PMC:7558914 / 32336-33562 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"895","span":{"begin":134,"end":158},"obj":"Disease"}],"attributes":[{"id":"A895","pred":"tao:has_database_id","subj":"895","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Table 3 Dosage and duration of treatment of corticosteroids, anticytokine or immunomodulatory agents, and immunoglobulin therapy for coronavirus disease 2019.\nCorticosteroids\nDexamethasone\nRegimen 1 20 mg every 24 h for 3–5 days\nRegimen 2 40 mg every 24 h for 3–5 days\nMethylprednisolone\nRegimen 1 125–250 mg every 24 h for 3–10 days\nRegimen 2 1 mg/kg every 24 h for 3–10 days\nPrednisone 40 mg every 24 h for 5 days\nAnticytokine or immunomodulatory agents\nTocilizumab\nRegimen 1 (Body weight \u003c75 kg) Single dose of 400 mgSecond dose of 400 mg could be administered 12–24 h later if required\nRegimen 2 (Body weight ≥75 kg) Single dose of 600 mg.Second dose of 400 mg could be administered 12–24 h later if required\nAnakinra\nRegimen 1 100 mg every 24 h for 3 days\nRegimen 2 200 mg every 12 h for 3 days\nRegimen 3 100 mg every 6 h (day 1), 100 mg every 12 h (day 2)Optionally 100 mg every 12 h (day 3)\nRegimen 4 200 mg every 24 h (day 1) and 100 mg every 24 h (day 2–5)\nRegimen 5 100 mg every 6 h (day 1), 100 mg every 8 h (day 2), and 100 mg every 12 h (day 3–7)\nRegimen 6 200 mg every 24 h (day 1), and 100 mg every 6-8 h for 5-10 days\nImmunoglobulins\nRegimen 400 mg/kg/day for 5 days\nkg: kilogram; mg: milligram."}

{"project":"LitCovid-sentences","denotations":[{"id":"T228","span":{"begin":0,"end":159},"obj":"Sentence"},{"id":"T229","span":{"begin":160,"end":175},"obj":"Sentence"},{"id":"T230","span":{"begin":176,"end":189},"obj":"Sentence"},{"id":"T231","span":{"begin":190,"end":230},"obj":"Sentence"},{"id":"T232","span":{"begin":231,"end":271},"obj":"Sentence"},{"id":"T233","span":{"begin":272,"end":290},"obj":"Sentence"},{"id":"T234","span":{"begin":291,"end":337},"obj":"Sentence"},{"id":"T235","span":{"begin":338,"end":381},"obj":"Sentence"},{"id":"T236","span":{"begin":382,"end":421},"obj":"Sentence"},{"id":"T237","span":{"begin":422,"end":461},"obj":"Sentence"},{"id":"T238","span":{"begin":462,"end":473},"obj":"Sentence"},{"id":"T239","span":{"begin":474,"end":596},"obj":"Sentence"},{"id":"T240","span":{"begin":597,"end":720},"obj":"Sentence"},{"id":"T241","span":{"begin":721,"end":729},"obj":"Sentence"},{"id":"T242","span":{"begin":730,"end":769},"obj":"Sentence"},{"id":"T243","span":{"begin":770,"end":809},"obj":"Sentence"},{"id":"T244","span":{"begin":810,"end":908},"obj":"Sentence"},{"id":"T245","span":{"begin":909,"end":977},"obj":"Sentence"},{"id":"T246","span":{"begin":978,"end":1072},"obj":"Sentence"},{"id":"T247","span":{"begin":1073,"end":1147},"obj":"Sentence"},{"id":"T248","span":{"begin":1148,"end":1163},"obj":"Sentence"},{"id":"T249","span":{"begin":1164,"end":1197},"obj":"Sentence"},{"id":"T250","span":{"begin":1198,"end":1226},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 3 Dosage and duration of treatment of corticosteroids, anticytokine or immunomodulatory agents, and immunoglobulin therapy for coronavirus disease 2019.\nCorticosteroids\nDexamethasone\nRegimen 1 20 mg every 24 h for 3–5 days\nRegimen 2 40 mg every 24 h for 3–5 days\nMethylprednisolone\nRegimen 1 125–250 mg every 24 h for 3–10 days\nRegimen 2 1 mg/kg every 24 h for 3–10 days\nPrednisone 40 mg every 24 h for 5 days\nAnticytokine or immunomodulatory agents\nTocilizumab\nRegimen 1 (Body weight \u003c75 kg) Single dose of 400 mgSecond dose of 400 mg could be administered 12–24 h later if required\nRegimen 2 (Body weight ≥75 kg) Single dose of 600 mg.Second dose of 400 mg could be administered 12–24 h later if required\nAnakinra\nRegimen 1 100 mg every 24 h for 3 days\nRegimen 2 200 mg every 12 h for 3 days\nRegimen 3 100 mg every 6 h (day 1), 100 mg every 12 h (day 2)Optionally 100 mg every 12 h (day 3)\nRegimen 4 200 mg every 24 h (day 1) and 100 mg every 24 h (day 2–5)\nRegimen 5 100 mg every 6 h (day 1), 100 mg every 8 h (day 2), and 100 mg every 12 h (day 3–7)\nRegimen 6 200 mg every 24 h (day 1), and 100 mg every 6-8 h for 5-10 days\nImmunoglobulins\nRegimen 400 mg/kg/day for 5 days\nkg: kilogram; mg: milligram."}