> top > docs > PMC:7556165 > spans > 70501-72722 > annotations

PMC:7556165 / 70501-72722 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T194 530-541 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T195 742-749 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T196 956-963 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T197 1798-1811 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T393 207-217 Species denotes SARS-CoV-2 NCBItxid:2697049
T394 207-211 Species denotes SARS NCBItxid:694009
T395 524-529 Species denotes human NCBItxid:9606
T396 588-596 Species denotes COVID-19 NCBItxid:2697049
T397 634-639 Species denotes human NCBItxid:9606
T398 894-902 Species denotes COVID-19 NCBItxid:2697049
T399 1274-1284 Species denotes SARS-CoV-2 NCBItxid:2697049
T400 1274-1278 Species denotes SARS NCBItxid:694009
T401 1310-1315 Species denotes human NCBItxid:9606
T402 1343-1348 Species denotes human NCBItxid:9606
T403 1504-1514 Species denotes SARS-CoV-2 NCBItxid:2697049
T404 1504-1508 Species denotes SARS NCBItxid:694009
T405 1611-1621 Species denotes SARS-CoV-2 NCBItxid:2697049
T406 1611-1615 Species denotes SARS NCBItxid:694009

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T418 0-32 Sentence denotes Exogenous Administration of ACE2
T419 33-441 Sentence denotes The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a).
T420 442-621 Sentence denotes A pilot clinical study is currently investigating the efficiency of a recombinant human angiotensin-converting enzyme 2 (rhACE2) in patients with COVID-19 (Zhang H. et al., 2020).
T421 622-826 Sentence denotes Recombinant human ACE 2, rhACE2 (hrsACE2, APN01, GSK2586881), sequesters circulating viral particles interfering with S-protein binding to its host target, beside its role in regulating the systemic RAAS.
T422 827-1182 Sentence denotes Taken together, these activities may offer therapeutic benefits in COVID-19 patients, although the large molecular weight of the protein may potentially limit its effects on local RAAS (Gheblawi et al., 2020). rhACE2 has already undergone phase 1 and 2 clinical trials in healthy volunteers and in a small cohort of patients with ARDS (Khan et al., 2017).
T423 1183-1389 Sentence denotes Moreover, it has been demonstrated that rhACE2 can significantly block the early stages of SARS-CoV-2 infections in engineered human blood vessel organoids and human kidney organoids (Monteil et al., 2020).
T424 1390-1551 Sentence denotes In this context, Procko (2020) was able to engineer hACE2 sequences to obtain soluble receptors able to sequester SARS-CoV-2 RBD and inhibit its cell attachment.
T425 1552-1758 Sentence denotes Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement.
T426 1759-1988 Sentence denotes Additionally, the availability of ACE2 nanoparticles applied to nose filters, chewing gums, clothes, filters and gloves could be of help in sequestering the virus thus preventing its entry into the host (Aydemir and Ulusu, 2020).
T427 1989-2221 Sentence denotes Prevention virus transmission could represent a more convenient strategy than therapeutic interventions on viral infection, avoiding interference with ACE2 and disturbance of the finely regulated RAAS axis (Aydemir and Ulusu, 2020).

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T150 402-406 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T151 1316-1328 Body_part denotes blood vessel http://purl.obolibrary.org/obo/UBERON_0001981
T152 1349-1355 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T153 1823-1827 Body_part denotes nose http://purl.obolibrary.org/obo/UBERON_0000004

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1932 89-93 Gene denotes ACE2 Gene:59272
1933 153-157 Gene denotes ACE2 Gene:59272
1934 304-308 Gene denotes ACE2 Gene:59272
1935 530-561 Gene denotes angiotensin-converting enzyme 2 Gene:59272
1936 207-217 Species denotes SARS-CoV-2 Tax:2697049
1937 524-529 Species denotes human Tax:9606
1938 574-582 Species denotes patients Tax:9606
1939 563-569 Chemical denotes rhACE2
1940 402-413 Disease denotes lung injury MESH:D055370
1941 588-596 Disease denotes COVID-19 MESH:C000657245
1960 740-749 Gene denotes S-protein Gene:43740568
1961 1442-1447 Gene denotes hACE2 Gene:59272
1962 1595-1599 Gene denotes ACE2 Gene:59272
1963 1709-1713 Gene denotes ACE2 Gene:59272
1965 903-911 Species denotes patients Tax:9606
1966 1143-1151 Species denotes patients Tax:9606
1967 1310-1315 Species denotes human Tax:9606
1968 1343-1348 Species denotes human Tax:9606
1969 1504-1514 Species denotes SARS-CoV-2 Tax:2697049
1970 1611-1621 Species denotes SARS-CoV-2 Tax:2697049
1971 1037-1043 Chemical denotes rhACE2
1972 1223-1229 Chemical denotes rhACE2
1973 894-902 Disease denotes COVID-19 MESH:C000657245
1974 1157-1161 Disease denotes ARDS MESH:D012128
1975 1274-1295 Disease denotes SARS-CoV-2 infections MESH:C000657245
1979 1793-1797 Gene denotes ACE2 Gene:59272
1980 2140-2144 Gene denotes ACE2 Gene:59272
1981 2096-2111 Disease denotes viral infection MESH:D001102

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T6179 28-32 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6180 89-93 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6181 153-157 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6182 304-308 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6183 530-561 Protein denotes angiotensin-converting enzyme 2 https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1
T6198 640-643 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6223 740-749 Protein denotes S-protein https://www.uniprot.org/uniprot/Q9D080|https://www.uniprot.org/uniprot/Q9BSH7|https://www.uniprot.org/uniprot/Q91X32|https://www.uniprot.org/uniprot/Q8VII4|https://www.uniprot.org/uniprot/Q5SYG4|https://www.uniprot.org/uniprot/P48819|https://www.uniprot.org/uniprot/P29788|https://www.uniprot.org/uniprot/P22458|https://www.uniprot.org/uniprot/P04004|https://www.uniprot.org/uniprot/P01141|https://www.uniprot.org/uniprot/B2R7G0
T6234 1515-1518 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T6243 1595-1599 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6244 1622-1625 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T6253 1709-1713 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6254 1793-1797 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6255 2140-2144 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T285 173-182 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T286 236-241 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T287 260-277 http://purl.obolibrary.org/obo/GO_0044409 denotes entry in the host
T288 273-277 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T289 278-282 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T290 765-769 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T291 1285-1298 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections in
T292 1316-1321 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T293 1535-1539 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T294 1916-1921 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T295 1942-1961 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T296 1957-1961 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T297 2000-2005 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T298 2102-2111 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T456 278-282 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T457 402-406 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T458 742-749 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T459 956-963 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T460 1316-1328 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T461 1349-1355 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T462 1535-1539 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T463 1823-1827 Body_part denotes nose http://purl.org/sig/ont/fma/fma46472
T464 2190-2194 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T416 207-217 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T417 207-211 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T418 407-413 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T419 588-596 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T420 894-902 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T421 1157-1161 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T422 1274-1284 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T423 1274-1278 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T424 1285-1298 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T425 1504-1514 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T426 1504-1508 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T427 1611-1621 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T428 1611-1615 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T429 2096-2111 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T136 402-406 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T137 1316-1328 http://purl.obolibrary.org/obo/MAT_0000393 denotes blood vessel
T138 1316-1321 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T139 1316-1321 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T140 1349-1355 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T141 1823-1827 http://purl.obolibrary.org/obo/MAT_0000139 denotes nose

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T151 254-282 http://purl.obolibrary.org/obo/GO_0046718 denotes viral entry in the host cell
T152 1837-1844 http://purl.obolibrary.org/obo/GO_0071626 denotes chewing
T153 1899-1911 http://purl.obolibrary.org/obo/GO_0051235 denotes sequestering
T154 1942-1961 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T155 2096-2111 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T156 254-282 http://purl.obolibrary.org/obo/GO_0046718 denotes viral entry in the host cell
T157 1837-1844 http://purl.obolibrary.org/obo/GO_0071626 denotes chewing
T158 1899-1911 http://purl.obolibrary.org/obo/GO_0051235 denotes sequestering
T159 1942-1961 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T160 2096-2111 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1932 89-93 Gene denotes ACE2 Gene:59272
1933 153-157 Gene denotes ACE2 Gene:59272
1934 304-308 Gene denotes ACE2 Gene:59272
1935 530-561 Gene denotes angiotensin-converting enzyme 2 Gene:59272
1936 207-217 Species denotes SARS-CoV-2 Tax:2697049
1937 524-529 Species denotes human Tax:9606
1938 574-582 Species denotes patients Tax:9606
1939 563-569 Chemical denotes rhACE2
1940 402-413 Disease denotes lung injury MESH:D055370
1941 588-596 Disease denotes COVID-19 MESH:C000657245
1959 640-645 Gene denotes ACE 2 Gene:59272
1960 740-749 Gene denotes S-protein Gene:43740568
1961 1442-1447 Gene denotes hACE2 Gene:59272
1962 1595-1599 Gene denotes ACE2 Gene:59272
1963 1709-1713 Gene denotes ACE2 Gene:59272
1964 634-639 Species denotes human Tax:9606
1965 903-911 Species denotes patients Tax:9606
1966 1143-1151 Species denotes patients Tax:9606
1967 1310-1315 Species denotes human Tax:9606
1968 1343-1348 Species denotes human Tax:9606
1969 1504-1514 Species denotes SARS-CoV-2 Tax:2697049
1970 1611-1621 Species denotes SARS-CoV-2 Tax:2697049
1971 1037-1043 Chemical denotes rhACE2
1972 1223-1229 Chemical denotes rhACE2
1973 894-902 Disease denotes COVID-19 MESH:C000657245
1974 1157-1161 Disease denotes ARDS MESH:D012128
1975 1274-1295 Disease denotes SARS-CoV-2 infections MESH:C000657245
1979 1793-1797 Gene denotes ACE2 Gene:59272
1980 2140-2144 Gene denotes ACE2 Gene:59272
1981 2096-2111 Disease denotes viral infection MESH:D001102

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T418 0-32 Sentence denotes Exogenous Administration of ACE2
T419 33-441 Sentence denotes The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a).
T420 442-621 Sentence denotes A pilot clinical study is currently investigating the efficiency of a recombinant human angiotensin-converting enzyme 2 (rhACE2) in patients with COVID-19 (Zhang H. et al., 2020).
T421 622-826 Sentence denotes Recombinant human ACE 2, rhACE2 (hrsACE2, APN01, GSK2586881), sequesters circulating viral particles interfering with S-protein binding to its host target, beside its role in regulating the systemic RAAS.
T422 827-1182 Sentence denotes Taken together, these activities may offer therapeutic benefits in COVID-19 patients, although the large molecular weight of the protein may potentially limit its effects on local RAAS (Gheblawi et al., 2020). rhACE2 has already undergone phase 1 and 2 clinical trials in healthy volunteers and in a small cohort of patients with ARDS (Khan et al., 2017).
T423 1183-1389 Sentence denotes Moreover, it has been demonstrated that rhACE2 can significantly block the early stages of SARS-CoV-2 infections in engineered human blood vessel organoids and human kidney organoids (Monteil et al., 2020).
T424 1390-1551 Sentence denotes In this context, Procko (2020) was able to engineer hACE2 sequences to obtain soluble receptors able to sequester SARS-CoV-2 RBD and inhibit its cell attachment.
T425 1552-1758 Sentence denotes Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement.
T426 1759-1988 Sentence denotes Additionally, the availability of ACE2 nanoparticles applied to nose filters, chewing gums, clothes, filters and gloves could be of help in sequestering the virus thus preventing its entry into the host (Aydemir and Ulusu, 2020).
T427 1989-2221 Sentence denotes Prevention virus transmission could represent a more convenient strategy than therapeutic interventions on viral infection, avoiding interference with ACE2 and disturbance of the finely regulated RAAS axis (Aydemir and Ulusu, 2020).