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PMC:7556165 / 71123-72259 JSONTXT

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LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T195 120-127 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T196 334-341 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T397 12-17 Species denotes human NCBItxid:9606
T398 272-280 Species denotes COVID-19 NCBItxid:2697049
T399 652-662 Species denotes SARS-CoV-2 NCBItxid:2697049
T400 652-656 Species denotes SARS NCBItxid:694009
T401 688-693 Species denotes human NCBItxid:9606
T402 721-726 Species denotes human NCBItxid:9606
T403 882-892 Species denotes SARS-CoV-2 NCBItxid:2697049
T404 882-886 Species denotes SARS NCBItxid:694009
T405 989-999 Species denotes SARS-CoV-2 NCBItxid:2697049
T406 989-993 Species denotes SARS NCBItxid:694009

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T421 0-204 Sentence denotes Recombinant human ACE 2, rhACE2 (hrsACE2, APN01, GSK2586881), sequesters circulating viral particles interfering with S-protein binding to its host target, beside its role in regulating the systemic RAAS.
T422 205-560 Sentence denotes Taken together, these activities may offer therapeutic benefits in COVID-19 patients, although the large molecular weight of the protein may potentially limit its effects on local RAAS (Gheblawi et al., 2020). rhACE2 has already undergone phase 1 and 2 clinical trials in healthy volunteers and in a small cohort of patients with ARDS (Khan et al., 2017).
T423 561-767 Sentence denotes Moreover, it has been demonstrated that rhACE2 can significantly block the early stages of SARS-CoV-2 infections in engineered human blood vessel organoids and human kidney organoids (Monteil et al., 2020).
T424 768-929 Sentence denotes In this context, Procko (2020) was able to engineer hACE2 sequences to obtain soluble receptors able to sequester SARS-CoV-2 RBD and inhibit its cell attachment.
T425 930-1136 Sentence denotes Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T151 694-706 Body_part denotes blood vessel http://purl.obolibrary.org/obo/UBERON_0001981
T152 727-733 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1960 118-127 Gene denotes S-protein Gene:43740568
1961 820-825 Gene denotes hACE2 Gene:59272
1962 973-977 Gene denotes ACE2 Gene:59272
1963 1087-1091 Gene denotes ACE2 Gene:59272
1965 281-289 Species denotes patients Tax:9606
1966 521-529 Species denotes patients Tax:9606
1967 688-693 Species denotes human Tax:9606
1968 721-726 Species denotes human Tax:9606
1969 882-892 Species denotes SARS-CoV-2 Tax:2697049
1970 989-999 Species denotes SARS-CoV-2 Tax:2697049
1971 415-421 Chemical denotes rhACE2
1972 601-607 Chemical denotes rhACE2
1973 272-280 Disease denotes COVID-19 MESH:C000657245
1974 535-539 Disease denotes ARDS MESH:D012128
1975 652-673 Disease denotes SARS-CoV-2 infections MESH:C000657245

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T6198 18-21 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6223 118-127 Protein denotes S-protein https://www.uniprot.org/uniprot/Q9D080|https://www.uniprot.org/uniprot/Q9BSH7|https://www.uniprot.org/uniprot/Q91X32|https://www.uniprot.org/uniprot/Q8VII4|https://www.uniprot.org/uniprot/Q5SYG4|https://www.uniprot.org/uniprot/P48819|https://www.uniprot.org/uniprot/P29788|https://www.uniprot.org/uniprot/P22458|https://www.uniprot.org/uniprot/P04004|https://www.uniprot.org/uniprot/P01141|https://www.uniprot.org/uniprot/B2R7G0
T6234 893-896 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T6243 973-977 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6244 1000-1003 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T6253 1087-1091 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T290 143-147 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T291 663-676 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections in
T292 694-699 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T293 913-917 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T458 120-127 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T459 334-341 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T460 694-706 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T461 727-733 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T462 913-917 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T420 272-280 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T421 535-539 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T422 652-662 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T423 652-656 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T424 663-676 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T425 882-892 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T426 882-886 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T427 989-999 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T428 989-993 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T137 694-706 http://purl.obolibrary.org/obo/MAT_0000393 denotes blood vessel
T138 694-699 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T139 694-699 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T140 727-733 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1959 18-23 Gene denotes ACE 2 Gene:59272
1960 118-127 Gene denotes S-protein Gene:43740568
1961 820-825 Gene denotes hACE2 Gene:59272
1962 973-977 Gene denotes ACE2 Gene:59272
1963 1087-1091 Gene denotes ACE2 Gene:59272
1964 12-17 Species denotes human Tax:9606
1965 281-289 Species denotes patients Tax:9606
1966 521-529 Species denotes patients Tax:9606
1967 688-693 Species denotes human Tax:9606
1968 721-726 Species denotes human Tax:9606
1969 882-892 Species denotes SARS-CoV-2 Tax:2697049
1970 989-999 Species denotes SARS-CoV-2 Tax:2697049
1971 415-421 Chemical denotes rhACE2
1972 601-607 Chemical denotes rhACE2
1973 272-280 Disease denotes COVID-19 MESH:C000657245
1974 535-539 Disease denotes ARDS MESH:D012128
1975 652-673 Disease denotes SARS-CoV-2 infections MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T421 0-204 Sentence denotes Recombinant human ACE 2, rhACE2 (hrsACE2, APN01, GSK2586881), sequesters circulating viral particles interfering with S-protein binding to its host target, beside its role in regulating the systemic RAAS.
T422 205-560 Sentence denotes Taken together, these activities may offer therapeutic benefits in COVID-19 patients, although the large molecular weight of the protein may potentially limit its effects on local RAAS (Gheblawi et al., 2020). rhACE2 has already undergone phase 1 and 2 clinical trials in healthy volunteers and in a small cohort of patients with ARDS (Khan et al., 2017).
T423 561-767 Sentence denotes Moreover, it has been demonstrated that rhACE2 can significantly block the early stages of SARS-CoV-2 infections in engineered human blood vessel organoids and human kidney organoids (Monteil et al., 2020).
T424 768-929 Sentence denotes In this context, Procko (2020) was able to engineer hACE2 sequences to obtain soluble receptors able to sequester SARS-CoV-2 RBD and inhibit its cell attachment.
T425 930-1136 Sentence denotes Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement.