PMC:7556165 / 67097-67424 JSONTXT

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T371","span":{"begin":200,"end":210},"obj":"Species"},{"id":"T372","span":{"begin":200,"end":204},"obj":"Species"}],"attributes":[{"id":"A371","pred":"ncbi_taxonomy_id","subj":"T371","obj":"NCBItxid:2697049"},{"id":"A372","pred":"ncbi_taxonomy_id","subj":"T372","obj":"NCBItxid:694009"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection. Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).\nOther conditions have been assumed"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T398","span":{"begin":108,"end":292},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection. Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).\nOther conditions have been assumed"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1833","span":{"begin":47,"end":51},"obj":"Gene"},{"id":"1834","span":{"begin":129,"end":135},"obj":"Gene"},{"id":"1835","span":{"begin":200,"end":210},"obj":"Species"},{"id":"1837","span":{"begin":91,"end":106},"obj":"Disease"}],"attributes":[{"id":"A1833","pred":"pubann:denotes","subj":"1833","obj":"Gene:59272"},{"id":"A1834","pred":"pubann:denotes","subj":"1834","obj":"Gene:6868"},{"id":"A1835","pred":"pubann:denotes","subj":"1835","obj":"Tax:2697049"},{"id":"A1837","pred":"pubann:denotes","subj":"1837","obj":"MESH:D001102"}],"text":"an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection. Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).\nOther conditions have been assumed"}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T6108","span":{"begin":47,"end":51},"obj":"Protein"},{"id":"T6109","span":{"begin":129,"end":135},"obj":"Protein"}],"attributes":[{"id":"A6108","pred":"uniprot_id","subj":"T6108","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A6109","pred":"uniprot_id","subj":"T6109","obj":"https://www.uniprot.org/uniprot/Q9Z1K9"},{"id":"A6110","pred":"uniprot_id","subj":"T6109","obj":"https://www.uniprot.org/uniprot/Q9Z0K3"},{"id":"A6111","pred":"uniprot_id","subj":"T6109","obj":"https://www.uniprot.org/uniprot/Q9Z0F8"},{"id":"A6112","pred":"uniprot_id","subj":"T6109","obj":"https://www.uniprot.org/uniprot/Q9R1U4"},{"id":"A6113","pred":"uniprot_id","subj":"T6109","obj":"https://www.uniprot.org/uniprot/Q505A7"},{"id":"A6114","pred":"uniprot_id","subj":"T6109","obj":"https://www.uniprot.org/uniprot/P78536"},{"id":"A6115","pred":"uniprot_id","subj":"T6109","obj":"https://www.uniprot.org/uniprot/O88726"},{"id":"A6116","pred":"uniprot_id","subj":"T6109","obj":"https://www.uniprot.org/uniprot/O77636"},{"id":"A6117","pred":"uniprot_id","subj":"T6109","obj":"https://www.uniprot.org/uniprot/O60226"}],"text":"an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection. Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).\nOther conditions have been assumed"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T269","span":{"begin":97,"end":106},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"}],"text":"an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection. Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).\nOther conditions have been assumed"}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T385","span":{"begin":91,"end":106},"obj":"Disease"},{"id":"T386","span":{"begin":200,"end":210},"obj":"Disease"},{"id":"T387","span":{"begin":200,"end":204},"obj":"Disease"}],"attributes":[{"id":"A385","pred":"mondo_id","subj":"T385","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A386","pred":"mondo_id","subj":"T386","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A387","pred":"mondo_id","subj":"T387","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection. Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).\nOther conditions have been assumed"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T142","span":{"begin":3,"end":24},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T143","span":{"begin":91,"end":106},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection. Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).\nOther conditions have been assumed"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T147","span":{"begin":3,"end":24},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T148","span":{"begin":91,"end":106},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection. Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).\nOther conditions have been assumed"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1833","span":{"begin":47,"end":51},"obj":"Gene"},{"id":"1834","span":{"begin":129,"end":135},"obj":"Gene"},{"id":"1835","span":{"begin":200,"end":210},"obj":"Species"},{"id":"1837","span":{"begin":91,"end":106},"obj":"Disease"}],"attributes":[{"id":"A1833","pred":"tao:has_database_id","subj":"1833","obj":"Gene:59272"},{"id":"A1834","pred":"tao:has_database_id","subj":"1834","obj":"Gene:6868"},{"id":"A1835","pred":"tao:has_database_id","subj":"1835","obj":"Tax:2697049"},{"id":"A1837","pred":"tao:has_database_id","subj":"1837","obj":"MESH:D001102"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection. Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).\nOther conditions have been assumed"}

{"project":"LitCovid-sentences","denotations":[{"id":"T398","span":{"begin":108,"end":292},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection. Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).\nOther conditions have been assumed"}