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LitCovid-sample-CHEBI

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T172","span":{"begin":455,"end":460},"obj":"Chemical"},{"id":"T173","span":{"begin":462,"end":465},"obj":"Chemical"}],"attributes":[{"id":"A172","pred":"chebi_id","subj":"T172","obj":"http://purl.obolibrary.org/obo/CHEBI_138157"},{"id":"A173","pred":"chebi_id","subj":"T173","obj":"http://purl.obolibrary.org/obo/CHEBI_132592"},{"id":"A174","pred":"chebi_id","subj":"T173","obj":"http://purl.obolibrary.org/obo/CHEBI_50099"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

LitCovid-sample-PD-NCBITaxon

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T360","span":{"begin":264,"end":272},"obj":"Species"}],"attributes":[{"id":"A360","pred":"ncbi_taxonomy_id","subj":"T360","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

LitCovid-sample-sentences

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T368","span":{"begin":0,"end":148},"obj":"Sentence"},{"id":"T369","span":{"begin":149,"end":287},"obj":"Sentence"},{"id":"T370","span":{"begin":288,"end":386},"obj":"Sentence"},{"id":"T371","span":{"begin":387,"end":512},"obj":"Sentence"},{"id":"T372","span":{"begin":513,"end":828},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

LitCovid-sample-Pubtator

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1703","span":{"begin":441,"end":446},"obj":"Gene"},{"id":"1704","span":{"begin":448,"end":453},"obj":"Gene"},{"id":"1705","span":{"begin":455,"end":460},"obj":"Gene"},{"id":"1706","span":{"begin":462,"end":467},"obj":"Gene"},{"id":"1707","span":{"begin":469,"end":473},"obj":"Gene"},{"id":"1708","span":{"begin":479,"end":484},"obj":"Gene"},{"id":"1709","span":{"begin":193,"end":201},"obj":"Species"},{"id":"1710","span":{"begin":307,"end":315},"obj":"Species"},{"id":"1711","span":{"begin":393,"end":401},"obj":"Species"},{"id":"1712","span":{"begin":505,"end":511},"obj":"Species"},{"id":"1713","span":{"begin":527,"end":535},"obj":"Species"},{"id":"1714","span":{"begin":138,"end":147},"obj":"Disease"},{"id":"1715","span":{"begin":264,"end":272},"obj":"Disease"},{"id":"1716","span":{"begin":277,"end":286},"obj":"Disease"},{"id":"1717","span":{"begin":316,"end":320},"obj":"Disease"}],"attributes":[{"id":"A1707","pred":"pubann:denotes","subj":"1707","obj":"Gene:3565"},{"id":"A1712","pred":"pubann:denotes","subj":"1712","obj":"Tax:9606"},{"id":"A1704","pred":"pubann:denotes","subj":"1704","obj":"Gene:3458"},{"id":"A1715","pred":"pubann:denotes","subj":"1715","obj":"MESH:C000657245"},{"id":"A1711","pred":"pubann:denotes","subj":"1711","obj":"Tax:9606"},{"id":"A1716","pred":"pubann:denotes","subj":"1716","obj":"MESH:D011014"},{"id":"A1713","pred":"pubann:denotes","subj":"1713","obj":"Tax:9606"},{"id":"A1705","pred":"pubann:denotes","subj":"1705","obj":"Gene:3627"},{"id":"A1709","pred":"pubann:denotes","subj":"1709","obj":"Tax:9606"},{"id":"A1710","pred":"pubann:denotes","subj":"1710","obj":"Tax:9606"},{"id":"A1706","pred":"pubann:denotes","subj":"1706","obj":"Gene:6347"},{"id":"A1708","pred":"pubann:denotes","subj":"1708","obj":"Gene:3586"},{"id":"A1714","pred":"pubann:denotes","subj":"1714","obj":"MESH:D007239"},{"id":"A1717","pred":"pubann:denotes","subj":"1717","obj":"MESH:D012128"},{"id":"A1703","pred":"pubann:denotes","subj":"1703","obj":"Gene:3552"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

LitCovid-sample-UniProt

LitCovid-sample-PD-IDO

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T234","span":{"begin":126,"end":130},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T235","span":{"begin":138,"end":147},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T236","span":{"begin":427,"end":437},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"},{"id":"T237","span":{"begin":796,"end":803},"obj":"http://purl.obolibrary.org/obo/OGMS_0000031"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

LitCovid-sample-PD-FMA

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T408","span":{"begin":441,"end":445},"obj":"Body_part"},{"id":"T409","span":{"begin":634,"end":643},"obj":"Body_part"},{"id":"T410","span":{"begin":720,"end":728},"obj":"Body_part"}],"attributes":[{"id":"A410","pred":"fma_id","subj":"T410","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A408","pred":"fma_id","subj":"T408","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A409","pred":"fma_id","subj":"T409","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

LitCovid-sample-PD-MONDO

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T362","span":{"begin":138,"end":147},"obj":"Disease"},{"id":"T363","span":{"begin":264,"end":272},"obj":"Disease"},{"id":"T364","span":{"begin":277,"end":286},"obj":"Disease"},{"id":"T365","span":{"begin":316,"end":320},"obj":"Disease"}],"attributes":[{"id":"A365","pred":"mondo_id","subj":"T365","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A362","pred":"mondo_id","subj":"T362","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A363","pred":"mondo_id","subj":"T363","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A364","pred":"mondo_id","subj":"T364","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

LitCovid-sample-PD-GO-BP-0

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T110","span":{"begin":462,"end":465},"obj":"http://purl.obolibrary.org/obo/GO_0004298"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

LitCovid-sample-PD-HP

{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T63","span":{"begin":277,"end":286},"obj":"Phenotype"},{"id":"T64","span":{"begin":720,"end":734},"obj":"Phenotype"}],"attributes":[{"id":"A64","pred":"hp_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A63","pred":"hp_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T66","span":{"begin":277,"end":286},"obj":"Phenotype"},{"id":"T67","span":{"begin":720,"end":734},"obj":"Phenotype"}],"attributes":[{"id":"A66","pred":"hp_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A67","pred":"hp_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"1703","span":{"begin":441,"end":446},"obj":"Gene"},{"id":"1704","span":{"begin":448,"end":453},"obj":"Gene"},{"id":"1705","span":{"begin":455,"end":460},"obj":"Gene"},{"id":"1706","span":{"begin":462,"end":467},"obj":"Gene"},{"id":"1707","span":{"begin":469,"end":473},"obj":"Gene"},{"id":"1708","span":{"begin":479,"end":484},"obj":"Gene"},{"id":"1709","span":{"begin":193,"end":201},"obj":"Species"},{"id":"1710","span":{"begin":307,"end":315},"obj":"Species"},{"id":"1711","span":{"begin":393,"end":401},"obj":"Species"},{"id":"1712","span":{"begin":505,"end":511},"obj":"Species"},{"id":"1713","span":{"begin":527,"end":535},"obj":"Species"},{"id":"1714","span":{"begin":138,"end":147},"obj":"Disease"},{"id":"1715","span":{"begin":264,"end":272},"obj":"Disease"},{"id":"1716","span":{"begin":277,"end":286},"obj":"Disease"},{"id":"1717","span":{"begin":316,"end":320},"obj":"Disease"}],"attributes":[{"id":"A1703","pred":"tao:has_database_id","subj":"1703","obj":"Gene:3552"},{"id":"A1704","pred":"tao:has_database_id","subj":"1704","obj":"Gene:3458"},{"id":"A1705","pred":"tao:has_database_id","subj":"1705","obj":"Gene:3627"},{"id":"A1706","pred":"tao:has_database_id","subj":"1706","obj":"Gene:6347"},{"id":"A1707","pred":"tao:has_database_id","subj":"1707","obj":"Gene:3565"},{"id":"A1708","pred":"tao:has_database_id","subj":"1708","obj":"Gene:3586"},{"id":"A1709","pred":"tao:has_database_id","subj":"1709","obj":"Tax:9606"},{"id":"A1710","pred":"tao:has_database_id","subj":"1710","obj":"Tax:9606"},{"id":"A1711","pred":"tao:has_database_id","subj":"1711","obj":"Tax:9606"},{"id":"A1712","pred":"tao:has_database_id","subj":"1712","obj":"Tax:9606"},{"id":"A1713","pred":"tao:has_database_id","subj":"1713","obj":"Tax:9606"},{"id":"A1714","pred":"tao:has_database_id","subj":"1714","obj":"MESH:D007239"},{"id":"A1715","pred":"tao:has_database_id","subj":"1715","obj":"MESH:C000657245"},{"id":"A1716","pred":"tao:has_database_id","subj":"1716","obj":"MESH:D011014"},{"id":"A1717","pred":"tao:has_database_id","subj":"1717","obj":"MESH:D012128"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T368","span":{"begin":0,"end":148},"obj":"Sentence"},{"id":"T369","span":{"begin":149,"end":287},"obj":"Sentence"},{"id":"T370","span":{"begin":288,"end":386},"obj":"Sentence"},{"id":"T371","span":{"begin":387,"end":512},"obj":"Sentence"},{"id":"T372","span":{"begin":513,"end":828},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection. Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia. In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required. These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people. Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020)."}

PMC:7556165 / 61337-62165 JSONTXT

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PMC:7556165 / 61337-62165 JSON TXT