PMC:7556165 / 62166-63571
Annnotations
LitCovid-sample-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T175 | 997-1004 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T176 | 1044-1051 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T177 | 1071-1078 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T178 | 1119-1126 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T373 | 0-118 | Sentence | denotes | The molecular mechanisms involved in the cytokine storm and the role of ACE2 are currently still not fully understood. |
T374 | 119-332 | Sentence | denotes | As discussed above, virus binding to the ACE2 is the event that initiates viral replication in susceptible cells, such as alveolar epithelial cells, vascular cells and immune system cells (macrophages, monocytes). |
T375 | 333-461 | Sentence | denotes | This has been suggested to trigger the primary inflammatory response, which involves apoptosis and pyroptosis (Fu et al., 2020). |
T376 | 462-712 | Sentence | denotes | The apoptosis pattern indices cell death to avoid viral replication in the absence of overt inflammation, whereas, pyroptosis is a violent form of programmed cell death, followed by an inflammatory storm (Cookson and Brennan, 2001; Liu et al., 2016). |
T377 | 713-959 | Sentence | denotes | In the standard pyroptosis model, when the pathogen enters the host cell, some specific structures on the pathogen surface (PAMPs–pathogen associated molecular patterns) are identified by pattern recognition receptors (PRRs) on the host membrane. |
T378 | 960-1405 | Sentence | denotes | One common PRR is NOD-like receptors protein 3 (NLRP3), which forms together with a protein caspase activating protein (ASC or apoptosis-associated speck-like protein containing a caspase recruitment domain) and pro-caspase 1, the inflammasome unit capable of recruiting proinflammatory cytokines and inducing cell lysis with further inflammation signals (Fernandes-Alnemri et al., 2007; Schroder and Tschopp, 2010; Wree et al., 2014; Figure 9). |
LitCovid-sample-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T144 | 287-300 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
1725 | 72-76 | Gene | denotes | ACE2 | Gene:59272 |
1726 | 160-164 | Gene | denotes | ACE2 | Gene:59272 |
1727 | 1008-1013 | Gene | denotes | NLRP3 | Gene:114548 |
1728 | 1176-1185 | Gene | denotes | caspase 1 | Gene:834 |
1729 | 950-958 | Gene | denotes | membrane | Gene:43740571 |
1730 | 554-566 | Disease | denotes | inflammation | MESH:D007249 |
1731 | 1294-1306 | Disease | denotes | inflammation | MESH:D007249 |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T5872 | 72-76 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5873 | 160-164 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5874 | 997-1006 | Protein | denotes | protein 3 | https://www.uniprot.org/uniprot/Q9JGT9|https://www.uniprot.org/uniprot/Q98663|https://www.uniprot.org/uniprot/Q8V3T9|https://www.uniprot.org/uniprot/Q6UBL8|https://www.uniprot.org/uniprot/Q6Q1S1|https://www.uniprot.org/uniprot/Q6E0W9|https://www.uniprot.org/uniprot/Q68Y30|https://www.uniprot.org/uniprot/Q5GA88|https://www.uniprot.org/uniprot/Q3LZX0|https://www.uniprot.org/uniprot/Q3I5J4|https://www.uniprot.org/uniprot/Q12988|https://www.uniprot.org/uniprot/Q0Q474|https://www.uniprot.org/uniprot/Q02967|https://www.uniprot.org/uniprot/Q00967|https://www.uniprot.org/uniprot/P09522|https://www.uniprot.org/uniprot/P05398|https://www.uniprot.org/uniprot/P03553|https://www.uniprot.org/uniprot/P03552|https://www.uniprot.org/uniprot/P03551 |
T5893 | 1042-1051 | Protein | denotes | a protein | https://www.uniprot.org/uniprot/Q38365|https://www.uniprot.org/uniprot/P25244|https://www.uniprot.org/uniprot/P25243|https://www.uniprot.org/uniprot/P15966|https://www.uniprot.org/uniprot/P09676|https://www.uniprot.org/uniprot/P07394|https://www.uniprot.org/uniprot/P03632|https://www.uniprot.org/uniprot/P03610|https://www.uniprot.org/uniprot/O64306 |
T5902 | 1052-1059 | Protein | denotes | caspase | https://www.uniprot.org/uniprot/Q9VAH1|https://www.uniprot.org/uniprot/O01382 |
T5904 | 1080-1083 | Protein | denotes | ASC | https://www.uniprot.org/uniprot/P50427|https://www.uniprot.org/uniprot/P15589|https://www.uniprot.org/uniprot/P08842|https://www.uniprot.org/uniprot/B2RA47 |
T5908 | 1140-1147 | Protein | denotes | caspase | https://www.uniprot.org/uniprot/Q9VAH1|https://www.uniprot.org/uniprot/O01382 |
T5910 | 1176-1185 | Protein | denotes | caspase 1 | https://www.uniprot.org/uniprot/Q9W1N0|https://www.uniprot.org/uniprot/Q9UCN3|https://www.uniprot.org/uniprot/Q9TV13|https://www.uniprot.org/uniprot/Q9N2I1|https://www.uniprot.org/uniprot/Q9MZV7|https://www.uniprot.org/uniprot/Q9MZV6|https://www.uniprot.org/uniprot/Q6PI75|https://www.uniprot.org/uniprot/Q6GSS3|https://www.uniprot.org/uniprot/Q6DMQ1|https://www.uniprot.org/uniprot/Q53EY6|https://www.uniprot.org/uniprot/P89116|https://www.uniprot.org/uniprot/P43527|https://www.uniprot.org/uniprot/P29466|https://www.uniprot.org/uniprot/P29452|https://www.uniprot.org/uniprot/O02002|https://www.uniprot.org/uniprot/B5MDZ1 |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T238 | 139-144 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T239 | 199-210 | http://purl.obolibrary.org/obo/IDO_0000608 | denotes | replication |
T240 | 214-225 | http://purl.obolibrary.org/obo/IDO_0000467 | denotes | susceptible |
T241 | 226-231 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T242 | 261-266 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T243 | 277-282 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T244 | 301-306 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T245 | 492-496 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T246 | 518-529 | http://purl.obolibrary.org/obo/IDO_0000608 | denotes | replication |
T247 | 620-624 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T248 | 756-764 | http://purl.obolibrary.org/obo/IDO_0000528 | denotes | pathogen |
T249 | 776-780 | http://purl.obolibrary.org/obo/IDO_0000531 | denotes | host |
T250 | 781-785 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T251 | 819-827 | http://purl.obolibrary.org/obo/IDO_0000528 | denotes | pathogen |
T252 | 843-851 | http://purl.obolibrary.org/obo/IDO_0000528 | denotes | pathogen |
T253 | 945-949 | http://purl.obolibrary.org/obo/IDO_0000531 | denotes | host |
T254 | 1270-1274 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T411 | 41-49 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T412 | 226-231 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T413 | 241-266 | Body_part | denotes | alveolar epithelial cells | http://purl.org/sig/ont/fma/fma62499 |
T414 | 261-266 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T415 | 277-282 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T416 | 287-300 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
T417 | 301-306 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T418 | 308-319 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
T419 | 321-330 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
T420 | 492-496 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T421 | 620-624 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T422 | 781-785 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T423 | 997-1004 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T424 | 1044-1051 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T425 | 1071-1078 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T426 | 1119-1126 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T427 | 1247-1256 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T428 | 1270-1274 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T366 | 554-566 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T367 | 932-936 | Disease | denotes | PRRs | http://purl.obolibrary.org/obo/MONDO_0025494 |
T368 | 978-981 | Disease | denotes | NOD | http://purl.obolibrary.org/obo/MONDO_0007435 |
T369 | 1080-1083 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
T370 | 1294-1306 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
LitCovid-sample-PD-GO-BP-0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T111 | 193-210 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T112 | 193-210 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T113 | 380-401 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
T114 | 418-427 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T115 | 418-427 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T116 | 466-475 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T117 | 466-475 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T118 | 492-502 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
T119 | 497-502 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
T120 | 512-529 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T121 | 512-529 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T122 | 554-566 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T123 | 609-630 | http://purl.obolibrary.org/obo/GO_0012501 | denotes | programmed cell death |
T124 | 620-630 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
T125 | 625-630 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
T126 | 1052-1070 | http://purl.obolibrary.org/obo/GO_0006919 | denotes | caspase activating |
T127 | 1087-1096 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T128 | 1087-1096 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T129 | 1275-1280 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | lysis |
T130 | 1294-1306 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-sample-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T65 | 41-55 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
LitCovid-sample-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T111 | 193-210 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T112 | 193-210 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T113 | 380-401 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
T114 | 418-427 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T115 | 418-427 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T116 | 432-442 | http://purl.obolibrary.org/obo/GO_0070269 | denotes | pyroptosis |
T117 | 466-475 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T118 | 466-475 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T119 | 492-502 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
T120 | 512-529 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T121 | 512-529 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T122 | 554-566 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T123 | 577-587 | http://purl.obolibrary.org/obo/GO_0070269 | denotes | pyroptosis |
T124 | 609-630 | http://purl.obolibrary.org/obo/GO_0012501 | denotes | programmed cell death |
T125 | 620-630 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
T126 | 729-739 | http://purl.obolibrary.org/obo/GO_0070269 | denotes | pyroptosis |
T127 | 1052-1070 | http://purl.obolibrary.org/obo/GO_0006919 | denotes | caspase activating |
T128 | 1087-1096 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T129 | 1087-1096 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T130 | 1275-1280 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | lysis |
T131 | 1294-1306 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T68 | 41-55 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1725 | 72-76 | Gene | denotes | ACE2 | Gene:59272 |
1726 | 160-164 | Gene | denotes | ACE2 | Gene:59272 |
1727 | 1008-1013 | Gene | denotes | NLRP3 | Gene:114548 |
1728 | 1176-1185 | Gene | denotes | caspase 1 | Gene:834 |
1729 | 950-958 | Gene | denotes | membrane | Gene:43740571 |
1730 | 554-566 | Disease | denotes | inflammation | MESH:D007249 |
1731 | 1294-1306 | Disease | denotes | inflammation | MESH:D007249 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T373 | 0-118 | Sentence | denotes | The molecular mechanisms involved in the cytokine storm and the role of ACE2 are currently still not fully understood. |
T374 | 119-332 | Sentence | denotes | As discussed above, virus binding to the ACE2 is the event that initiates viral replication in susceptible cells, such as alveolar epithelial cells, vascular cells and immune system cells (macrophages, monocytes). |
T375 | 333-461 | Sentence | denotes | This has been suggested to trigger the primary inflammatory response, which involves apoptosis and pyroptosis (Fu et al., 2020). |
T376 | 462-712 | Sentence | denotes | The apoptosis pattern indices cell death to avoid viral replication in the absence of overt inflammation, whereas, pyroptosis is a violent form of programmed cell death, followed by an inflammatory storm (Cookson and Brennan, 2001; Liu et al., 2016). |
T377 | 713-959 | Sentence | denotes | In the standard pyroptosis model, when the pathogen enters the host cell, some specific structures on the pathogen surface (PAMPs–pathogen associated molecular patterns) are identified by pattern recognition receptors (PRRs) on the host membrane. |
T378 | 960-1405 | Sentence | denotes | One common PRR is NOD-like receptors protein 3 (NLRP3), which forms together with a protein caspase activating protein (ASC or apoptosis-associated speck-like protein containing a caspase recruitment domain) and pro-caspase 1, the inflammasome unit capable of recruiting proinflammatory cytokines and inducing cell lysis with further inflammation signals (Fernandes-Alnemri et al., 2007; Schroder and Tschopp, 2010; Wree et al., 2014; Figure 9). |