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PMC:7556165 / 8275-8848 JSONTXT

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LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T43 153-156 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T44 238-241 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T45 368-381 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T46 385-399 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T47 465-468 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T41 37-41 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T43 66-77 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T44 290-300 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T45 368-381 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T47 385-399 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T50 420-430 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T51 486-496 Chemical denotes lisinopril http://purl.obolibrary.org/obo/CHEBI_43755
T52 501-510 Chemical denotes captopril http://purl.obolibrary.org/obo/CHEBI_3380

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T35 533-537 Species denotes Rice NCBItxid:4530

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T58 0-120 Sentence denotes The ACE2 gene codifies for a typical zinc-metallopeptidase of 805 amino acids (120 kDa), with a unique catalytic domain.
T59 121-231 Sentence denotes Despite the high resemblance of ACE and ACE2, considerable differences exist in their substrates and products.
T60 232-321 Sentence denotes While ACE acts as dipeptidase, ACE2 removes only a single amino acid from its substrates.
T61 322-573 Sentence denotes Therefore, ACE2 is not active in transforming angiotensin I to angiotensin II and in inactivating bradykinin; moreover, ACE2 is insensitive to ACE inhibitors, like lisinopril and captopril (Tipnis et al., 2000; Rice et al., 2004; Turner et al., 2004).

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
282 4-8 Gene denotes ACE2 Gene:59272
283 153-156 Gene denotes ACE Gene:1636
284 161-165 Gene denotes ACE2 Gene:59272
285 238-241 Gene denotes ACE Gene:1636
286 263-267 Gene denotes ACE2 Gene:59272
287 333-337 Gene denotes ACE2 Gene:59272
288 368-381 Gene denotes angiotensin I Gene:183
289 385-399 Gene denotes angiotensin II Gene:183
290 420-430 Gene denotes bradykinin Gene:3827
291 442-446 Gene denotes ACE2 Gene:59272
292 465-468 Gene denotes ACE Gene:1636
293 469-479 Chemical denotes inhibitors
294 486-496 Chemical denotes lisinopril MESH:D017706
295 501-510 Chemical denotes captopril MESH:D002216

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1301 4-8 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1302 153-156 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1327 161-165 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1328 238-241 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1353 263-267 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1354 333-337 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1355 368-381 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T1372 385-399 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T1389 420-430 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T1426 442-446 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1427 465-468 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T25 222-230 http://purl.obolibrary.org/obo/IDO_0000607 denotes products

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T34 9-13 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T35 66-77 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T36 290-300 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
282 4-8 Gene denotes ACE2 Gene:59272
283 153-156 Gene denotes ACE Gene:1636
284 161-165 Gene denotes ACE2 Gene:59272
285 238-241 Gene denotes ACE Gene:1636
286 263-267 Gene denotes ACE2 Gene:59272
287 333-337 Gene denotes ACE2 Gene:59272
288 368-381 Gene denotes angiotensin I Gene:183
289 385-399 Gene denotes angiotensin II Gene:183
290 420-430 Gene denotes bradykinin Gene:3827
291 442-446 Gene denotes ACE2 Gene:59272
292 465-468 Gene denotes ACE Gene:1636
293 469-479 Chemical denotes inhibitors
294 486-496 Chemical denotes lisinopril MESH:D017706
295 501-510 Chemical denotes captopril MESH:D002216

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T58 0-120 Sentence denotes The ACE2 gene codifies for a typical zinc-metallopeptidase of 805 amino acids (120 kDa), with a unique catalytic domain.
T59 121-231 Sentence denotes Despite the high resemblance of ACE and ACE2, considerable differences exist in their substrates and products.
T60 232-321 Sentence denotes While ACE acts as dipeptidase, ACE2 removes only a single amino acid from its substrates.
T61 322-573 Sentence denotes Therefore, ACE2 is not active in transforming angiotensin I to angiotensin II and in inactivating bradykinin; moreover, ACE2 is insensitive to ACE inhibitors, like lisinopril and captopril (Tipnis et al., 2000; Rice et al., 2004; Turner et al., 2004).