PMC:7560808 / 10877-12076
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T58 | 292-300 | Body_part | denotes | syndecan | http://purl.org/sig/ont/fma/fma63021 |
| T59 | 336-341 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T60 | 404-426 | Body_part | denotes | transmembrane proteins | http://purl.org/sig/ont/fma/fma67858 |
| T61 | 577-582 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T62 | 723-725 | Body_part | denotes | HS | http://purl.org/sig/ont/fma/fma63023 |
| T63 | 776-783 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T64 | 953-958 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T21 | 228-238 | Body_part | denotes | sublingual | http://purl.obolibrary.org/obo/UBERON_2001275 |
| T22 | 336-341 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T23 | 577-582 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T24 | 953-958 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T72 | 21-27 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T73 | 143-149 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T74 | 160-168 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T75 | 877-885 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T76 | 944-952 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T77 | 1103-1109 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T78 | 1190-1198 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T91 | 79-80 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T92 | 336-341 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T93 | 336-341 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T94 | 577-582 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T95 | 577-582 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T96 | 687-695 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T97 | 771-775 | http://purl.obolibrary.org/obo/CLO_0001236 | denotes | 2, a |
| T98 | 789-792 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T99 | 811-812 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T100 | 982-985 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | ECs |
| T101 | 1078-1079 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T48 | 418-426 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T49 | 723-725 | Chemical | denotes | HS | http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815 |
| T51 | 776-783 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T52 | 824-834 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7 | 726-737 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
| T8 | 900-911 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T121 | 0-169 | Sentence | denotes | In summary, we found injury of the eGC and speculate that this might represent a potentially critical hallmark of later widespread endothelial injury in severe COVID-19. |
| T122 | 170-263 | Sentence | denotes | Reduced eGC thickness was visualized in vivo by employing sublingual SDF imaging in patients. |
| T123 | 264-515 | Sentence | denotes | At the same time, increased syndecan-1 and sTie-2 concentrations in the blood of these patients indicated shedding of important endothelial transmembrane proteins responsible for building (5) and maintaining (6) the structure of the eGC, respectively. |
| T124 | 516-653 | Sentence | denotes | Interestingly, eGC shedding could be reproduced when patient blood was transferred ex vivo into an endothelial microcapillary chip model. |
| T125 | 654-886 | Sentence | denotes | Although Hpa-1 and its enzymatic activity (primarily responsible for HS degradation) (7) was found to be normal, Hpa-2, a protein that has been described as a protective antagonist of Hpa-1 (8, 9), was severely depleted in COVID-19. |
| T126 | 887-1007 | Sentence | denotes | Importantly, degradation of the eGC after perfusion with COVID-19 serum could be attenuated in ECs overexpressing Hpa-2. |
| T127 | 1008-1199 | Sentence | denotes | We therefore postulate that acquired Hpa-2 deficiency might represent a potential mechanism of injury to the eGC, which could later progress to widespread endothelial dysfunction in COVID-19. |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T10 | 723-725 | GlycoEpitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T11 | 1163-1186 | Phenotype | denotes | endothelial dysfunction | http://purl.obolibrary.org/obo/HP_0032654 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 296 | 292-302 | Gene | denotes | syndecan-1 | Gene:6382 |
| 297 | 663-668 | Gene | denotes | Hpa-1 | Gene:10855 |
| 298 | 767-772 | Gene | denotes | Hpa-2 | Gene:60495 |
| 299 | 838-843 | Gene | denotes | Hpa-1 | Gene:10855 |
| 300 | 1001-1006 | Gene | denotes | Hpa-2 | Gene:60495 |
| 301 | 254-262 | Species | denotes | patients | Tax:9606 |
| 302 | 351-359 | Species | denotes | patients | Tax:9606 |
| 303 | 569-576 | Species | denotes | patient | Tax:9606 |
| 304 | 178-181 | Chemical | denotes | eGC | |
| 305 | 239-242 | Chemical | denotes | SDF | |
| 306 | 919-922 | Chemical | denotes | eGC | |
| 307 | 1117-1120 | Chemical | denotes | eGC | |
| 308 | 131-149 | Disease | denotes | endothelial injury | MESH:D014947 |
| 309 | 160-168 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 310 | 877-885 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 311 | 944-952 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 312 | 1045-1061 | Disease | denotes | Hpa-2 deficiency | MESH:C000657245 |
| 313 | 1190-1198 | Disease | denotes | COVID-19 | MESH:C000657245 |