PMC:7556165 / 91-497 JSONTXT

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T2","span":{"begin":40,"end":43},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T3","span":{"begin":111,"end":114},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A2","pred":"meddra_id","subj":"T2","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"},{"id":"A3","pred":"meddra_id","subj":"T3","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"}],"text":"onverting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T5","span":{"begin":116,"end":204},"obj":"Sentence"},{"id":"T6","span":{"begin":205,"end":327},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"onverting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T1","span":{"begin":186,"end":190},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"onverting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"47","span":{"begin":20,"end":24},"obj":"Gene"},{"id":"48","span":{"begin":40,"end":43},"obj":"Gene"},{"id":"49","span":{"begin":111,"end":114},"obj":"Gene"},{"id":"50","span":{"begin":116,"end":120},"obj":"Gene"},{"id":"51","span":{"begin":205,"end":209},"obj":"Gene"},{"id":"52","span":{"begin":334,"end":338},"obj":"Gene"},{"id":"67","span":{"begin":363,"end":367},"obj":"Gene"},{"id":"68","span":{"begin":256,"end":260},"obj":"Gene"},{"id":"77","span":{"begin":186,"end":203},"obj":"Disease"}],"attributes":[{"id":"A52","pred":"pubann:denotes","subj":"52","obj":"Gene:59272"},{"id":"A50","pred":"pubann:denotes","subj":"50","obj":"Gene:59272"},{"id":"A67","pred":"pubann:denotes","subj":"67","obj":"Gene:159371"},{"id":"A77","pred":"pubann:denotes","subj":"77","obj":"MESH:D011014"},{"id":"A51","pred":"pubann:denotes","subj":"51","obj":"Gene:59272"},{"id":"A47","pred":"pubann:denotes","subj":"47","obj":"Gene:59272"},{"id":"A49","pred":"pubann:denotes","subj":"49","obj":"Gene:1636"},{"id":"A68","pred":"pubann:denotes","subj":"68","obj":"Gene:159371"},{"id":"A48","pred":"pubann:denotes","subj":"48","obj":"Gene:1636"}],"text":"onverting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T17","span":{"begin":20,"end":24},"obj":"Protein"},{"id":"T18","span":{"begin":40,"end":43},"obj":"Protein"},{"id":"T43","span":{"begin":111,"end":114},"obj":"Protein"},{"id":"T68","span":{"begin":116,"end":120},"obj":"Protein"},{"id":"T69","span":{"begin":205,"end":209},"obj":"Protein"},{"id":"T70","span":{"begin":334,"end":338},"obj":"Protein"}],"attributes":[{"id":"A17","pred":"uniprot_id","subj":"T17","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A18","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q9GLN7"},{"id":"A19","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q9GLN6"},{"id":"A20","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q9EQM9"},{"id":"A21","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q8CFN1"},{"id":"A22","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q7TMC6"},{"id":"A23","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q7M4L4"},{"id":"A24","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q6GTS2"},{"id":"A25","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q59GY8"},{"id":"A26","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q53YX9"},{"id":"A27","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q50JE5"},{"id":"A28","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q10751"},{"id":"A29","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q0GA41"},{"id":"A30","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/P47820"},{"id":"A31","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/P22968"},{"id":"A32","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/P22967"},{"id":"A33","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/P22966"},{"id":"A34","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/P12822"},{"id":"A35","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/P12821"},{"id":"A36","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/P12820"},{"id":"A37","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/P09470"},{"id":"A38","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/O02852"},{"id":"A39","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/E7EU16"},{"id":"A40","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/B4DXI3"},{"id":"A41","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/B0LPF0"},{"id":"A42","pred":"uniprot_id","subj":"T18","obj":"https://www.uniprot.org/uniprot/Q9VJV3"},{"id":"A43","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q9GLN7"},{"id":"A44","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q9GLN6"},{"id":"A45","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q9EQM9"},{"id":"A46","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q8CFN1"},{"id":"A47","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q7TMC6"},{"id":"A48","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q7M4L4"},{"id":"A49","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q6GTS2"},{"id":"A50","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q59GY8"},{"id":"A51","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q53YX9"},{"id":"A52","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q50JE5"},{"id":"A53","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q10751"},{"id":"A54","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/Q0GA41"},{"id":"A55","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/P47820"},{"id":"A56","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/P22968"},{"id":"A57","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/P22967"},{"id":"A58","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/P22966"},{"id":"A59","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/P12822"},{"id":"A60","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/P12821"},{"id":"A61","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/P12820"},{"id":"A62","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/P09470"},{"id":"A63","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/O02852"},{"id":"A64","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/E7EU16"},{"id":"A65","pred":"uniprot_id","subj":"T43","obj":"https://www.uniprot.org/uniprot/B4DXI3"},{"id":"A66","pred":"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enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T1","span":{"begin":186,"end":190},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"onverting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T3","span":{"begin":191,"end":203},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"onverting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T1","span":{"begin":186,"end":190},"obj":"http://purl.obolibrary.org/obo/MAT_0000135"}],"text":"onverting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T1","span":{"begin":191,"end":203},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T2","span":{"begin":236,"end":251},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T3","span":{"begin":261,"end":276},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T4","span":{"begin":368,"end":383},"obj":"http://purl.obolibrary.org/obo/GO_0006412"},{"id":"T5","span":{"begin":387,"end":400},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"text":"onverting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T1","span":{"begin":191,"end":203},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T2","span":{"begin":236,"end":251},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T3","span":{"begin":261,"end":276},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T4","span":{"begin":368,"end":383},"obj":"http://purl.obolibrary.org/obo/GO_0006412"},{"id":"T5","span":{"begin":387,"end":400},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"text":"onverting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}

{"project":"LitCovid-PubTator","denotations":[{"id":"47","span":{"begin":20,"end":24},"obj":"Gene"},{"id":"48","span":{"begin":40,"end":43},"obj":"Gene"},{"id":"49","span":{"begin":111,"end":114},"obj":"Gene"},{"id":"50","span":{"begin":116,"end":120},"obj":"Gene"},{"id":"51","span":{"begin":205,"end":209},"obj":"Gene"},{"id":"52","span":{"begin":334,"end":338},"obj":"Gene"},{"id":"67","span":{"begin":363,"end":367},"obj":"Gene"},{"id":"68","span":{"begin":256,"end":260},"obj":"Gene"},{"id":"77","span":{"begin":186,"end":203},"obj":"Disease"}],"attributes":[{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"Gene:59272"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"Gene:1636"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"Gene:1636"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"Gene:59272"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"Gene:59272"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Gene:59272"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"Gene:159371"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"Gene:159371"},{"id":"A77","pred":"tao:has_database_id","subj":"77","obj":"MESH:D011014"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"onverting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}

{"project":"LitCovid-sentences","denotations":[{"id":"T5","span":{"begin":116,"end":204},"obj":"Sentence"},{"id":"T6","span":{"begin":205,"end":327},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"onverting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE. ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation. ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs. Also, ACE2 expression is regulated post-translationally by glycosylation, phos"}