PMC:7560808 / 94-927 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7560808","sourcedb":"PMC","sourceid":"7560808","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7560808","text":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the so-called coronavirus disease (COVID-19), which is characterized by a broad spectrum of clinical presentations ranging from asymptomatic patients to critically ill individuals with a high case fatality rate (1). The critical care community has increasingly recognized that cardiovascular and thrombotic complications are relatively common in COVID-19 (2). Indeed, direct involvement of the vascular endothelium was recently reported in a series of patients suffering from severe COVID-19 (3). The endothelial glycocalyx (eGC), which covers the luminal surface of endothelial cells, contributes to the maintenance of vascular homeostasis, whereas disruption of the eGC is observed early in critically ill patients and is associated with inferior outcomes (4, 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