PMC:7558233 / 27272-28687 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7558233","sourcedb":"PMC","sourceid":"7558233","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7558233","text":"Treatment Target population Reduces viral loads Improvement in clinical outcomes Main adverse effects\nLopinavir–ritonavir Severe COVID-19 Probable No significant acceleration in the time to clinical improvement Gastrointestinal tract symptoms; impairment of liver and kidney function\n\u2028\u2028\nRemdesivir Severe COVID-19 Probable No significant acceleration in the time to clinical improvement Gastrointestinal tract symptoms; impairment of liver and kidney function\n\u2028\u2028\nFavipiravir Severe COVID-19 Yes Increase the rate of improvement of chest computed tomographic findings Diarrhea; impairment of liver and kidney function\n\u2028\u2028\nChloroquine Moderate-to-severe COVID-19 Yes No significant acceleration in the time to clinical improvement Prolongation of Qt intervals; impairment of liver and kidney function\n\u2028\u2028\nConvalescent plasma Critical illness of COVID-19 Yes No significant acceleration in the time to clinical improvement Unknown\n\u2028\u2028\nLianhuaqingwen capsule Moderate COVID-19 No Accelerate symptom improvement and increase the rate of symptom improvement impairment of liver and kidney function\n\u2028\u2028\nGranulocyte colony stimulating factor Lymphopenic patients with COVID-19 No Decrease the likelihood of disease progression and increase the rate of symptom improvement Leukocytosis; osteodynia\n\u2028\u2028\nHydrogen oxygen mixed gas inhalation Symptomatic patients with COVID-19 Unknown Rapidly ameliorate respiratory symptoms 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