PMC:7556165 / 56765-57794 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7556165","sourcedb":"PMC","sourceid":"7556165","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7556165","text":"Hence, following the SARS-CoV-2 outbreak, it has been speculated that the use of ACEI and ARB could increase viral invasion and should therefore be temporarily suspended. This topic has been abundantly debated in the last few months (March–May 2020), with contradictory views (Bavishi et al., 2020; Buckley et al., 2020; Danser et al., 2020; Fang et al., 2020; Huang Z. et al., 2020; Kreutz et al., 2020; Kuster et al., 2020; Mourad and Levy, 2020; Park et al., 2020; Rico-Mesa et al., 2020; Sommerstein et al., 2020; South et al., 2020; Tignanelli et al., 2020; Vaduganathan et al., 2020; Verdecchia et al., 2020b; Zhang P. et al., 2020). As a consequence of this debate, several clinical societies have stated that suspension of ACEI and ARB is not justified on the basis of the present scientific evidence, although a recent BMJ editorial (Aronson and Ferner, 2020) suggested to consider stopping ACE inhibitors or angiotensin receptor blockers in patients with mild hypertension who are at high risk of coronavirus infection.","tracks":[{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T170","span":{"begin":918,"end":929},"obj":"Chemical"}],"attributes":[{"id":"A170","pred":"chebi_id","subj":"T170","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"subj":"T170","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T341","span":{"begin":21,"end":31},"obj":"Species"},{"id":"T342","span":{"begin":21,"end":25},"obj":"Species"}],"attributes":[{"id":"A342","pred":"ncbi_taxonomy_id","subj":"T342","obj":"NCBItxid:694009"},{"id":"A341","pred":"ncbi_taxonomy_id","subj":"T341","obj":"NCBItxid:2697049"},{"subj":"T341","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T342","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T350","span":{"begin":0,"end":170},"obj":"Sentence"},{"id":"T351","span":{"begin":171,"end":639},"obj":"Sentence"},{"id":"T352","span":{"begin":640,"end":1029},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T350","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T351","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T352","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1581","span":{"begin":900,"end":903},"obj":"Gene"},{"id":"1582","span":{"begin":21,"end":31},"obj":"Species"},{"id":"1583","span":{"begin":951,"end":959},"obj":"Species"},{"id":"1584","span":{"begin":970,"end":982},"obj":"Disease"},{"id":"1585","span":{"begin":1007,"end":1028},"obj":"Disease"}],"attributes":[{"id":"A1581","pred":"pubann:denotes","subj":"1581","obj":"Gene:1636"},{"id":"A1583","pred":"pubann:denotes","subj":"1583","obj":"Tax:9606"},{"id":"A1584","pred":"pubann:denotes","subj":"1584","obj":"MESH:D006973"},{"id":"A1582","pred":"pubann:denotes","subj":"1582","obj":"Tax:2697049"},{"id":"A1585","pred":"pubann:denotes","subj":"1585","obj":"MESH:D018352"},{"subj":"1581","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1582","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1583","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1584","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1585","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T5736","span":{"begin":900,"end":903},"obj":"Protein"},{"id":"T5761","span":{"begin":918,"end":929},"obj":"Protein"}],"attributes":[{"id":"A5736","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q9GLN7"},{"id":"A5737","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q9GLN6"},{"id":"A5738","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q9EQM9"},{"id":"A5739","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q8CFN1"},{"id":"A5740","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q7TMC6"},{"id":"A5741","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q7M4L4"},{"id":"A5742","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q6GTS2"},{"id":"A5743","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q59GY8"},{"id":"A5744","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q53YX9"},{"id":"A5745","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q50JE5"},{"id":"A5746","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q10751"},{"id":"A5747","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q0GA41"},{"id":"A5748","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/P47820"},{"id":"A5749","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/P22968"},{"id":"A5750","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/P22967"},{"id":"A5751","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/P22966"},{"id":"A5752","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/P12822"},{"id":"A5753","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/P12821"},{"id":"A5754","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/P12820"},{"id":"A5755","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/P09470"},{"id":"A5756","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/O02852"},{"id":"A5757","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/E7EU16"},{"id":"A5758","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/B4DXI3"},{"id":"A5759","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/B0LPF0"},{"id":"A5760","pred":"uniprot_id","subj":"T5736","obj":"https://www.uniprot.org/uniprot/Q9VJV3"},{"id":"A5761","pred":"uniprot_id","subj":"T5761","obj":"https://www.uniprot.org/uniprot/Q10757"},{"subj":"T5736","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5761","pred":"source","obj":"LitCovid-sample-UniProt"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T218","span":{"begin":1019,"end":1028},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"}],"attributes":[{"subj":"T218","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T322","span":{"begin":21,"end":31},"obj":"Disease"},{"id":"T323","span":{"begin":21,"end":25},"obj":"Disease"},{"id":"T324","span":{"begin":90,"end":93},"obj":"Disease"},{"id":"T325","span":{"begin":449,"end":453},"obj":"Disease"},{"id":"T326","span":{"begin":740,"end":743},"obj":"Disease"},{"id":"T327","span":{"begin":970,"end":982},"obj":"Disease"},{"id":"T328","span":{"begin":1019,"end":1028},"obj":"Disease"}],"attributes":[{"id":"A327","pred":"mondo_id","subj":"T327","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A322","pred":"mondo_id","subj":"T322","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A324","pred":"mondo_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/MONDO_0012733"},{"id":"A326","pred":"mondo_id","subj":"T326","obj":"http://purl.obolibrary.org/obo/MONDO_0012733"},{"id":"A325","pred":"mondo_id","subj":"T325","obj":"http://purl.obolibrary.org/obo/MONDO_0008199"},{"id":"A328","pred":"mondo_id","subj":"T328","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A323","pred":"mondo_id","subj":"T323","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T322","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T323","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T324","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T325","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T326","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T327","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T328","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T56","span":{"begin":970,"end":982},"obj":"Phenotype"}],"attributes":[{"id":"A56","pred":"hp_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"subj":"T56","pred":"source","obj":"LitCovid-sample-PD-HP"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T59","span":{"begin":970,"end":982},"obj":"Phenotype"}],"attributes":[{"id":"A59","pred":"hp_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1581","span":{"begin":900,"end":903},"obj":"Gene"},{"id":"1582","span":{"begin":21,"end":31},"obj":"Species"},{"id":"1583","span":{"begin":951,"end":959},"obj":"Species"},{"id":"1584","span":{"begin":970,"end":982},"obj":"Disease"},{"id":"1585","span":{"begin":1007,"end":1028},"obj":"Disease"}],"attributes":[{"id":"A1581","pred":"tao:has_database_id","subj":"1581","obj":"Gene:1636"},{"id":"A1582","pred":"tao:has_database_id","subj":"1582","obj":"Tax:2697049"},{"id":"A1583","pred":"tao:has_database_id","subj":"1583","obj":"Tax:9606"},{"id":"A1584","pred":"tao:has_database_id","subj":"1584","obj":"MESH:D006973"},{"id":"A1585","pred":"tao:has_database_id","subj":"1585","obj":"MESH:D018352"},{"subj":"1581","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1582","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1583","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1584","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1585","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T350","span":{"begin":0,"end":170},"obj":"Sentence"},{"id":"T351","span":{"begin":171,"end":639},"obj":"Sentence"},{"id":"T352","span":{"begin":640,"end":1029},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T350","pred":"source","obj":"LitCovid-sentences"},{"subj":"T351","pred":"source","obj":"LitCovid-sentences"},{"subj":"T352","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sample-CHEBI","color":"#ecb593","default":true},{"id":"LitCovid-sample-PD-NCBITaxon","color":"#9b93ec"},{"id":"LitCovid-sample-sentences","color":"#a4ec93"},{"id":"LitCovid-sample-Pubtator","color":"#ec93be"},{"id":"LitCovid-sample-UniProt","color":"#93d8ec"},{"id":"LitCovid-sample-PD-IDO","color":"#ece693"},{"id":"LitCovid-sample-PD-MONDO","color":"#cc93ec"},{"id":"LitCovid-sample-PD-HP","color":"#93ecb2"},{"id":"LitCovid-PD-HP","color":"#ec9893"},{"id":"LitCovid-PubTator","color":"#93a8ec"},{"id":"LitCovid-sentences","color":"#c2ec93"}]}]}}