PMC:7558914 / 10063-11436 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7558914","sourcedb":"PMC","sourceid":"7558914","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7558914","text":"For treating mild respiratory illness in patients with clinical risk factors, up to six antiviral options were found. Monotherapy with regimen 1 of hydroxychloroquine was the most frequent antiviral treatment recommended (5/15 protocols, 33.3%), followed by hydroxychloroquine regimen 1 plus azithromycin (3/15, 20%). Dual antiviral treatment using hydroxychloroquine with azithromycin or lopinavir/ritonavir in combination was found in 40% of protocols. No treatment was recommended in two protocols. In regard to mild pneumonia, 14 protocols recommended dual therapy: seven recommended hydroxychloroquine plus azithromycin, and seven recommended hydroxychloroquine plus lopinavir/ritonavir. Only one protocol did not recommend any antiviral treatment. For moderate pneumonia, hydroxychloroquine regimen 1 in combination with lopinavir/ritonavir regimen 2 was the most recommended treatment (5/15, 33.3%). Different combinations of hydroxychloroquine and lopinavir/ritonavir (7/15, 46.7%) and triple therapy with hydroxychloroquine regimen 3, and azithromycin and lopinavir/ritonavir regimen 2 (6/15, 40%) were the most recommended treatments for patients with severe pneumonia. Most protocols showed a preference for dual or triple antiviral therapy for patients with pneumonia. Further details about recommended antiviral treatment of COVID-19 are summarized in Table 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