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PMC:7556165 / 69222-70499 JSON TXT

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LitCovid-sample-CHEBI

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T191	234-242	Chemical	denotes	peptides	http://purl.obolibrary.org/obo/CHEBI_16670
T192	498-536	Chemical	denotes	N-(2-aminoethyl)-1aziridine-ethanamine	http://purl.obolibrary.org/obo/CHEBI_145998
T193	845-852	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-PD-NCBITaxon

Id	Subject	Object	Predicate	Lexical cue	ncbi_taxonomy_id
T386	411-419	Species	denotes	SARS-CoV	NCBItxid:694009
T387	411-415	Species	denotes	SARS	NCBItxid:694009
T388	633-641	Species	denotes	SARS-CoV	NCBItxid:694009
T389	633-637	Species	denotes	SARS	NCBItxid:694009
T390	936-940	Species	denotes	SARS	NCBItxid:694009
T391	1091-1107	Species	denotes	SARS coronavirus	NCBItxid:694009
T392	1091-1095	Species	denotes	SARS	NCBItxid:694009

LitCovid-sample-sentences

Id	Subject	Object	Predicate	Lexical cue
T412	0-13	Sentence	denotes	ACE2 Blockers
T413	14-264	Sentence	denotes	Blockade of ACE2 receptor could be achieved through specific antibodies (Li et al., 2003), rationally designed small molecules (Dales et al., 2002; Huentelman et al., 2004; Gross et al., 2020; Pillaiyar et al., 2020) or peptides (Huang et al., 2003).
T414	265-453	Sentence	denotes	Although their efficacy needs to be confirmed, some of these agents are currently available on the market and have been show to effectively block SARS-CoV invasion (Li S.-R. et al., 2020).
T415	454-781	Sentence	denotes	For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004).
T416	782-980	Sentence	denotes	Therefore, although ACE2 catalytic site is distinct from the S-protein-binding domain, NAAE exerts dual inhibitory effects on ACE2 catalytic activity and SARS binding (Adedeji and Sarafianos, 2014).
T417	981-1277	Sentence	denotes	However, since a protecting role for ACE2 receptor against virus-induced acute lung injury in infections with SARS coronavirus has not been excluded (Imai et al., 2005; Kuba et al., 2005; Li S.-R. et al., 2020), the choice of ACE2 inhibition as therapeutic approach should be carefully evaluated.

LitCovid-sample-PD-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T149	1060-1064	Body_part	denotes	lung	http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-sample-Pubtator

Id	Subject	Object	Predicate	Lexical cue	pubann:denotes
1891	0-4	Gene	denotes	ACE2	Gene:59272
1907	26-30	Gene	denotes	ACE2	Gene:59272
1908	550-554	Gene	denotes	ACE2	Gene:59272
1909	802-806	Gene	denotes	ACE2	Gene:59272
1910	908-912	Gene	denotes	ACE2	Gene:59272
1911	1018-1022	Gene	denotes	ACE2	Gene:59272
1912	1207-1211	Gene	denotes	ACE2	Gene:59272
1913	411-419	Species	denotes	SARS-CoV	Tax:694009
1914	633-641	Species	denotes	SARS-CoV	Tax:694009
1915	1091-1107	Species	denotes	SARS coronavirus	Tax:694009
1916	843-852	Gene	denotes	S-protein	Gene:43740568
1917	498-536	Chemical	denotes	N-(2-aminoethyl)-1aziridine-ethanamine
1918	538-542	Chemical	denotes	NAAE
1919	869-873	Chemical	denotes	NAAE
1920	1054-1071	Disease	denotes	acute lung injury	MESH:D055371
1921	1075-1085	Disease	denotes	infections	MESH:D007239

LitCovid-sample-UniProt

Id	Subject	Object	Predicate	Lexical cue	uniprot_id
T6161	0-4	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T6162	26-30	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T6163	550-554	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T6164	802-806	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T6165	843-852	Protein	denotes	S-protein	https://www.uniprot.org/uniprot/Q9D080\|https://www.uniprot.org/uniprot/Q9BSH7\|https://www.uniprot.org/uniprot/Q91X32\|https://www.uniprot.org/uniprot/Q8VII4\|https://www.uniprot.org/uniprot/Q5SYG4\|https://www.uniprot.org/uniprot/P48819\|https://www.uniprot.org/uniprot/P29788\|https://www.uniprot.org/uniprot/P22458\|https://www.uniprot.org/uniprot/P04004\|https://www.uniprot.org/uniprot/P01141\|https://www.uniprot.org/uniprot/B2R7G0
T6176	908-912	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T6177	1018-1022	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T6178	1207-1211	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id	Subject	Object	Predicate	Lexical cue
T279	562-566	http://purl.obolibrary.org/obo/BFO_0000029	denotes	site
T280	738-742	http://purl.obolibrary.org/obo/CL_0000000	denotes	cell
T281	743-747	http://purl.obolibrary.org/obo/CL_0000000	denotes	cell
T282	817-821	http://purl.obolibrary.org/obo/BFO_0000029	denotes	site
T283	1040-1045	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	virus
T284	1075-1085	http://purl.obolibrary.org/obo/IDO_0000586	denotes	infections

LitCovid-sample-PD-FMA

Id	Subject	Object	Predicate	Lexical cue	fma_id
T452	738-742	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T453	743-747	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T454	845-852	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T455	1060-1064	Body_part	denotes	lung	http://purl.org/sig/ont/fma/fma7195

LitCovid-sample-PD-MONDO

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T407	411-419	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091
T408	411-415	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T409	633-641	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091
T410	633-637	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T411	936-940	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T412	1054-1071	Disease	denotes	acute lung injury	http://purl.obolibrary.org/obo/MONDO_0006502\|http://purl.obolibrary.org/obo/MONDO_0015796
T414	1075-1085	Disease	denotes	infections	http://purl.obolibrary.org/obo/MONDO_0005550
T415	1091-1095	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-sample-PD-MAT

Id	Subject	Object	Predicate	Lexical cue
T135	1060-1064	http://purl.obolibrary.org/obo/MAT_0000135	denotes	lung

LitCovid-sample-PD-GO-BP-0

Id	Subject	Object	Predicate	Lexical cue
T147	738-754	http://purl.obolibrary.org/obo/GO_0000768	denotes	cell-cell fusion
T148	738-754	http://purl.obolibrary.org/obo/GO_0045026	denotes	cell-cell fusion
T149	743-754	http://purl.obolibrary.org/obo/GO_0000747	denotes	cell fusion
T150	913-931	http://purl.obolibrary.org/obo/GO_0003824	denotes	catalytic activity

LitCovid-sample-GO-BP

Id	Subject	Object	Predicate	Lexical cue
T152	738-754	http://purl.obolibrary.org/obo/GO_0140253	denotes	cell-cell fusion
T153	738-754	http://purl.obolibrary.org/obo/GO_0045026	denotes	cell-cell fusion
T154	743-754	http://purl.obolibrary.org/obo/GO_0000768	denotes	cell fusion
T155	743-754	http://purl.obolibrary.org/obo/GO_0000747	denotes	cell fusion

LitCovid-PD-HP

Id	Subject	Object	Predicate	Lexical cue	hp_id
T77	1054-1071	Phenotype	denotes	acute lung injury	http://www.orpha.net/ORDO/Orphanet_178320

LitCovid-PubTator

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
1891	0-4	Gene	denotes	ACE2	Gene:59272
1907	26-30	Gene	denotes	ACE2	Gene:59272
1908	550-554	Gene	denotes	ACE2	Gene:59272
1909	802-806	Gene	denotes	ACE2	Gene:59272
1910	908-912	Gene	denotes	ACE2	Gene:59272
1911	1018-1022	Gene	denotes	ACE2	Gene:59272
1912	1207-1211	Gene	denotes	ACE2	Gene:59272
1913	411-419	Species	denotes	SARS-CoV	Tax:694009
1914	633-641	Species	denotes	SARS-CoV	Tax:694009
1915	1091-1107	Species	denotes	SARS coronavirus	Tax:694009
1916	843-852	Gene	denotes	S-protein	Gene:43740568
1917	498-536	Chemical	denotes	N-(2-aminoethyl)-1aziridine-ethanamine
1918	538-542	Chemical	denotes	NAAE
1919	869-873	Chemical	denotes	NAAE
1920	1054-1071	Disease	denotes	acute lung injury	MESH:D055371
1921	1075-1085	Disease	denotes	infections	MESH:D007239

LitCovid-sentences

Id	Subject	Object	Predicate	Lexical cue
T412	0-13	Sentence	denotes	ACE2 Blockers
T413	14-264	Sentence	denotes	Blockade of ACE2 receptor could be achieved through specific antibodies (Li et al., 2003), rationally designed small molecules (Dales et al., 2002; Huentelman et al., 2004; Gross et al., 2020; Pillaiyar et al., 2020) or peptides (Huang et al., 2003).
T414	265-453	Sentence	denotes	Although their efficacy needs to be confirmed, some of these agents are currently available on the market and have been show to effectively block SARS-CoV invasion (Li S.-R. et al., 2020).
T415	454-781	Sentence	denotes	For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004).
T416	782-980	Sentence	denotes	Therefore, although ACE2 catalytic site is distinct from the S-protein-binding domain, NAAE exerts dual inhibitory effects on ACE2 catalytic activity and SARS binding (Adedeji and Sarafianos, 2014).
T417	981-1277	Sentence	denotes	However, since a protecting role for ACE2 receptor against virus-induced acute lung injury in infections with SARS coronavirus has not been excluded (Imai et al., 2005; Kuba et al., 2005; Li S.-R. et al., 2020), the choice of ACE2 inhibition as therapeutic approach should be carefully evaluated.