> top > docs > PMC:7556165 > spans > 44914-49334 > annotations

PMC:7556165 / 44914-49334 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T79 522-532 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes microscopy http://purl.bioontology.org/ontology/MEDDRA/10069374
T80 908-920 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T81 945-950 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes X-ray http://purl.bioontology.org/ontology/MEDDRA/10048064
T82 2030-2042 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T83 2524-2536 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T84 3932-3945 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes protein and S http://purl.bioontology.org/ontology/MEDDRA/10050417

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T154 236-243 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T155 805-813 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T156 1289-1298 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T157 1483-1488 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T158 2259-2266 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T159 3111-3118 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T160 3687-3694 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T161 3932-3939 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T198 0-10 Species denotes SARS-CoV-2 NCBItxid:2697049
T199 0-4 Species denotes SARS NCBItxid:694009
T200 44-54 Species denotes SARS-CoV-2 NCBItxid:2697049
T201 44-48 Species denotes SARS NCBItxid:694009
T202 59-67 Species denotes SARS-CoV NCBItxid:694009
T203 59-63 Species denotes SARS NCBItxid:694009
T204 135-145 Species denotes SARS-CoV-2 NCBItxid:2697049
T205 135-139 Species denotes SARS NCBItxid:694009
T206 176-184 Species denotes SARS-CoV NCBItxid:694009
T207 176-180 Species denotes SARS NCBItxid:694009
T208 186-194 Species denotes SARS-CoV NCBItxid:694009
T209 186-190 Species denotes SARS NCBItxid:694009
T210 312-322 Species denotes SARS-CoV-2 NCBItxid:2697049
T211 312-316 Species denotes SARS NCBItxid:694009
T212 369-377 Species denotes SARS-CoV NCBItxid:694009
T213 369-373 Species denotes SARS NCBItxid:694009
T214 485-495 Species denotes SARS-CoV-2 NCBItxid:2697049
T215 485-489 Species denotes SARS NCBItxid:694009
T216 541-551 Species denotes SARS-CoV-2 NCBItxid:2697049
T217 541-545 Species denotes SARS NCBItxid:694009
T218 722-726 Species denotes MERS NCBItxid:1335626
T219 872-882 Species denotes SARS-CoV-2 NCBItxid:2697049
T220 872-876 Species denotes SARS NCBItxid:694009
T221 979-989 Species denotes SARS-CoV-2 NCBItxid:2697049
T222 979-983 Species denotes SARS NCBItxid:694009
T223 1409-1419 Species denotes SARS-COV-2 NCBItxid:2697049
T224 1409-1413 Species denotes SARS NCBItxid:694009
T225 1424-1432 Species denotes SARS-CoV NCBItxid:694009
T226 1424-1428 Species denotes SARS NCBItxid:694009
T227 1642-1652 Species denotes SARS-CoV-2 NCBItxid:2697049
T228 1642-1646 Species denotes SARS NCBItxid:694009
T229 1796-1806 Species denotes SARS-CoV-2 NCBItxid:2697049
T230 1796-1800 Species denotes SARS NCBItxid:694009
T231 2062-2072 Species denotes SARS-CoV-2 NCBItxid:2697049
T232 2062-2066 Species denotes SARS NCBItxid:694009
T233 2159-2169 Species denotes SARS-CoV-2 NCBItxid:2697049
T234 2159-2163 Species denotes SARS NCBItxid:694009
T235 2630-2640 Species denotes SARS-CoV-2 NCBItxid:2697049
T236 2630-2634 Species denotes SARS NCBItxid:694009
T237 2699-2707 Species denotes SARS-CoV NCBItxid:694009
T238 2699-2703 Species denotes SARS NCBItxid:694009
T239 2879-2889 Species denotes SARS-CoV-2 NCBItxid:2697049
T240 2879-2883 Species denotes SARS NCBItxid:694009
T241 2927-2937 Species denotes SARS-CoV-2 NCBItxid:2697049
T242 2927-2931 Species denotes SARS NCBItxid:694009
T243 2961-2969 Species denotes SARS-CoV NCBItxid:694009
T244 2961-2965 Species denotes SARS NCBItxid:694009
T245 3098-3108 Species denotes SARS-CoV-2 NCBItxid:2697049
T246 3098-3102 Species denotes SARS NCBItxid:694009
T247 3158-3162 Species denotes SARS NCBItxid:694009
T248 3225-3235 Species denotes SARS-CoV-2 NCBItxid:2697049
T249 3225-3229 Species denotes SARS NCBItxid:694009
T250 3294-3302 Species denotes SARS-CoV NCBItxid:694009
T251 3294-3298 Species denotes SARS NCBItxid:694009
T252 3472-3482 Species denotes SARS-CoV-2 NCBItxid:2697049
T253 3472-3476 Species denotes SARS NCBItxid:694009
T254 3487-3495 Species denotes SARS-CoV NCBItxid:694009
T255 3487-3491 Species denotes SARS NCBItxid:694009
T256 3531-3541 Species denotes SARS-CoV-2 NCBItxid:2697049
T257 3531-3535 Species denotes SARS NCBItxid:694009
T258 3844-3854 Species denotes SARS-CoV-2 NCBItxid:2697049
T259 3844-3848 Species denotes SARS NCBItxid:694009
T260 3911-3921 Species denotes SARS-CoV-2 NCBItxid:2697049
T261 3911-3915 Species denotes SARS NCBItxid:694009
T262 4009-4015 Species denotes SARS-2 NCBItxid:2697049
T263 4009-4013 Species denotes SARS NCBItxid:694009
T264 4049-4055 Species denotes SARS-2 NCBItxid:2697049
T265 4049-4053 Species denotes SARS NCBItxid:694009
T266 4087-4093 Species denotes SARS-2 NCBItxid:2697049
T267 4087-4091 Species denotes SARS NCBItxid:694009
T268 4137-4143 Species denotes SARS-2 NCBItxid:2697049
T269 4137-4141 Species denotes SARS NCBItxid:694009
T270 4190-4196 Species denotes SARS-2 NCBItxid:2697049
T271 4190-4194 Species denotes SARS NCBItxid:694009
T272 4240-4246 Species denotes SARS-2 NCBItxid:2697049
T273 4240-4244 Species denotes SARS NCBItxid:694009
T274 4288-4294 Species denotes SARS-2 NCBItxid:2697049
T275 4288-4292 Species denotes SARS NCBItxid:694009
T276 4355-4361 Species denotes SARS-2 NCBItxid:2697049
T277 4355-4359 Species denotes SARS NCBItxid:694009

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T275 0-37 Sentence denotes SARS-CoV-2 RBD and Its Receptor, ACE2
T276 38-185 Sentence denotes Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV.
T277 186-262 Sentence denotes SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005).
T278 263-402 Sentence denotes Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020).
T279 403-533 Sentence denotes Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy.
T280 534-737 Sentence denotes Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor).
T281 738-867 Sentence denotes Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner.
T282 868-944 Sentence denotes The SARS-CoV-2 RBD sequence was further investigated by structural analysis.
T283 945-1342 Sentence denotes X-ray crystallography showed that SARS-CoV-2 RBD folds into two structural domains (Figure 8): (1) the core subdomain with five antiparallel β-strands (β1, β2, β3, β4, β7), (2) the external subdomain, which inserts between β4 and β7, and it is characterized by the two small β5 and β6 strands [β1’ and β2’ in Wang et al. (2020)] connected by a disulfide bond (Lan et al., 2020; Wang et al., 2020).
T284 1343-1610 Sentence denotes In keeping with their high sequence homology, the 3D structure of SARS-COV-2 and SARS-CoV RBD nearly superimpose (RMSD = 0.475 Å for 128 Cα atoms; Wang et al., 2020) with the exception of the β5/β6 loop, which actually entailed the larger primary sequence difference.
T285 1611-1845 Sentence denotes FIGURE 8 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2. (A) Cartoon representation. (B) Gaussian surface representation. hACE2 is in green, the core of SARS-CoV-2 RBD is in red, and the RBM is in blue.
T286 1846-1918 Sentence denotes The β1-β7 typical motifs of RBD (Lan et al., 2020) are indicated in (A).
T287 1919-2009 Sentence denotes The structures have been drawn from PDB 6MOJ (Lan et al., 2020) by Mol on the PDB website.
T288 2010-2087 Sentence denotes Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2.
T289 2088-2174 Sentence denotes Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD.
T290 2175-2335 Sentence denotes To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch.
T291 2336-2450 Sentence denotes In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1).
T292 2451-2599 Sentence denotes Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b).
T293 2600-2791 Sentence denotes In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020).
T294 2792-3009 Sentence denotes The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020).
T295 3010-3187 Sentence denotes Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a).
T296 3188-3431 Sentence denotes This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host.
T297 3432-3758 Sentence denotes Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases.
T298 3759-3876 Sentence denotes Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells.
T299 3877-3970 Sentence denotes TABLE 1 Binding affinity between SARS-CoV-2 spike (S) protein and S subset regions and ACE2.
T300 3971-4008 Sentence denotes Sequence KD (nM) Method References
T301 4009-4048 Sentence denotes SARS-2 S 14.7 SPR Wrapp et al., 2020
T302 4049-4086 Sentence denotes SARS-2 S 11.2 SPR Lei et al., 2020
T303 4087-4136 Sentence denotes SARS-2 S20–685 (S1) 94.6 SPR Wang et al., 2020
T304 4137-4189 Sentence denotes SARS-2 S319–541 (RBD) 133.3 SPR Wang et al., 2020
T305 4190-4239 Sentence denotes SARS-2 S319–541 (RBD) 4.7 SPR Lan et al., 2020
T306 4240-4287 Sentence denotes SARS-2 S319–529 44.2 SPR Shang et al., 2020b
T307 4288-4354 Sentence denotes SARS-2 S319–591 34.6 Biolayer interferometry Wrapp et al., 2020
T308 4355-4420 Sentence denotes SARS-2 S328–533 1.2 Biolayer interferometry Walls et al., 2020

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T139 3405-3418 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1201 0-10 Species denotes SARS-CoV-2 Tax:2697049
1217 607-611 Gene denotes ACE2 Gene:59272
1218 715-720 Gene denotes hDPP4 Gene:1803
1219 760-764 Gene denotes ACE2 Gene:59272
1220 818-822 Gene denotes ACE2 Gene:59272
1221 696-704 Gene denotes membrane Gene:43740571
1222 44-54 Species denotes SARS-CoV-2 Tax:2697049
1223 59-67 Species denotes SARS-CoV Tax:694009
1224 135-145 Species denotes SARS-CoV-2 Tax:2697049
1225 176-184 Species denotes SARS-CoV Tax:694009
1226 186-194 Species denotes SARS-CoV Tax:694009
1227 312-322 Species denotes SARS-CoV-2 Tax:2697049
1228 369-377 Species denotes SARS-CoV Tax:694009
1229 485-495 Species denotes SARS-CoV-2 Tax:2697049
1230 541-551 Species denotes SARS-CoV-2 Tax:2697049
1231 641-644 CellLine denotes HEK CVCL:M624
1248 1097-1099 Gene denotes β1 Gene:597
1249 1101-1103 Gene denotes β2 Gene:170589
1250 1105-1107 Gene denotes β3 Gene:28883
1251 1109-1111 Gene denotes β4 Gene:28898
1252 1113-1115 Gene denotes β7 Gene:28885
1253 1168-1170 Gene denotes β4 Gene:28898
1254 1247-1250 Gene denotes β2’ Gene:170589
1255 1239-1242 Gene denotes β1’ Gene:597
1256 1227-1229 Gene denotes β6 Gene:28873
1257 1220-1222 Gene denotes β5 Gene:28884
1258 1175-1177 Gene denotes β7 Gene:28885
1259 872-882 Species denotes SARS-CoV-2 Tax:2697049
1260 979-989 Species denotes SARS-CoV-2 Tax:2697049
1261 1409-1419 Species denotes SARS-COV-2 Tax:2697049
1262 1424-1432 Species denotes SARS-CoV Tax:694009
1263 1289-1298 Chemical denotes disulfide MESH:D004220
1271 1694-1698 Gene denotes ACE2 Gene:59272
1272 1765-1770 Gene denotes hACE2 Gene:59272
1273 1653-1658 Gene denotes spike Gene:43740568
1274 1997-2000 Gene denotes PDB Gene:5131
1275 1955-1958 Gene denotes PDB Gene:5131
1276 1409-1419 Species denotes SARS-COV-2 Tax:2697049
1277 1796-1806 Species denotes SARS-CoV-2 Tax:2697049
1301 2082-2086 Gene denotes ACE2 Gene:59272
1302 2401-2405 Gene denotes ACE2 Gene:59272
1303 2670-2674 Gene denotes ACE2 Gene:59272
1304 2902-2906 Gene denotes ACE2 Gene:59272
1305 3061-3065 Gene denotes ACE2 Gene:59272
1306 3584-3588 Gene denotes ACE2 Gene:59272
1307 3163-3164 Gene denotes S Gene:43740568
1308 3109-3110 Gene denotes S Gene:43740568
1309 2257-2258 Gene denotes S Gene:43740568
1310 2062-2072 Species denotes SARS-CoV-2 Tax:2697049
1311 2159-2169 Species denotes SARS-CoV-2 Tax:2697049
1312 2630-2640 Species denotes SARS-CoV-2 Tax:2697049
1313 2699-2707 Species denotes SARS-CoV Tax:694009
1314 2879-2889 Species denotes SARS-CoV-2 Tax:2697049
1315 2927-2937 Species denotes SARS-CoV-2 Tax:2697049
1316 2961-2969 Species denotes SARS-CoV Tax:694009
1317 3098-3108 Species denotes SARS-CoV-2 Tax:2697049
1318 3225-3235 Species denotes SARS-CoV-2 Tax:2697049
1319 3294-3302 Species denotes SARS-CoV Tax:694009
1320 3472-3482 Species denotes SARS-CoV-2 Tax:2697049
1321 3487-3495 Species denotes SARS-CoV Tax:694009
1322 3531-3541 Species denotes SARS-CoV-2 Tax:2697049
1323 3844-3854 Species denotes SARS-CoV-2 Tax:2697049
1329 3922-3927 Gene denotes spike Gene:43740568
1330 3929-3930 Gene denotes S Gene:43740568
1331 3965-3969 Gene denotes ACE2 Gene:59272
1332 3944-3945 Gene denotes S Gene:43740568
1333 3911-3921 Species denotes SARS-CoV-2 Tax:2697049
1344 4056-4057 Gene denotes S Gene:43740568
1345 4016-4017 Gene denotes S Gene:43740568
1346 4009-4015 Species denotes SARS-2 Tax:2697049
1347 4049-4055 Species denotes SARS-2 Tax:2697049
1348 4087-4093 Species denotes SARS-2 Tax:2697049
1349 4137-4143 Species denotes SARS-2 Tax:2697049
1350 4190-4196 Species denotes SARS-2 Tax:2697049
1351 4288-4294 Species denotes SARS-2 Tax:2697049
1352 4355-4361 Species denotes SARS-2 Tax:2697049
1353 4240-4261 CellLine denotes SARS-2 S319–529 44.2 CVCL:Z232

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T4961 11-14 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4970 33-37 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T4971 163-166 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4980 195-198 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4989 234-243 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5022 378-381 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5031 496-499 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5040 607-611 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5041 641-644 Protein denotes HEK https://www.uniprot.org/uniprot/Q9H2V4|https://www.uniprot.org/uniprot/Q9H2V3|https://www.uniprot.org/uniprot/P29320
T5044 760-764 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5045 818-822 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5046 883-886 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5055 990-993 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5064 1433-1436 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5073 1694-1698 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5074 1807-1810 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5083 1874-1877 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5092 2073-2076 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5101 2082-2086 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5102 2170-2173 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5111 2257-2266 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5144 2276-2279 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5153 2401-2405 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5154 2406-2409 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5163 2641-2644 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5172 2670-2674 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5173 2708-2711 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5182 2902-2906 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5183 3061-3065 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5184 3109-3118 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5217 3236-3239 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5226 3303-3306 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5235 3584-3588 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5236 3622-3625 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5245 3685-3694 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5278 3928-3939 Protein denotes (S) protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5311 3965-3969 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5312 4025-4028 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5334 4065-4068 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5356 4114-4117 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5378 4154-4157 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5387 4167-4170 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5409 4207-4210 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5418 4218-4221 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5440 4263-4266 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T185 83-87 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T186 88-92 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T187 625-629 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T188 645-650 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T189 834-839 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T190 2920-2925 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T191 3426-3430 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T192 3743-3747 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T193 3865-3869 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T194 3870-3875 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T195 3946-3952 http://www.geneontology.org/formats/oboInOwl#Subset denotes subset

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T375 88-92 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T376 236-243 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T377 625-637 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T378 625-629 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T379 645-650 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T380 805-813 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T381 834-839 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T382 2259-2266 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T383 2920-2925 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T384 3111-3118 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T385 3405-3418 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T386 3687-3694 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T387 3870-3875 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T388 3932-3939 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T179 0-10 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T180 0-4 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T181 44-54 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T182 44-48 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T183 59-67 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T184 59-63 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T185 135-145 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T186 135-139 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T187 176-184 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T188 176-180 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T189 186-194 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T190 186-190 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T191 312-322 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T192 312-316 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T193 369-377 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T194 369-373 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T195 485-495 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T196 485-489 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T197 541-551 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T198 541-545 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T199 872-882 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T200 872-876 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T201 979-989 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T202 979-983 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T203 1409-1419 Disease denotes SARS-COV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T204 1409-1413 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T205 1424-1432 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T206 1424-1428 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T207 1642-1652 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T208 1642-1646 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T209 1796-1806 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T210 1796-1800 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T211 2062-2072 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T212 2062-2066 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T213 2159-2169 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T214 2159-2163 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T215 2630-2640 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T216 2630-2634 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T217 2699-2707 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T218 2699-2703 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T219 2879-2889 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T220 2879-2883 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T221 2927-2937 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T222 2927-2931 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T223 2961-2969 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T224 2961-2965 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T225 3098-3108 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T226 3098-3102 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T227 3158-3162 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T228 3225-3235 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T229 3225-3229 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T230 3294-3302 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T231 3294-3298 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T232 3472-3482 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T233 3472-3476 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T234 3487-3495 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T235 3487-3491 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T236 3531-3541 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T237 3531-3535 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T238 3844-3854 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T239 3844-3848 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T240 3911-3921 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T241 3911-3915 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T242 4009-4013 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T243 4049-4053 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T244 4087-4091 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T245 4137-4141 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T246 4190-4194 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T247 4240-4244 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T248 4288-4292 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T249 4355-4359 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T14 2451-2454 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T15 2451-2454 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T16 2451-2454 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T17 2451-2454 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T18 2451-2454 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T19 2451-2454 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T20 2451-2454 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T21 2451-2454 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T22 2451-2454 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T23 2451-2454 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
328 1997-2000 Gene denotes PDB Gene:5131
1201 0-10 Species denotes SARS-CoV-2 Tax:2697049
1217 607-611 Gene denotes ACE2 Gene:59272
1218 715-720 Gene denotes hDPP4 Gene:1803
1219 760-764 Gene denotes ACE2 Gene:59272
1220 818-822 Gene denotes ACE2 Gene:59272
1221 696-704 Gene denotes membrane Gene:43740571
1222 44-54 Species denotes SARS-CoV-2 Tax:2697049
1223 59-67 Species denotes SARS-CoV Tax:694009
1224 135-145 Species denotes SARS-CoV-2 Tax:2697049
1225 176-184 Species denotes SARS-CoV Tax:694009
1226 186-194 Species denotes SARS-CoV Tax:694009
1227 312-322 Species denotes SARS-CoV-2 Tax:2697049
1228 369-377 Species denotes SARS-CoV Tax:694009
1229 485-495 Species denotes SARS-CoV-2 Tax:2697049
1230 541-551 Species denotes SARS-CoV-2 Tax:2697049
1231 641-644 CellLine denotes HEK CVCL:M624
1248 1097-1099 Gene denotes β1 Gene:597
1249 1101-1103 Gene denotes β2 Gene:170589
1250 1105-1107 Gene denotes β3 Gene:28883
1251 1109-1111 Gene denotes β4 Gene:28898
1252 1113-1115 Gene denotes β7 Gene:28885
1253 1168-1170 Gene denotes β4 Gene:28898
1254 1247-1250 Gene denotes β2’ Gene:170589
1255 1239-1242 Gene denotes β1’ Gene:597
1256 1227-1229 Gene denotes β6 Gene:28873
1257 1220-1222 Gene denotes β5 Gene:28884
1258 1175-1177 Gene denotes β7 Gene:28885
1259 872-882 Species denotes SARS-CoV-2 Tax:2697049
1260 979-989 Species denotes SARS-CoV-2 Tax:2697049
1261 1409-1419 Species denotes SARS-COV-2 Tax:2697049
1262 1424-1432 Species denotes SARS-CoV Tax:694009
1263 1289-1298 Chemical denotes disulfide MESH:D004220
1271 1694-1698 Gene denotes ACE2 Gene:59272
1272 1765-1770 Gene denotes hACE2 Gene:59272
1273 1653-1658 Gene denotes spike Gene:43740568
1275 1955-1958 Gene denotes PDB Gene:5131
1276 1642-1652 Species denotes SARS-CoV-2 Tax:2697049
1277 1796-1806 Species denotes SARS-CoV-2 Tax:2697049
1301 2082-2086 Gene denotes ACE2 Gene:59272
1302 2401-2405 Gene denotes ACE2 Gene:59272
1303 2670-2674 Gene denotes ACE2 Gene:59272
1304 2902-2906 Gene denotes ACE2 Gene:59272
1305 3061-3065 Gene denotes ACE2 Gene:59272
1306 3584-3588 Gene denotes ACE2 Gene:59272
1307 3163-3164 Gene denotes S Gene:43740568
1308 3109-3110 Gene denotes S Gene:43740568
1309 2257-2258 Gene denotes S Gene:43740568
1310 2062-2072 Species denotes SARS-CoV-2 Tax:2697049
1311 2159-2169 Species denotes SARS-CoV-2 Tax:2697049
1312 2630-2640 Species denotes SARS-CoV-2 Tax:2697049
1313 2699-2707 Species denotes SARS-CoV Tax:694009
1314 2879-2889 Species denotes SARS-CoV-2 Tax:2697049
1315 2927-2937 Species denotes SARS-CoV-2 Tax:2697049
1316 2961-2969 Species denotes SARS-CoV Tax:694009
1317 3098-3108 Species denotes SARS-CoV-2 Tax:2697049
1318 3225-3235 Species denotes SARS-CoV-2 Tax:2697049
1319 3294-3302 Species denotes SARS-CoV Tax:694009
1320 3472-3482 Species denotes SARS-CoV-2 Tax:2697049
1321 3487-3495 Species denotes SARS-CoV Tax:694009
1322 3531-3541 Species denotes SARS-CoV-2 Tax:2697049
1323 3844-3854 Species denotes SARS-CoV-2 Tax:2697049
1329 3922-3927 Gene denotes spike Gene:43740568
1330 3929-3930 Gene denotes S Gene:43740568
1331 3965-3969 Gene denotes ACE2 Gene:59272
1332 3944-3945 Gene denotes S Gene:43740568
1333 3911-3921 Species denotes SARS-CoV-2 Tax:2697049
1344 4056-4057 Gene denotes S Gene:43740568
1345 4016-4017 Gene denotes S Gene:43740568
1346 4009-4015 Species denotes SARS-2 Tax:2697049
1347 4049-4055 Species denotes SARS-2 Tax:2697049
1348 4087-4093 Species denotes SARS-2 Tax:2697049
1349 4137-4143 Species denotes SARS-2 Tax:2697049
1350 4190-4196 Species denotes SARS-2 Tax:2697049
1351 4268-4294 Species denotes Shang et al., 2020b SARS-2 Tax:2697049
1352 4355-4361 Species denotes SARS-2 Tax:2697049
1353 4240-4261 CellLine denotes SARS-2 S319–529 44.2 CVCL:Z232

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T275 0-37 Sentence denotes SARS-CoV-2 RBD and Its Receptor, ACE2
T276 38-185 Sentence denotes Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV.
T277 186-262 Sentence denotes SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005).
T278 263-402 Sentence denotes Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020).
T279 403-533 Sentence denotes Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy.
T280 534-737 Sentence denotes Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor).
T281 738-867 Sentence denotes Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner.
T282 868-944 Sentence denotes The SARS-CoV-2 RBD sequence was further investigated by structural analysis.
T283 945-1342 Sentence denotes X-ray crystallography showed that SARS-CoV-2 RBD folds into two structural domains (Figure 8): (1) the core subdomain with five antiparallel β-strands (β1, β2, β3, β4, β7), (2) the external subdomain, which inserts between β4 and β7, and it is characterized by the two small β5 and β6 strands [β1’ and β2’ in Wang et al. (2020)] connected by a disulfide bond (Lan et al., 2020; Wang et al., 2020).
T284 1343-1610 Sentence denotes In keeping with their high sequence homology, the 3D structure of SARS-COV-2 and SARS-CoV RBD nearly superimpose (RMSD = 0.475 Å for 128 Cα atoms; Wang et al., 2020) with the exception of the β5/β6 loop, which actually entailed the larger primary sequence difference.
T285 1611-1845 Sentence denotes FIGURE 8 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2. (A) Cartoon representation. (B) Gaussian surface representation. hACE2 is in green, the core of SARS-CoV-2 RBD is in red, and the RBM is in blue.
T286 1846-1918 Sentence denotes The β1-β7 typical motifs of RBD (Lan et al., 2020) are indicated in (A).
T287 1919-2009 Sentence denotes The structures have been drawn from PDB 6MOJ (Lan et al., 2020) by Mol on the PDB website.
T288 2010-2087 Sentence denotes Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2.
T289 2088-2174 Sentence denotes Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD.
T290 2175-2335 Sentence denotes To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch.
T291 2336-2450 Sentence denotes In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1).
T292 2451-2599 Sentence denotes Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b).
T293 2600-2791 Sentence denotes In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020).
T294 2792-3009 Sentence denotes The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020).
T295 3010-3187 Sentence denotes Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a).
T296 3188-3431 Sentence denotes This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host.
T297 3432-3758 Sentence denotes Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases.
T298 3759-3876 Sentence denotes Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells.
T299 3877-3970 Sentence denotes TABLE 1 Binding affinity between SARS-CoV-2 spike (S) protein and S subset regions and ACE2.
T300 3971-4008 Sentence denotes Sequence KD (nM) Method References
T301 4009-4048 Sentence denotes SARS-2 S 14.7 SPR Wrapp et al., 2020
T302 4049-4086 Sentence denotes SARS-2 S 11.2 SPR Lei et al., 2020
T303 4087-4136 Sentence denotes SARS-2 S20–685 (S1) 94.6 SPR Wang et al., 2020
T304 4137-4189 Sentence denotes SARS-2 S319–541 (RBD) 133.3 SPR Wang et al., 2020
T305 4190-4239 Sentence denotes SARS-2 S319–541 (RBD) 4.7 SPR Lan et al., 2020
T306 4240-4287 Sentence denotes SARS-2 S319–529 44.2 SPR Shang et al., 2020b
T307 4288-4354 Sentence denotes SARS-2 S319–591 34.6 Biolayer interferometry Wrapp et al., 2020
T308 4355-4420 Sentence denotes SARS-2 S328–533 1.2 Biolayer interferometry Walls et al., 2020