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PMC:7556165 / 4655-7721 JSONTXT

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LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T19 0-3 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T20 36-65 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Angiotensin-converting enzyme http://purl.bioontology.org/ontology/MEDDRA/10050289
T21 67-70 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T22 218-221 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T23 242-245 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T24 395-398 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T25 515-518 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T26 600-605 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes renin http://purl.bioontology.org/ontology/MEDDRA/10038555
T27 763-766 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T28 892-905 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T29 956-959 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T30 1053-1066 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T31 1079-1093 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T32 1179-1182 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T33 1301-1304 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T34 1423-1426 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T35 1702-1705 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T36 1861-1864 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T37 2073-2076 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T38 2401-2404 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T39 2674-2677 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T40 2705-2708 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T15 36-47 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T16 357-364 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T17 606-617 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T18 618-629 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T20 875-883 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T21 892-905 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T23 910-920 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T24 992-1003 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T25 1053-1066 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T27 1079-1093 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T30 1225-1235 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T31 1272-1279 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T32 1368-1372 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T34 2138-2155 Chemical denotes glutamate residue http://purl.obolibrary.org/obo/CHEBI_32484
T35 2169-2173 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T37 2635-2639 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T39 2691-2698 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T40 2749-2756 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T28 30-35 Species denotes Human NCBItxid:9606
T29 1493-1498 Species denotes human NCBItxid:9606
T30 1696-1701 Species denotes human NCBItxid:9606
T31 1921-1928 Species denotes insects NCBItxid:6960|NCBItxid:50557
T33 1965-1970 Species denotes human NCBItxid:9606
T34 2390-2395 Species denotes human NCBItxid:9606

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T33 0-29 Sentence denotes ACE System and ACE2 Discovery
T34 30-253 Sentence denotes Human Angiotensin-converting enzyme (ACE) belongs to the M2 gluzincin family of metalloproteinases and (Ehlers and Riordan, 1989; Masuyer et al., 2014) exists in two forms, namely somatic ACE (sACE) and germinal ACE (tACE).
T35 254-476 Sentence denotes Both are derived from the same gene, controlled by alternative promotors. sACE is an integral membrane protein, which can be also cleaved by ACE secretases to produce a circulating form of the enzyme (Natesh et al., 2003).
T36 477-713 Sentence denotes sACE, hereafter referred to simply as ACE, has been extensively studied, because of its crucial role in the homeostasis of renin-angiotensin-aldosterone (RAAS) system and in cardiovascular diseases (Takimoto-Ohnishi and Murakami, 2019).
T37 714-947 Sentence denotes The two extracellular domains N and C domains of ACE (Wei et al., 1991; Jaspard et al., 1993; Natesh et al., 2003; Riordan, 2003) can both hydrolase two crucial peptides, namely angiotensin I and bradykinin, with the same efficiency.
T38 948-1168 Sentence denotes Indeed, ACE carries out the cleavage of two amino acids (dipeptidase action) from the C-terminal part of angiotensin I to generate angiotensin II, which exerts a potent vasopressor, proliferative, and profibrotic effect.
T39 1169-1280 Sentence denotes Moreover, ACE mediates the cleavage and inactivation of bradykinin, which is a vasodilator hypotensive peptide.
T40 1281-1408 Sentence denotes The pivotal role of ACE in the RAAS system allows a refined blood pressure control and salt homeostasis (Sayer and Bhat, 2014).
T41 1409-1597 Sentence denotes Following the ACE discovery in mid-1950s, despite intense research in the field, no human homologs of the enzyme have been found for more than 50 years (Isaac et al., 1998; Riordan, 2003).
T42 1598-1749 Sentence denotes It was only in 2000 that two independent research groups identified, almost simultaneously, a new human ACE-like enzyme, with two different approaches.
T43 1750-1929 Sentence denotes Tipnis et al. (2000) searched for new metalloproteases in an expressed sequence tag (EST) database, finding an ACE homolog (ACEH) with a single domain, similar to that of insects.
T44 1930-1993 Sentence denotes Subsequently they cloned it from a human lymphoma cDNA library.
T45 1994-2182 Sentence denotes Interestingly ACEH showed high homology (40% identity and 60% similarity) with ACE, particularly around the HEXXH sequence and highly conserved glutamate residue, involved in zinc binding.
T46 2183-2275 Sentence denotes Moreover, they demonstrated the presence of seven glycosylation sites (Tipnis et al., 2000).
T47 2276-2596 Sentence denotes In the same year, Donoghue et al. (2000b) were searching for new genes involved in heart failure and identified a human cDNA ACE homolog, named ACE2, among 19,000 5’end sequences by RACE (rapid amplification of cDNA ends) in the heart ventricle cDNA library, obtained from a woman with idiopathic dilated cardiomyopathy.
T48 2597-2699 Sentence denotes ACE2 showed a transmembrane domain, a zinc catalytic domain 42% identical to ACE and a signal peptide.
T49 2700-2757 Sentence denotes Like ACE, ACE2 seemed to be an ectoenzyme type I protein.
T50 2758-2926 Sentence denotes The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b).
T51 2927-3066 Sentence denotes In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T8 1341-1346 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T9 2359-2364 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T10 2505-2510 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T11 2823-2828 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T12 2840-2846 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
156 0-3 Gene denotes ACE Gene:1636
157 15-19 Gene denotes ACE2 Gene:59272
167 36-65 Gene denotes Angiotensin-converting enzyme Gene:1636
168 67-70 Gene denotes ACE Gene:1636
169 242-245 Gene denotes ACE Gene:1636
170 247-251 Gene denotes tACE Gene:6868
171 395-398 Gene denotes ACE Gene:1636
172 218-221 Gene denotes ACE Gene:1636
173 348-356 Gene denotes membrane Gene:43740571
174 30-35 Species denotes Human Tax:9606
175 90-99 Chemical denotes gluzincin
191 515-518 Gene denotes ACE Gene:1636
192 763-766 Gene denotes ACE Gene:1636
193 892-905 Gene denotes angiotensin I Gene:183
194 910-920 Gene denotes bradykinin Gene:3827
195 956-959 Gene denotes ACE Gene:1636
196 1053-1066 Gene denotes angiotensin I Gene:183
197 1079-1093 Gene denotes angiotensin II Gene:183
198 1179-1182 Gene denotes ACE Gene:1636
199 1225-1235 Gene denotes bradykinin Gene:3827
200 1301-1304 Gene denotes ACE Gene:1636
201 606-629 Chemical denotes angiotensin-aldosterone
202 631-635 Chemical denotes RAAS
203 1368-1372 Chemical denotes salt MESH:D012492
204 651-674 Disease denotes cardiovascular diseases MESH:D002318
205 1260-1271 Disease denotes hypotensive MESH:D007022
228 1423-1426 Gene denotes ACE Gene:1636
229 1702-1705 Gene denotes ACE Gene:1636
230 1861-1864 Gene denotes ACE Gene:1636
231 2073-2076 Gene denotes ACE Gene:1636
232 2401-2404 Gene denotes ACE Gene:1636
233 2420-2424 Gene denotes ACE2 Gene:59272
234 2597-2601 Gene denotes ACE2 Gene:59272
235 2674-2677 Gene denotes ACE Gene:1636
236 2705-2708 Gene denotes ACE Gene:1636
237 2710-2714 Gene denotes ACE2 Gene:59272
238 2781-2785 Gene denotes ACE2 Gene:59272
239 2870-2874 Gene denotes ACE2 Gene:59272
240 2951-2955 Gene denotes ACE2 Gene:59272
241 1493-1498 Species denotes human Tax:9606
242 1696-1701 Species denotes human Tax:9606
243 1965-1970 Species denotes human Tax:9606
244 2390-2395 Species denotes human Tax:9606
245 2551-2556 Species denotes woman Tax:9606
246 2138-2147 Chemical denotes glutamate MESH:D018698
247 1971-1979 Disease denotes lymphoma MESH:D008223
248 2359-2372 Disease denotes heart failure MESH:D006333
249 2562-2595 Disease denotes idiopathic dilated cardiomyopathy MESH:C536277

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T534 0-3 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T559 15-19 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T560 36-65 Protein denotes Angiotensin-converting enzyme https://www.uniprot.org/uniprot/Q9VJV3|https://www.uniprot.org/uniprot/Q9TX66|https://www.uniprot.org/uniprot/Q9NKE4|https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6Q4G4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q27572|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q10715|https://www.uniprot.org/uniprot/Q10714|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/A4V0P3
T592 67-70 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T617 218-221 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T642 242-245 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T667 348-364 Protein denotes membrane protein https://www.uniprot.org/uniprot/Q9WCD1|https://www.uniprot.org/uniprot/Q9QAR9|https://www.uniprot.org/uniprot/Q9PY97|https://www.uniprot.org/uniprot/Q9PWZ0|https://www.uniprot.org/uniprot/Q9JEB4|https://www.uniprot.org/uniprot/Q9J4B3|https://www.uniprot.org/uniprot/Q9J4A6|https://www.uniprot.org/uniprot/Q9J3P3|https://www.uniprot.org/uniprot/Q9J3P2|https://www.uniprot.org/uniprot/Q9J3P1|https://www.uniprot.org/uniprot/Q9J3P0|https://www.uniprot.org/uniprot/Q9J3N9|https://www.uniprot.org/uniprot/Q9J3N8|https://www.uniprot.org/uniprot/Q9IKC7|https://www.uniprot.org/uniprot/Q9DLM9|https://www.uniprot.org/uniprot/Q99AS5|https://www.uniprot.org/uniprot/Q91QS9|https://www.uniprot.org/uniprot/Q91GB7|https://www.uniprot.org/uniprot/Q91AU9|https://www.uniprot.org/uniprot/Q91A23|https://www.uniprot.org/uniprot/Q910E2|https://www.uniprot.org/uniprot/Q8V433|https://www.uniprot.org/uniprot/Q8JSP5|https://www.uniprot.org/uniprot/Q8BB24|https://www.uniprot.org/uniprot/Q7TA12|https://www.uniprot.org/uniprot/Q7T7S6|https://www.uniprot.org/uniprot/Q7T7P6|https://www.uniprot.org/uniprot/Q7T726|https://www.uniprot.org/uniprot/Q7T6S9|https://www.uniprot.org/uniprot/Q7T6S3|https://www.uniprot.org/uniprot/Q7T6S0|https://www.uniprot.org/uniprot/Q7T6R5|https://www.uniprot.org/uniprot/Q7T6R1|https://www.uniprot.org/uniprot/Q7T6Q8|https://www.uniprot.org/uniprot/Q6TNF6|https://www.uniprot.org/uniprot/Q6S8E5|https://www.uniprot.org/uniprot/Q6Q1R9|https://www.uniprot.org/uniprot/Q5MQC7|https://www.uniprot.org/uniprot/Q5I5X5|https://www.uniprot.org/uniprot/Q52PA8|https://www.uniprot.org/uniprot/Q4ZJS7|https://www.uniprot.org/uniprot/Q4U5F8|https://www.uniprot.org/uniprot/Q3T8I9|https://www.uniprot.org/uniprot/Q3LZX9|https://www.uniprot.org/uniprot/Q3I5J2|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q14EA7|https://www.uniprot.org/uniprot/Q0ZME4|https://www.uniprot.org/uniprot/Q0Q4E7|https://www.uniprot.org/uniprot/Q0Q472|https://www.uniprot.org/uniprot/Q0Q463|https://www.uniprot.org/uniprot/Q07504|https://www.uniprot.org/uniprot/Q04565|https://www.uniprot.org/uniprot/Q01455|https://www.uniprot.org/uniprot/Q008X3|https://www.uniprot.org/uniprot/P69705|https://www.uniprot.org/uniprot/P69704|https://www.uniprot.org/uniprot/P69703|https://www.uniprot.org/uniprot/P69607|https://www.uniprot.org/uniprot/P69606|https://www.uniprot.org/uniprot/P69605|https://www.uniprot.org/uniprot/P69604|https://www.uniprot.org/uniprot/P69603|https://www.uniprot.org/uniprot/P69602|https://www.uniprot.org/uniprot/P69601|https://www.uniprot.org/uniprot/P69600|https://www.uniprot.org/uniprot/P69599|https://www.uniprot.org/uniprot/P59771|https://www.uniprot.org/uniprot/P59770|https://www.uniprot.org/uniprot/P59596|https://www.uniprot.org/uniprot/P36359|https://www.uniprot.org/uniprot/P36299|https://www.uniprot.org/uniprot/P33464|https://www.uniprot.org/uniprot/P28991|https://www.uniprot.org/uniprot/P27904|https://www.uniprot.org/uniprot/P26021|https://www.uniprot.org/uniprot/P25878|https://www.uniprot.org/uniprot/P24412|https://www.uniprot.org/uniprot/P24266|https://www.uniprot.org/uniprot/P16629|https://www.uniprot.org/uniprot/P15422|https://www.uniprot.org/uniprot/P12649|https://www.uniprot.org/uniprot/P11222|https://www.uniprot.org/uniprot/P10526|https://www.uniprot.org/uniprot/P0DTC5|https://www.uniprot.org/uniprot/P09175|https://www.uniprot.org/uniprot/P08549|https://www.uniprot.org/uniprot/P05136|https://www.uniprot.org/uniprot/P04327|https://www.uniprot.org/uniprot/P04135|https://www.uniprot.org/uniprot/P03415|https://www.uniprot.org/uniprot/O90305|https://www.uniprot.org/uniprot/K9N7A1|https://www.uniprot.org/uniprot/A3EXG9|https://www.uniprot.org/uniprot/A3EXD6|https://www.uniprot.org/uniprot/A3EXA0|https://www.uniprot.org/uniprot/A0MD35
T764 395-398 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T789 515-518 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T814 600-605 Protein denotes renin https://www.uniprot.org/uniprot/Q9TSZ1|https://www.uniprot.org/uniprot/Q6T5C2|https://www.uniprot.org/uniprot/Q6FI38|https://www.uniprot.org/uniprot/Q6DYE7|https://www.uniprot.org/uniprot/Q6DLW5|https://www.uniprot.org/uniprot/Q6DLS0|https://www.uniprot.org/uniprot/Q63497|https://www.uniprot.org/uniprot/P60016|https://www.uniprot.org/uniprot/P52115|https://www.uniprot.org/uniprot/P08424|https://www.uniprot.org/uniprot/P00797
T825 606-617 Protein denotes angiotensin https://www.uniprot.org/uniprot/Q10757
T826 763-766 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T851 892-905 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T868 910-920 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T905 956-959 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T930 1053-1066 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T947 1079-1093 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T964 1179-1182 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T989 1225-1235 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T1026 1301-1304 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1051 1423-1426 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1076 1702-1705 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1101 1861-1864 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1126 1874-1878 Protein denotes ACEH https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/C7ECU1
T1132 2008-2012 Protein denotes ACEH https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/C7ECU1
T1138 2073-2076 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1163 2401-2404 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1188 2420-2424 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1189 2458-2462 Protein denotes RACE https://www.uniprot.org/uniprot/O93323
T1190 2597-2601 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1191 2674-2677 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1216 2705-2708 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1241 2710-2714 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1242 2781-2785 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1243 2870-2874 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1244 2951-2955 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T18 666-674 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T19 1341-1346 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T20 2247-2252 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T21 2999-3007 http://purl.obolibrary.org/obo/BFO_0000034 denotes function

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T19 285-289 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T20 357-364 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T21 992-1003 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T22 1341-1346 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T23 2359-2364 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T24 2505-2510 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T25 2749-2756 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T26 2823-2828 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T27 2840-2846 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T37 651-674 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T38 1835-1838 Disease denotes EST http://purl.obolibrary.org/obo/MONDO_0023726
T39 1971-1979 Disease denotes lymphoma http://purl.obolibrary.org/obo/MONDO_0005062
T40 2359-2372 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T41 2562-2595 Disease denotes idiopathic dilated cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0016333

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T8 1341-1346 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T9 1341-1346 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T10 2359-2364 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T11 2505-2520 http://purl.obolibrary.org/obo/MAT_0000497 denotes heart ventricle
T12 2505-2510 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T13 2823-2828 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T14 2840-2846 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T9 585-596 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T10 1373-1384 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T11 2233-2246 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T8 651-674 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T9 1971-1979 Phenotype denotes lymphoma http://purl.obolibrary.org/obo/HP_0002665
T10 2359-2372 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T11 2573-2595 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T9 585-596 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T10 1373-1384 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T11 2233-2246 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T8 651-674 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T9 1971-1979 Phenotype denotes lymphoma http://purl.obolibrary.org/obo/HP_0002665
T10 2359-2372 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T11 2573-2595 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
156 0-3 Gene denotes ACE Gene:1636
157 15-19 Gene denotes ACE2 Gene:59272
167 36-65 Gene denotes Angiotensin-converting enzyme Gene:1636
168 67-70 Gene denotes ACE Gene:1636
169 242-245 Gene denotes ACE Gene:1636
170 247-251 Gene denotes tACE Gene:6868
171 395-398 Gene denotes ACE Gene:1636
172 218-221 Gene denotes ACE Gene:1636
173 348-356 Gene denotes membrane Gene:43740571
174 30-35 Species denotes Human Tax:9606
175 90-99 Chemical denotes gluzincin
191 515-518 Gene denotes ACE Gene:1636
192 763-766 Gene denotes ACE Gene:1636
193 892-905 Gene denotes angiotensin I Gene:183
194 910-920 Gene denotes bradykinin Gene:3827
195 956-959 Gene denotes ACE Gene:1636
196 1053-1066 Gene denotes angiotensin I Gene:183
197 1079-1093 Gene denotes angiotensin II Gene:183
198 1179-1182 Gene denotes ACE Gene:1636
199 1225-1235 Gene denotes bradykinin Gene:3827
200 1301-1304 Gene denotes ACE Gene:1636
201 606-629 Chemical denotes angiotensin-aldosterone
202 631-635 Chemical denotes RAAS
203 1368-1372 Chemical denotes salt MESH:D012492
204 651-674 Disease denotes cardiovascular diseases MESH:D002318
205 1260-1271 Disease denotes hypotensive MESH:D007022
228 1423-1426 Gene denotes ACE Gene:1636
229 1702-1705 Gene denotes ACE Gene:1636
230 1861-1864 Gene denotes ACE Gene:1636
231 2073-2076 Gene denotes ACE Gene:1636
232 2401-2404 Gene denotes ACE Gene:1636
233 2420-2424 Gene denotes ACE2 Gene:59272
234 2597-2601 Gene denotes ACE2 Gene:59272
235 2674-2677 Gene denotes ACE Gene:1636
236 2705-2708 Gene denotes ACE Gene:1636
237 2710-2714 Gene denotes ACE2 Gene:59272
238 2781-2785 Gene denotes ACE2 Gene:59272
239 2870-2874 Gene denotes ACE2 Gene:59272
240 2951-2955 Gene denotes ACE2 Gene:59272
241 1493-1498 Species denotes human Tax:9606
242 1696-1701 Species denotes human Tax:9606
243 1965-1970 Species denotes human Tax:9606
244 2390-2395 Species denotes human Tax:9606
245 2551-2556 Species denotes woman Tax:9606
246 2138-2147 Chemical denotes glutamate MESH:D018698
247 1971-1979 Disease denotes lymphoma MESH:D008223
248 2359-2372 Disease denotes heart failure MESH:D006333
249 2562-2595 Disease denotes idiopathic dilated cardiomyopathy MESH:C536277

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T33 0-29 Sentence denotes ACE System and ACE2 Discovery
T34 30-253 Sentence denotes Human Angiotensin-converting enzyme (ACE) belongs to the M2 gluzincin family of metalloproteinases and (Ehlers and Riordan, 1989; Masuyer et al., 2014) exists in two forms, namely somatic ACE (sACE) and germinal ACE (tACE).
T35 254-476 Sentence denotes Both are derived from the same gene, controlled by alternative promotors. sACE is an integral membrane protein, which can be also cleaved by ACE secretases to produce a circulating form of the enzyme (Natesh et al., 2003).
T36 477-713 Sentence denotes sACE, hereafter referred to simply as ACE, has been extensively studied, because of its crucial role in the homeostasis of renin-angiotensin-aldosterone (RAAS) system and in cardiovascular diseases (Takimoto-Ohnishi and Murakami, 2019).
T37 714-947 Sentence denotes The two extracellular domains N and C domains of ACE (Wei et al., 1991; Jaspard et al., 1993; Natesh et al., 2003; Riordan, 2003) can both hydrolase two crucial peptides, namely angiotensin I and bradykinin, with the same efficiency.
T38 948-1168 Sentence denotes Indeed, ACE carries out the cleavage of two amino acids (dipeptidase action) from the C-terminal part of angiotensin I to generate angiotensin II, which exerts a potent vasopressor, proliferative, and profibrotic effect.
T39 1169-1280 Sentence denotes Moreover, ACE mediates the cleavage and inactivation of bradykinin, which is a vasodilator hypotensive peptide.
T40 1281-1408 Sentence denotes The pivotal role of ACE in the RAAS system allows a refined blood pressure control and salt homeostasis (Sayer and Bhat, 2014).
T41 1409-1597 Sentence denotes Following the ACE discovery in mid-1950s, despite intense research in the field, no human homologs of the enzyme have been found for more than 50 years (Isaac et al., 1998; Riordan, 2003).
T42 1598-1749 Sentence denotes It was only in 2000 that two independent research groups identified, almost simultaneously, a new human ACE-like enzyme, with two different approaches.
T43 1750-1929 Sentence denotes Tipnis et al. (2000) searched for new metalloproteases in an expressed sequence tag (EST) database, finding an ACE homolog (ACEH) with a single domain, similar to that of insects.
T44 1930-1993 Sentence denotes Subsequently they cloned it from a human lymphoma cDNA library.
T45 1994-2182 Sentence denotes Interestingly ACEH showed high homology (40% identity and 60% similarity) with ACE, particularly around the HEXXH sequence and highly conserved glutamate residue, involved in zinc binding.
T46 2183-2275 Sentence denotes Moreover, they demonstrated the presence of seven glycosylation sites (Tipnis et al., 2000).
T47 2276-2596 Sentence denotes In the same year, Donoghue et al. (2000b) were searching for new genes involved in heart failure and identified a human cDNA ACE homolog, named ACE2, among 19,000 5’end sequences by RACE (rapid amplification of cDNA ends) in the heart ventricle cDNA library, obtained from a woman with idiopathic dilated cardiomyopathy.
T48 2597-2699 Sentence denotes ACE2 showed a transmembrane domain, a zinc catalytic domain 42% identical to ACE and a signal peptide.
T49 2700-2757 Sentence denotes Like ACE, ACE2 seemed to be an ectoenzyme type I protein.
T50 2758-2926 Sentence denotes The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b).
T51 2927-3066 Sentence denotes In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.