PMC:7556614 / 29216-31056
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7556614","sourcedb":"PMC","sourceid":"7556614","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7556614","text":"Particle Size and PDI Analysis\nParticle size and PDI obtained from all 17 formulations were recorded in Table IV as observed values and illustrated in Fig. 2 c. The particle size ranged from 155.31 ± 6.87 to 264.82 ± 4.33 nm, with PDI ranged from 0.179 ± 0.03 to 0.429 ± 0.12. In overall, the results were accepted as it is capable of exhibiting enhanced permeability and retention (EPR) effect. Equation (11) describes the effect of three independent factors on particle size, with high r2 value of 0.9162 to prove that the equation is reliable.11 Y2=162.83+16.23X1+18.39X2+16.72X3+14.47X1X2–14.07X1X3–15.65X2X3+17.39X12+26.7X22+47.32X32\nWe observed that particle size was significantly impacted by amount of lecithin, chitosan, and PEG 2000 used, as shown in Fig. 3 g–i.\nThe particle size of PALN increased with the amount of lecithin and chitosan used in the nanoparticles. As more lecithin and chitosan were used, more drugs attracted and entrapped in the core, forming bulkier nanoparticle. The nanoparticles formed showed a size smaller than 200 nm, as a proven larger proportion of smaller nanoparticle size area in Fig. 4. To decrease the amount of chitosan injudiciously was not preferred as it might be insufficient to form a complete spherical structure with lecithin, which was bulkier with attached drug. Thus, lecithin to chitosan ratio must be adjust to ensure complete self-assembling process as it leads to rigid spherical nanoparticle occupying less space. On the other hand, increment in PEG 2000 thickens the layer on PALN, resulting in size increment (32). It is also observed that without sufficient PEG 2000, the drug residence time in systemic blood circulation might not be able to be significantly prolonged for nanoparticles.\nFig. 4 SEM image of PALN1 at a × 12,000, b× 30,000, and HRTEM image of PALNs at c× 7800","divisions":[{"label":"title","span":{"begin":0,"end":30}},{"label":"p","span":{"begin":31,"end":638}},{"label":"label","span":{"begin":546,"end":548}},{"label":"p","span":{"begin":639,"end":772}},{"label":"label","span":{"begin":1753,"end":1759}}],"tracks":[]}