PMC:7558333 / 1574-2625 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7558333","sourcedb":"PMC","sourceid":"7558333","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7558333","text":"Molecular tools as diagnostic criteria for invasive fungal diseases (IFD) has long been questioned because of a lack of reproducibility and insufficient standardization of protocols. Thanks to initiatives such as FPCRI (www.fpcri.eu [1]) and to the dramatic improvement of the quality assessment of molecular technics, Aspergillus PCR is now included in the new EORTC criteria for classification [2]. Regarding intensive care units (ICU) patients, the classification of IFD mainly refers on criteria adapted from neutropenic patients or relies on single center experiences. One algorithm has emerged as a valuable tool to classify invasive aspergillosis (IA) in ICU patients: the AspICU algorithm [3]. This classification is considered as robust because it has been evaluated in patients for whom autopsy results were available, but it is quite awkward to use in routine practice, particularly in COVID-19 patients with clinical and CT-scan signs hard to interpret [4]. Besides, it does not include molecular markers, which are now used routinely 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