PMC:7556165 / 7394-8050 JSONTXT

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    LitCovid-sample-MedDRA

    {"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T41","span":{"begin":490,"end":493},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T42","span":{"begin":580,"end":583},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A41","pred":"meddra_id","subj":"T41","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"},{"id":"A42","pred":"meddra_id","subj":"T42","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"}],"text":"me type I protein. The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b). In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.\n\nACE2: Structure, Expression, Tissue Distribution, and Function\n\nStructure of ACE2\nACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17. The 18 exons of ACE2 are remarkably similar to ACE exons. The ACE2 gene depicts a large polymorphism and several novel poly"}

    LitCovid-sample-CHEBI

    {"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T40","span":{"begin":10,"end":17},"obj":"Chemical"}],"attributes":[{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"me type I protein. The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b). In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.\n\nACE2: Structure, Expression, Tissue Distribution, and Function\n\nStructure of ACE2\nACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17. The 18 exons of ACE2 are remarkably similar to ACE exons. The ACE2 gene depicts a large polymorphism and several novel poly"}

    LitCovid-sample-sentences

    {"project":"LitCovid-sample-sentences","denotations":[{"id":"T50","span":{"begin":19,"end":187},"obj":"Sentence"},{"id":"T51","span":{"begin":188,"end":327},"obj":"Sentence"},{"id":"T52","span":{"begin":329,"end":334},"obj":"Sentence"},{"id":"T53","span":{"begin":335,"end":391},"obj":"Sentence"},{"id":"T54","span":{"begin":393,"end":410},"obj":"Sentence"},{"id":"T55","span":{"begin":411,"end":532},"obj":"Sentence"},{"id":"T56","span":{"begin":533,"end":590},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"me type I protein. The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b). In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.\n\nACE2: Structure, Expression, Tissue Distribution, and Function\n\nStructure of ACE2\nACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17. The 18 exons of ACE2 are remarkably similar to ACE exons. The ACE2 gene depicts a large polymorphism and several novel poly"}

    LitCovid-sample-PD-UBERON

    {"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T11","span":{"begin":84,"end":89},"obj":"Body_part"},{"id":"T12","span":{"begin":101,"end":107},"obj":"Body_part"},{"id":"T13","span":{"begin":358,"end":364},"obj":"Body_part"}],"attributes":[{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"me type I protein. The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b). In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.\n\nACE2: Structure, Expression, Tissue Distribution, and Function\n\nStructure of ACE2\nACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17. The 18 exons of ACE2 are remarkably similar to ACE exons. The ACE2 gene depicts a large polymorphism and several novel poly"}

    LitCovid-sample-Pubtator

    {"project":"LitCovid-sample-Pubtator","denotations":[{"id":"238","span":{"begin":42,"end":46},"obj":"Gene"},{"id":"239","span":{"begin":131,"end":135},"obj":"Gene"},{"id":"240","span":{"begin":212,"end":216},"obj":"Gene"},{"id":"251","span":{"begin":329,"end":333},"obj":"Gene"},{"id":"260","span":{"begin":411,"end":415},"obj":"Gene"},{"id":"261","span":{"begin":490,"end":493},"obj":"Gene"},{"id":"262","span":{"begin":549,"end":553},"obj":"Gene"},{"id":"263","span":{"begin":580,"end":583},"obj":"Gene"},{"id":"264","span":{"begin":595,"end":599},"obj":"Gene"}],"attributes":[{"id":"A251","pred":"pubann:denotes","subj":"251","obj":"Gene:59272"},{"id":"A240","pred":"pubann:denotes","subj":"240","obj":"Gene:59272"},{"id":"A263","pred":"pubann:denotes","subj":"263","obj":"Gene:1636"},{"id":"A261","pred":"pubann:denotes","subj":"261","obj":"Gene:1636"},{"id":"A262","pred":"pubann:denotes","subj":"262","obj":"Gene:59272"},{"id":"A238","pred":"pubann:denotes","subj":"238","obj":"Gene:59272"},{"id":"A264","pred":"pubann:denotes","subj":"264","obj":"Gene:59272"},{"id":"A260","pred":"pubann:denotes","subj":"260","obj":"Gene:59272"},{"id":"A239","pred":"pubann:denotes","subj":"239","obj":"Gene:59272"}],"text":"me type I protein. The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b). In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.\n\nACE2: Structure, Expression, Tissue Distribution, and Function\n\nStructure of ACE2\nACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17. The 18 exons of ACE2 are remarkably similar to ACE exons. The ACE2 gene depicts a large polymorphism and several novel poly"}

    LitCovid-sample-UniProt

    {"project":"LitCovid-sample-UniProt","denotations":[{"id":"T1242","span":{"begin":42,"end":46},"obj":"Protein"},{"id":"T1243","span":{"begin":131,"end":135},"obj":"Protein"},{"id":"T1244","span":{"begin":212,"end":216},"obj":"Protein"},{"id":"T1245","span":{"begin":329,"end":333},"obj":"Protein"},{"id":"T1246","span":{"begin":406,"end":410},"obj":"Protein"},{"id":"T1247","span":{"begin":411,"end":415},"obj":"Protein"},{"id":"T1248","span":{"begin":490,"end":493},"obj":"Protein"},{"id":"T1273","span":{"begin":549,"end":553},"obj":"Protein"},{"id":"T1274","span":{"begin":580,"end":583},"obj":"Protein"},{"id":"T1299","span":{"begin":595,"end":599},"obj":"Protein"}],"attributes":[{"id":"A1242","pred":"uniprot_id","subj":"T1242","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A1243","pred":"uniprot_id","subj":"T1243","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A1244","pred":"uniprot_id","subj":"T1244","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A1245","pred":"uniprot_id","subj":"T1245","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A1246","pred":"uniprot_id","subj":"T1246","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A1247","pred":"uniprot_id","subj":"T1247","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A1248","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q9GLN7"},{"id":"A1249","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q9GLN6"},{"id":"A1250","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q9EQM9"},{"id":"A1251","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q8CFN1"},{"id":"A1252","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q7TMC6"},{"id":"A1253","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q7M4L4"},{"id":"A1254","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q6GTS2"},{"id":"A1255","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q59GY8"},{"id":"A1256","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q53YX9"},{"id":"A1257","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q50JE5"},{"id":"A1258","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q10751"},{"id":"A1259","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q0GA41"},{"id":"A1260","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/P47820"},{"id":"A1261","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/P22968"},{"id":"A1262","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/P22967"},{"id":"A1263","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/P22966"},{"id":"A1264","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/P12822"},{"id":"A1265","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/P12821"},{"id":"A1266","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/P12820"},{"id":"A1267","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/P09470"},{"id":"A1268","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/O02852"},{"id":"A1269","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/E7EU16"},{"id":"A1270","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/B4DXI3"},{"id":"A1271","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/B0LPF0"},{"id":"A1272","pred":"uniprot_id","subj":"T1248","obj":"https://www.uniprot.org/uniprot/Q9VJV3"},{"id":"A1273","pred":"uniprot_id","subj":"T1273","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A1274","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q9GLN7"},{"id":"A1275","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q9GLN6"},{"id":"A1276","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q9EQM9"},{"id":"A1277","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q8CFN1"},{"id":"A1278","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q7TMC6"},{"id":"A1279","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q7M4L4"},{"id":"A1280","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q6GTS2"},{"id":"A1281","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q59GY8"},{"id":"A1282","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q53YX9"},{"id":"A1283","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q50JE5"},{"id":"A1284","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q10751"},{"id":"A1285","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q0GA41"},{"id":"A1286","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/P47820"},{"id":"A1287","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/P22968"},{"id":"A1288","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/P22967"},{"id":"A1289","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/P22966"},{"id":"A1290","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/P12822"},{"id":"A1291","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/P12821"},{"id":"A1292","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/P12820"},{"id":"A1293","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/P09470"},{"id":"A1294","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/O02852"},{"id":"A1295","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/E7EU16"},{"id":"A1296","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/B4DXI3"},{"id":"A1297","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/B0LPF0"},{"id":"A1298","pred":"uniprot_id","subj":"T1274","obj":"https://www.uniprot.org/uniprot/Q9VJV3"},{"id":"A1299","pred":"uniprot_id","subj":"T1299","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"me type I protein. The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b). In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.\n\nACE2: Structure, Expression, Tissue Distribution, and Function\n\nStructure of ACE2\nACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17. The 18 exons of ACE2 are remarkably similar to ACE exons. The ACE2 gene depicts a large polymorphism and several novel poly"}

    LitCovid-sample-PD-IDO

    {"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T21","span":{"begin":260,"end":268},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T22","span":{"begin":383,"end":391},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"}],"text":"me type I protein. The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b). In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.\n\nACE2: Structure, Expression, Tissue Distribution, and Function\n\nStructure of ACE2\nACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17. The 18 exons of ACE2 are remarkably similar to ACE exons. The ACE2 gene depicts a large polymorphism and several novel poly"}

    LitCovid-sample-PD-FMA

    {"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T25","span":{"begin":10,"end":17},"obj":"Body_part"},{"id":"T26","span":{"begin":84,"end":89},"obj":"Body_part"},{"id":"T27","span":{"begin":101,"end":107},"obj":"Body_part"},{"id":"T28","span":{"begin":358,"end":364},"obj":"Body_part"},{"id":"T29","span":{"begin":427,"end":431},"obj":"Body_part"},{"id":"T30","span":{"begin":456,"end":466},"obj":"Body_part"},{"id":"T31","span":{"begin":494,"end":498},"obj":"Body_part"},{"id":"T32","span":{"begin":518,"end":528},"obj":"Body_part"},{"id":"T33","span":{"begin":600,"end":604},"obj":"Body_part"}],"attributes":[{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma67093"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma67093"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma74402"}],"text":"me type I protein. The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b). In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.\n\nACE2: Structure, Expression, Tissue Distribution, and Function\n\nStructure of ACE2\nACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17. The 18 exons of ACE2 are remarkably similar to ACE exons. The ACE2 gene depicts a large polymorphism and several novel poly"}

    LitCovid-sample-PD-MAT

    {"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T13","span":{"begin":84,"end":89},"obj":"http://purl.obolibrary.org/obo/MAT_0000036"},{"id":"T14","span":{"begin":101,"end":107},"obj":"http://purl.obolibrary.org/obo/MAT_0000119"}],"text":"me type I protein. The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b). In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.\n\nACE2: Structure, Expression, Tissue Distribution, and Function\n\nStructure of ACE2\nACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17. The 18 exons of ACE2 are remarkably similar to ACE exons. The ACE2 gene depicts a large polymorphism and several novel poly"}

    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"238","span":{"begin":42,"end":46},"obj":"Gene"},{"id":"239","span":{"begin":131,"end":135},"obj":"Gene"},{"id":"240","span":{"begin":212,"end":216},"obj":"Gene"},{"id":"251","span":{"begin":329,"end":333},"obj":"Gene"},{"id":"260","span":{"begin":411,"end":415},"obj":"Gene"},{"id":"261","span":{"begin":490,"end":493},"obj":"Gene"},{"id":"262","span":{"begin":549,"end":553},"obj":"Gene"},{"id":"263","span":{"begin":580,"end":583},"obj":"Gene"},{"id":"264","span":{"begin":595,"end":599},"obj":"Gene"}],"attributes":[{"id":"A238","pred":"tao:has_database_id","subj":"238","obj":"Gene:59272"},{"id":"A239","pred":"tao:has_database_id","subj":"239","obj":"Gene:59272"},{"id":"A240","pred":"tao:has_database_id","subj":"240","obj":"Gene:59272"},{"id":"A251","pred":"tao:has_database_id","subj":"251","obj":"Gene:59272"},{"id":"A260","pred":"tao:has_database_id","subj":"260","obj":"Gene:59272"},{"id":"A261","pred":"tao:has_database_id","subj":"261","obj":"Gene:1636"},{"id":"A262","pred":"tao:has_database_id","subj":"262","obj":"Gene:59272"},{"id":"A263","pred":"tao:has_database_id","subj":"263","obj":"Gene:1636"},{"id":"A264","pred":"tao:has_database_id","subj":"264","obj":"Gene:59272"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"me type I protein. The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b). In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.\n\nACE2: Structure, Expression, Tissue Distribution, and Function\n\nStructure of ACE2\nACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17. The 18 exons of ACE2 are remarkably similar to ACE exons. The ACE2 gene depicts a large polymorphism and several novel poly"}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T50","span":{"begin":19,"end":187},"obj":"Sentence"},{"id":"T51","span":{"begin":188,"end":327},"obj":"Sentence"},{"id":"T52","span":{"begin":329,"end":334},"obj":"Sentence"},{"id":"T53","span":{"begin":335,"end":391},"obj":"Sentence"},{"id":"T54","span":{"begin":393,"end":410},"obj":"Sentence"},{"id":"T55","span":{"begin":411,"end":532},"obj":"Sentence"},{"id":"T56","span":{"begin":533,"end":590},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"me type I protein. The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b). In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.\n\nACE2: Structure, Expression, Tissue Distribution, and Function\n\nStructure of ACE2\nACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17. The 18 exons of ACE2 are remarkably similar to ACE exons. The ACE2 gene depicts a large polymorphism and several novel poly"}