PMC:7565665 / 24622-26877
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T146 | 320-324 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T147 | 540-544 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T148 | 589-597 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T149 | 823-826 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T150 | 937-957 | Body_part | denotes | alveolar macrophages | http://purl.org/sig/ont/fma/fma83023 |
| T151 | 978-981 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T152 | 1110-1113 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T153 | 1153-1162 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T154 | 1197-1202 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T155 | 1299-1303 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T156 | 1514-1517 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T157 | 1560-1564 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T158 | 1560-1562 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T159 | 1585-1589 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T160 | 1774-1778 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T161 | 1774-1776 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T162 | 1853-1857 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T163 | 1874-1877 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T42 | 320-324 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T43 | 540-544 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T44 | 1299-1303 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T45 | 1585-1589 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T46 | 1853-1857 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T198 | 26-61 | Disease | denotes | Acute Respiratory Distress Syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T199 | 32-61 | Disease | denotes | Respiratory Distress Syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T200 | 63-67 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T201 | 90-93 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T202 | 110-145 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T203 | 116-145 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T204 | 150-154 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T205 | 234-238 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T206 | 277-281 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T207 | 400-403 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T208 | 700-703 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T209 | 704-708 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T210 | 842-845 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T211 | 846-850 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T212 | 1247-1250 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T213 | 1251-1255 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T214 | 1304-1310 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T215 | 1337-1341 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T216 | 1408-1411 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T217 | 1534-1538 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T218 | 1889-1892 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T219 | 1893-1897 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T220 | 1974-1977 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T221 | 1978-1982 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T222 | 2099-2102 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T223 | 2103-2107 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T224 | 2238-2242 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T273 | 166-169 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T274 | 189-190 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T275 | 320-324 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T276 | 320-324 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T277 | 414-415 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T278 | 540-544 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T279 | 540-544 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T280 | 602-617 | http://purl.obolibrary.org/obo/PR_000010543 | denotes | myeloperoxidase |
| T281 | 619-622 | http://purl.obolibrary.org/obo/PR_000010543 | denotes | MPO |
| T282 | 651-652 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T283 | 760-761 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T284 | 1032-1041 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T285 | 1071-1074 | http://purl.obolibrary.org/obo/CLO_0054061 | denotes | 132 |
| T286 | 1197-1202 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T287 | 1257-1260 | http://purl.obolibrary.org/obo/CLO_0054061 | denotes | 132 |
| T288 | 1299-1303 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T289 | 1299-1303 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T290 | 1355-1365 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T291 | 1382-1385 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T292 | 1425-1426 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T293 | 1585-1589 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T294 | 1585-1589 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T295 | 1618-1626 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | arterial |
| T296 | 1618-1626 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | arterial |
| T297 | 1666-1667 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T298 | 1716-1726 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T299 | 1793-1794 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T300 | 1853-1857 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T301 | 1853-1857 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T302 | 2020-2023 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T303 | 2029-2030 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T127 | 470-479 | Chemical | denotes | rapamycin | http://purl.obolibrary.org/obo/CHEBI_9168 |
| T128 | 762-772 | Chemical | denotes | lipoxin A4 | http://purl.obolibrary.org/obo/CHEBI_6498|http://purl.obolibrary.org/obo/CHEBI_67026 |
| T130 | 762-769 | Chemical | denotes | lipoxin | http://purl.obolibrary.org/obo/CHEBI_6497 |
| T131 | 782-792 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T132 | 823-826 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T135 | 978-981 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T138 | 1110-1113 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T141 | 1287-1289 | Chemical | denotes | MV | http://purl.obolibrary.org/obo/CHEBI_73616 |
| T142 | 1514-1517 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T145 | 1523-1525 | Chemical | denotes | MV | http://purl.obolibrary.org/obo/CHEBI_73616 |
| T146 | 1560-1562 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T148 | 1749-1751 | Chemical | denotes | MV | http://purl.obolibrary.org/obo/CHEBI_73616 |
| T149 | 1774-1776 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T151 | 1874-1877 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T154 | 1878-1880 | Chemical | denotes | MV | http://purl.obolibrary.org/obo/CHEBI_73616 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 610 | 26-61 | Disease | denotes | Acute Respiratory Distress Syndrome | MESH:D012128 |
| 611 | 63-67 | Disease | denotes | ARDS | MESH:D012128 |
| 643 | 409-412 | Gene | denotes | CLP | Gene:12950 |
| 644 | 602-617 | Gene | denotes | myeloperoxidase | Gene:17523 |
| 645 | 619-622 | Gene | denotes | MPO | Gene:17523 |
| 646 | 762-781 | Gene | denotes | lipoxin A4 receptor | Gene:681706 |
| 647 | 1016-1021 | Gene | denotes | MAPK1 | Gene:5594 |
| 648 | 1026-1031 | Gene | denotes | MAPK8 | Gene:5599 |
| 649 | 1065-1069 | Gene | denotes | mTOR | Gene:2475 |
| 650 | 1560-1565 | Gene | denotes | IL-1β | Gene:3552 |
| 651 | 1774-1779 | Gene | denotes | IL-1β | Gene:3552 |
| 652 | 383-389 | Species | denotes | murine | Tax:10090 |
| 653 | 854-858 | Species | denotes | rats | Tax:10116 |
| 654 | 1193-1196 | Species | denotes | rat | Tax:10116 |
| 655 | 2246-2254 | Species | denotes | patients | Tax:9606 |
| 656 | 470-479 | Chemical | denotes | rapamycin | MESH:D020123 |
| 657 | 110-145 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 658 | 150-154 | Disease | denotes | ARDS | MESH:D012128 |
| 659 | 234-238 | Disease | denotes | ARDS | MESH:D012128 |
| 660 | 277-281 | Disease | denotes | ARDS | MESH:D012128 |
| 661 | 346-351 | Disease | denotes | death | MESH:D003643 |
| 662 | 685-691 | Disease | denotes | sepsis | MESH:D018805 |
| 663 | 704-708 | Disease | denotes | ARDS | MESH:D012128 |
| 664 | 835-850 | Disease | denotes | septic ALI/ARDS | MESH:D012128 |
| 665 | 1251-1255 | Disease | denotes | ARDS | MESH:D012128 |
| 666 | 1299-1310 | Disease | denotes | lung injury | MESH:D055370 |
| 667 | 1337-1341 | Disease | denotes | ARDS | MESH:D012128 |
| 668 | 1534-1538 | Disease | denotes | ARDS | MESH:D012128 |
| 669 | 1828-1837 | Disease | denotes | hypoxemia | MESH:D000860 |
| 670 | 1893-1897 | Disease | denotes | ARDS | MESH:D012128 |
| 671 | 1978-1982 | Disease | denotes | ARDS | MESH:D012128 |
| 672 | 2103-2107 | Disease | denotes | ARDS | MESH:D012128 |
| 673 | 2238-2242 | Disease | denotes | ARDS | MESH:D012128 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T84 | 32-52 | Phenotype | denotes | Respiratory Distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T85 | 90-93 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
| T86 | 116-136 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T87 | 400-403 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
| T88 | 685-691 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T89 | 700-703 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
| T90 | 842-845 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
| T91 | 1247-1250 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
| T92 | 1408-1411 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
| T93 | 1828-1837 | Phenotype | denotes | hypoxemia | http://purl.obolibrary.org/obo/HP_0012418 |
| T94 | 1889-1892 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
| T95 | 1974-1977 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
| T96 | 2099-2102 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T343 | 5-14 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | Autophagy |
| T344 | 5-14 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | Autophagy |
| T345 | 156-165 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | Autophagy |
| T346 | 156-165 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | Autophagy |
| T347 | 447-456 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T348 | 447-456 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T349 | 672-681 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T350 | 672-681 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T351 | 892-911 | http://purl.obolibrary.org/obo/GO_0043066 | denotes | inhibited apoptosis |
| T352 | 902-911 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T353 | 902-911 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T354 | 924-933 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T355 | 924-933 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T356 | 962-981 | http://purl.obolibrary.org/obo/GO_0032496 | denotes | response to the LPS |
| T357 | 1032-1041 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T358 | 1176-1185 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T359 | 1176-1185 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T360 | 1462-1471 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T361 | 1462-1471 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T362 | 1652-1661 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T363 | 1652-1661 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T364 | 1961-1970 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T365 | 1961-1970 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T366 | 2073-2082 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T367 | 2073-2082 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T368 | 2175-2184 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T369 | 2175-2184 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T128 | 0-4 | Sentence | denotes | 4.2. |
| T129 | 5-68 | Sentence | denotes | Autophagy Defects in Acute Respiratory Distress Syndrome (ARDS) |
| T130 | 69-155 | Sentence | denotes | More severe forms of ALI may progress to acute respiratory distress syndrome, or ARDS. |
| T131 | 156-245 | Sentence | denotes | Autophagy has been shown to play a critical role in regulating the outcome of ARDS [120]. |
| T132 | 246-352 | Sentence | denotes | The clinical manifestations of ARDS are very severe and may lead to rapid lung function decline and death. |
| T133 | 353-715 | Sentence | denotes | Using one of most widely used murine models of ALI, the CLP, a recent study demonstrated that autophagy induction by rapamycin was able to improve the survival rate, histological scores, lung wet/dry ratios, PaO2/FiO2, and inflammatory cytokine and myeloperoxidase (MPO) levels in BALF, suggesting a protective role of autophagy in sepsis-induced ALI/ARDS [120]. |
| T134 | 716-859 | Sentence | denotes | In another study, the potential of BML-111, a lipoxin A4 receptor antagonist, was evaluated in controlling LPS-induced septic ALI/ARDS in rats. |
| T135 | 860-1076 | Sentence | denotes | The authors showed that BML-111 inhibited apoptosis and induced autophagy in alveolar macrophages, in response to the LPS challenge, via the suppression of MAPK1 and MAPK8 signaling and was independent of mTOR [132]. |
| T136 | 1077-1262 | Sentence | denotes | Moreover, BML-111 controlled the LPS-induced production of pro-inflammatory cytokines, and reduced apoptosis in the rat lungs, and thus warrants further investigation in ALI/ARDS [132]. |
| T137 | 1263-1421 | Sentence | denotes | Mechanical ventilation (MV)-induced lung injury is another severe form of ARDS, wherein the activation of inflammasome has been shown to mediate ALI symptoms. |
| T138 | 1422-1645 | Sentence | denotes | In a recent article, starvation-induced autophagy augmentation was shown to protect against LPS- and MV-induced ARDS features by reducing IL-1β levels, decreasing lung permeability, and improving arterial oxygenation [133]. |
| T139 | 1646-1904 | Sentence | denotes | Thus, autophagy had a protective role in controlling the inflammasome activation and resolution of the MV-induced production of IL-1β, which plays a pathogenic role through inducing hypoxemia and increasing lung permeability in LPS/MV-induced ALI/ARDS [133]. |
| T140 | 1905-2161 | Sentence | denotes | Although some contrasting reports regarding the role of autophagy in ALI/ARDS were initially reported [134], there has been a consensus on the therapeutic advantage of autophagy augmentation in ALI/ARDS based on significant validation studies [64,120,122]. |
| T141 | 2162-2255 | Sentence | denotes | Thus, proper autophagy function is essential in attenuating the severity of ARDS in patients. |