PMC:7561592 / 15477-16536
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7561592","sourcedb":"PMC","sourceid":"7561592","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7561592","text":"The effect of different administration scenarios and testing conditions was investigated by varying the dissolution test parameters, as described in Table II. These were as follows: (1) effect of co-administration of formulation with selected vehicles in comparison to direct administration of formulation; (2) effect of different mixing patterns (i.e. time between preparation and administration/testing of the formulation-vehicle mixture); and (3) effect of hydrodynamics (50 vs 100 rpm, in selected studies of Pentasa® and Singulair® granules).\nTable II Dosing Scenarios and Testing Conditions Investigated\nSetup Agitation speed (rpm) Scenario: direct introduction Scenario: mixing with vehicles Formulations Mixing pattern (h)\n1 50 ✓ M, OJ, BLS, PY, APSUK, F, OS, GY, APSDE All 0\n2 50 N/A M, OJ, BLS, PY, APSUK All 4\n3 100 ✓ M, OJ, BLS, PY, APSUK Singulair®, Pentasa® 0\nBLS, blackcurrant squash; OS, orange squash; M, milk; F, formula; OJ, orange juice; PY, plain yoghurt; GY, Greek yoghurt; APSUK, applesauce UK; APSDE, applesauce DE; N/A, not applicable","divisions":[{"label":"label","span":{"begin":548,"end":556}},{"label":"caption","span":{"begin":557,"end":609}},{"label":"p","span":{"begin":557,"end":609}},{"label":"table","span":{"begin":610,"end":873}},{"label":"tr","span":{"begin":610,"end":730}},{"label":"th","span":{"begin":610,"end":615}},{"label":"th","span":{"begin":616,"end":637}},{"label":"th","span":{"begin":638,"end":667}},{"label":"th","span":{"begin":668,"end":698}},{"label":"th","span":{"begin":699,"end":711}},{"label":"th","span":{"begin":712,"end":730}},{"label":"tr","span":{"begin":731,"end":783}},{"label":"td","span":{"begin":731,"end":732}},{"label":"td","span":{"begin":733,"end":735}},{"label":"td","span":{"begin":736,"end":737}},{"label":"td","span":{"begin":738,"end":777}},{"label":"td","span":{"begin":778,"end":781}},{"label":"td","span":{"begin":782,"end":783}},{"label":"tr","span":{"begin":784,"end":820}},{"label":"td","span":{"begin":784,"end":785}},{"label":"td","span":{"begin":786,"end":788}},{"label":"td","span":{"begin":789,"end":792}},{"label":"td","span":{"begin":793,"end":814}},{"label":"td","span":{"begin":815,"end":818}},{"label":"td","span":{"begin":819,"end":820}},{"label":"tr","span":{"begin":821,"end":873}},{"label":"td","span":{"begin":821,"end":822}},{"label":"td","span":{"begin":823,"end":826}},{"label":"td","span":{"begin":827,"end":828}},{"label":"td","span":{"begin":829,"end":850}},{"label":"td","span":{"begin":851,"end":871}},{"label":"td","span":{"begin":872,"end":873}}],"tracks":[]}