PMC:7565665 / 19476-20098
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T107 | 299-306 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T108 | 576-587 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T152 | 163-165 | Disease | denotes | CF | http://purl.obolibrary.org/obo/MONDO_0009061 |
| T153 | 533-535 | Disease | denotes | CF | http://purl.obolibrary.org/obo/MONDO_0009061 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T214 | 18-22 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T215 | 23-26 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T216 | 108-112 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T217 | 230-234 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T218 | 287-291 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T219 | 432-436 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
| T220 | 508-515 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airways |
| T221 | 607-611 | http://purl.obolibrary.org/obo/PR_000001044 | denotes | CFTR |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T76 | 299-306 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 467 | 18-22 | Gene | denotes | CFTR | Gene:1080 |
| 468 | 108-112 | Gene | denotes | CFTR | Gene:1080 |
| 469 | 230-234 | Gene | denotes | CFTR | Gene:1080 |
| 470 | 287-291 | Gene | denotes | CFTR | Gene:1080 |
| 471 | 432-436 | Gene | denotes | CFTR | Gene:1080 |
| 472 | 607-611 | Gene | denotes | CFTR | Gene:1080 |
| 473 | 212-220 | Species | denotes | patients | Tax:9606 |
| 474 | 519-527 | Species | denotes | patients | Tax:9606 |
| 475 | 593-606 | Disease | denotes | dysfunctional | MESH:D009461 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T268 | 18-22 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T269 | 51-60 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T270 | 51-60 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T271 | 108-112 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T272 | 230-234 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T273 | 287-291 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T274 | 432-436 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
| T275 | 446-455 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T276 | 446-455 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T277 | 607-611 | http://purl.obolibrary.org/obo/GO_0005260 | denotes | CFTR |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T101 | 0-80 | Sentence | denotes | The expression of CFTR has been shown to influence autophagy as discussed above. |
| T102 | 81-249 | Sentence | denotes | One mechanism of decreased CFTR expression is due to the genetic defects found in CF, where the most common mutation seen in these patients is ΔF508-CFTR [102,103,104]. |
| T103 | 250-398 | Sentence | denotes | Studies have demonstrated that ΔF508-CFTR causes protein misfolding that forms aggregates potentially impairing cellular proteostasis [20,42,53,61]. |
| T104 | 399-541 | Sentence | denotes | This dysfunction caused by ΔF508-CFTR includes autophagy dysfunction and decreases pathogen clearance in the airways of patients with CF [53]. |
| T105 | 542-622 | Sentence | denotes | Similar findings were observed in macrophages with dysfunctional CFTR [105,106]. |