PMC:7561592 / 31229-32699 JSONTXT

{"project":"2_test","denotations":[{"id":"33063245-32592045-28144","span":{"begin":380,"end":382},"obj":"32592045"}],"text":"For Singulair® granules, delaying testing by 4 h after mixing led to a higher percentage of drug dissolved and a significantly higher AUC0–4h for co-administration with milk, orange juice and applesauce UK (p \u003c 0.05). This is probably due to the solubility of montelukast in these vehicles, which resulted in an increased drug solubilisation and dissolution during the 4-h delay (11). From the three cases, the differences in drug dissolution between the two testing scenarios were most accentuated when the granules were mixed with milk. As observed in the ‘Effect of Medicine Co-administration with Food and Drinks on Drug Dissolution’ section, this is probably due to the pH of milk which leads to an increase in drug solubilisation and dissolution, in comparison with when the granules are mixed with other vehicles. Results from this test show that this increase is even more evident if there is a delay between preparation and administration of the mixture. In contrast, delaying testing after mixing the Singulair® granules with blackcurrant squash had no effect on drug dissolution, whereas delaying the time between mixing with plain yoghurt and testing resulted in a significantly lower AUC0–4h. Delaying testing by 4 h after mixing the granules with applesauce UK and plain yoghurt led to a drop in drug concentration after the media change from SGFsp pH 1.2 to SIFsp pH 6.8. This might be related to the sudden change in pH and increase in media volume (10)."}