PMC:7556165 / 70534-70942 JSONTXT

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T393","span":{"begin":174,"end":184},"obj":"Species"},{"id":"T394","span":{"begin":174,"end":178},"obj":"Species"}],"attributes":[{"id":"A393","pred":"ncbi_taxonomy_id","subj":"T393","obj":"NCBItxid:2697049"},{"id":"A394","pred":"ncbi_taxonomy_id","subj":"T394","obj":"NCBItxid:694009"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T419","span":{"begin":0,"end":408},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T150","span":{"begin":369,"end":373},"obj":"Body_part"}],"attributes":[{"id":"A150","pred":"uberon_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1932","span":{"begin":56,"end":60},"obj":"Gene"},{"id":"1933","span":{"begin":120,"end":124},"obj":"Gene"},{"id":"1934","span":{"begin":271,"end":275},"obj":"Gene"},{"id":"1936","span":{"begin":174,"end":184},"obj":"Species"},{"id":"1940","span":{"begin":369,"end":380},"obj":"Disease"}],"attributes":[{"id":"A1932","pred":"pubann:denotes","subj":"1932","obj":"Gene:59272"},{"id":"A1933","pred":"pubann:denotes","subj":"1933","obj":"Gene:59272"},{"id":"A1934","pred":"pubann:denotes","subj":"1934","obj":"Gene:59272"},{"id":"A1936","pred":"pubann:denotes","subj":"1936","obj":"Tax:2697049"},{"id":"A1940","pred":"pubann:denotes","subj":"1940","obj":"MESH:D055370"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T6180","span":{"begin":56,"end":60},"obj":"Protein"},{"id":"T6181","span":{"begin":120,"end":124},"obj":"Protein"},{"id":"T6182","span":{"begin":271,"end":275},"obj":"Protein"}],"attributes":[{"id":"A6180","pred":"uniprot_id","subj":"T6180","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A6181","pred":"uniprot_id","subj":"T6181","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A6182","pred":"uniprot_id","subj":"T6182","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T285","span":{"begin":140,"end":149},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T286","span":{"begin":203,"end":208},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T287","span":{"begin":227,"end":244},"obj":"http://purl.obolibrary.org/obo/GO_0044409"},{"id":"T288","span":{"begin":240,"end":244},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T289","span":{"begin":245,"end":249},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T456","span":{"begin":245,"end":249},"obj":"Body_part"},{"id":"T457","span":{"begin":369,"end":373},"obj":"Body_part"}],"attributes":[{"id":"A456","pred":"fma_id","subj":"T456","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A457","pred":"fma_id","subj":"T457","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T416","span":{"begin":174,"end":184},"obj":"Disease"},{"id":"T417","span":{"begin":174,"end":178},"obj":"Disease"},{"id":"T418","span":{"begin":374,"end":380},"obj":"Disease"}],"attributes":[{"id":"A416","pred":"mondo_id","subj":"T416","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A417","pred":"mondo_id","subj":"T417","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A418","pred":"mondo_id","subj":"T418","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T136","span":{"begin":369,"end":373},"obj":"http://purl.obolibrary.org/obo/MAT_0000135"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T151","span":{"begin":221,"end":249},"obj":"http://purl.obolibrary.org/obo/GO_0046718"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T156","span":{"begin":221,"end":249},"obj":"http://purl.obolibrary.org/obo/GO_0046718"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1932","span":{"begin":56,"end":60},"obj":"Gene"},{"id":"1933","span":{"begin":120,"end":124},"obj":"Gene"},{"id":"1934","span":{"begin":271,"end":275},"obj":"Gene"},{"id":"1936","span":{"begin":174,"end":184},"obj":"Species"},{"id":"1940","span":{"begin":369,"end":380},"obj":"Disease"}],"attributes":[{"id":"A1932","pred":"tao:has_database_id","subj":"1932","obj":"Gene:59272"},{"id":"A1933","pred":"tao:has_database_id","subj":"1933","obj":"Gene:59272"},{"id":"A1934","pred":"tao:has_database_id","subj":"1934","obj":"Gene:59272"},{"id":"A1936","pred":"tao:has_database_id","subj":"1936","obj":"Tax:2697049"},{"id":"A1940","pred":"tao:has_database_id","subj":"1940","obj":"MESH:D055370"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T419","span":{"begin":0,"end":408},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a)."}