PMC:7556165 / 44914-49334
Annnotations
LitCovid-sample-MedDRA
Id | Subject | Object | Predicate | Lexical cue | meddra_id |
---|---|---|---|---|---|
T79 | 522-532 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | microscopy | http://purl.bioontology.org/ontology/MEDDRA/10069374 |
T80 | 908-920 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | investigated | http://purl.bioontology.org/ontology/MEDDRA/10062026 |
T81 | 945-950 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | X-ray | http://purl.bioontology.org/ontology/MEDDRA/10048064 |
T82 | 2030-2042 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | investigated | http://purl.bioontology.org/ontology/MEDDRA/10062026 |
T83 | 2524-2536 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | investigated | http://purl.bioontology.org/ontology/MEDDRA/10062026 |
T84 | 3932-3945 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | protein and S | http://purl.bioontology.org/ontology/MEDDRA/10050417 |
LitCovid-sample-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T154 | 236-243 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T155 | 805-813 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T156 | 1289-1298 | Chemical | denotes | disulfide | http://purl.obolibrary.org/obo/CHEBI_48343 |
T157 | 1483-1488 | Chemical | denotes | atoms | http://purl.obolibrary.org/obo/CHEBI_33250 |
T158 | 2259-2266 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T159 | 3111-3118 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T160 | 3687-3694 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T161 | 3932-3939 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sample-PD-NCBITaxon
Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
---|---|---|---|---|---|
T198 | 0-10 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T199 | 0-4 | Species | denotes | SARS | NCBItxid:694009 |
T200 | 44-54 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T201 | 44-48 | Species | denotes | SARS | NCBItxid:694009 |
T202 | 59-67 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T203 | 59-63 | Species | denotes | SARS | NCBItxid:694009 |
T204 | 135-145 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T205 | 135-139 | Species | denotes | SARS | NCBItxid:694009 |
T206 | 176-184 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T207 | 176-180 | Species | denotes | SARS | NCBItxid:694009 |
T208 | 186-194 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T209 | 186-190 | Species | denotes | SARS | NCBItxid:694009 |
T210 | 312-322 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T211 | 312-316 | Species | denotes | SARS | NCBItxid:694009 |
T212 | 369-377 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T213 | 369-373 | Species | denotes | SARS | NCBItxid:694009 |
T214 | 485-495 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T215 | 485-489 | Species | denotes | SARS | NCBItxid:694009 |
T216 | 541-551 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T217 | 541-545 | Species | denotes | SARS | NCBItxid:694009 |
T218 | 722-726 | Species | denotes | MERS | NCBItxid:1335626 |
T219 | 872-882 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T220 | 872-876 | Species | denotes | SARS | NCBItxid:694009 |
T221 | 979-989 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T222 | 979-983 | Species | denotes | SARS | NCBItxid:694009 |
T223 | 1409-1419 | Species | denotes | SARS-COV-2 | NCBItxid:2697049 |
T224 | 1409-1413 | Species | denotes | SARS | NCBItxid:694009 |
T225 | 1424-1432 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T226 | 1424-1428 | Species | denotes | SARS | NCBItxid:694009 |
T227 | 1642-1652 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T228 | 1642-1646 | Species | denotes | SARS | NCBItxid:694009 |
T229 | 1796-1806 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T230 | 1796-1800 | Species | denotes | SARS | NCBItxid:694009 |
T231 | 2062-2072 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T232 | 2062-2066 | Species | denotes | SARS | NCBItxid:694009 |
T233 | 2159-2169 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T234 | 2159-2163 | Species | denotes | SARS | NCBItxid:694009 |
T235 | 2630-2640 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T236 | 2630-2634 | Species | denotes | SARS | NCBItxid:694009 |
T237 | 2699-2707 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T238 | 2699-2703 | Species | denotes | SARS | NCBItxid:694009 |
T239 | 2879-2889 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T240 | 2879-2883 | Species | denotes | SARS | NCBItxid:694009 |
T241 | 2927-2937 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T242 | 2927-2931 | Species | denotes | SARS | NCBItxid:694009 |
T243 | 2961-2969 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T244 | 2961-2965 | Species | denotes | SARS | NCBItxid:694009 |
T245 | 3098-3108 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T246 | 3098-3102 | Species | denotes | SARS | NCBItxid:694009 |
T247 | 3158-3162 | Species | denotes | SARS | NCBItxid:694009 |
T248 | 3225-3235 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T249 | 3225-3229 | Species | denotes | SARS | NCBItxid:694009 |
T250 | 3294-3302 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T251 | 3294-3298 | Species | denotes | SARS | NCBItxid:694009 |
T252 | 3472-3482 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T253 | 3472-3476 | Species | denotes | SARS | NCBItxid:694009 |
T254 | 3487-3495 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T255 | 3487-3491 | Species | denotes | SARS | NCBItxid:694009 |
T256 | 3531-3541 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T257 | 3531-3535 | Species | denotes | SARS | NCBItxid:694009 |
T258 | 3844-3854 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T259 | 3844-3848 | Species | denotes | SARS | NCBItxid:694009 |
T260 | 3911-3921 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T261 | 3911-3915 | Species | denotes | SARS | NCBItxid:694009 |
T262 | 4009-4015 | Species | denotes | SARS-2 | NCBItxid:2697049 |
T263 | 4009-4013 | Species | denotes | SARS | NCBItxid:694009 |
T264 | 4049-4055 | Species | denotes | SARS-2 | NCBItxid:2697049 |
T265 | 4049-4053 | Species | denotes | SARS | NCBItxid:694009 |
T266 | 4087-4093 | Species | denotes | SARS-2 | NCBItxid:2697049 |
T267 | 4087-4091 | Species | denotes | SARS | NCBItxid:694009 |
T268 | 4137-4143 | Species | denotes | SARS-2 | NCBItxid:2697049 |
T269 | 4137-4141 | Species | denotes | SARS | NCBItxid:694009 |
T270 | 4190-4196 | Species | denotes | SARS-2 | NCBItxid:2697049 |
T271 | 4190-4194 | Species | denotes | SARS | NCBItxid:694009 |
T272 | 4240-4246 | Species | denotes | SARS-2 | NCBItxid:2697049 |
T273 | 4240-4244 | Species | denotes | SARS | NCBItxid:694009 |
T274 | 4288-4294 | Species | denotes | SARS-2 | NCBItxid:2697049 |
T275 | 4288-4292 | Species | denotes | SARS | NCBItxid:694009 |
T276 | 4355-4361 | Species | denotes | SARS-2 | NCBItxid:2697049 |
T277 | 4355-4359 | Species | denotes | SARS | NCBItxid:694009 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T275 | 0-37 | Sentence | denotes | SARS-CoV-2 RBD and Its Receptor, ACE2 |
T276 | 38-185 | Sentence | denotes | Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. |
T277 | 186-262 | Sentence | denotes | SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). |
T278 | 263-402 | Sentence | denotes | Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). |
T279 | 403-533 | Sentence | denotes | Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. |
T280 | 534-737 | Sentence | denotes | Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). |
T281 | 738-867 | Sentence | denotes | Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner. |
T282 | 868-944 | Sentence | denotes | The SARS-CoV-2 RBD sequence was further investigated by structural analysis. |
T283 | 945-1342 | Sentence | denotes | X-ray crystallography showed that SARS-CoV-2 RBD folds into two structural domains (Figure 8): (1) the core subdomain with five antiparallel β-strands (β1, β2, β3, β4, β7), (2) the external subdomain, which inserts between β4 and β7, and it is characterized by the two small β5 and β6 strands [β1’ and β2’ in Wang et al. (2020)] connected by a disulfide bond (Lan et al., 2020; Wang et al., 2020). |
T284 | 1343-1610 | Sentence | denotes | In keeping with their high sequence homology, the 3D structure of SARS-COV-2 and SARS-CoV RBD nearly superimpose (RMSD = 0.475 Å for 128 Cα atoms; Wang et al., 2020) with the exception of the β5/β6 loop, which actually entailed the larger primary sequence difference. |
T285 | 1611-1845 | Sentence | denotes | FIGURE 8 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2. (A) Cartoon representation. (B) Gaussian surface representation. hACE2 is in green, the core of SARS-CoV-2 RBD is in red, and the RBM is in blue. |
T286 | 1846-1918 | Sentence | denotes | The β1-β7 typical motifs of RBD (Lan et al., 2020) are indicated in (A). |
T287 | 1919-2009 | Sentence | denotes | The structures have been drawn from PDB 6MOJ (Lan et al., 2020) by Mol on the PDB website. |
T288 | 2010-2087 | Sentence | denotes | Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2. |
T289 | 2088-2174 | Sentence | denotes | Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD. |
T290 | 2175-2335 | Sentence | denotes | To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch. |
T291 | 2336-2450 | Sentence | denotes | In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1). |
T292 | 2451-2599 | Sentence | denotes | Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b). |
T293 | 2600-2791 | Sentence | denotes | In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020). |
T294 | 2792-3009 | Sentence | denotes | The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020). |
T295 | 3010-3187 | Sentence | denotes | Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a). |
T296 | 3188-3431 | Sentence | denotes | This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host. |
T297 | 3432-3758 | Sentence | denotes | Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases. |
T298 | 3759-3876 | Sentence | denotes | Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells. |
T299 | 3877-3970 | Sentence | denotes | TABLE 1 Binding affinity between SARS-CoV-2 spike (S) protein and S subset regions and ACE2. |
T300 | 3971-4008 | Sentence | denotes | Sequence KD (nM) Method References |
T301 | 4009-4048 | Sentence | denotes | SARS-2 S 14.7 SPR Wrapp et al., 2020 |
T302 | 4049-4086 | Sentence | denotes | SARS-2 S 11.2 SPR Lei et al., 2020 |
T303 | 4087-4136 | Sentence | denotes | SARS-2 S20–685 (S1) 94.6 SPR Wang et al., 2020 |
T304 | 4137-4189 | Sentence | denotes | SARS-2 S319–541 (RBD) 133.3 SPR Wang et al., 2020 |
T305 | 4190-4239 | Sentence | denotes | SARS-2 S319–541 (RBD) 4.7 SPR Lan et al., 2020 |
T306 | 4240-4287 | Sentence | denotes | SARS-2 S319–529 44.2 SPR Shang et al., 2020b |
T307 | 4288-4354 | Sentence | denotes | SARS-2 S319–591 34.6 Biolayer interferometry Wrapp et al., 2020 |
T308 | 4355-4420 | Sentence | denotes | SARS-2 S328–533 1.2 Biolayer interferometry Walls et al., 2020 |
LitCovid-sample-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T139 | 3405-3418 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
1201 | 0-10 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1217 | 607-611 | Gene | denotes | ACE2 | Gene:59272 |
1218 | 715-720 | Gene | denotes | hDPP4 | Gene:1803 |
1219 | 760-764 | Gene | denotes | ACE2 | Gene:59272 |
1220 | 818-822 | Gene | denotes | ACE2 | Gene:59272 |
1221 | 696-704 | Gene | denotes | membrane | Gene:43740571 |
1222 | 44-54 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1223 | 59-67 | Species | denotes | SARS-CoV | Tax:694009 |
1224 | 135-145 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1225 | 176-184 | Species | denotes | SARS-CoV | Tax:694009 |
1226 | 186-194 | Species | denotes | SARS-CoV | Tax:694009 |
1227 | 312-322 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1228 | 369-377 | Species | denotes | SARS-CoV | Tax:694009 |
1229 | 485-495 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1230 | 541-551 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1231 | 641-644 | CellLine | denotes | HEK | CVCL:M624 |
1248 | 1097-1099 | Gene | denotes | β1 | Gene:597 |
1249 | 1101-1103 | Gene | denotes | β2 | Gene:170589 |
1250 | 1105-1107 | Gene | denotes | β3 | Gene:28883 |
1251 | 1109-1111 | Gene | denotes | β4 | Gene:28898 |
1252 | 1113-1115 | Gene | denotes | β7 | Gene:28885 |
1253 | 1168-1170 | Gene | denotes | β4 | Gene:28898 |
1254 | 1247-1250 | Gene | denotes | β2’ | Gene:170589 |
1255 | 1239-1242 | Gene | denotes | β1’ | Gene:597 |
1256 | 1227-1229 | Gene | denotes | β6 | Gene:28873 |
1257 | 1220-1222 | Gene | denotes | β5 | Gene:28884 |
1258 | 1175-1177 | Gene | denotes | β7 | Gene:28885 |
1259 | 872-882 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1260 | 979-989 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1261 | 1409-1419 | Species | denotes | SARS-COV-2 | Tax:2697049 |
1262 | 1424-1432 | Species | denotes | SARS-CoV | Tax:694009 |
1263 | 1289-1298 | Chemical | denotes | disulfide | MESH:D004220 |
1271 | 1694-1698 | Gene | denotes | ACE2 | Gene:59272 |
1272 | 1765-1770 | Gene | denotes | hACE2 | Gene:59272 |
1273 | 1653-1658 | Gene | denotes | spike | Gene:43740568 |
1274 | 1997-2000 | Gene | denotes | PDB | Gene:5131 |
1275 | 1955-1958 | Gene | denotes | PDB | Gene:5131 |
1276 | 1409-1419 | Species | denotes | SARS-COV-2 | Tax:2697049 |
1277 | 1796-1806 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1301 | 2082-2086 | Gene | denotes | ACE2 | Gene:59272 |
1302 | 2401-2405 | Gene | denotes | ACE2 | Gene:59272 |
1303 | 2670-2674 | Gene | denotes | ACE2 | Gene:59272 |
1304 | 2902-2906 | Gene | denotes | ACE2 | Gene:59272 |
1305 | 3061-3065 | Gene | denotes | ACE2 | Gene:59272 |
1306 | 3584-3588 | Gene | denotes | ACE2 | Gene:59272 |
1307 | 3163-3164 | Gene | denotes | S | Gene:43740568 |
1308 | 3109-3110 | Gene | denotes | S | Gene:43740568 |
1309 | 2257-2258 | Gene | denotes | S | Gene:43740568 |
1310 | 2062-2072 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1311 | 2159-2169 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1312 | 2630-2640 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1313 | 2699-2707 | Species | denotes | SARS-CoV | Tax:694009 |
1314 | 2879-2889 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1315 | 2927-2937 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1316 | 2961-2969 | Species | denotes | SARS-CoV | Tax:694009 |
1317 | 3098-3108 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1318 | 3225-3235 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1319 | 3294-3302 | Species | denotes | SARS-CoV | Tax:694009 |
1320 | 3472-3482 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1321 | 3487-3495 | Species | denotes | SARS-CoV | Tax:694009 |
1322 | 3531-3541 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1323 | 3844-3854 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1329 | 3922-3927 | Gene | denotes | spike | Gene:43740568 |
1330 | 3929-3930 | Gene | denotes | S | Gene:43740568 |
1331 | 3965-3969 | Gene | denotes | ACE2 | Gene:59272 |
1332 | 3944-3945 | Gene | denotes | S | Gene:43740568 |
1333 | 3911-3921 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1344 | 4056-4057 | Gene | denotes | S | Gene:43740568 |
1345 | 4016-4017 | Gene | denotes | S | Gene:43740568 |
1346 | 4009-4015 | Species | denotes | SARS-2 | Tax:2697049 |
1347 | 4049-4055 | Species | denotes | SARS-2 | Tax:2697049 |
1348 | 4087-4093 | Species | denotes | SARS-2 | Tax:2697049 |
1349 | 4137-4143 | Species | denotes | SARS-2 | Tax:2697049 |
1350 | 4190-4196 | Species | denotes | SARS-2 | Tax:2697049 |
1351 | 4288-4294 | Species | denotes | SARS-2 | Tax:2697049 |
1352 | 4355-4361 | Species | denotes | SARS-2 | Tax:2697049 |
1353 | 4240-4261 | CellLine | denotes | SARS-2 S319–529 44.2 | CVCL:Z232 |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T4961 | 11-14 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T4970 | 33-37 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T4971 | 163-166 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T4980 | 195-198 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T4989 | 234-243 | Protein | denotes | S protein | https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9 |
T5022 | 378-381 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5031 | 496-499 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5040 | 607-611 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5041 | 641-644 | Protein | denotes | HEK | https://www.uniprot.org/uniprot/Q9H2V4|https://www.uniprot.org/uniprot/Q9H2V3|https://www.uniprot.org/uniprot/P29320 |
T5044 | 760-764 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5045 | 818-822 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5046 | 883-886 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5055 | 990-993 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5064 | 1433-1436 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5073 | 1694-1698 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5074 | 1807-1810 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5083 | 1874-1877 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5092 | 2073-2076 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5101 | 2082-2086 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5102 | 2170-2173 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5111 | 2257-2266 | Protein | denotes | S protein | https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9 |
T5144 | 2276-2279 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5153 | 2401-2405 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5154 | 2406-2409 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5163 | 2641-2644 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5172 | 2670-2674 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5173 | 2708-2711 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5182 | 2902-2906 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5183 | 3061-3065 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5184 | 3109-3118 | Protein | denotes | S protein | https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9 |
T5217 | 3236-3239 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5226 | 3303-3306 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5235 | 3584-3588 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5236 | 3622-3625 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5245 | 3685-3694 | Protein | denotes | S protein | https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9 |
T5278 | 3928-3939 | Protein | denotes | (S) protein | https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9 |
T5311 | 3965-3969 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5312 | 4025-4028 | Protein | denotes | SPR | https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0 |
T5334 | 4065-4068 | Protein | denotes | SPR | https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0 |
T5356 | 4114-4117 | Protein | denotes | SPR | https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0 |
T5378 | 4154-4157 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5387 | 4167-4170 | Protein | denotes | SPR | https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0 |
T5409 | 4207-4210 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5418 | 4218-4221 | Protein | denotes | SPR | https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0 |
T5440 | 4263-4266 | Protein | denotes | SPR | https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0 |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T185 | 83-87 | http://purl.obolibrary.org/obo/IDO_0000531 | denotes | host |
T186 | 88-92 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T187 | 625-629 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T188 | 645-650 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T189 | 834-839 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T190 | 2920-2925 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T191 | 3426-3430 | http://purl.obolibrary.org/obo/IDO_0000531 | denotes | host |
T192 | 3743-3747 | http://purl.obolibrary.org/obo/IDO_0000531 | denotes | host |
T193 | 3865-3869 | http://purl.obolibrary.org/obo/IDO_0000531 | denotes | host |
T194 | 3870-3875 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T195 | 3946-3952 | http://www.geneontology.org/formats/oboInOwl#Subset | denotes | subset |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T375 | 88-92 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T376 | 236-243 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T377 | 625-637 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
T378 | 625-629 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T379 | 645-650 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T380 | 805-813 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T381 | 834-839 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T382 | 2259-2266 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T383 | 2920-2925 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T384 | 3111-3118 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T385 | 3405-3418 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
T386 | 3687-3694 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T387 | 3870-3875 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T388 | 3932-3939 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T179 | 0-10 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T180 | 0-4 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T181 | 44-54 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T182 | 44-48 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T183 | 59-67 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T184 | 59-63 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T185 | 135-145 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T186 | 135-139 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T187 | 176-184 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T188 | 176-180 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T189 | 186-194 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T190 | 186-190 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T191 | 312-322 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T192 | 312-316 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T193 | 369-377 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T194 | 369-373 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T195 | 485-495 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T196 | 485-489 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T197 | 541-551 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T198 | 541-545 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T199 | 872-882 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T200 | 872-876 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T201 | 979-989 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T202 | 979-983 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T203 | 1409-1419 | Disease | denotes | SARS-COV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T204 | 1409-1413 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T205 | 1424-1432 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T206 | 1424-1428 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T207 | 1642-1652 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T208 | 1642-1646 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T209 | 1796-1806 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T210 | 1796-1800 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T211 | 2062-2072 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T212 | 2062-2066 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T213 | 2159-2169 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T214 | 2159-2163 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T215 | 2630-2640 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T216 | 2630-2634 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T217 | 2699-2707 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T218 | 2699-2703 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T219 | 2879-2889 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T220 | 2879-2883 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T221 | 2927-2937 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T222 | 2927-2931 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T223 | 2961-2969 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T224 | 2961-2965 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T225 | 3098-3108 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T226 | 3098-3102 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T227 | 3158-3162 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T228 | 3225-3235 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T229 | 3225-3229 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T230 | 3294-3302 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T231 | 3294-3298 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T232 | 3472-3482 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T233 | 3472-3476 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T234 | 3487-3495 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T235 | 3487-3491 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T236 | 3531-3541 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T237 | 3531-3535 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T238 | 3844-3854 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T239 | 3844-3848 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T240 | 3911-3921 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T241 | 3911-3915 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T242 | 4009-4013 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T243 | 4049-4053 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T244 | 4087-4091 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T245 | 4137-4141 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T246 | 4190-4194 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T247 | 4240-4244 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T248 | 4288-4292 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T249 | 4355-4359 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-sample-Glycan
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T14 | 2451-2454 | https://glytoucan.org/Structures/Glycans/G02780QX | denotes | Non |
T15 | 2451-2454 | https://glytoucan.org/Structures/Glycans/G18425DX | denotes | Non |
T16 | 2451-2454 | https://glytoucan.org/Structures/Glycans/G18630JE | denotes | Non |
T17 | 2451-2454 | https://glytoucan.org/Structures/Glycans/G87301QZ | denotes | Non |
T18 | 2451-2454 | https://glytoucan.org/Structures/Glycans/G01004IT | denotes | Non |
T19 | 2451-2454 | https://glytoucan.org/Structures/Glycans/G39790GW | denotes | Non |
T20 | 2451-2454 | https://glytoucan.org/Structures/Glycans/G68183GR | denotes | Non |
T21 | 2451-2454 | https://glytoucan.org/Structures/Glycans/G42928BB | denotes | Non |
T22 | 2451-2454 | https://glytoucan.org/Structures/Glycans/G51134HC | denotes | Non |
T23 | 2451-2454 | https://glytoucan.org/Structures/Glycans/G54702VY | denotes | Non |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
328 | 1997-2000 | Gene | denotes | PDB | Gene:5131 |
1201 | 0-10 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1217 | 607-611 | Gene | denotes | ACE2 | Gene:59272 |
1218 | 715-720 | Gene | denotes | hDPP4 | Gene:1803 |
1219 | 760-764 | Gene | denotes | ACE2 | Gene:59272 |
1220 | 818-822 | Gene | denotes | ACE2 | Gene:59272 |
1221 | 696-704 | Gene | denotes | membrane | Gene:43740571 |
1222 | 44-54 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1223 | 59-67 | Species | denotes | SARS-CoV | Tax:694009 |
1224 | 135-145 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1225 | 176-184 | Species | denotes | SARS-CoV | Tax:694009 |
1226 | 186-194 | Species | denotes | SARS-CoV | Tax:694009 |
1227 | 312-322 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1228 | 369-377 | Species | denotes | SARS-CoV | Tax:694009 |
1229 | 485-495 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1230 | 541-551 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1231 | 641-644 | CellLine | denotes | HEK | CVCL:M624 |
1248 | 1097-1099 | Gene | denotes | β1 | Gene:597 |
1249 | 1101-1103 | Gene | denotes | β2 | Gene:170589 |
1250 | 1105-1107 | Gene | denotes | β3 | Gene:28883 |
1251 | 1109-1111 | Gene | denotes | β4 | Gene:28898 |
1252 | 1113-1115 | Gene | denotes | β7 | Gene:28885 |
1253 | 1168-1170 | Gene | denotes | β4 | Gene:28898 |
1254 | 1247-1250 | Gene | denotes | β2’ | Gene:170589 |
1255 | 1239-1242 | Gene | denotes | β1’ | Gene:597 |
1256 | 1227-1229 | Gene | denotes | β6 | Gene:28873 |
1257 | 1220-1222 | Gene | denotes | β5 | Gene:28884 |
1258 | 1175-1177 | Gene | denotes | β7 | Gene:28885 |
1259 | 872-882 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1260 | 979-989 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1261 | 1409-1419 | Species | denotes | SARS-COV-2 | Tax:2697049 |
1262 | 1424-1432 | Species | denotes | SARS-CoV | Tax:694009 |
1263 | 1289-1298 | Chemical | denotes | disulfide | MESH:D004220 |
1271 | 1694-1698 | Gene | denotes | ACE2 | Gene:59272 |
1272 | 1765-1770 | Gene | denotes | hACE2 | Gene:59272 |
1273 | 1653-1658 | Gene | denotes | spike | Gene:43740568 |
1275 | 1955-1958 | Gene | denotes | PDB | Gene:5131 |
1276 | 1642-1652 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1277 | 1796-1806 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1301 | 2082-2086 | Gene | denotes | ACE2 | Gene:59272 |
1302 | 2401-2405 | Gene | denotes | ACE2 | Gene:59272 |
1303 | 2670-2674 | Gene | denotes | ACE2 | Gene:59272 |
1304 | 2902-2906 | Gene | denotes | ACE2 | Gene:59272 |
1305 | 3061-3065 | Gene | denotes | ACE2 | Gene:59272 |
1306 | 3584-3588 | Gene | denotes | ACE2 | Gene:59272 |
1307 | 3163-3164 | Gene | denotes | S | Gene:43740568 |
1308 | 3109-3110 | Gene | denotes | S | Gene:43740568 |
1309 | 2257-2258 | Gene | denotes | S | Gene:43740568 |
1310 | 2062-2072 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1311 | 2159-2169 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1312 | 2630-2640 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1313 | 2699-2707 | Species | denotes | SARS-CoV | Tax:694009 |
1314 | 2879-2889 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1315 | 2927-2937 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1316 | 2961-2969 | Species | denotes | SARS-CoV | Tax:694009 |
1317 | 3098-3108 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1318 | 3225-3235 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1319 | 3294-3302 | Species | denotes | SARS-CoV | Tax:694009 |
1320 | 3472-3482 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1321 | 3487-3495 | Species | denotes | SARS-CoV | Tax:694009 |
1322 | 3531-3541 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1323 | 3844-3854 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1329 | 3922-3927 | Gene | denotes | spike | Gene:43740568 |
1330 | 3929-3930 | Gene | denotes | S | Gene:43740568 |
1331 | 3965-3969 | Gene | denotes | ACE2 | Gene:59272 |
1332 | 3944-3945 | Gene | denotes | S | Gene:43740568 |
1333 | 3911-3921 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1344 | 4056-4057 | Gene | denotes | S | Gene:43740568 |
1345 | 4016-4017 | Gene | denotes | S | Gene:43740568 |
1346 | 4009-4015 | Species | denotes | SARS-2 | Tax:2697049 |
1347 | 4049-4055 | Species | denotes | SARS-2 | Tax:2697049 |
1348 | 4087-4093 | Species | denotes | SARS-2 | Tax:2697049 |
1349 | 4137-4143 | Species | denotes | SARS-2 | Tax:2697049 |
1350 | 4190-4196 | Species | denotes | SARS-2 | Tax:2697049 |
1351 | 4268-4294 | Species | denotes | Shang et al., 2020b SARS-2 | Tax:2697049 |
1352 | 4355-4361 | Species | denotes | SARS-2 | Tax:2697049 |
1353 | 4240-4261 | CellLine | denotes | SARS-2 S319–529 44.2 | CVCL:Z232 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T275 | 0-37 | Sentence | denotes | SARS-CoV-2 RBD and Its Receptor, ACE2 |
T276 | 38-185 | Sentence | denotes | Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. |
T277 | 186-262 | Sentence | denotes | SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). |
T278 | 263-402 | Sentence | denotes | Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). |
T279 | 403-533 | Sentence | denotes | Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. |
T280 | 534-737 | Sentence | denotes | Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). |
T281 | 738-867 | Sentence | denotes | Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner. |
T282 | 868-944 | Sentence | denotes | The SARS-CoV-2 RBD sequence was further investigated by structural analysis. |
T283 | 945-1342 | Sentence | denotes | X-ray crystallography showed that SARS-CoV-2 RBD folds into two structural domains (Figure 8): (1) the core subdomain with five antiparallel β-strands (β1, β2, β3, β4, β7), (2) the external subdomain, which inserts between β4 and β7, and it is characterized by the two small β5 and β6 strands [β1’ and β2’ in Wang et al. (2020)] connected by a disulfide bond (Lan et al., 2020; Wang et al., 2020). |
T284 | 1343-1610 | Sentence | denotes | In keeping with their high sequence homology, the 3D structure of SARS-COV-2 and SARS-CoV RBD nearly superimpose (RMSD = 0.475 Å for 128 Cα atoms; Wang et al., 2020) with the exception of the β5/β6 loop, which actually entailed the larger primary sequence difference. |
T285 | 1611-1845 | Sentence | denotes | FIGURE 8 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2. (A) Cartoon representation. (B) Gaussian surface representation. hACE2 is in green, the core of SARS-CoV-2 RBD is in red, and the RBM is in blue. |
T286 | 1846-1918 | Sentence | denotes | The β1-β7 typical motifs of RBD (Lan et al., 2020) are indicated in (A). |
T287 | 1919-2009 | Sentence | denotes | The structures have been drawn from PDB 6MOJ (Lan et al., 2020) by Mol on the PDB website. |
T288 | 2010-2087 | Sentence | denotes | Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2. |
T289 | 2088-2174 | Sentence | denotes | Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD. |
T290 | 2175-2335 | Sentence | denotes | To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch. |
T291 | 2336-2450 | Sentence | denotes | In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1). |
T292 | 2451-2599 | Sentence | denotes | Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b). |
T293 | 2600-2791 | Sentence | denotes | In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020). |
T294 | 2792-3009 | Sentence | denotes | The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020). |
T295 | 3010-3187 | Sentence | denotes | Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a). |
T296 | 3188-3431 | Sentence | denotes | This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host. |
T297 | 3432-3758 | Sentence | denotes | Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases. |
T298 | 3759-3876 | Sentence | denotes | Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells. |
T299 | 3877-3970 | Sentence | denotes | TABLE 1 Binding affinity between SARS-CoV-2 spike (S) protein and S subset regions and ACE2. |
T300 | 3971-4008 | Sentence | denotes | Sequence KD (nM) Method References |
T301 | 4009-4048 | Sentence | denotes | SARS-2 S 14.7 SPR Wrapp et al., 2020 |
T302 | 4049-4086 | Sentence | denotes | SARS-2 S 11.2 SPR Lei et al., 2020 |
T303 | 4087-4136 | Sentence | denotes | SARS-2 S20–685 (S1) 94.6 SPR Wang et al., 2020 |
T304 | 4137-4189 | Sentence | denotes | SARS-2 S319–541 (RBD) 133.3 SPR Wang et al., 2020 |
T305 | 4190-4239 | Sentence | denotes | SARS-2 S319–541 (RBD) 4.7 SPR Lan et al., 2020 |
T306 | 4240-4287 | Sentence | denotes | SARS-2 S319–529 44.2 SPR Shang et al., 2020b |
T307 | 4288-4354 | Sentence | denotes | SARS-2 S319–591 34.6 Biolayer interferometry Wrapp et al., 2020 |
T308 | 4355-4420 | Sentence | denotes | SARS-2 S328–533 1.2 Biolayer interferometry Walls et al., 2020 |