PMC:7556165 / 72053-72259 JSONTXT

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T405","span":{"begin":59,"end":69},"obj":"Species"},{"id":"T406","span":{"begin":59,"end":63},"obj":"Species"}],"attributes":[{"id":"A405","pred":"ncbi_taxonomy_id","subj":"T405","obj":"NCBItxid:2697049"},{"id":"A406","pred":"ncbi_taxonomy_id","subj":"T406","obj":"NCBItxid:694009"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T425","span":{"begin":0,"end":206},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1962","span":{"begin":43,"end":47},"obj":"Gene"},{"id":"1963","span":{"begin":157,"end":161},"obj":"Gene"},{"id":"1970","span":{"begin":59,"end":69},"obj":"Species"}],"attributes":[{"id":"A1962","pred":"pubann:denotes","subj":"1962","obj":"Gene:59272"},{"id":"A1963","pred":"pubann:denotes","subj":"1963","obj":"Gene:59272"},{"id":"A1970","pred":"pubann:denotes","subj":"1970","obj":"Tax:2697049"}],"text":"Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T6243","span":{"begin":43,"end":47},"obj":"Protein"},{"id":"T6244","span":{"begin":70,"end":73},"obj":"Protein"},{"id":"T6253","span":{"begin":157,"end":161},"obj":"Protein"}],"attributes":[{"id":"A6243","pred":"uniprot_id","subj":"T6243","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A6244","pred":"uniprot_id","subj":"T6244","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A6245","pred":"uniprot_id","subj":"T6244","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A6246","pred":"uniprot_id","subj":"T6244","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A6247","pred":"uniprot_id","subj":"T6244","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A6248","pred":"uniprot_id","subj":"T6244","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A6249","pred":"uniprot_id","subj":"T6244","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A6250","pred":"uniprot_id","subj":"T6244","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A6251","pred":"uniprot_id","subj":"T6244","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A6252","pred":"uniprot_id","subj":"T6244","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A6253","pred":"uniprot_id","subj":"T6253","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T427","span":{"begin":59,"end":69},"obj":"Disease"},{"id":"T428","span":{"begin":59,"end":63},"obj":"Disease"}],"attributes":[{"id":"A427","pred":"mondo_id","subj":"T427","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A428","pred":"mondo_id","subj":"T428","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1962","span":{"begin":43,"end":47},"obj":"Gene"},{"id":"1963","span":{"begin":157,"end":161},"obj":"Gene"},{"id":"1970","span":{"begin":59,"end":69},"obj":"Species"}],"attributes":[{"id":"A1962","pred":"tao:has_database_id","subj":"1962","obj":"Gene:59272"},{"id":"A1963","pred":"tao:has_database_id","subj":"1963","obj":"Gene:59272"},{"id":"A1970","pred":"tao:has_database_id","subj":"1970","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement."}

{"project":"LitCovid-sentences","denotations":[{"id":"T425","span":{"begin":0,"end":206},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement."}