PMC:7556165 / 48346-48672 JSONTXT

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T160","span":{"begin":255,"end":262},"obj":"Chemical"}],"attributes":[{"id":"A160","pred":"chebi_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T252","span":{"begin":40,"end":50},"obj":"Species"},{"id":"T253","span":{"begin":40,"end":44},"obj":"Species"},{"id":"T254","span":{"begin":55,"end":63},"obj":"Species"},{"id":"T255","span":{"begin":55,"end":59},"obj":"Species"},{"id":"T256","span":{"begin":99,"end":109},"obj":"Species"},{"id":"T257","span":{"begin":99,"end":103},"obj":"Species"}],"attributes":[{"id":"A252","pred":"ncbi_taxonomy_id","subj":"T252","obj":"NCBItxid:2697049"},{"id":"A253","pred":"ncbi_taxonomy_id","subj":"T253","obj":"NCBItxid:694009"},{"id":"A254","pred":"ncbi_taxonomy_id","subj":"T254","obj":"NCBItxid:694009"},{"id":"A255","pred":"ncbi_taxonomy_id","subj":"T255","obj":"NCBItxid:694009"},{"id":"A256","pred":"ncbi_taxonomy_id","subj":"T256","obj":"NCBItxid:2697049"},{"id":"A257","pred":"ncbi_taxonomy_id","subj":"T257","obj":"NCBItxid:694009"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T297","span":{"begin":0,"end":326},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1306","span":{"begin":152,"end":156},"obj":"Gene"},{"id":"1320","span":{"begin":40,"end":50},"obj":"Species"},{"id":"1321","span":{"begin":55,"end":63},"obj":"Species"},{"id":"1322","span":{"begin":99,"end":109},"obj":"Species"}],"attributes":[{"id":"A1306","pred":"pubann:denotes","subj":"1306","obj":"Gene:59272"},{"id":"A1320","pred":"pubann:denotes","subj":"1320","obj":"Tax:2697049"},{"id":"A1321","pred":"pubann:denotes","subj":"1321","obj":"Tax:694009"},{"id":"A1322","pred":"pubann:denotes","subj":"1322","obj":"Tax:2697049"}],"text":"Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T5235","span":{"begin":152,"end":156},"obj":"Protein"},{"id":"T5236","span":{"begin":190,"end":193},"obj":"Protein"},{"id":"T5245","span":{"begin":253,"end":262},"obj":"Protein"}],"attributes":[{"id":"A5235","pred":"uniprot_id","subj":"T5235","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A5236","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5237","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5238","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5239","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5240","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5241","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5242","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5243","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5244","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5245","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UIP0"},{"id":"A5246","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UIN9"},{"id":"A5247","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UIN8"},{"id":"A5248","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UIN7"},{"id":"A5249","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UIN6"},{"id":"A5250","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UBH8"},{"id":"A5251","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NRH8"},{"id":"A5252","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NRH7"},{"id":"A5253","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NRH6"},{"id":"A5254","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NRH5"},{"id":"A5255","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NRH4"},{"id":"A5256","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NPG5"},{"id":"A5257","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NPE0"},{"id":"A5258","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NP52"},{"id":"A5259","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q95IF9"},{"id":"A5260","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q8N5P3"},{"id":"A5261","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q8IZU6"},{"id":"A5262","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q8IZU5"},{"id":"A5263","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q8IZU4"},{"id":"A5264","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q86Z04"},{"id":"A5265","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q7YR44"},{"id":"A5266","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q7LA71"},{"id":"A5267","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q7LA70"},{"id":"A5268","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q5STD2"},{"id":"A5269","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q5SQ85"},{"id":"A5270","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q1XI16"},{"id":"A5271","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q1XI12"},{"id":"A5272","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q15517"},{"id":"A5273","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/O43509"},{"id":"A5274","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/O19084"},{"id":"A5275","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/B0UYZ7"},{"id":"A5276","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/B0S7V2"},{"id":"A5277","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/A5A6L9"}],"text":"Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T192","span":{"begin":311,"end":315},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"}],"text":"Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T386","span":{"begin":255,"end":262},"obj":"Body_part"}],"attributes":[{"id":"A386","pred":"fma_id","subj":"T386","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T232","span":{"begin":40,"end":50},"obj":"Disease"},{"id":"T233","span":{"begin":40,"end":44},"obj":"Disease"},{"id":"T234","span":{"begin":55,"end":63},"obj":"Disease"},{"id":"T235","span":{"begin":55,"end":59},"obj":"Disease"},{"id":"T236","span":{"begin":99,"end":109},"obj":"Disease"},{"id":"T237","span":{"begin":99,"end":103},"obj":"Disease"}],"attributes":[{"id":"A232","pred":"mondo_id","subj":"T232","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A233","pred":"mondo_id","subj":"T233","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A234","pred":"mondo_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A235","pred":"mondo_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A236","pred":"mondo_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A237","pred":"mondo_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1306","span":{"begin":152,"end":156},"obj":"Gene"},{"id":"1320","span":{"begin":40,"end":50},"obj":"Species"},{"id":"1321","span":{"begin":55,"end":63},"obj":"Species"},{"id":"1322","span":{"begin":99,"end":109},"obj":"Species"}],"attributes":[{"id":"A1306","pred":"tao:has_database_id","subj":"1306","obj":"Gene:59272"},{"id":"A1320","pred":"tao:has_database_id","subj":"1320","obj":"Tax:2697049"},{"id":"A1321","pred":"tao:has_database_id","subj":"1321","obj":"Tax:694009"},{"id":"A1322","pred":"tao:has_database_id","subj":"1322","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases."}

{"project":"LitCovid-sentences","denotations":[{"id":"T297","span":{"begin":0,"end":326},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases."}