PMC:7561592 / 24379-25554 JSONTXT

{"project":"2_test","denotations":[{"id":"33063245-32592045-28142","span":{"begin":1171,"end":1173},"obj":"32592045"}],"text":"Dissolution of the crushed Actavis® chewable tablets mixed with vehicles resulted in a higher percentage of drug dissolved at 4 h and significantly higher AUC0–4h in comparison with direct administration of the crushed formulation. Amongst vehicles, drug dissolution was the highest when the crushed tablets were mixed with milk and formula (72.5 and 67.8%, respectively) and the lowest when the formulation was mixed with blackcurrant squash (11.1%). Significant differences in AUC0–4h were revealed between mixing the formulation with milky and fruity drinks, and between mixing with the different squashes tested. Twofold differences were observed between AUC0–4h when mixing with vehicles of the same subtype (plain in comparison with Greek yoghurt and between the applesauce UK and applesauce USA; p \u003c 0.05). These differences could be attributed to the physicochemical properties (e.g. different pH and protein content of dairy vs fruity drinks, and different viscosity of the applesauces) and macronutrient composition of the vehicles (e.g. different sugar content between the squashes), which affect drug solubilisation and may impact drug dissolution behaviour (11)."}