PMC:7556165 / 69676-70003 JSONTXT

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T192","span":{"begin":44,"end":82},"obj":"Chemical"}],"attributes":[{"id":"A192","pred":"chebi_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/CHEBI_145998"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T388","span":{"begin":179,"end":187},"obj":"Species"},{"id":"T389","span":{"begin":179,"end":183},"obj":"Species"}],"attributes":[{"id":"A388","pred":"ncbi_taxonomy_id","subj":"T388","obj":"NCBItxid:694009"},{"id":"A389","pred":"ncbi_taxonomy_id","subj":"T389","obj":"NCBItxid:694009"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T415","span":{"begin":0,"end":327},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1908","span":{"begin":96,"end":100},"obj":"Gene"},{"id":"1914","span":{"begin":179,"end":187},"obj":"Species"},{"id":"1917","span":{"begin":44,"end":82},"obj":"Chemical"},{"id":"1918","span":{"begin":84,"end":88},"obj":"Chemical"}],"attributes":[{"id":"A1908","pred":"pubann:denotes","subj":"1908","obj":"Gene:59272"},{"id":"A1914","pred":"pubann:denotes","subj":"1914","obj":"Tax:694009"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T6163","span":{"begin":96,"end":100},"obj":"Protein"}],"attributes":[{"id":"A6163","pred":"uniprot_id","subj":"T6163","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T279","span":{"begin":108,"end":112},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T280","span":{"begin":284,"end":288},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T281","span":{"begin":289,"end":293},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T452","span":{"begin":284,"end":288},"obj":"Body_part"},{"id":"T453","span":{"begin":289,"end":293},"obj":"Body_part"}],"attributes":[{"id":"A452","pred":"fma_id","subj":"T452","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A453","pred":"fma_id","subj":"T453","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T409","span":{"begin":179,"end":187},"obj":"Disease"},{"id":"T410","span":{"begin":179,"end":183},"obj":"Disease"}],"attributes":[{"id":"A409","pred":"mondo_id","subj":"T409","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A410","pred":"mondo_id","subj":"T410","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T147","span":{"begin":284,"end":300},"obj":"http://purl.obolibrary.org/obo/GO_0000768"},{"id":"T148","span":{"begin":284,"end":300},"obj":"http://purl.obolibrary.org/obo/GO_0045026"},{"id":"T149","span":{"begin":289,"end":300},"obj":"http://purl.obolibrary.org/obo/GO_0000747"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T152","span":{"begin":284,"end":300},"obj":"http://purl.obolibrary.org/obo/GO_0140253"},{"id":"T153","span":{"begin":284,"end":300},"obj":"http://purl.obolibrary.org/obo/GO_0045026"},{"id":"T154","span":{"begin":289,"end":300},"obj":"http://purl.obolibrary.org/obo/GO_0000768"},{"id":"T155","span":{"begin":289,"end":300},"obj":"http://purl.obolibrary.org/obo/GO_0000747"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1908","span":{"begin":96,"end":100},"obj":"Gene"},{"id":"1914","span":{"begin":179,"end":187},"obj":"Species"},{"id":"1917","span":{"begin":44,"end":82},"obj":"Chemical"},{"id":"1918","span":{"begin":84,"end":88},"obj":"Chemical"}],"attributes":[{"id":"A1908","pred":"tao:has_database_id","subj":"1908","obj":"Gene:59272"},{"id":"A1914","pred":"tao:has_database_id","subj":"1914","obj":"Tax:694009"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T415","span":{"begin":0,"end":327},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004)."}