815-1819 Disease denotes ARDS MESH:D012128
763 1890-1911 Disease denotes SARS-CoV-2 infections MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T101 1072-1092 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T102 1647-1661 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T103 1719-1731 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T388 30-39 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T389 30-39 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T390 113-129 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T391 207-216 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T392 207-216 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T393 399-408 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T394 399-408 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T395 508-517 http://purl.obolibrary.org/obo/GO_0016236 denotes Autophagy
T396 508-517 http://purl.obolibrary.org/obo/GO_0006914 denotes Autophagy
T397 788-797 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T398 788-797 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T399 971-980 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T400 971-980 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T401 1053-1068 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T402 1188-1207 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostatic process
T403 1208-1217 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T404 1208-1217 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T405 1589-1598 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T406 1589-1598 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T407 1671-1683 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T408 1776-1785 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T409 1776-1785 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T410 1845-1854 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T411 1845-1854 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T152 0-144 Sentence denotes The elimination of viruses by autophagy (sometimes termed as virophagy) has been well described for a variety of viral infections [8,84,85,137].
T153 145-318 Sentence denotes Although, the virus has multiple ways of entry into the cell, autophagy augmentation provides strategic advantage in reducing viral load by promoting its clearance [90,137].
T154 319-507 Sentence denotes As a proof of concept, recent study demonstrated the utility of three different autophagy-inducing drugs, spermidine, MK02206, and niclosamide, in restricting SARS-CoV-2 propagation [138].
T155 508-697 Sentence denotes Autophagy induction and related upregulation of overall immunity helps combat exacerbations and is suggested as an immunity boosting strategy as a preventive measure against COVID-19 [139].
T156 698-950 Sentence denotes In addition to boosting immunity, dampening viral load, and allowing SARS-COV2 clearance, autophagy induction may provide strategic advantage in the treatment of COVID-19 and prevention of negative outcomes, which makes it a subject of ongoing studies.
T157 951-1218 Sentence denotes In support of this, autophagy inhibiting drugs, such as hydroxychloroquine (HCQ) that help dampen the immune response in rheumatoid arthritis, malaria, and other illnesses but weakens cellular ability for viral clearance by the critical homeostatic process autophagy.
T158 1219-1441 Sentence denotes Despite early claims that HCQ may provide benefit in treating COVID-19 [90,91,92], it has since been deemed unsafe for use in COVID-19 treatment by the FDA based on randomized double blind placebo control trials [140,141].
T159 1442-1732 Sentence denotes In addition, earlier studies on Middle East respiratory syndrome (MERS) coronavirus [50] provide proof-of-concept data on therapeutic potential of autophagy modulating drugs to combat SARS-COV2 infection, cytokine storm, and the pathogenesis of severe ARDS-like COVID-19 fatal lung disease.
T160 1733-2063 Sentence denotes Prior studies showing a protective role of autophagy induction in other models of ARDS demonstrate the scope of autophagy augmenting strategies in combating SARS-CoV-2 infections (Figure 1) and thus is part of ongoing validation and rapid clinical development studies that may help limit the burden and spread of this novel virus.