PMC:7556165 / 64652-64996 JSONTXT

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T385","span":{"begin":0,"end":344},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1774","span":{"begin":11,"end":15},"obj":"Gene"},{"id":"1775","span":{"begin":69,"end":76},"obj":"Gene"},{"id":"1776","span":{"begin":92,"end":96},"obj":"Gene"},{"id":"1777","span":{"begin":113,"end":117},"obj":"Gene"},{"id":"1778","span":{"begin":199,"end":203},"obj":"Gene"},{"id":"1779","span":{"begin":209,"end":213},"obj":"Gene"}],"attributes":[{"id":"A1774","pred":"pubann:denotes","subj":"1774","obj":"Gene:185"},{"id":"A1775","pred":"pubann:denotes","subj":"1775","obj":"Gene:6868"},{"id":"A1776","pred":"pubann:denotes","subj":"1776","obj":"Gene:7124"},{"id":"A1777","pred":"pubann:denotes","subj":"1777","obj":"Gene:6868"},{"id":"A1778","pred":"pubann:denotes","subj":"1778","obj":"Gene:1956"},{"id":"A1779","pred":"pubann:denotes","subj":"1779","obj":"Gene:7124"}],"text":"The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T5954","span":{"begin":33,"end":44},"obj":"Protein"},{"id":"T5965","span":{"begin":69,"end":76},"obj":"Protein"},{"id":"T5974","span":{"begin":166,"end":189},"obj":"Protein"}],"attributes":[{"id":"A5954","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q9YI19"},{"id":"A5955","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q9PVK9"},{"id":"A5956","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q9IAX6"},{"id":"A5957","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q7SZE0"},{"id":"A5958","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q7SZD7"},{"id":"A5959","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q7SZD6"},{"id":"A5960","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q5EE07"},{"id":"A5961","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/P0DMH4"},{"id":"A5962","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/P0C6E3"},{"id":"A5963","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/O73795"},{"id":"A5964","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/E9NW26"},{"id":"A5965","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/Q9Z1K9"},{"id":"A5966","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/Q9Z0K3"},{"id":"A5967","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/Q9Z0F8"},{"id":"A5968","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/Q9R1U4"},{"id":"A5969","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/Q505A7"},{"id":"A5970","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/P78536"},{"id":"A5971","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/O88726"},{"id":"A5972","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/O77636"},{"id":"A5973","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/O60226"},{"id":"A5974","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q9GU69"},{"id":"A5975","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q9BEA0"},{"id":"A5976","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q9BDQ0"},{"id":"A5977","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q95ND4"},{"id":"A5978","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q6P9J2"},{"id":"A5979","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q63183"},{"id":"A5980","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q569W5"},{"id":"A5981","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q52LZ6"},{"id":"A5982","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q00968"},{"id":"A5983","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/P07522"},{"id":"A5984","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/P01133"},{"id":"A5985","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/P01132"},{"id":"A5986","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/O62759"},{"id":"A5987","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/E9QNX6"},{"id":"A5988","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/E9PBF0"},{"id":"A5989","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/E7EVD2"},{"id":"A5990","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/B4DRK7"}],"text":"The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T259","span":{"begin":152,"end":162},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"},{"id":"T260","span":{"begin":176,"end":182},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T261","span":{"begin":214,"end":224},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"}],"text":"The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T436","span":{"begin":326,"end":335},"obj":"Body_part"}],"attributes":[{"id":"A436","pred":"fma_id","subj":"T436","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T132","span":{"begin":176,"end":182},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T133","span":{"begin":199,"end":203},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T134","span":{"begin":261,"end":274},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T136","span":{"begin":176,"end":182},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T137","span":{"begin":199,"end":203},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T138","span":{"begin":261,"end":281},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T139","span":{"begin":261,"end":274},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1774","span":{"begin":11,"end":15},"obj":"Gene"},{"id":"1775","span":{"begin":69,"end":76},"obj":"Gene"},{"id":"1776","span":{"begin":92,"end":96},"obj":"Gene"},{"id":"1777","span":{"begin":113,"end":117},"obj":"Gene"},{"id":"1778","span":{"begin":199,"end":203},"obj":"Gene"},{"id":"1779","span":{"begin":209,"end":213},"obj":"Gene"}],"attributes":[{"id":"A1774","pred":"tao:has_database_id","subj":"1774","obj":"Gene:185"},{"id":"A1775","pred":"tao:has_database_id","subj":"1775","obj":"Gene:6868"},{"id":"A1776","pred":"tao:has_database_id","subj":"1776","obj":"Gene:7124"},{"id":"A1777","pred":"tao:has_database_id","subj":"1777","obj":"Gene:6868"},{"id":"A1778","pred":"tao:has_database_id","subj":"1778","obj":"Gene:1956"},{"id":"A1779","pred":"tao:has_database_id","subj":"1779","obj":"Gene:7124"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release."}

{"project":"LitCovid-sentences","denotations":[{"id":"T385","span":{"begin":0,"end":344},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release."}