PMC:7561592 / 27396-28736 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7561592","sourcedb":"PMC","sourceid":"7561592","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7561592","text":"The percentage of mesalazine dissolved from Salofalk® granules (4 h) was also affected by the different vehicles. The percentage of drug dissolution was the highest when the granules were mixed with orange squash (17.3%), followed by blackcurrant squash (16.7%), formula (16.1%), milk (12.4%), orange juice (11.7%), direct introduction (11.4%) and soft foods. AUC0–4h was significantly different for the direct administration scenario compared with co-administration with vehicles, except milk, orange juice and applesauce DE (p \u003e 0.05). For co-administration with soft foods, the percentage of drug dissolved at 4 h was the lowest when the formulation was mixed with Greek yoghurt (0.6%) and the highest when mixed with applesauce DE (9.9%), indicating that vehicles of the same type (e.g. soft foods) have a distinct impact on drug dissolution. The lower drug dissolution observed when the granules were mixed with soft foods was likely due to a physical barrier that these vehicles create around the formulation, which prevents mixing with GI fluids and hinders drug release, ultimately, reducing drug exposure at the site of absorption (13). Dissolution of mesalazine from Salofalk® granules also differed when mixed with vehicles of the same subtype, namely, applesauce UK vs USA, milk vs formula and plain vs Greek yoghurt (p \u003c 0.05).","tracks":[{"project":"2_test","denotations":[{"id":"33063245-24934549-28143","span":{"begin":1141,"end":1143},"obj":"24934549"}],"attributes":[{"subj":"33063245-24934549-28143","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#a7ec93","default":true}]}]}}