PMC:7565665 / 15859-17432
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T89 | 155-160 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T90 | 232-236 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T91 | 254-256 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T92 | 320-322 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T93 | 500-502 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T94 | 603-605 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T95 | 732-734 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T96 | 788-796 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T97 | 927-929 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T98 | 1350-1352 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T99 | 1456-1458 | Body_part | denotes | CS | http://purl.org/sig/ont/fma/fma284995 |
| T100 | 1480-1484 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T26 | 232-236 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T27 | 1480-1484 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T141 | 384-386 | Disease | denotes | EB | http://purl.obolibrary.org/obo/MONDO_0006541 |
| T142 | 1557-1567 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T183 | 155-160 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T184 | 384-386 | http://purl.obolibrary.org/obo/CLO_0002867 | denotes | EB |
| T185 | 395-396 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T186 | 568-578 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T187 | 806-807 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T188 | 1186-1189 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T189 | 1283-1285 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
| T190 | 1319-1320 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T191 | 1375-1376 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T192 | 1480-1484 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T193 | 1480-1484 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T60 | 254-256 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T61 | 320-322 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T62 | 384-386 | Chemical | denotes | EB | http://purl.obolibrary.org/obo/CHEBI_53197 |
| T63 | 500-502 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T64 | 603-605 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T65 | 732-734 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T66 | 788-796 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T67 | 927-929 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T68 | 1332-1341 | Chemical | denotes | biomarker | http://purl.obolibrary.org/obo/CHEBI_59163 |
| T69 | 1350-1352 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
| T70 | 1456-1458 | Chemical | denotes | CS | http://purl.obolibrary.org/obo/CHEBI_73462 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 403 | 363-386 | Gene | denotes | transcription factor-EB | Gene:7942 |
| 404 | 388-392 | Gene | denotes | TFEB | Gene:7942 |
| 405 | 480-484 | Gene | denotes | TFEB | Gene:7942 |
| 406 | 544-548 | Gene | denotes | TFEB | Gene:7942 |
| 407 | 638-642 | Gene | denotes | TFEB | Gene:7942 |
| 408 | 801-804 | Gene | denotes | p62 | Gene:51164 |
| 409 | 1456-1458 | Gene | denotes | CS | Gene:1431 |
| 410 | 927-929 | Gene | denotes | CS | Gene:1431 |
| 411 | 237-252 | Gene | denotes | cigarette smoke | Gene:1431 |
| 412 | 1350-1352 | Gene | denotes | CS | Gene:1431 |
| 413 | 732-734 | Gene | denotes | CS | Gene:1431 |
| 414 | 603-605 | Gene | denotes | CS | Gene:1431 |
| 415 | 500-502 | Gene | denotes | CS | Gene:1431 |
| 416 | 320-322 | Gene | denotes | CS | Gene:1431 |
| 417 | 254-256 | Gene | denotes | CS | Gene:1431 |
| 418 | 93-106 | Disease | denotes | dysfunctional | MESH:D009461 |
| 419 | 452-465 | Disease | denotes | dysfunctional | MESH:D009461 |
| 420 | 1139-1160 | Disease | denotes | pulmonary dysfunction | MESH:D011660 |
| 421 | 1557-1567 | Disease | denotes | infections | MESH:D007239 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T213 | 26-35 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T214 | 26-35 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T215 | 183-192 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T216 | 183-192 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T217 | 271-276 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
| T218 | 363-383 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factor |
| T219 | 363-376 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T220 | 404-413 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T221 | 404-413 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T222 | 528-540 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
| T223 | 582-591 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T224 | 582-591 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T225 | 614-623 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T226 | 614-623 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T227 | 818-827 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T228 | 818-827 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T229 | 879-888 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T230 | 879-888 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T231 | 942-951 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T232 | 942-951 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T233 | 1035-1044 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T234 | 1035-1044 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T235 | 1165-1174 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T236 | 1165-1174 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T237 | 1405-1414 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T238 | 1405-1414 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T239 | 1485-1490 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
| T240 | 1517-1526 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T241 | 1517-1526 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T79 | 0-147 | Sentence | denotes | Despite the importance of autophagy, there are many conditions where this process can become dysfunctional, leading to various pathological states. |
| T80 | 148-288 | Sentence | denotes | In the lungs, the major sources of autophagy dysfunction includes first- and second-hand cigarette smoke (CS) exposure and aging [35,62,93]. |
| T81 | 289-432 | Sentence | denotes | Studies have demonstrated that CS exposure can decrease the expression of transcription factor-EB (TFEB), a master autophagy regulator [34,35]. |
| T82 | 433-597 | Sentence | denotes | This occurs by the dysfunctional processing of TFEB in response to CS, causing the perinuclear localization of TFEB which prevents the activation of autophagy [62]. |
| T83 | 598-695 | Sentence | denotes | This CS-induced autophagy impairment of TFEB leads to impaired bacterial clearance [22,33,34,35]. |
| T84 | 696-897 | Sentence | denotes | Furthermore, there is evidence that CS exposure increases the accumulation of ubiquitinated proteins and p62 (a marker of autophagy impairment) in aggresome bodies, further impairing autophagy [22,34]. |
| T85 | 898-1098 | Sentence | denotes | These deleterious effects of CS exposure on autophagy have also been demonstrated to be present in eCV exposure, which similarly impairs autophagy through the accumulation of aggresome bodies [39,94]. |
| T86 | 1099-1342 | Sentence | denotes | Furthermore, increasing the severity of pulmonary dysfunction and autophagy impairment has been observed to statistically correlate directly with increased levels of aggresome bodies [36], demonstrating its potential as a prognostic biomarker. |
| T87 | 1343-1446 | Sentence | denotes | Hence, CS exposure demonstrates a common, but preventable way autophagy can be impaired in individuals. |
| T88 | 1447-1573 | Sentence | denotes | Notably, CS exposure accelerates lung aging, known to be initiated by autophagy decline, which can exacerbate infections [33]. |