PMC:7561592 / 36685-37738 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7561592","sourcedb":"PMC","sourceid":"7561592","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7561592","text":"For Singulair® granules, higher agitation conditions resulted in a higher percentage of drug dissolved (4 h) when the formulation was mixed with milk, orange juice, applesauce and plain yoghurt (increase in percentage of drug dissolved (4 h) = 16.1, 27.5, 1.4 and 8.6%, respectively). A significantly higher AUC0–4h was observed when the granules were mixed with these vehicles and tested at 100 rpm, in comparison with 50 rpm (Fig. 9). This is probably related to the effect of the increased hydrodynamics, which result in a better dispersion of the drug product-vehicle mixture and, consequently, facilitate drug dissolution from the vehicles (35). Dissolution testing of the granules mixed with blackcurrant squash at high agitation rate (100 rpm) resulted in a significantly lower AUC0–4h in comparison with the dissolution testing at low agitation rate (50 rpm.) For the scenario of direct administration, drug dissolution was likely limited by the drug solubility in the media and not significantly affected by the increase in agitation rate (11).","tracks":[{"project":"2_test","denotations":[{"id":"33063245-19034672-28147","span":{"begin":646,"end":648},"obj":"19034672"},{"id":"33063245-32592045-28148","span":{"begin":1049,"end":1051},"obj":"32592045"}],"attributes":[{"subj":"33063245-19034672-28147","pred":"source","obj":"2_test"},{"subj":"33063245-32592045-28148","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#a293ec","default":true}]}]}}