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PMC:7556165 / 35226-44912 JSONTXT

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LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T78 210-215 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes lipid http://purl.bioontology.org/ontology/MEDDRA/10024587

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T127 43-50 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T128 90-98 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T129 167-175 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T130 183-191 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T131 210-215 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T132 392-399 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T133 415-420 Chemical denotes crown http://purl.obolibrary.org/obo/CHEBI_37409
T134 512-524 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T135 697-704 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T136 924-931 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T137 1314-1321 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T138 1356-1363 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T139 2101-2108 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T140 2204-2211 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T141 2289-2296 Chemical denotes glycine http://purl.obolibrary.org/obo/CHEBI_15428|http://purl.obolibrary.org/obo/CHEBI_29947|http://purl.obolibrary.org/obo/CHEBI_57305
T144 2304-2311 Chemical denotes alanine http://purl.obolibrary.org/obo/CHEBI_16449
T145 2721-2729 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T146 3930-3937 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T147 4612-4619 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T148 6042-6049 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 6696-6703 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T150 7030-7037 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 7157-7164 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T152 7813-7825 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T153 9260-9263 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T159 3317-3325 Species denotes MERS CoV NCBItxid:1335626
T119 684-694 Species denotes SARS-CoV-2 NCBItxid:2697049
T120 684-688 Species denotes SARS NCBItxid:694009
T121 768-782 Species denotes human SARS-CoV NCBItxid:694009
T122 774-778 Species denotes SARS NCBItxid:694009
T123 847-857 Species denotes SARS-CoV-2 NCBItxid:2697049
T124 847-851 Species denotes SARS NCBItxid:694009
T125 901-909 Species denotes SARS-CoV NCBItxid:694009
T126 901-905 Species denotes SARS NCBItxid:694009
T127 1039-1047 Species denotes SARS-CoV NCBItxid:694009
T128 1039-1043 Species denotes SARS NCBItxid:694009
T129 1053-1063 Species denotes SARS-CoV-2 NCBItxid:2697049
T130 1053-1057 Species denotes SARS NCBItxid:694009
T131 1140-1148 Species denotes SARS-CoV NCBItxid:694009
T132 1140-1144 Species denotes SARS NCBItxid:694009
T133 1152-1162 Species denotes SARS-CoV-2 NCBItxid:2697049
T134 1152-1156 Species denotes SARS NCBItxid:694009
T135 1163-1170 Species denotes viruses NCBItxid:10239
T136 1325-1333 Species denotes SARS-CoV NCBItxid:694009
T137 1325-1329 Species denotes SARS NCBItxid:694009
T138 1338-1348 Species denotes SARS-CoV-2 NCBItxid:2697049
T139 1338-1342 Species denotes SARS NCBItxid:694009
T140 1863-1871 Species denotes SARS-CoV NCBItxid:694009
T141 1863-1867 Species denotes SARS NCBItxid:694009
T142 1887-1897 Species denotes SARS-CoV-2 NCBItxid:2697049
T143 1887-1891 Species denotes SARS NCBItxid:694009
T144 2733-2741 Species denotes SARS-CoV NCBItxid:694009
T145 2733-2737 Species denotes SARS NCBItxid:694009
T146 2746-2756 Species denotes SARS-CoV-2 NCBItxid:2697049
T147 2746-2750 Species denotes SARS NCBItxid:694009
T148 2817-2824 Species denotes viruses NCBItxid:10239
T149 2968-2973 Species denotes human NCBItxid:9606
T150 2975-2978 Species denotes bat NCBItxid:9397
T151 2991-2994 Species denotes pig NCBItxid:9823
T152 3004-3009 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T154 3168-3178 Species denotes SARS-CoV-2 NCBItxid:2697049
T155 3168-3172 Species denotes SARS NCBItxid:694009
T156 3182-3190 Species denotes SARS-CoV NCBItxid:694009
T157 3182-3186 Species denotes SARS NCBItxid:694009
T158 3258-3263 Species denotes human NCBItxid:9606
T160 3330-3339 Species denotes HCoV-229E NCBItxid:11137
T161 3370-3381 Species denotes pseudovirus NCBItxid:186672
T162 3479-3489 Species denotes SARS-CoV-2 NCBItxid:2697049
T163 3479-3483 Species denotes SARS NCBItxid:694009
T164 3540-3547 Species denotes viruses NCBItxid:10239
T165 3696-3704 Species denotes SARS-CoV NCBItxid:694009
T166 3696-3700 Species denotes SARS NCBItxid:694009
T167 3709-3719 Species denotes SARS-CoV-2 NCBItxid:2697049
T168 3709-3713 Species denotes SARS NCBItxid:694009
T169 3780-3788 Species denotes SARS-CoV NCBItxid:694009
T170 3780-3784 Species denotes SARS NCBItxid:694009
T171 3793-3803 Species denotes SARS-CoV-2 NCBItxid:2697049
T172 3793-3797 Species denotes SARS NCBItxid:694009
T173 7041-7051 Species denotes SARS-CoV-2 NCBItxid:2697049
T174 7041-7045 Species denotes SARS NCBItxid:694009
T175 7422-7432 Species denotes SARS-CoV-2 NCBItxid:2697049
T176 7422-7426 Species denotes SARS NCBItxid:694009
T177 7496-7506 Species denotes SARS-CoV-2 NCBItxid:2697049
T178 7496-7500 Species denotes SARS NCBItxid:694009
T179 7530-7538 Species denotes SARS-CoV NCBItxid:694009
T180 7530-7534 Species denotes SARS NCBItxid:694009
T181 7556-7573 Species denotes bat coronaviruses NCBItxid:1508220
T182 7860-7873 Species denotes pseudoviruses NCBItxid:186672
T183 7882-7892 Species denotes SARS-CoV-2 NCBItxid:2697049
T184 7882-7886 Species denotes SARS NCBItxid:694009
T185 8004-8017 Species denotes pseudoviruses NCBItxid:186672
T186 8026-8034 Species denotes SARS-CoV NCBItxid:694009
T187 8026-8030 Species denotes SARS NCBItxid:694009
T188 8060-8070 Species denotes SARS-COV-2 NCBItxid:2697049
T189 8060-8064 Species denotes SARS NCBItxid:694009
T190 8512-8522 Species denotes SARS-CoV-2 NCBItxid:2697049
T191 8512-8516 Species denotes SARS NCBItxid:694009
T192 8565-8573 Species denotes COVID-19 NCBItxid:2697049
T193 8901-8908 Species denotes viruses NCBItxid:10239
T194 8991-8998 Species denotes viruses NCBItxid:10239
T195 9050-9057 Species denotes viruses NCBItxid:10239
T196 9276-9283 Species denotes viruses NCBItxid:10239
T197 9600-9607 Species denotes viruses NCBItxid:10239

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T216 0-50 Sentence denotes Mechanism of Viral Entry Mediated by the S Protein
T217 51-176 Sentence denotes A coronavirus contains four structural proteins, namely spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins.
T218 177-303 Sentence denotes These proteins assemble around a lipid bilayer to provide the shell enclosing the viral genome (Figure 4A; Tang et al., 2020).
T219 304-495 Sentence denotes Homotrimers of S protrude from the viral surface, and are densely decorated by N-linked glycans, creating the “crown” (“Corona” in Latin) that christens this virus group (Walls et al., 2016).
T220 496-650 Sentence denotes S is a ∼180 kDa glycoprotein anchored in the viral membrane, which plays the most important roles in viral attachment, fusion and entry (Ou et al., 2020).
T221 651-801 Sentence denotes Sequence analysis has shown that SARS-CoV-2 S protein shares 76% of the primary sequence with the corresponding S of human SARS-CoV (Ou et al., 2020).
T222 802-932 Sentence denotes Accordingly, it has been early proposed that SARS-CoV-2 utilizes a similar cell entry mechanism as SARS-CoV, pivoted on S protein.
T223 933-1003 Sentence denotes This hypothesis has been confirmed from an experimental point of view.
T224 1004-1216 Sentence denotes By using pseudotyped virus bearing SARS-CoV S or SARS-CoV-2 S, it was shown that a large panel of cell lines allows comparable entry of SARS-CoV or SARS-CoV-2 viruses (Hoffmann et al., 2020b; Walls et al., 2020).
T225 1217-1349 Sentence denotes FIGURE 4 (A) Structure of a Coronavirus. (B) Functional motifs in the sequence of the S “spike” protein of SARS-CoV and SARS-CoV-2.
T226 1350-1631 Sentence denotes The S protein consists of ∼1300 aminoacids and it is composed by a N-terminal “S1”subunit (∼700 aa) and a C-terminal “S2”subunit (∼600 aa); binding to the host receptor is mediated by S1, whereas S2 induces fusion of the viral envelope with cellular membranes (Walls et al., 2017).
T227 1632-1758 Sentence denotes S1 and S2 can be further subdivided in functional segments with different roles in viral entry (Figure 4B; Tang et al., 2020).
T228 1759-1859 Sentence denotes The S1 subunit contains two subdomains, the N-terminal domain (NTD) and the C-terminal domain (CTD).
T229 1860-2063 Sentence denotes In SARS-CoV (Li, 2015) and SARS-CoV-2 (Wang et al., 2020) CTD encloses the receptor-binding domain (RBD), and the RBD section that directly contacts the receptor is named as receptor-binding motif (RBM).
T230 2064-2217 Sentence denotes The N-region of S2 contains a fusion peptide (FP), two heptapeptide repeat domains (HR1, HR2), a transmembrane domain (TM), and cytoplasmic peptide (CP).
T231 2218-2385 Sentence denotes FP is a short segment composed of mostly hydrophobic residues, such as glycine (G) or alanine (A), which inserts in the host cell membrane to trigger the fusion event.
T232 2386-2569 Sentence denotes HR1 and HR2 are composed of a repetitive heptapeptide with HPPHCPC sequence, where H represents hydrophobic or bulky residues, P polar or hydrophilic residues, and C charged residues.
T233 2570-2668 Sentence denotes HR regions typically fold into α-helices with a hydrophobic interface that drives membrane fusion.
T234 2669-2866 Sentence denotes On the basis of the strong similarity between the S proteins of SARS-CoV and SARS-CoV-2, many researchers early set-out to demonstrate whether both viruses target the same host cell receptor, ACE2.
T235 2867-3025 Sentence denotes Zhou et al. (2020) highlighted that the virus was able to infect cell lines only when they expressed human, bat, civet, and pig (but not mouse) ACE2 receptor.
T236 3026-3217 Sentence denotes Hoffmann et al. (2020b), Ou et al. (2020), and Walls et al. (2020) elegantly outlined that the BHK cell line could be infected by pseudotyped SARS-CoV-2 or SARS-CoV only upon ACE2 expression.
T237 3218-3423 Sentence denotes Conversely, the expression of different human receptors used by other CoVs (hDPP4 and APN, used by MERS CoV and HCoV-229E, respectively) did not enable pseudovirus access to cells (Hoffmann et al., 2020b).
T238 3424-3518 Sentence denotes Taken together, these findings are solid evidence that SARS-CoV-2 engages ACE2 for cell entry.
T239 3519-3742 Sentence denotes Nonetheless, the two viruses were demonstrated by Xia to share also the membrane fusion mechanism, as strongly suggested by the impressive 89.9% sequence identity of S2 between SARS-CoV and SARS-CoV-2 (Xia et al., 2020a,b).
T240 3743-3968 Sentence denotes To date, the cell entry mechanism of SARS-CoV and SARS-CoV-2 has been understood in its general details and it is based on a concerted action of receptor binding and proteolysis of the S protein (Figure 5; Tang et al., 2020).
T241 3969-4160 Sentence denotes Ultrastructural studies showed a metastable “prefusion” V-shaped trimer composed by three S1 heads sitting on top of a trimeric S2 stalk anchored into the virus membrane (Walls et al., 2016).
T242 4161-4378 Sentence denotes The RBD constantly switches between a standing-up (“open”) position for receptor binding and a lying-down (“closed”) configuration, the latter allowing immune evasion (Figure 6; Song et al., 2018; Wrapp et al., 2020).
T243 4379-4497 Sentence denotes Yet only one of the three RBD in trimeric S can flip up at a time and interact with the receptor (Wrapp et al., 2020).
T244 4498-4660 Sentence denotes The second key feature of the fusion mechanism is “priming” by host proteases, which recognize and cleave a short peptide motif at the S1/S2 boundary (Figure 4B).
T245 4661-5024 Sentence denotes This cleavage does not disassemble S1 from S2 in pre-fusion conditions (Belouzard et al., 2009), but the binding interaction of RBD with its receptor, accompanied by a further cleavage in a second site in S2 (S2’site, upstream of FP, Figure 4B), triggers the possible dissociation of S1 and the irreversible refolding of S2 into a “post-fusion” state (Figure 4B).
T246 5025-5260 Sentence denotes In detail, HR1 undergoes a dramatic “jack-knife” conformational change, converting four helical stretches that run in an antiparallel fashion into a single long (∼130 aa) α-helix (Heald-Sargent and Gallagher, 2012; Walls et al., 2017).
T247 5261-5375 Sentence denotes At first, three of these helices assemble into a homotrimeric bundle and stick the FP into the host cell membrane.
T248 5376-5530 Sentence denotes Then, HR2 (one for each S2 chain) fold backward and bind to HR1, yielding the “six-helix bundle fusion core” (6-HB) of post-fusion S2 (Song et al., 2018).
T249 5531-5763 Sentence denotes This conformational foldback brings the FP (at N-terminus of HR1) and the TM (at the C terminus of HR2) close to each other, so that the viral and host cell membranes approach until their outer leaflets merge (hemifusion, Figure 5).
T250 5764-5974 Sentence denotes Eventually the inner leaflets merge (pore formation), enabling a connection between the interior of the virus and the host cell cytoplasm, that allows the delivery of viral genome (Figure 5; Tang et al., 2020).
T251 5975-6024 Sentence denotes FIGURE 5 Coronavirus viral fusion pathway model.
T252 6025-6088 Sentence denotes Initially, the S protein is in the pre-fusion native state (1).
T253 6089-6387 Sentence denotes Then S undergoes priming of the S1 subunit at S1/S2 by local proteases yielding the pre-fusion metastable state (2); note that priming at S1/S2 could also happen upon virus formation in releasing cell: in such a case the virus attaches to a host cell already in the pre-fusion metastable state (2).
T254 6388-6567 Sentence denotes Subsequent triggering by a protease on S2’ enables the FP to insert in the host membrane upon the “jack-knife” transition of HR1 and HR2 yielding the pre-hairpin intermediate (3).
T255 6568-6682 Sentence denotes The pre-hairpin folds back on itself due to HR1 and HR2 interactions eventually forming the post-fusion (6) state.
T256 6683-6853 Sentence denotes During the S protein foldback, the two membranes approach each other until the outer leaflets merge (hemifusion) and eventually the inner leaflets merge (pore formation).
T257 6854-6975 Sentence denotes Note that cell membrane may refer to plasma membrane (direct fusion) or endosomal membrane (fusion in endocytic vesicle).
T258 6976-7008 Sentence denotes Adapted from Tang et al. (2020).
T259 7009-7085 Sentence denotes FIGURE 6 Trimeric S protein of SARS-CoV-2 in the ”Closed” and “Open” forms.
T260 7086-7174 Sentence denotes Note the single RBD protruding out of the V-shaped conformation of the protein assembly.
T261 7175-7223 Sentence denotes The structures have been drawn from PDB 6X2C (R.
T262 7224-7287 Sentence denotes Henderson, 10.1101/2020.05.18.10208) by Mol on the PDB website.
T263 7288-7457 Sentence denotes Although not directly related to ACE2, the role of S “priming” by host cell proteases deserves particular attention in the context of SARS-CoV-2 virus entry and tropism.
T264 7458-7670 Sentence denotes Possibly, the most notable feature of SARS-CoV-2 genome, as compared to SARS-CoV and some related bat coronaviruses, is a four basic aminoacid insert (PRRA) at the S1/S2 junction (Figure 4B; Jaimes et al., 2020).
T265 7671-7826 Sentence denotes This site is potentially cleavable by the protease furin, a proprotein convertase widely recognized to activate the fusion machinery of viral glycoprotein.
T266 7827-8059 Sentence denotes Indeed, many authors showed that pseudoviruses bearing SARS-CoV-2 S were already “primed” (i.e., cleaved) at the S1/S2 boundary by furin upon assembly in the cell, at odds with pseudoviruses bearing SARS-CoV S (Shang et al., 2020a).
T267 8060-8453 Sentence denotes SARS-COV-2 shows a large flexibility with regard to protease priming, which may independently occur by a) furin and furin-like proteases intracellularly, b) trypsin-like proteases such as TMPRSS2 that are present on the host cell membrane (particularly on airway epithelial cells), and 3) endosomal cathepsins activated by a drop in pH (e.g., cathepsin L) (Figure 7; Hoffmann et al., 2020a,b).
T268 8454-8605 Sentence denotes This flexibility could be the crucial factor that explain SARS-CoV-2 cell tropism and the peculiar features of COVID-19 symptoms (Jaimes et al., 2020).
T269 8606-8791 Sentence denotes Additionally, the kind of protease “priming” may determine whether the membrane fusion process occur directly at the plasma membrane or at endosomal level (Tang et al., 2020; Figure 7).
T270 8792-8877 Sentence denotes FIGURE 7 Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells.
T271 8878-9038 Sentence denotes The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell.
T272 9039-9264 Sentence denotes The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA.
T273 9265-9575 Sentence denotes Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles.
T274 9576-9686 Sentence denotes Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T134 239-244 Body_part denotes shell http://purl.obolibrary.org/obo/UBERON_0006612
T135 5198-5203 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T136 5459-5464 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T137 5801-5805 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T138 6837-6841 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1080 3498-3502 Gene denotes ACE2 Gene:59272
1081 2733-2741 Species denotes SARS-CoV Tax:694009
1014 107-112 Gene denotes spike Gene:43740568
1015 132-140 Gene denotes membrane Gene:43740571
1016 118-126 Gene denotes envelope Gene:43740570
1017 1064-1065 Gene denotes S Gene:43740568
1018 763-764 Gene denotes S Gene:43740568
1019 695-696 Gene denotes S Gene:43740568
1020 547-555 Gene denotes membrane Gene:43740571
1021 53-64 Species denotes coronavirus Tax:11118
1022 684-694 Species denotes SARS-CoV-2 Tax:2697049
1023 768-773 Species denotes human Tax:9606
1024 774-782 Species denotes SARS-CoV Tax:694009
1025 847-857 Species denotes SARS-CoV-2 Tax:2697049
1026 901-909 Species denotes SARS-CoV Tax:694009
1027 1039-1047 Species denotes SARS-CoV Tax:694009
1028 1053-1063 Species denotes SARS-CoV-2 Tax:2697049
1029 1140-1148 Species denotes SARS-CoV Tax:694009
1030 1152-1162 Species denotes SARS-CoV-2 Tax:2697049
1031 383-399 Chemical denotes N-linked glycans
1035 1246-1257 Species denotes Coronavirus Tax:11118
1036 1325-1333 Species denotes SARS-CoV Tax:694009
1037 1338-1348 Species denotes SARS-CoV-2 Tax:2697049
1048 1577-1585 Gene denotes envelope Gene:43740570
1049 1354-1355 Gene denotes S Gene:43740568
1052 1863-1871 Species denotes SARS-CoV Tax:694009
1053 3709-3719 Species denotes SARS-CoV-2 Tax:2697049
1054 1485-1487 Gene denotes aa Gene:351
1055 1446-1448 Gene denotes aa Gene:351
1076 2861-2865 Gene denotes ACE2 Gene:59272
1077 3011-3015 Gene denotes ACE2 Gene:70008
1078 3201-3205 Gene denotes ACE2 Gene:59272
1079 3294-3299 Gene denotes hDPP4 Gene:1803
1082 2746-2756 Species denotes SARS-CoV-2 Tax:2697049
1083 2968-2973 Species denotes human Tax:9606
1084 2991-2994 Species denotes pig Tax:9823
1085 3004-3009 Species denotes mouse Tax:10090
1086 3168-3178 Species denotes SARS-CoV-2 Tax:2697049
1087 3182-3190 Species denotes SARS-CoV Tax:694009
1088 3258-3263 Species denotes human Tax:9606
1089 3288-3292 Species denotes CoVs Tax:11118
1090 3317-3325 Species denotes MERS CoV Tax:1335626
1091 3330-3339 Species denotes HCoV-229E Tax:11137
1092 3479-3489 Species denotes SARS-CoV-2 Tax:2697049
1093 3144-3152 Disease denotes infected MESH:D007239
1097 3591-3599 Gene denotes membrane Gene:43740571
1098 3696-3704 Species denotes SARS-CoV Tax:694009
1099 3709-3719 Species denotes SARS-CoV-2 Tax:2697049
1109 4421-4422 Gene denotes S Gene:43740568
1110 3928-3929 Gene denotes S Gene:43740568
1111 5495-5499 Gene denotes post Gene:159371
1112 4993-4997 Gene denotes post Gene:159371
1113 5366-5374 Gene denotes membrane Gene:43740571
1114 4130-4138 Gene denotes membrane Gene:43740571
1115 3780-3788 Species denotes SARS-CoV Tax:694009
1116 3793-3803 Species denotes SARS-CoV-2 Tax:2697049
1117 5192-5194 Gene denotes aa Gene:351
1127 6694-6695 Gene denotes S Gene:43740568
1128 6094-6095 Gene denotes S Gene:43740568
1129 6040-6041 Gene denotes S Gene:43740568
1130 6660-6664 Gene denotes post Gene:159371
1131 6936-6944 Gene denotes membrane Gene:43740571
1132 6898-6906 Gene denotes membrane Gene:43740571
1133 6869-6877 Gene denotes membrane Gene:43740571
1134 6468-6476 Gene denotes membrane Gene:43740571
1135 5985-5996 Species denotes Coronavirus Tax:11118
1139 7275-7278 Gene denotes PDB Gene:5131
1140 7028-7029 Gene denotes S Gene:43740568
1141 7041-7051 Species denotes SARS-CoV-2 Tax:2697049
1163 7321-7325 Gene denotes ACE2 Gene:59272
1164 8166-8171 Gene denotes furin Gene:5045
1165 8248-8255 Gene denotes TMPRSS2 Gene:7113
1166 8403-8414 Gene denotes cathepsin L Gene:1514
1167 7722-7727 Gene denotes furin Gene:5045
1168 7958-7963 Gene denotes furin Gene:5045
1169 7893-7894 Gene denotes S Gene:43740568
1170 7339-7340 Gene denotes S Gene:43740568
1171 8730-8738 Gene denotes membrane Gene:43740571
1172 8677-8685 Gene denotes membrane Gene:43740571
1173 8290-8298 Gene denotes membrane Gene:43740571
1174 7422-7432 Species denotes SARS-CoV-2 Tax:2697049
1175 7496-7506 Species denotes SARS-CoV-2 Tax:2697049
1176 7530-7538 Species denotes SARS-CoV Tax:694009
1177 7560-7573 Species denotes coronaviruses Tax:11118
1178 7882-7892 Species denotes SARS-CoV-2 Tax:2697049
1179 8026-8034 Species denotes SARS-CoV Tax:694009
1180 8060-8070 Species denotes SARS-COV-2 Tax:2697049
1181 8512-8522 Species denotes SARS-CoV-2 Tax:2697049
1182 8176-8181 Gene denotes furin Gene:5045
1183 8565-8573 Disease denotes COVID-19 MESH:C000657245
1192 9160-9167 Gene denotes TMPRSS2 Gene:487770
1193 8962-8967 Gene denotes furin Gene:5045
1194 8815-8816 Gene denotes S Gene:43740568
1195 9435-9439 Gene denotes fuse Gene:2522
1196 9456-9464 Gene denotes membrane Gene:43740571
1197 9375-9383 Gene denotes membrane Gene:43740571
1198 9222-9230 Gene denotes membrane Gene:43740571
1199 9135-9143 Gene denotes membrane Gene:43740571

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T2876 41-50 Protein denotes S Protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T2909 79-98 Protein denotes structural proteins https://www.uniprot.org/uniprot/Q6LEG6|https://www.uniprot.org/uniprot/Q04766|https://www.uniprot.org/uniprot/Q04765
T2912 512-524 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T2997 695-704 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3030 922-931 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3063 1307-1321 Protein denotes spike” protein https://www.uniprot.org/uniprot/P31340
T3064 1354-1363 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3097 1960-1963 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3106 1974-1977 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3115 2719-2729 Protein denotes S proteins https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3148 2861-2865 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3149 3011-3015 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3150 3201-3205 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3151 3304-3307 Protein denotes APN https://www.uniprot.org/uniprot/Q9UCE0|https://www.uniprot.org/uniprot/Q9JHP4|https://www.uniprot.org/uniprot/Q99K63|https://www.uniprot.org/uniprot/Q91YH8|https://www.uniprot.org/uniprot/Q8IVH3|https://www.uniprot.org/uniprot/Q8IUK3|https://www.uniprot.org/uniprot/Q6GT90|https://www.uniprot.org/uniprot/Q3MHR1|https://www.uniprot.org/uniprot/Q29242|https://www.uniprot.org/uniprot/Q16728|https://www.uniprot.org/uniprot/Q10737|https://www.uniprot.org/uniprot/P97449|https://www.uniprot.org/uniprot/P91887|https://www.uniprot.org/uniprot/P91885|https://www.uniprot.org/uniprot/P81731|https://www.uniprot.org/uniprot/P79171|https://www.uniprot.org/uniprot/P79143|https://www.uniprot.org/uniprot/P79098|https://www.uniprot.org/uniprot/P15684|https://www.uniprot.org/uniprot/P15541|https://www.uniprot.org/uniprot/P15145|https://www.uniprot.org/uniprot/P15144|https://www.uniprot.org/uniprot/O97783|https://www.uniprot.org/uniprot/F1PCB5
T3175 3498-3502 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3176 3928-3937 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3209 4165-4168 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3218 4405-4408 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3227 4789-4792 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3236 6040-6049 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3269 6415-6423 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T3513 6694-6703 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3546 7028-7037 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3579 7102-7105 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3588 7321-7325 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3589 7713-7721 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T3833 7722-7727 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T3841 7813-7825 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T3926 7958-7963 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T3934 8112-8120 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4178 8166-8171 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4186 8176-8181 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4194 8217-8239 Protein denotes trypsin-like proteases https://www.uniprot.org/uniprot/Q9UBX7|https://www.uniprot.org/uniprot/Q9NS65|https://www.uniprot.org/uniprot/Q8IXD7|https://www.uniprot.org/uniprot/Q0WXX5|https://www.uniprot.org/uniprot/O75837
T4199 8403-8414 Protein denotes cathepsin L https://www.uniprot.org/uniprot/Q9QV07|https://www.uniprot.org/uniprot/Q9GL24|https://www.uniprot.org/uniprot/Q9GKL8|https://www.uniprot.org/uniprot/Q96QJ0|https://www.uniprot.org/uniprot/Q95029|https://www.uniprot.org/uniprot/Q91UZ0|https://www.uniprot.org/uniprot/Q6IAV1|https://www.uniprot.org/uniprot/Q5U121|https://www.uniprot.org/uniprot/Q3T0P2|https://www.uniprot.org/uniprot/Q28944|https://www.uniprot.org/uniprot/Q26636|https://www.uniprot.org/uniprot/Q26534|https://www.uniprot.org/uniprot/Q10991|https://www.uniprot.org/uniprot/P25975|https://www.uniprot.org/uniprot/P25773|https://www.uniprot.org/uniprot/P09648|https://www.uniprot.org/uniprot/P07711|https://www.uniprot.org/uniprot/P07154|https://www.uniprot.org/uniprot/P06797|https://www.uniprot.org/uniprot/O97431|https://www.uniprot.org/uniprot/O77502|https://www.uniprot.org/uniprot/M3WXJ1
T4221 8632-8640 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4465 8962-8967 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4473 9144-9152 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4717 9417-9425 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T119 462-467 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T120 877-881 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T121 1025-1030 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T122 1102-1106 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T123 1163-1170 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T124 1263-1273 http://purl.obolibrary.org/obo/BFO_0000034 denotes Functional
T125 1505-1509 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T126 1671-1681 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional
T127 2338-2342 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T128 2343-2347 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T129 2817-2824 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T130 2841-2845 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T131 2846-2850 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T132 2907-2912 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T133 2925-2931 http://purl.obolibrary.org/obo/IDO_0000586 denotes infect
T134 2932-2936 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T135 3125-3129 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T136 3144-3155 http://purl.obolibrary.org/obo/IDO_0000464 denotes infected by
T137 3144-3152 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T138 3392-3397 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T139 3507-3511 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T140 3540-3547 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T141 3756-3760 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T142 4124-4129 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T143 4561-4565 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T144 4858-4862 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T145 4873-4877 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T146 5356-5360 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T147 5361-5365 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T148 5678-5682 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T149 5683-5687 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T150 5868-5873 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T151 5882-5886 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T152 5887-5891 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T153 6256-6261 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T154 6285-6289 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T155 6310-6315 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T156 6330-6334 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T157 6335-6339 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T158 6463-6467 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T159 6864-6868 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T160 7354-7358 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T161 7359-7363 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T162 7433-7438 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T163 7676-7680 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T164 7985-7989 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T165 8280-8284 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T166 8285-8289 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T167 8334-8339 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T168 8523-8527 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T169 8574-8582 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T170 8836-8840 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T171 8871-8876 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T172 8887-8892 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T173 8901-8908 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T174 8991-8998 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T175 9033-9037 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T176 9050-9057 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T177 9109-9113 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T178 9188-9192 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T179 9276-9283 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T180 9334-9339 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T181 9352-9356 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T182 9490-9495 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T183 9600-9607 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T184 9681-9685 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T303 43-50 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T304 90-98 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T305 167-175 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T306 183-191 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T307 210-215 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T308 265-271 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T309 512-524 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T310 697-704 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T311 877-881 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T312 924-931 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T313 1102-1106 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T314 1314-1321 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T315 1356-1363 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T316 1382-1392 Body_part denotes aminoacids http://purl.org/sig/ont/fma/fma82739
T317 1591-1609 Body_part denotes cellular membranes http://purl.org/sig/ont/fma/fma63841
T318 2000-2021 Body_part denotes contacts the receptor http://purl.org/sig/ont/fma/fma85595
T319 2192-2203 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T320 2289-2296 Body_part denotes glycine http://purl.org/sig/ont/fma/fma82753
T321 2304-2311 Body_part denotes alanine http://purl.org/sig/ont/fma/fma82749
T322 2343-2356 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T323 2343-2347 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T324 2721-2729 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T325 2846-2850 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T326 2932-2936 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T327 3125-3129 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T328 3392-3397 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T329 3507-3511 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T330 3756-3760 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T331 3930-3937 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T332 5198-5203 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T333 5361-5374 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T334 5361-5365 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T335 5459-5464 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T336 5683-5697 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T337 5683-5687 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T338 5887-5891 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T339 5892-5901 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T340 5937-5943 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T341 6042-6049 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T342 6285-6289 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T343 6335-6339 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T344 6696-6703 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T345 6864-6877 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T346 6864-6868 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T347 6891-6906 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T348 6926-6935 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T349 6956-6973 Body_part denotes endocytic vesicle http://purl.org/sig/ont/fma/fma67463
T350 7030-7037 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T351 7157-7164 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T352 7359-7363 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T353 7507-7513 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T354 7591-7600 Body_part denotes aminoacid http://purl.org/sig/ont/fma/fma82739
T355 7813-7825 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T356 7985-7989 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T357 8285-8298 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T358 8285-8289 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T359 8323-8339 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T360 8334-8339 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T361 8349-8358 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T362 8523-8527 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T363 8723-8738 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T364 8745-8754 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T365 8871-8876 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T366 8887-8892 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T367 9033-9037 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T368 9109-9113 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T369 9260-9263 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T370 9302-9308 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T371 9352-9356 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T372 9449-9464 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T373 9556-9574 Body_part denotes endocytic vesicles http://purl.org/sig/ont/fma/fma67463
T374 9681-9685 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T120 684-694 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T121 684-688 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T122 774-782 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T123 774-778 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T124 847-857 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T125 847-851 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T126 901-909 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T127 901-905 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T128 1039-1047 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T129 1039-1043 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T130 1053-1063 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T131 1053-1057 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T132 1140-1148 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T133 1140-1144 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T134 1152-1162 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T135 1152-1156 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T136 1325-1333 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T137 1325-1329 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T138 1338-1348 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T139 1338-1342 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T140 1863-1871 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T141 1863-1867 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T142 1887-1897 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T143 1887-1891 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T144 2733-2741 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T145 2733-2737 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T146 2746-2756 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T147 2746-2750 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T148 3168-3178 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T149 3168-3172 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T150 3182-3190 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T151 3182-3186 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T152 3479-3489 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T153 3479-3483 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T154 3696-3704 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 3696-3700 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T156 3709-3719 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T157 3709-3713 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T158 3780-3788 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T159 3780-3784 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T160 3793-3803 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T161 3793-3797 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T162 7041-7051 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T163 7041-7045 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T164 7422-7432 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T165 7422-7426 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T166 7496-7506 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T167 7496-7500 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T168 7530-7538 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T169 7530-7534 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T170 7882-7892 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T171 7882-7886 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T172 8026-8034 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T173 8026-8030 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T174 8060-8070 Disease denotes SARS-COV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T175 8060-8064 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T176 8512-8522 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T177 8512-8516 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T178 8565-8573 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T125 4062-4067 http://purl.obolibrary.org/obo/MAT_0000294 denotes heads

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T89 2652-2667 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T90 3591-3606 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T91 3909-3920 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T92 4313-4327 http://purl.obolibrary.org/obo/GO_0020012 denotes immune evasion
T93 4313-4327 http://purl.obolibrary.org/obo/GO_0051805 denotes immune evasion
T94 5801-5815 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T95 5806-5815 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T96 6262-6271 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T97 6837-6851 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T98 6842-6851 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T99 7449-7456 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T100 8528-8535 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T101 8677-8692 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T102 9222-9237 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T103 9515-9526 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T92 2652-2667 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T93 3591-3606 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T94 3909-3920 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T95 4313-4327 http://purl.obolibrary.org/obo/GO_0042783 denotes immune evasion
T96 5801-5815 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T97 5806-5815 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T98 6262-6271 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T99 6837-6851 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T100 6842-6851 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T101 7449-7456 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T102 8528-8535 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T103 8677-8692 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T104 9222-9237 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T105 9515-9526 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T4 9265-9268 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T5 9265-9268 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T6 9265-9268 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T7 9265-9268 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T8 9265-9268 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T9 9265-9268 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T10 9265-9268 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T11 9265-9268 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T12 9265-9268 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T13 9265-9268 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
995 41-42 Gene denotes S Gene:43740568
1014 107-112 Gene denotes spike Gene:43740568
1015 132-140 Gene denotes membrane Gene:43740571
1016 118-126 Gene denotes envelope Gene:43740570
1017 1064-1065 Gene denotes S Gene:43740568
1018 763-764 Gene denotes S Gene:43740568
1019 695-696 Gene denotes S Gene:43740568
1020 547-555 Gene denotes membrane Gene:43740571
1021 53-64 Species denotes coronavirus Tax:11118
1022 684-694 Species denotes SARS-CoV-2 Tax:2697049
1023 768-773 Species denotes human Tax:9606
1024 774-782 Species denotes SARS-CoV Tax:694009
1025 847-857 Species denotes SARS-CoV-2 Tax:2697049
1026 901-909 Species denotes SARS-CoV Tax:694009
1027 1039-1047 Species denotes SARS-CoV Tax:694009
1028 1053-1063 Species denotes SARS-CoV-2 Tax:2697049
1029 1140-1148 Species denotes SARS-CoV Tax:694009
1030 1152-1162 Species denotes SARS-CoV-2 Tax:2697049
1031 383-399 Chemical denotes N-linked glycans
1035 1246-1257 Species denotes Coronavirus Tax:11118
1036 1325-1333 Species denotes SARS-CoV Tax:694009
1037 1338-1348 Species denotes SARS-CoV-2 Tax:2697049
1048 1577-1585 Gene denotes envelope Gene:43740570
1049 1354-1355 Gene denotes S Gene:43740568
1050 2652-2660 Gene denotes membrane Gene:43740571
1051 2348-2356 Gene denotes membrane Gene:43740571
1052 1863-1871 Species denotes SARS-CoV Tax:694009
1053 1887-1897 Species denotes SARS-CoV-2 Tax:2697049
1054 1485-1487 Gene denotes aa Gene:351
1055 1446-1448 Gene denotes aa Gene:351
1056 2289-2296 Chemical denotes glycine MESH:D005998
1057 2304-2311 Chemical denotes alanine MESH:D000409
1076 2861-2865 Gene denotes ACE2 Gene:59272
1077 3011-3015 Gene denotes ACE2 Gene:70008
1078 3201-3205 Gene denotes ACE2 Gene:59272
1079 3294-3299 Gene denotes hDPP4 Gene:1803
1080 3498-3502 Gene denotes ACE2 Gene:59272
1081 2733-2741 Species denotes SARS-CoV Tax:694009
1082 2746-2756 Species denotes SARS-CoV-2 Tax:2697049
1083 2968-2973 Species denotes human Tax:9606
1084 2991-2994 Species denotes pig Tax:9823
1085 3004-3009 Species denotes mouse Tax:10090
1086 3168-3178 Species denotes SARS-CoV-2 Tax:2697049
1087 3182-3190 Species denotes SARS-CoV Tax:694009
1088 3258-3263 Species denotes human Tax:9606
1089 3288-3292 Species denotes CoVs Tax:11118
1090 3317-3325 Species denotes MERS CoV Tax:1335626
1091 3330-3339 Species denotes HCoV-229E Tax:11137
1092 3479-3489 Species denotes SARS-CoV-2 Tax:2697049
1093 3144-3152 Disease denotes infected MESH:D007239
1097 3591-3599 Gene denotes membrane Gene:43740571
1098 3696-3704 Species denotes SARS-CoV Tax:694009
1099 3709-3719 Species denotes SARS-CoV-2 Tax:2697049
1109 4421-4422 Gene denotes S Gene:43740568
1110 3928-3929 Gene denotes S Gene:43740568
1111 5495-5499 Gene denotes post Gene:159371
1112 4993-4997 Gene denotes post Gene:159371
1113 5366-5374 Gene denotes membrane Gene:43740571
1114 4130-4138 Gene denotes membrane Gene:43740571
1115 3780-3788 Species denotes SARS-CoV Tax:694009
1116 3793-3803 Species denotes SARS-CoV-2 Tax:2697049
1117 5192-5194 Gene denotes aa Gene:351
1127 6694-6695 Gene denotes S Gene:43740568
1128 6094-6095 Gene denotes S Gene:43740568
1129 6040-6041 Gene denotes S Gene:43740568
1130 6660-6664 Gene denotes post Gene:159371
1131 6936-6944 Gene denotes membrane Gene:43740571
1132 6898-6906 Gene denotes membrane Gene:43740571
1133 6869-6877 Gene denotes membrane Gene:43740571
1134 6468-6476 Gene denotes membrane Gene:43740571
1135 5985-5996 Species denotes Coronavirus Tax:11118
1139 7275-7278 Gene denotes PDB Gene:5131
1140 7028-7029 Gene denotes S Gene:43740568
1141 7041-7051 Species denotes SARS-CoV-2 Tax:2697049
1163 7321-7325 Gene denotes ACE2 Gene:59272
1164 8166-8171 Gene denotes furin Gene:5045
1165 8248-8255 Gene denotes TMPRSS2 Gene:7113
1166 8403-8414 Gene denotes cathepsin L Gene:1514
1167 7722-7727 Gene denotes furin Gene:5045
1168 7958-7963 Gene denotes furin Gene:5045
1169 7893-7894 Gene denotes S Gene:43740568
1170 7339-7340 Gene denotes S Gene:43740568
1171 8730-8738 Gene denotes membrane Gene:43740571
1172 8677-8685 Gene denotes membrane Gene:43740571
1173 8290-8298 Gene denotes membrane Gene:43740571
1174 7422-7432 Species denotes SARS-CoV-2 Tax:2697049
1175 7496-7506 Species denotes SARS-CoV-2 Tax:2697049
1176 7530-7538 Species denotes SARS-CoV Tax:694009
1177 7560-7573 Species denotes coronaviruses Tax:11118
1178 7882-7892 Species denotes SARS-CoV-2 Tax:2697049
1179 8026-8034 Species denotes SARS-CoV Tax:694009
1180 8060-8070 Species denotes SARS-COV-2 Tax:2697049
1181 8512-8522 Species denotes SARS-CoV-2 Tax:2697049
1182 8176-8181 Gene denotes furin Gene:5045
1183 8565-8573 Disease denotes COVID-19 MESH:C000657245
1192 9160-9167 Gene denotes TMPRSS2 Gene:487770
1193 8962-8967 Gene denotes furin Gene:5045
1194 8815-8816 Gene denotes S Gene:43740568
1195 9435-9439 Gene denotes fuse Gene:2522
1196 9456-9464 Gene denotes membrane Gene:43740571
1197 9375-9383 Gene denotes membrane Gene:43740571
1198 9222-9230 Gene denotes membrane Gene:43740571
1199 9135-9143 Gene denotes membrane Gene:43740571

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T216 0-50 Sentence denotes Mechanism of Viral Entry Mediated by the S Protein
T217 51-176 Sentence denotes A coronavirus contains four structural proteins, namely spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins.
T218 177-303 Sentence denotes These proteins assemble around a lipid bilayer to provide the shell enclosing the viral genome (Figure 4A; Tang et al., 2020).
T219 304-495 Sentence denotes Homotrimers of S protrude from the viral surface, and are densely decorated by N-linked glycans, creating the “crown” (“Corona” in Latin) that christens this virus group (Walls et al., 2016).
T220 496-650 Sentence denotes S is a ∼180 kDa glycoprotein anchored in the viral membrane, which plays the most important roles in viral attachment, fusion and entry (Ou et al., 2020).
T221 651-801 Sentence denotes Sequence analysis has shown that SARS-CoV-2 S protein shares 76% of the primary sequence with the corresponding S of human SARS-CoV (Ou et al., 2020).
T222 802-932 Sentence denotes Accordingly, it has been early proposed that SARS-CoV-2 utilizes a similar cell entry mechanism as SARS-CoV, pivoted on S protein.
T223 933-1003 Sentence denotes This hypothesis has been confirmed from an experimental point of view.
T224 1004-1216 Sentence denotes By using pseudotyped virus bearing SARS-CoV S or SARS-CoV-2 S, it was shown that a large panel of cell lines allows comparable entry of SARS-CoV or SARS-CoV-2 viruses (Hoffmann et al., 2020b; Walls et al., 2020).
T225 1217-1349 Sentence denotes FIGURE 4 (A) Structure of a Coronavirus. (B) Functional motifs in the sequence of the S “spike” protein of SARS-CoV and SARS-CoV-2.
T226 1350-1631 Sentence denotes The S protein consists of ∼1300 aminoacids and it is composed by a N-terminal “S1”subunit (∼700 aa) and a C-terminal “S2”subunit (∼600 aa); binding to the host receptor is mediated by S1, whereas S2 induces fusion of the viral envelope with cellular membranes (Walls et al., 2017).
T227 1632-1758 Sentence denotes S1 and S2 can be further subdivided in functional segments with different roles in viral entry (Figure 4B; Tang et al., 2020).
T228 1759-1859 Sentence denotes The S1 subunit contains two subdomains, the N-terminal domain (NTD) and the C-terminal domain (CTD).
T229 1860-2063 Sentence denotes In SARS-CoV (Li, 2015) and SARS-CoV-2 (Wang et al., 2020) CTD encloses the receptor-binding domain (RBD), and the RBD section that directly contacts the receptor is named as receptor-binding motif (RBM).
T230 2064-2217 Sentence denotes The N-region of S2 contains a fusion peptide (FP), two heptapeptide repeat domains (HR1, HR2), a transmembrane domain (TM), and cytoplasmic peptide (CP).
T231 2218-2385 Sentence denotes FP is a short segment composed of mostly hydrophobic residues, such as glycine (G) or alanine (A), which inserts in the host cell membrane to trigger the fusion event.
T232 2386-2569 Sentence denotes HR1 and HR2 are composed of a repetitive heptapeptide with HPPHCPC sequence, where H represents hydrophobic or bulky residues, P polar or hydrophilic residues, and C charged residues.
T233 2570-2668 Sentence denotes HR regions typically fold into α-helices with a hydrophobic interface that drives membrane fusion.
T234 2669-2866 Sentence denotes On the basis of the strong similarity between the S proteins of SARS-CoV and SARS-CoV-2, many researchers early set-out to demonstrate whether both viruses target the same host cell receptor, ACE2.
T235 2867-3025 Sentence denotes Zhou et al. (2020) highlighted that the virus was able to infect cell lines only when they expressed human, bat, civet, and pig (but not mouse) ACE2 receptor.
T236 3026-3217 Sentence denotes Hoffmann et al. (2020b), Ou et al. (2020), and Walls et al. (2020) elegantly outlined that the BHK cell line could be infected by pseudotyped SARS-CoV-2 or SARS-CoV only upon ACE2 expression.
T237 3218-3423 Sentence denotes Conversely, the expression of different human receptors used by other CoVs (hDPP4 and APN, used by MERS CoV and HCoV-229E, respectively) did not enable pseudovirus access to cells (Hoffmann et al., 2020b).
T238 3424-3518 Sentence denotes Taken together, these findings are solid evidence that SARS-CoV-2 engages ACE2 for cell entry.
T239 3519-3742 Sentence denotes Nonetheless, the two viruses were demonstrated by Xia to share also the membrane fusion mechanism, as strongly suggested by the impressive 89.9% sequence identity of S2 between SARS-CoV and SARS-CoV-2 (Xia et al., 2020a,b).
T240 3743-3968 Sentence denotes To date, the cell entry mechanism of SARS-CoV and SARS-CoV-2 has been understood in its general details and it is based on a concerted action of receptor binding and proteolysis of the S protein (Figure 5; Tang et al., 2020).
T241 3969-4160 Sentence denotes Ultrastructural studies showed a metastable “prefusion” V-shaped trimer composed by three S1 heads sitting on top of a trimeric S2 stalk anchored into the virus membrane (Walls et al., 2016).
T242 4161-4378 Sentence denotes The RBD constantly switches between a standing-up (“open”) position for receptor binding and a lying-down (“closed”) configuration, the latter allowing immune evasion (Figure 6; Song et al., 2018; Wrapp et al., 2020).
T243 4379-4497 Sentence denotes Yet only one of the three RBD in trimeric S can flip up at a time and interact with the receptor (Wrapp et al., 2020).
T244 4498-4660 Sentence denotes The second key feature of the fusion mechanism is “priming” by host proteases, which recognize and cleave a short peptide motif at the S1/S2 boundary (Figure 4B).
T245 4661-5024 Sentence denotes This cleavage does not disassemble S1 from S2 in pre-fusion conditions (Belouzard et al., 2009), but the binding interaction of RBD with its receptor, accompanied by a further cleavage in a second site in S2 (S2’site, upstream of FP, Figure 4B), triggers the possible dissociation of S1 and the irreversible refolding of S2 into a “post-fusion” state (Figure 4B).
T246 5025-5260 Sentence denotes In detail, HR1 undergoes a dramatic “jack-knife” conformational change, converting four helical stretches that run in an antiparallel fashion into a single long (∼130 aa) α-helix (Heald-Sargent and Gallagher, 2012; Walls et al., 2017).
T247 5261-5375 Sentence denotes At first, three of these helices assemble into a homotrimeric bundle and stick the FP into the host cell membrane.
T248 5376-5530 Sentence denotes Then, HR2 (one for each S2 chain) fold backward and bind to HR1, yielding the “six-helix bundle fusion core” (6-HB) of post-fusion S2 (Song et al., 2018).
T249 5531-5763 Sentence denotes This conformational foldback brings the FP (at N-terminus of HR1) and the TM (at the C terminus of HR2) close to each other, so that the viral and host cell membranes approach until their outer leaflets merge (hemifusion, Figure 5).
T250 5764-5974 Sentence denotes Eventually the inner leaflets merge (pore formation), enabling a connection between the interior of the virus and the host cell cytoplasm, that allows the delivery of viral genome (Figure 5; Tang et al., 2020).
T251 5975-6024 Sentence denotes FIGURE 5 Coronavirus viral fusion pathway model.
T252 6025-6088 Sentence denotes Initially, the S protein is in the pre-fusion native state (1).
T253 6089-6387 Sentence denotes Then S undergoes priming of the S1 subunit at S1/S2 by local proteases yielding the pre-fusion metastable state (2); note that priming at S1/S2 could also happen upon virus formation in releasing cell: in such a case the virus attaches to a host cell already in the pre-fusion metastable state (2).
T254 6388-6567 Sentence denotes Subsequent triggering by a protease on S2’ enables the FP to insert in the host membrane upon the “jack-knife” transition of HR1 and HR2 yielding the pre-hairpin intermediate (3).
T255 6568-6682 Sentence denotes The pre-hairpin folds back on itself due to HR1 and HR2 interactions eventually forming the post-fusion (6) state.
T256 6683-6853 Sentence denotes During the S protein foldback, the two membranes approach each other until the outer leaflets merge (hemifusion) and eventually the inner leaflets merge (pore formation).
T257 6854-6975 Sentence denotes Note that cell membrane may refer to plasma membrane (direct fusion) or endosomal membrane (fusion in endocytic vesicle).
T258 6976-7008 Sentence denotes Adapted from Tang et al. (2020).
T259 7009-7085 Sentence denotes FIGURE 6 Trimeric S protein of SARS-CoV-2 in the ”Closed” and “Open” forms.
T260 7086-7174 Sentence denotes Note the single RBD protruding out of the V-shaped conformation of the protein assembly.
T261 7175-7223 Sentence denotes The structures have been drawn from PDB 6X2C (R.
T262 7224-7287 Sentence denotes Henderson, 10.1101/2020.05.18.10208) by Mol on the PDB website.
T263 7288-7457 Sentence denotes Although not directly related to ACE2, the role of S “priming” by host cell proteases deserves particular attention in the context of SARS-CoV-2 virus entry and tropism.
T264 7458-7670 Sentence denotes Possibly, the most notable feature of SARS-CoV-2 genome, as compared to SARS-CoV and some related bat coronaviruses, is a four basic aminoacid insert (PRRA) at the S1/S2 junction (Figure 4B; Jaimes et al., 2020).
T265 7671-7826 Sentence denotes This site is potentially cleavable by the protease furin, a proprotein convertase widely recognized to activate the fusion machinery of viral glycoprotein.
T266 7827-8059 Sentence denotes Indeed, many authors showed that pseudoviruses bearing SARS-CoV-2 S were already “primed” (i.e., cleaved) at the S1/S2 boundary by furin upon assembly in the cell, at odds with pseudoviruses bearing SARS-CoV S (Shang et al., 2020a).
T267 8060-8453 Sentence denotes SARS-COV-2 shows a large flexibility with regard to protease priming, which may independently occur by a) furin and furin-like proteases intracellularly, b) trypsin-like proteases such as TMPRSS2 that are present on the host cell membrane (particularly on airway epithelial cells), and 3) endosomal cathepsins activated by a drop in pH (e.g., cathepsin L) (Figure 7; Hoffmann et al., 2020a,b).
T268 8454-8605 Sentence denotes This flexibility could be the crucial factor that explain SARS-CoV-2 cell tropism and the peculiar features of COVID-19 symptoms (Jaimes et al., 2020).
T269 8606-8791 Sentence denotes Additionally, the kind of protease “priming” may determine whether the membrane fusion process occur directly at the plasma membrane or at endosomal level (Tang et al., 2020; Figure 7).
T270 8792-8877 Sentence denotes FIGURE 7 Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells.
T271 8878-9038 Sentence denotes The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell.
T272 9039-9264 Sentence denotes The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA.
T273 9265-9575 Sentence denotes Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles.
T274 9576-9686 Sentence denotes Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell.