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PMC:7556165 / 7787-10683 JSONTXT

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LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T41 97-100 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T42 187-190 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T43 641-644 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T44 726-729 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T45 856-869 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T46 873-887 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T47 953-956 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T48 1924-1927 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T49 2135-2138 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T50 2356-2359 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T41 525-529 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T43 554-565 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T44 778-788 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T45 856-869 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T47 873-887 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T50 908-918 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T51 974-984 Chemical denotes lisinopril http://purl.obolibrary.org/obo/CHEBI_43755
T52 989-998 Chemical denotes captopril http://purl.obolibrary.org/obo/CHEBI_3380
T53 1383-1390 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T54 2081-2091 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T55 2408-2415 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T56 2438-2449 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T57 2668-2676 Chemical denotes zinc ion http://purl.obolibrary.org/obo/CHEBI_27365

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T35 1021-1025 Species denotes Rice NCBItxid:4530

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T54 0-17 Sentence denotes Structure of ACE2
T55 18-139 Sentence denotes ACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17.
T56 140-197 Sentence denotes The 18 exons of ACE2 are remarkably similar to ACE exons.
T57 198-487 Sentence denotes The ACE2 gene depicts a large polymorphism and several novel polymorphisms of ACE2, with specific geographical distribution, have been described and associated with susceptibility to hypertension and cardiovascular disease (Burrell et al., 2013; Patel et al., 2014; Pinheiro et al., 2019).
T58 488-608 Sentence denotes The ACE2 gene codifies for a typical zinc-metallopeptidase of 805 amino acids (120 kDa), with a unique catalytic domain.
T59 609-719 Sentence denotes Despite the high resemblance of ACE and ACE2, considerable differences exist in their substrates and products.
T60 720-809 Sentence denotes While ACE acts as dipeptidase, ACE2 removes only a single amino acid from its substrates.
T61 810-1061 Sentence denotes Therefore, ACE2 is not active in transforming angiotensin I to angiotensin II and in inactivating bradykinin; moreover, ACE2 is insensitive to ACE inhibitors, like lisinopril and captopril (Tipnis et al., 2000; Rice et al., 2004; Turner et al., 2004).
T62 1062-1159 Sentence denotes These differences depend on variances in the three-dimensional structure (3D) of the two enzymes.
T63 1160-1268 Sentence denotes Comparative homology modeling and crystallography contributed to shed light on ACE2 3D structure (Figure 1).
T64 1269-1421 Sentence denotes Prabakaran et al. (2004) clarified the major characteristic of ACE2, which is a deep channel on the summit of the protein, hosting the catalytic domain.
T65 1422-1570 Sentence denotes Specific loops, like the long loop N210-Q221 that is exclusive of ACE2, α helices and a portion of β-sheet are located around the catalytic channel.
T66 1571-1731 Sentence denotes The negative charge of the channel and the presence of distinct hydrophobic regions contribute to the specificity of the binding site (Prabakaran et al., 2004).
T67 1732-1994 Sentence denotes The determination of the crystal structure of the extracellular domain to 2.2-3-A resolution from Towler et al. (2004) and the model from Guy et al. (2003) showed that the catalytic domain of ACE and ACE2 are very conserved and have similar mechanisms of action.
T68 1995-2266 Sentence denotes The main difference stems from the smaller ACE2 pocket, thereby lodging only a single amino acid: the crucial substitution of the Gln281 in ACE binding pocket with Arg273 in ACE2 is likely to be responsible for the steric conflict (Guy et al., 2003; Towler et al., 2004).
T69 2267-2503 Sentence denotes Another surprise of the ACE2 structure was its C-terminal domain, which—differently from ACE—revealed high homology with collectrin, a renal protein, which is involved in amino acids trafficking through the membrane (Yang et al., 2017).
T70 2504-2540 Sentence denotes FIGURE 1 Crystal structure of ACE2.
T71 2541-2656 Sentence denotes The peptidase domain (PD) is in green, whereas the collectrin homology domain is enclosed in the light cyan square.
T72 2657-2802 Sentence denotes The active zinc ion is showed enclosed in a red circle, whereas the glycosylation moieties are showed as cyan cubes and denoted by dashed arrows.
T73 2803-2896 Sentence denotes The structures have been drawn from PDB 1R42 (Towler et al., 2004) by Mol on the PDB website.

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
260 18-22 Gene denotes ACE2 Gene:59272
261 97-100 Gene denotes ACE Gene:1636
262 156-160 Gene denotes ACE2 Gene:59272
263 187-190 Gene denotes ACE Gene:1636
264 202-206 Gene denotes ACE2 Gene:59272
265 276-280 Gene denotes ACE2 Gene:59272
266 381-393 Disease denotes hypertension MESH:D006973
267 398-420 Disease denotes cardiovascular disease MESH:D002318
282 492-496 Gene denotes ACE2 Gene:59272
283 641-644 Gene denotes ACE Gene:1636
284 649-653 Gene denotes ACE2 Gene:59272
285 726-729 Gene denotes ACE Gene:1636
286 751-755 Gene denotes ACE2 Gene:59272
287 821-825 Gene denotes ACE2 Gene:59272
288 856-869 Gene denotes angiotensin I Gene:183
289 873-887 Gene denotes angiotensin II Gene:183
290 908-918 Gene denotes bradykinin Gene:3827
291 930-934 Gene denotes ACE2 Gene:59272
292 953-956 Gene denotes ACE Gene:1636
293 957-967 Chemical denotes inhibitors
294 974-984 Chemical denotes lisinopril MESH:D017706
295 989-998 Chemical denotes captopril MESH:D002216
310 1239-1243 Gene denotes ACE2 Gene:59272
311 1332-1336 Gene denotes ACE2 Gene:59272
312 1488-1492 Gene denotes ACE2 Gene:59272
313 1924-1927 Gene denotes ACE Gene:1636
314 1932-1936 Gene denotes ACE2 Gene:59272
315 2038-2042 Gene denotes ACE2 Gene:59272
316 2135-2138 Gene denotes ACE Gene:1636
317 2169-2173 Gene denotes ACE2 Gene:59272
318 2291-2295 Gene denotes ACE2 Gene:59272
319 2388-2398 Gene denotes collectrin Gene:57393
320 2356-2359 Gene denotes ACE Gene:1636
321 2474-2482 Gene denotes membrane Gene:43740571
322 2125-2131 Chemical denotes Gln281
323 2159-2165 Chemical denotes Arg273
327 2535-2539 Gene denotes ACE2 Gene:59272
328 2884-2887 Gene denotes PDB Gene:5131
329 2592-2602 Gene denotes collectrin Gene:57393

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1246 13-17 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1247 18-22 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1248 97-100 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1273 156-160 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1274 187-190 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1299 202-206 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1300 276-280 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1301 492-496 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1302 641-644 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1327 649-653 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1328 726-729 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1353 751-755 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1354 821-825 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1355 856-869 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T1372 873-887 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T1389 908-918 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T1426 930-934 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1427 953-956 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1452 1239-1243 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1453 1332-1336 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1454 1488-1492 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1455 1924-1927 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1480 1932-1936 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1481 2038-2042 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1482 2135-2138 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1507 2169-2173 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1508 2291-2295 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1509 2356-2359 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1534 2388-2398 Protein denotes collectrin https://www.uniprot.org/uniprot/Q9HBJ8|https://www.uniprot.org/uniprot/Q9ESG4|https://www.uniprot.org/uniprot/Q9ESG3|https://www.uniprot.org/uniprot/Q6UW07|https://www.uniprot.org/uniprot/Q6AYY2|https://www.uniprot.org/uniprot/Q3UFF6|https://www.uniprot.org/uniprot/Q0VCT4|https://www.uniprot.org/uniprot/B2R9M1
T1542 2535-2539 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1543 2592-2602 Protein denotes collectrin https://www.uniprot.org/uniprot/Q9HBJ8|https://www.uniprot.org/uniprot/Q9ESG4|https://www.uniprot.org/uniprot/Q9ESG3|https://www.uniprot.org/uniprot/Q6UW07|https://www.uniprot.org/uniprot/Q6AYY2|https://www.uniprot.org/uniprot/Q3UFF6|https://www.uniprot.org/uniprot/Q0VCT4|https://www.uniprot.org/uniprot/B2R9M1

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T23 363-377 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T24 413-420 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T25 710-718 http://purl.obolibrary.org/obo/IDO_0000607 denotes products
T26 1392-1399 http://purl.obolibrary.org/obo/IDO_0000531 denotes hosting
T27 1700-1704 http://purl.obolibrary.org/obo/BFO_0000029 denotes site

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T29 34-38 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T30 63-73 Body_part denotes chromosome http://purl.org/sig/ont/fma/fma67093
T31 101-105 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T32 125-135 Body_part denotes chromosome http://purl.org/sig/ont/fma/fma67093
T33 207-211 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T34 497-501 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T35 554-565 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T36 778-788 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T37 1383-1390 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T38 2081-2091 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T39 2408-2415 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T40 2438-2449 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T42 381-420 Disease denotes hypertension and cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0001302

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T15 2015-2020 http://purl.obolibrary.org/obo/MAT_0000239 denotes stems

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T12 2725-2738 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T12 381-393 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T13 398-420 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T12 2725-2738 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T12 381-393 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T13 398-420 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
260 18-22 Gene denotes ACE2 Gene:59272
261 97-100 Gene denotes ACE Gene:1636
262 156-160 Gene denotes ACE2 Gene:59272
263 187-190 Gene denotes ACE Gene:1636
264 202-206 Gene denotes ACE2 Gene:59272
265 276-280 Gene denotes ACE2 Gene:59272
266 381-393 Disease denotes hypertension MESH:D006973
267 398-420 Disease denotes cardiovascular disease MESH:D002318
282 492-496 Gene denotes ACE2 Gene:59272
283 641-644 Gene denotes ACE Gene:1636
284 649-653 Gene denotes ACE2 Gene:59272
285 726-729 Gene denotes ACE Gene:1636
286 751-755 Gene denotes ACE2 Gene:59272
287 821-825 Gene denotes ACE2 Gene:59272
288 856-869 Gene denotes angiotensin I Gene:183
289 873-887 Gene denotes angiotensin II Gene:183
290 908-918 Gene denotes bradykinin Gene:3827
291 930-934 Gene denotes ACE2 Gene:59272
292 953-956 Gene denotes ACE Gene:1636
293 957-967 Chemical denotes inhibitors
294 974-984 Chemical denotes lisinopril MESH:D017706
295 989-998 Chemical denotes captopril MESH:D002216
310 1239-1243 Gene denotes ACE2 Gene:59272
311 1332-1336 Gene denotes ACE2 Gene:59272
312 1488-1492 Gene denotes ACE2 Gene:59272
313 1924-1927 Gene denotes ACE Gene:1636
314 1932-1936 Gene denotes ACE2 Gene:59272
315 2038-2042 Gene denotes ACE2 Gene:59272
316 2135-2138 Gene denotes ACE Gene:1636
317 2169-2173 Gene denotes ACE2 Gene:59272
318 2291-2295 Gene denotes ACE2 Gene:59272
319 2388-2398 Gene denotes collectrin Gene:57393
320 2356-2359 Gene denotes ACE Gene:1636
321 2474-2482 Gene denotes membrane Gene:43740571
322 2125-2131 Chemical denotes Gln281
323 2159-2165 Chemical denotes Arg273
327 2535-2539 Gene denotes ACE2 Gene:59272
329 2592-2602 Gene denotes collectrin Gene:57393

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T54 0-17 Sentence denotes Structure of ACE2
T55 18-139 Sentence denotes ACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17.
T56 140-197 Sentence denotes The 18 exons of ACE2 are remarkably similar to ACE exons.
T57 198-487 Sentence denotes The ACE2 gene depicts a large polymorphism and several novel polymorphisms of ACE2, with specific geographical distribution, have been described and associated with susceptibility to hypertension and cardiovascular disease (Burrell et al., 2013; Patel et al., 2014; Pinheiro et al., 2019).
T58 488-608 Sentence denotes The ACE2 gene codifies for a typical zinc-metallopeptidase of 805 amino acids (120 kDa), with a unique catalytic domain.
T59 609-719 Sentence denotes Despite the high resemblance of ACE and ACE2, considerable differences exist in their substrates and products.
T60 720-809 Sentence denotes While ACE acts as dipeptidase, ACE2 removes only a single amino acid from its substrates.
T61 810-1061 Sentence denotes Therefore, ACE2 is not active in transforming angiotensin I to angiotensin II and in inactivating bradykinin; moreover, ACE2 is insensitive to ACE inhibitors, like lisinopril and captopril (Tipnis et al., 2000; Rice et al., 2004; Turner et al., 2004).
T62 1062-1159 Sentence denotes These differences depend on variances in the three-dimensional structure (3D) of the two enzymes.
T63 1160-1268 Sentence denotes Comparative homology modeling and crystallography contributed to shed light on ACE2 3D structure (Figure 1).
T64 1269-1421 Sentence denotes Prabakaran et al. (2004) clarified the major characteristic of ACE2, which is a deep channel on the summit of the protein, hosting the catalytic domain.
T65 1422-1570 Sentence denotes Specific loops, like the long loop N210-Q221 that is exclusive of ACE2, α helices and a portion of β-sheet are located around the catalytic channel.
T66 1571-1731 Sentence denotes The negative charge of the channel and the presence of distinct hydrophobic regions contribute to the specificity of the binding site (Prabakaran et al., 2004).
T67 1732-1994 Sentence denotes The determination of the crystal structure of the extracellular domain to 2.2-3-A resolution from Towler et al. (2004) and the model from Guy et al. (2003) showed that the catalytic domain of ACE and ACE2 are very conserved and have similar mechanisms of action.
T68 1995-2266 Sentence denotes The main difference stems from the smaller ACE2 pocket, thereby lodging only a single amino acid: the crucial substitution of the Gln281 in ACE binding pocket with Arg273 in ACE2 is likely to be responsible for the steric conflict (Guy et al., 2003; Towler et al., 2004).
T69 2267-2503 Sentence denotes Another surprise of the ACE2 structure was its C-terminal domain, which—differently from ACE—revealed high homology with collectrin, a renal protein, which is involved in amino acids trafficking through the membrane (Yang et al., 2017).
T70 2504-2540 Sentence denotes FIGURE 1 Crystal structure of ACE2.
T71 2541-2656 Sentence denotes The peptidase domain (PD) is in green, whereas the collectrin homology domain is enclosed in the light cyan square.
T72 2657-2802 Sentence denotes The active zinc ion is showed enclosed in a red circle, whereas the glycosylation moieties are showed as cyan cubes and denoted by dashed arrows.
T73 2803-2896 Sentence denotes The structures have been drawn from PDB 1R42 (Towler et al., 2004) by Mol on the PDB website.