PMC:7561592 / 39594-40173 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7561592","sourcedb":"PMC","sourceid":"7561592","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7561592","text":"For the dissolution of montelukast from the granules and crushed chewable tablets, the PLS-R model developed was defined by three components and showed a good fit to the experimental values (R2 = 0.83) and a good predictive power (Q2 = 0.79). The statistical analysis revealed that vehicle pH and percentage of fat and drug solubility in each vehicle were the factors with the most significant positive impact on drug dissolution from the two montelukast formulations tested, with a moderate negative impact from vehicle osmolality, viscosity, percentage of sugar and of protein.","tracks":[]}