PMC:7565482 / 14536-15133 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T70","span":{"begin":209,"end":212},"obj":"Body_part"},{"id":"T71","span":{"begin":404,"end":407},"obj":"Body_part"},{"id":"T72","span":{"begin":460,"end":470},"obj":"Body_part"},{"id":"T73","span":{"begin":575,"end":579},"obj":"Body_part"}],"attributes":[{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Mismatches between the sequence of in vitro antigen sets and the autologous virus in an infected individual can lead to missed responses. This has been described for highly variable pathogens, such as HCV and HIV, and showed a direct relationship between sequence entropy and the frequency of detected responses [56,57]. Even though the variability of SARS-CoV-2 reported is substantially lower than for HIV and HCV, the sequence entropy was calculated at the amino acid level and as the mean OLP entropy in order to identify positions and OLP that may escape detection in T cell screening assays."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T42","span":{"begin":352,"end":360},"obj":"Disease"}],"attributes":[{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Mismatches between the sequence of in vitro antigen sets and the autologous virus in an infected individual can lead to missed responses. This has been described for highly variable pathogens, such as HCV and HIV, and showed a direct relationship between sequence entropy and the frequency of detected responses [56,57]. Even though the variability of SARS-CoV-2 reported is substantially lower than for HIV and HCV, the sequence entropy was calculated at the amino acid level and as the mean OLP entropy in order to identify positions and OLP that may escape detection in T cell screening assays."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T126","span":{"begin":76,"end":81},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T127","span":{"begin":143,"end":146},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T128","span":{"begin":225,"end":226},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T129","span":{"begin":573,"end":579},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"Mismatches between the sequence of in vitro antigen sets and the autologous virus in an infected individual can lead to missed responses. This has been described for highly variable pathogens, such as HCV and HIV, and showed a direct relationship between sequence entropy and the frequency of detected responses [56,57]. Even though the variability of SARS-CoV-2 reported is substantially lower than for HIV and HCV, the sequence entropy was calculated at the amino acid level and as the mean OLP entropy in order to identify positions and OLP that may escape detection in T cell screening assays."}

{"project":"LitCovid-PubTator","denotations":[{"id":"166","span":{"begin":352,"end":362},"obj":"Species"},{"id":"167","span":{"begin":88,"end":96},"obj":"Disease"}],"attributes":[{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"Tax:2697049"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Mismatches between the sequence of in vitro antigen sets and the autologous virus in an infected individual can lead to missed responses. This has been described for highly variable pathogens, such as HCV and HIV, and showed a direct relationship between sequence entropy and the frequency of detected responses [56,57]. Even though the variability of SARS-CoV-2 reported is substantially lower than for HIV and HCV, the sequence entropy was calculated at the amino acid level and as the mean OLP entropy in order to identify positions and OLP that may escape detection in T cell screening assays."}

{"project":"LitCovid-sentences","denotations":[{"id":"T97","span":{"begin":0,"end":137},"obj":"Sentence"},{"id":"T98","span":{"begin":138,"end":320},"obj":"Sentence"},{"id":"T99","span":{"begin":321,"end":597},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Mismatches between the sequence of in vitro antigen sets and the autologous virus in an infected individual can lead to missed responses. This has been described for highly variable pathogens, such as HCV and HIV, and showed a direct relationship between sequence entropy and the frequency of detected responses [56,57]. Even though the variability of SARS-CoV-2 reported is substantially lower than for HIV and HCV, the sequence entropy was calculated at the amino acid level and as the mean OLP entropy in order to identify positions and OLP that may escape detection in T cell screening assays."}