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LitCovid-sample-CHEBI

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T153","span":{"begin":458,"end":461},"obj":"Chemical"}],"attributes":[{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_33697"}],"text":"Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell."}

LitCovid-sample-PD-NCBITaxon

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T193","span":{"begin":99,"end":106},"obj":"Species"},{"id":"T194","span":{"begin":189,"end":196},"obj":"Species"},{"id":"T195","span":{"begin":248,"end":255},"obj":"Species"},{"id":"T196","span":{"begin":474,"end":481},"obj":"Species"},{"id":"T197","span":{"begin":798,"end":805},"obj":"Species"}],"attributes":[{"id":"A193","pred":"ncbi_taxonomy_id","subj":"T193","obj":"NCBItxid:10239"},{"id":"A194","pred":"ncbi_taxonomy_id","subj":"T194","obj":"NCBItxid:10239"},{"id":"A195","pred":"ncbi_taxonomy_id","subj":"T195","obj":"NCBItxid:10239"},{"id":"A196","pred":"ncbi_taxonomy_id","subj":"T196","obj":"NCBItxid:10239"},{"id":"A197","pred":"ncbi_taxonomy_id","subj":"T197","obj":"NCBItxid:10239"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell."}

LitCovid-sample-sentences

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T271","span":{"begin":76,"end":236},"obj":"Sentence"},{"id":"T272","span":{"begin":237,"end":462},"obj":"Sentence"},{"id":"T273","span":{"begin":463,"end":773},"obj":"Sentence"},{"id":"T274","span":{"begin":774,"end":884},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell."}

LitCovid-sample-Pubtator

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1192","span":{"begin":358,"end":365},"obj":"Gene"},{"id":"1193","span":{"begin":160,"end":165},"obj":"Gene"},{"id":"1194","span":{"begin":13,"end":14},"obj":"Gene"},{"id":"1195","span":{"begin":633,"end":637},"obj":"Gene"},{"id":"1196","span":{"begin":654,"end":662},"obj":"Gene"},{"id":"1197","span":{"begin":573,"end":581},"obj":"Gene"},{"id":"1198","span":{"begin":420,"end":428},"obj":"Gene"},{"id":"1199","span":{"begin":333,"end":341},"obj":"Gene"}],"attributes":[{"id":"A1194","pred":"pubann:denotes","subj":"1194","obj":"Gene:43740568"},{"id":"A1197","pred":"pubann:denotes","subj":"1197","obj":"Gene:43740571"},{"id":"A1195","pred":"pubann:denotes","subj":"1195","obj":"Gene:2522"},{"id":"A1196","pred":"pubann:denotes","subj":"1196","obj":"Gene:43740571"},{"id":"A1199","pred":"pubann:denotes","subj":"1199","obj":"Gene:43740571"},{"id":"A1198","pred":"pubann:denotes","subj":"1198","obj":"Gene:43740571"},{"id":"A1193","pred":"pubann:denotes","subj":"1193","obj":"Gene:5045"},{"id":"A1192","pred":"pubann:denotes","subj":"1192","obj":"Gene:487770"}],"text":"Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell."}

LitCovid-sample-UniProt

LitCovid-sample-PD-IDO

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T170","span":{"begin":34,"end":38},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T171","span":{"begin":69,"end":74},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T172","span":{"begin":85,"end":90},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T173","span":{"begin":99,"end":106},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T174","span":{"begin":189,"end":196},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T175","span":{"begin":231,"end":235},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T176","span":{"begin":248,"end":255},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T177","span":{"begin":307,"end":311},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T178","span":{"begin":386,"end":390},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T179","span":{"begin":474,"end":481},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T180","span":{"begin":532,"end":537},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T181","span":{"begin":550,"end":554},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T182","span":{"begin":688,"end":693},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T183","span":{"begin":798,"end":805},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T184","span":{"begin":879,"end":883},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell."}

LitCovid-sample-PD-FMA

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T365","span":{"begin":69,"end":74},"obj":"Body_part"},{"id":"T366","span":{"begin":85,"end":90},"obj":"Body_part"},{"id":"T367","span":{"begin":231,"end":235},"obj":"Body_part"},{"id":"T368","span":{"begin":307,"end":311},"obj":"Body_part"},{"id":"T369","span":{"begin":458,"end":461},"obj":"Body_part"},{"id":"T370","span":{"begin":500,"end":506},"obj":"Body_part"},{"id":"T371","span":{"begin":550,"end":554},"obj":"Body_part"},{"id":"T372","span":{"begin":647,"end":662},"obj":"Body_part"},{"id":"T373","span":{"begin":754,"end":772},"obj":"Body_part"},{"id":"T374","span":{"begin":879,"end":883},"obj":"Body_part"}],"attributes":[{"id":"A374","pred":"fma_id","subj":"T374","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A366","pred":"fma_id","subj":"T366","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A367","pred":"fma_id","subj":"T367","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A370","pred":"fma_id","subj":"T370","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A365","pred":"fma_id","subj":"T365","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A372","pred":"fma_id","subj":"T372","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A368","pred":"fma_id","subj":"T368","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A369","pred":"fma_id","subj":"T369","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A371","pred":"fma_id","subj":"T371","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A373","pred":"fma_id","subj":"T373","obj":"http://purl.org/sig/ont/fma/fma67463"}],"text":"Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell."}

LitCovid-sample-PD-GO-BP-0

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T102","span":{"begin":420,"end":435},"obj":"http://purl.obolibrary.org/obo/GO_0061025"},{"id":"T103","span":{"begin":713,"end":724},"obj":"http://purl.obolibrary.org/obo/GO_0006897"}],"text":"Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell."}

LitCovid-sample-GO-BP

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T104","span":{"begin":420,"end":435},"obj":"http://purl.obolibrary.org/obo/GO_0061025"},{"id":"T105","span":{"begin":713,"end":724},"obj":"http://purl.obolibrary.org/obo/GO_0006897"}],"text":"Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell."}

LitCovid-sample-Glycan

{"project":"LitCovid-sample-Glycan","denotations":[{"id":"T4","span":{"begin":463,"end":466},"obj":"https://glytoucan.org/Structures/Glycans/G02780QX"},{"id":"T5","span":{"begin":463,"end":466},"obj":"https://glytoucan.org/Structures/Glycans/G18425DX"},{"id":"T6","span":{"begin":463,"end":466},"obj":"https://glytoucan.org/Structures/Glycans/G18630JE"},{"id":"T7","span":{"begin":463,"end":466},"obj":"https://glytoucan.org/Structures/Glycans/G87301QZ"},{"id":"T8","span":{"begin":463,"end":466},"obj":"https://glytoucan.org/Structures/Glycans/G01004IT"},{"id":"T9","span":{"begin":463,"end":466},"obj":"https://glytoucan.org/Structures/Glycans/G39790GW"},{"id":"T10","span":{"begin":463,"end":466},"obj":"https://glytoucan.org/Structures/Glycans/G68183GR"},{"id":"T11","span":{"begin":463,"end":466},"obj":"https://glytoucan.org/Structures/Glycans/G42928BB"},{"id":"T12","span":{"begin":463,"end":466},"obj":"https://glytoucan.org/Structures/Glycans/G51134HC"},{"id":"T13","span":{"begin":463,"end":466},"obj":"https://glytoucan.org/Structures/Glycans/G54702VY"}],"text":"Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell."}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"1192","span":{"begin":358,"end":365},"obj":"Gene"},{"id":"1193","span":{"begin":160,"end":165},"obj":"Gene"},{"id":"1194","span":{"begin":13,"end":14},"obj":"Gene"},{"id":"1195","span":{"begin":633,"end":637},"obj":"Gene"},{"id":"1196","span":{"begin":654,"end":662},"obj":"Gene"},{"id":"1197","span":{"begin":573,"end":581},"obj":"Gene"},{"id":"1198","span":{"begin":420,"end":428},"obj":"Gene"},{"id":"1199","span":{"begin":333,"end":341},"obj":"Gene"}],"attributes":[{"id":"A1192","pred":"tao:has_database_id","subj":"1192","obj":"Gene:487770"},{"id":"A1193","pred":"tao:has_database_id","subj":"1193","obj":"Gene:5045"},{"id":"A1194","pred":"tao:has_database_id","subj":"1194","obj":"Gene:43740568"},{"id":"A1195","pred":"tao:has_database_id","subj":"1195","obj":"Gene:2522"},{"id":"A1196","pred":"tao:has_database_id","subj":"1196","obj":"Gene:43740571"},{"id":"A1197","pred":"tao:has_database_id","subj":"1197","obj":"Gene:43740571"},{"id":"A1198","pred":"tao:has_database_id","subj":"1198","obj":"Gene:43740571"},{"id":"A1199","pred":"tao:has_database_id","subj":"1199","obj":"Gene:43740571"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T271","span":{"begin":76,"end":236},"obj":"Sentence"},{"id":"T272","span":{"begin":237,"end":462},"obj":"Sentence"},{"id":"T273","span":{"begin":463,"end":773},"obj":"Sentence"},{"id":"T274","span":{"begin":774,"end":884},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell."}

PMC:7556165 / 44028-44912 JSONTXT

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PMC:7556165 / 44028-44912 JSON TXT