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PMC:7556165 / 33372-76636 JSONTXT

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LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T78 2064-2069 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes lipid http://purl.bioontology.org/ontology/MEDDRA/10024587
T79 12064-12074 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes microscopy http://purl.bioontology.org/ontology/MEDDRA/10069374
T80 12450-12462 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T81 12487-12492 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes X-ray http://purl.bioontology.org/ontology/MEDDRA/10048064
T82 13572-13584 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T83 14066-14078 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T84 15474-15487 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes protein and S http://purl.bioontology.org/ontology/MEDDRA/10050417

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T124 342-345 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T125 511-523 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T126 838-850 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T127 1897-1904 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T128 1944-1952 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T129 2021-2029 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T130 2037-2045 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T131 2064-2069 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T132 2246-2253 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T133 2269-2274 Chemical denotes crown http://purl.obolibrary.org/obo/CHEBI_37409
T134 2366-2378 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T135 2551-2558 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T136 2778-2785 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T137 3168-3175 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T138 3210-3217 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T139 3955-3962 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T140 4058-4065 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T141 4143-4150 Chemical denotes glycine http://purl.obolibrary.org/obo/CHEBI_15428|http://purl.obolibrary.org/obo/CHEBI_29947|http://purl.obolibrary.org/obo/CHEBI_57305
T144 4158-4165 Chemical denotes alanine http://purl.obolibrary.org/obo/CHEBI_16449
T145 4575-4583 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T146 5784-5791 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T147 6466-6473 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T148 7896-7903 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 8550-8557 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T150 8884-8891 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 9011-9018 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T152 9667-9679 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T153 11114-11117 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T154 11778-11785 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T155 12347-12355 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T156 12831-12840 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T157 13025-13030 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T158 13801-13808 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T159 14653-14660 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T160 15229-15236 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T161 15474-15481 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T162 16833-16840 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T163 17064-17071 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T164 18043-18054 Chemical denotes Pro-Pro-Ala http://purl.obolibrary.org/obo/CHEBI_162578
T165 18081-18092 Chemical denotes Gly-Val-Glu http://purl.obolibrary.org/obo/CHEBI_164159
T166 18093-18096 Chemical denotes Gly http://purl.obolibrary.org/obo/CHEBI_15428
T167 18323-18326 Chemical denotes Ile http://purl.obolibrary.org/obo/CHEBI_17191|http://purl.obolibrary.org/obo/CHEBI_30009
T169 19497-19504 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T170 24311-24322 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T171 26768-26776 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T172 28420-28425 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T173 28427-28430 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T175 29791-29798 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T176 29838-29845 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T177 29865-29872 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T178 29913-29920 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T179 32302-32309 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T180 32828-32835 Chemical denotes phorbol http://purl.obolibrary.org/obo/CHEBI_8116
T181 32836-32845 Chemical denotes myristate http://purl.obolibrary.org/obo/CHEBI_30807
T182 32846-32853 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T184 32890-32901 Chemical denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T185 33143-33158 Chemical denotes hydroxamic acid http://purl.obolibrary.org/obo/CHEBI_24650
T186 34119-34128 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T187 34467-34476 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T188 34569-34578 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T189 34785-34794 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T190 35750-35757 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T191 36084-36092 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T192 36348-36386 Chemical denotes N-(2-aminoethyl)-1aziridine-ethanamine http://purl.obolibrary.org/obo/CHEBI_145998
T193 36695-36702 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T194 37659-37670 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T195 37871-37878 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T196 38085-38092 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T197 38927-38940 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T198 39396-39403 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T199 39535-39542 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T200 39555-39566 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T201 39583-39590 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T202 39710-39721 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T203 39778-39788 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T204 39930-39937 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234
T206 40020-40027 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T207 40357-40365 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T159 5171-5179 Species denotes MERS CoV NCBItxid:1335626
T94 23-31 Species denotes COVID-19 NCBItxid:2697049
T95 134-167 Species denotes severe acute respiratory syndrome NCBItxid:694009
T96 169-173 Species denotes SARS NCBItxid:694009
T97 342-351 Species denotes RNA virus NCBItxid:2559587
T98 398-406 Species denotes SARS-CoV NCBItxid:694009
T99 398-402 Species denotes SARS NCBItxid:694009
T100 740-748 Species denotes SARS-CoV NCBItxid:694009
T101 740-744 Species denotes SARS NCBItxid:694009
T102 778-784 Species denotes Monkey NCBItxid:9527|NCBItxid:9479
T104 940-948 Species denotes SARS-CoV NCBItxid:694009
T105 940-944 Species denotes SARS NCBItxid:694009
T106 960-964 Species denotes SARS NCBItxid:694009
T107 1094-1099 Species denotes human NCBItxid:9606
T108 1286-1296 Species denotes SARS-CoV-2 NCBItxid:2697049
T109 1286-1290 Species denotes SARS NCBItxid:694009
T110 1330-1338 Species denotes SARS-CoV NCBItxid:694009
T111 1330-1334 Species denotes SARS NCBItxid:694009
T112 1386-1394 Species denotes COVID-19 NCBItxid:2697049
T113 1396-1420 Species denotes COronaVIrus Disease 2019 NCBItxid:2697049
T114 1471-1481 Species denotes SARS-CoV-2 NCBItxid:2697049
T115 1471-1475 Species denotes SARS NCBItxid:694009
T116 1628-1636 Species denotes COVID-19 NCBItxid:2697049
T117 1683-1693 Species denotes SARS-CoV-2 NCBItxid:2697049
T118 1683-1687 Species denotes SARS NCBItxid:694009
T119 2538-2548 Species denotes SARS-CoV-2 NCBItxid:2697049
T120 2538-2542 Species denotes SARS NCBItxid:694009
T121 2622-2636 Species denotes human SARS-CoV NCBItxid:694009
T122 2628-2632 Species denotes SARS NCBItxid:694009
T123 2701-2711 Species denotes SARS-CoV-2 NCBItxid:2697049
T124 2701-2705 Species denotes SARS NCBItxid:694009
T125 2755-2763 Species denotes SARS-CoV NCBItxid:694009
T126 2755-2759 Species denotes SARS NCBItxid:694009
T127 2893-2901 Species denotes SARS-CoV NCBItxid:694009
T128 2893-2897 Species denotes SARS NCBItxid:694009
T129 2907-2917 Species denotes SARS-CoV-2 NCBItxid:2697049
T130 2907-2911 Species denotes SARS NCBItxid:694009
T131 2994-3002 Species denotes SARS-CoV NCBItxid:694009
T132 2994-2998 Species denotes SARS NCBItxid:694009
T133 3006-3016 Species denotes SARS-CoV-2 NCBItxid:2697049
T134 3006-3010 Species denotes SARS NCBItxid:694009
T135 3017-3024 Species denotes viruses NCBItxid:10239
T136 3179-3187 Species denotes SARS-CoV NCBItxid:694009
T137 3179-3183 Species denotes SARS NCBItxid:694009
T138 3192-3202 Species denotes SARS-CoV-2 NCBItxid:2697049
T139 3192-3196 Species denotes SARS NCBItxid:694009
T140 3717-3725 Species denotes SARS-CoV NCBItxid:694009
T141 3717-3721 Species denotes SARS NCBItxid:694009
T142 3741-3751 Species denotes SARS-CoV-2 NCBItxid:2697049
T143 3741-3745 Species denotes SARS NCBItxid:694009
T144 4587-4595 Species denotes SARS-CoV NCBItxid:694009
T145 4587-4591 Species denotes SARS NCBItxid:694009
T146 4600-4610 Species denotes SARS-CoV-2 NCBItxid:2697049
T147 4600-4604 Species denotes SARS NCBItxid:694009
T148 4671-4678 Species denotes viruses NCBItxid:10239
T149 4822-4827 Species denotes human NCBItxid:9606
T150 4829-4832 Species denotes bat NCBItxid:9397
T151 4845-4848 Species denotes pig NCBItxid:9823
T152 4858-4863 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T154 5022-5032 Species denotes SARS-CoV-2 NCBItxid:2697049
T155 5022-5026 Species denotes SARS NCBItxid:694009
T156 5036-5044 Species denotes SARS-CoV NCBItxid:694009
T157 5036-5040 Species denotes SARS NCBItxid:694009
T158 5112-5117 Species denotes human NCBItxid:9606
T160 5184-5193 Species denotes HCoV-229E NCBItxid:11137
T161 5224-5235 Species denotes pseudovirus NCBItxid:186672
T162 5333-5343 Species denotes SARS-CoV-2 NCBItxid:2697049
T163 5333-5337 Species denotes SARS NCBItxid:694009
T164 5394-5401 Species denotes viruses NCBItxid:10239
T165 5550-5558 Species denotes SARS-CoV NCBItxid:694009
T166 5550-5554 Species denotes SARS NCBItxid:694009
T167 5563-5573 Species denotes SARS-CoV-2 NCBItxid:2697049
T168 5563-5567 Species denotes SARS NCBItxid:694009
T169 5634-5642 Species denotes SARS-CoV NCBItxid:694009
T170 5634-5638 Species denotes SARS NCBItxid:694009
T171 5647-5657 Species denotes SARS-CoV-2 NCBItxid:2697049
T172 5647-5651 Species denotes SARS NCBItxid:694009
T173 8895-8905 Species denotes SARS-CoV-2 NCBItxid:2697049
T174 8895-8899 Species denotes SARS NCBItxid:694009
T175 9276-9286 Species denotes SARS-CoV-2 NCBItxid:2697049
T176 9276-9280 Species denotes SARS NCBItxid:694009
T177 9350-9360 Species denotes SARS-CoV-2 NCBItxid:2697049
T178 9350-9354 Species denotes SARS NCBItxid:694009
T179 9384-9392 Species denotes SARS-CoV NCBItxid:694009
T180 9384-9388 Species denotes SARS NCBItxid:694009
T181 9410-9427 Species denotes bat coronaviruses NCBItxid:1508220
T182 9714-9727 Species denotes pseudoviruses NCBItxid:186672
T183 9736-9746 Species denotes SARS-CoV-2 NCBItxid:2697049
T184 9736-9740 Species denotes SARS NCBItxid:694009
T185 9858-9871 Species denotes pseudoviruses NCBItxid:186672
T186 9880-9888 Species denotes SARS-CoV NCBItxid:694009
T187 9880-9884 Species denotes SARS NCBItxid:694009
T188 9914-9924 Species denotes SARS-COV-2 NCBItxid:2697049
T189 9914-9918 Species denotes SARS NCBItxid:694009
T190 10366-10376 Species denotes SARS-CoV-2 NCBItxid:2697049
T191 10366-10370 Species denotes SARS NCBItxid:694009
T192 10419-10427 Species denotes COVID-19 NCBItxid:2697049
T193 10755-10762 Species denotes viruses NCBItxid:10239
T194 10845-10852 Species denotes viruses NCBItxid:10239
T195 10904-10911 Species denotes viruses NCBItxid:10239
T196 11130-11137 Species denotes viruses NCBItxid:10239
T197 11454-11461 Species denotes viruses NCBItxid:10239
T198 11542-11552 Species denotes SARS-CoV-2 NCBItxid:2697049
T199 11542-11546 Species denotes SARS NCBItxid:694009
T200 11586-11596 Species denotes SARS-CoV-2 NCBItxid:2697049
T201 11586-11590 Species denotes SARS NCBItxid:694009
T202 11601-11609 Species denotes SARS-CoV NCBItxid:694009
T203 11601-11605 Species denotes SARS NCBItxid:694009
T204 11677-11687 Species denotes SARS-CoV-2 NCBItxid:2697049
T205 11677-11681 Species denotes SARS NCBItxid:694009
T206 11718-11726 Species denotes SARS-CoV NCBItxid:694009
T207 11718-11722 Species denotes SARS NCBItxid:694009
T208 11728-11736 Species denotes SARS-CoV NCBItxid:694009
T209 11728-11732 Species denotes SARS NCBItxid:694009
T210 11854-11864 Species denotes SARS-CoV-2 NCBItxid:2697049
T211 11854-11858 Species denotes SARS NCBItxid:694009
T212 11911-11919 Species denotes SARS-CoV NCBItxid:694009
T213 11911-11915 Species denotes SARS NCBItxid:694009
T214 12027-12037 Species denotes SARS-CoV-2 NCBItxid:2697049
T215 12027-12031 Species denotes SARS NCBItxid:694009
T216 12083-12093 Species denotes SARS-CoV-2 NCBItxid:2697049
T217 12083-12087 Species denotes SARS NCBItxid:694009
T218 12264-12268 Species denotes MERS NCBItxid:1335626
T219 12414-12424 Species denotes SARS-CoV-2 NCBItxid:2697049
T220 12414-12418 Species denotes SARS NCBItxid:694009
T221 12521-12531 Species denotes SARS-CoV-2 NCBItxid:2697049
T222 12521-12525 Species denotes SARS NCBItxid:694009
T223 12951-12961 Species denotes SARS-COV-2 NCBItxid:2697049
T224 12951-12955 Species denotes SARS NCBItxid:694009
T225 12966-12974 Species denotes SARS-CoV NCBItxid:694009
T226 12966-12970 Species denotes SARS NCBItxid:694009
T227 13184-13194 Species denotes SARS-CoV-2 NCBItxid:2697049
T228 13184-13188 Species denotes SARS NCBItxid:694009
T229 13338-13348 Species denotes SARS-CoV-2 NCBItxid:2697049
T230 13338-13342 Species denotes SARS NCBItxid:694009
T231 13604-13614 Species denotes SARS-CoV-2 NCBItxid:2697049
T232 13604-13608 Species denotes SARS NCBItxid:694009
T233 13701-13711 Species denotes SARS-CoV-2 NCBItxid:2697049
T234 13701-13705 Species denotes SARS NCBItxid:694009
T235 14172-14182 Species denotes SARS-CoV-2 NCBItxid:2697049
T236 14172-14176 Species denotes SARS NCBItxid:694009
T237 14241-14249 Species denotes SARS-CoV NCBItxid:694009
T238 14241-14245 Species denotes SARS NCBItxid:694009
T239 14421-14431 Species denotes SARS-CoV-2 NCBItxid:2697049
T240 14421-14425 Species denotes SARS NCBItxid:694009
T241 14469-14479 Species denotes SARS-CoV-2 NCBItxid:2697049
T242 14469-14473 Species denotes SARS NCBItxid:694009
T243 14503-14511 Species denotes SARS-CoV NCBItxid:694009
T244 14503-14507 Species denotes SARS NCBItxid:694009
T245 14640-14650 Species denotes SARS-CoV-2 NCBItxid:2697049
T246 14640-14644 Species denotes SARS NCBItxid:694009
T247 14700-14704 Species denotes SARS NCBItxid:694009
T248 14767-14777 Species denotes SARS-CoV-2 NCBItxid:2697049
T249 14767-14771 Species denotes SARS NCBItxid:694009
T250 14836-14844 Species denotes SARS-CoV NCBItxid:694009
T251 14836-14840 Species denotes SARS NCBItxid:694009
T252 15014-15024 Species denotes SARS-CoV-2 NCBItxid:2697049
T253 15014-15018 Species denotes SARS NCBItxid:694009
T254 15029-15037 Species denotes SARS-CoV NCBItxid:694009
T255 15029-15033 Species denotes SARS NCBItxid:694009
T256 15073-15083 Species denotes SARS-CoV-2 NCBItxid:2697049
T257 15073-15077 Species denotes SARS NCBItxid:694009
T258 15386-15396 Species denotes SARS-CoV-2 NCBItxid:2697049
T259 15386-15390 Species denotes SARS NCBItxid:694009
T260 15453-15463 Species denotes SARS-CoV-2 NCBItxid:2697049
T261 15453-15457 Species denotes SARS NCBItxid:694009
T262 15551-15557 Species denotes SARS-2 NCBItxid:2697049
T263 15551-15555 Species denotes SARS NCBItxid:694009
T264 15591-15597 Species denotes SARS-2 NCBItxid:2697049
T265 15591-15595 Species denotes SARS NCBItxid:694009
T266 15629-15635 Species denotes SARS-2 NCBItxid:2697049
T267 15629-15633 Species denotes SARS NCBItxid:694009
T268 15679-15685 Species denotes SARS-2 NCBItxid:2697049
T269 15679-15683 Species denotes SARS NCBItxid:694009
T270 15732-15738 Species denotes SARS-2 NCBItxid:2697049
T271 15732-15736 Species denotes SARS NCBItxid:694009
T272 15782-15788 Species denotes SARS-2 NCBItxid:2697049
T273 15782-15786 Species denotes SARS NCBItxid:694009
T274 15830-15836 Species denotes SARS-2 NCBItxid:2697049
T275 15830-15834 Species denotes SARS NCBItxid:694009
T276 15897-15903 Species denotes SARS-2 NCBItxid:2697049
T277 15897-15901 Species denotes SARS NCBItxid:694009
T278 16140-16148 Species denotes SARS-CoV NCBItxid:694009
T279 16140-16144 Species denotes SARS NCBItxid:694009
T280 16264-16272 Species denotes SARS-CoV NCBItxid:694009
T281 16264-16268 Species denotes SARS NCBItxid:694009
T282 16443-16453 Species denotes SARS-CoV-2 NCBItxid:2697049
T283 16443-16447 Species denotes SARS NCBItxid:694009
T284 16519-16529 Species denotes SARS-CoV-2 NCBItxid:2697049
T285 16519-16523 Species denotes SARS NCBItxid:694009
T286 17193-17201 Species denotes SARS-CoV NCBItxid:694009
T287 17193-17197 Species denotes SARS NCBItxid:694009
T288 17215-17225 Species denotes SARS-CoV-2 NCBItxid:2697049
T289 17215-17219 Species denotes SARS NCBItxid:694009
T290 17290-17300 Species denotes SARS-CoV-2 NCBItxid:2697049
T291 17290-17294 Species denotes SARS NCBItxid:694009
T292 17360-17368 Species denotes SARS-CoV NCBItxid:694009
T293 17360-17364 Species denotes SARS NCBItxid:694009
T294 17961-17971 Species denotes SARS-CoV-2 NCBItxid:2697049
T295 17961-17965 Species denotes SARS NCBItxid:694009
T296 17976-17984 Species denotes SARS-CoV NCBItxid:694009
T297 17976-17980 Species denotes SARS NCBItxid:694009
T298 18013-18021 Species denotes SARS-CoV NCBItxid:694009
T299 18013-18017 Species denotes SARS NCBItxid:694009
T300 18100-18110 Species denotes SARS-CoV-2 NCBItxid:2697049
T301 18100-18104 Species denotes SARS NCBItxid:694009
T302 18292-18302 Species denotes SARS-CoV-2 NCBItxid:2697049
T303 18292-18296 Species denotes SARS NCBItxid:694009
T304 18330-18334 Species denotes SARS NCBItxid:694009
T305 18669-18679 Species denotes SARS-CoV-2 NCBItxid:2697049
T306 18669-18673 Species denotes SARS NCBItxid:694009
T307 18696-18700 Species denotes SARS NCBItxid:694009
T308 18805-18815 Species denotes SARS-CoV-2 NCBItxid:2697049
T309 18805-18809 Species denotes SARS NCBItxid:694009
T310 19386-19393 Species denotes mammals NCBItxid:40674
T311 19418-19422 Species denotes cats NCBItxid:9685
T312 19427-19431 Species denotes dogs NCBItxid:9615
T313 19484-19494 Species denotes SARS-CoV-2 NCBItxid:2697049
T314 19484-19488 Species denotes SARS NCBItxid:694009
T315 19519-19527 Species denotes COVID-19 NCBItxid:2697049
T316 19667-19672 Species denotes human NCBItxid:9606
T317 19678-19687 Species denotes hCoV-NL63 NCBItxid:277944
T318 19817-19821 Species denotes SARS NCBItxid:694009
T319 19834-19844 Species denotes SARS-CoV-2 NCBItxid:2697049
T320 19834-19838 Species denotes SARS NCBItxid:694009
T321 19890-19899 Species denotes hCoV-NL63 NCBItxid:277944
T322 19922-19930 Species denotes SARS-CoV NCBItxid:694009
T323 19922-19926 Species denotes SARS NCBItxid:694009
T324 20073-20083 Species denotes SARS-CoV-2 NCBItxid:2697049
T325 20073-20077 Species denotes SARS NCBItxid:694009
T326 20275-20281 Species denotes humans NCBItxid:9605
T327 20337-20340 Species denotes bat NCBItxid:9397
T328 20390-20393 Species denotes bat NCBItxid:9397
T329 20508-20518 Species denotes SARS-CoV-2 NCBItxid:2697049
T330 20508-20512 Species denotes SARS NCBItxid:694009
T331 20575-20578 Species denotes bat NCBItxid:9397
T332 20697-20705 Species denotes COVID-19 NCBItxid:2697049
T333 21674-21682 Species denotes COVID-19 NCBItxid:2697049
T334 22516-22524 Species denotes COVID-19 NCBItxid:2697049
T335 22611-22621 Species denotes SARS-CoV-2 NCBItxid:2697049
T336 22611-22615 Species denotes SARS NCBItxid:694009
T337 23226-23234 Species denotes SARS-CoV NCBItxid:694009
T338 23226-23230 Species denotes SARS NCBItxid:694009
T339 23318-23328 Species denotes SARS-CoV-2 NCBItxid:2697049
T340 23318-23322 Species denotes SARS NCBItxid:694009
T341 23414-23424 Species denotes SARS-CoV-2 NCBItxid:2697049
T342 23414-23418 Species denotes SARS NCBItxid:694009
T343 24909-24919 Species denotes SARS-CoV-2 NCBItxid:2697049
T344 24909-24913 Species denotes SARS NCBItxid:694009
T345 25153-25163 Species denotes SARS-CoV-2 NCBItxid:2697049
T346 25153-25157 Species denotes SARS NCBItxid:694009
T347 25823-25831 Species denotes COVID-19 NCBItxid:2697049
T348 26224-26232 Species denotes COVID-19 NCBItxid:2697049
T349 26342-26350 Species denotes COVID-19 NCBItxid:2697049
T350 26565-26575 Species denotes SARS-CoV-2 NCBItxid:2697049
T351 26565-26569 Species denotes SARS NCBItxid:694009
T352 26589-26594 Species denotes human NCBItxid:9606
T353 26723-26728 Species denotes human NCBItxid:9606
T354 26875-26883 Species denotes COVID-19 NCBItxid:2697049
T355 26984-26994 Species denotes SARS-CoV-2 NCBItxid:2697049
T356 26984-26988 Species denotes SARS NCBItxid:694009
T357 27045-27052 Species denotes COVID19 NCBItxid:2697049
T358 27386-27394 Species denotes COVID-19 NCBItxid:2697049
T359 27849-27857 Species denotes COVID-19 NCBItxid:2697049
T360 28229-28237 Species denotes COVID-19 NCBItxid:2697049
T361 30296-30306 Species denotes SARS-CoV-2 NCBItxid:2697049
T362 30296-30300 Species denotes SARS NCBItxid:694009
T363 30315-30325 Species denotes SARS-CoV-2 NCBItxid:2697049
T364 30315-30319 Species denotes SARS NCBItxid:694009
T365 30533-30541 Species denotes COVID-19 NCBItxid:2697049
T366 30738-30746 Species denotes COVID-19 NCBItxid:2697049
T367 30930-30940 Species denotes SARS-CoV-2 NCBItxid:2697049
T368 30930-30934 Species denotes SARS NCBItxid:694009
T369 32739-32744 Species denotes human NCBItxid:9606
T370 32788-32793 Species denotes human NCBItxid:9606
T371 33925-33935 Species denotes SARS-CoV-2 NCBItxid:2697049
T372 33925-33929 Species denotes SARS NCBItxid:694009
T373 34093-34103 Species denotes SARS-CoV-2 NCBItxid:2697049
T374 34093-34097 Species denotes SARS NCBItxid:694009
T375 34296-34304 Species denotes COVID-19 NCBItxid:2697049
T376 34481-34491 Species denotes SARS-CoV-2 NCBItxid:2697049
T377 34481-34485 Species denotes SARS NCBItxid:694009
T378 34524-34534 Species denotes SARS-CoV-2 NCBItxid:2697049
T379 34524-34528 Species denotes SARS NCBItxid:694009
T380 34897-34907 Species denotes SARS-CoV-2 NCBItxid:2697049
T381 34897-34901 Species denotes SARS NCBItxid:694009
T382 35096-35104 Species denotes COVID-19 NCBItxid:2697049
T383 35156-35166 Species denotes SARS-CoV-2 NCBItxid:2697049
T384 35156-35160 Species denotes SARS NCBItxid:694009
T385 35635-35640 Species denotes human NCBItxid:9606
T386 36261-36269 Species denotes SARS-CoV NCBItxid:694009
T387 36261-36265 Species denotes SARS NCBItxid:694009
T388 36483-36491 Species denotes SARS-CoV NCBItxid:694009
T389 36483-36487 Species denotes SARS NCBItxid:694009
T390 36786-36790 Species denotes SARS NCBItxid:694009
T391 36941-36957 Species denotes SARS coronavirus NCBItxid:694009
T392 36941-36945 Species denotes SARS NCBItxid:694009
T393 37336-37346 Species denotes SARS-CoV-2 NCBItxid:2697049
T394 37336-37340 Species denotes SARS NCBItxid:694009
T395 37653-37658 Species denotes human NCBItxid:9606
T396 37717-37725 Species denotes COVID-19 NCBItxid:2697049
T397 37763-37768 Species denotes human NCBItxid:9606
T398 38023-38031 Species denotes COVID-19 NCBItxid:2697049
T399 38403-38413 Species denotes SARS-CoV-2 NCBItxid:2697049
T400 38403-38407 Species denotes SARS NCBItxid:694009
T401 38439-38444 Species denotes human NCBItxid:9606
T402 38472-38477 Species denotes human NCBItxid:9606
T403 38633-38643 Species denotes SARS-CoV-2 NCBItxid:2697049
T404 38633-38637 Species denotes SARS NCBItxid:694009
T405 38740-38750 Species denotes SARS-CoV-2 NCBItxid:2697049
T406 38740-38744 Species denotes SARS NCBItxid:694009
T407 39812-39826 Species denotes gut microbiome NCBItxid:749906
T408 40898-40903 Species denotes human NCBItxid:9606
T409 40918-40922 Species denotes mice NCBItxid:10095|NCBItxid:10088
T411 41380-41388 Species denotes COVID-19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T205 0-31 Sentence denotes Links Between ACE2 and COVID-19
T206 32-280 Sentence denotes A “second life” for ACE2 was discovered in 2003, when a novel respiratory infective disease, known as severe acute respiratory syndrome (SARS), appeared in China and spread all over Asia and Canada, with a lethality rate of 10% (Rota et al., 2003).
T207 281-430 Sentence denotes The responsible pathogen was identified in a positive strand RNA virus belonging to the coronavirus family and named SARS-CoV (Ksiazek et al., 2003).
T208 431-651 Sentence denotes The virus genome was sequenced and this allowed the identification of the spike glycoprotein (S), whose N-terminal portion, or S1-domain, was found to mediate the high affinity binding to host cells (Marra et al., 2003).
T209 652-939 Sentence denotes The group of Farzan et al. succeeded in identifying the cell receptor: they showed that SARS-CoV efficiently infected African Monkey kidney cell line Vero E6 and co-immunoprecipitated a glycoprotein responsible for virus binding and entry, which was identified as ACE2 (Li et al., 2003).
T210 940-1046 Sentence denotes SARS-CoV caused the SARS epidemic in 2002–2003, with over 8,000 infections and a fatality rate around 10%.
T211 1047-1243 Sentence denotes In late 2019, another coronavirus emerged as a human pathogen in the city of Wuhan in China, producing symptoms such as fever, severe respiratory impairment, and pneumonia (Petersen et al., 2020).
T212 1244-1422 Sentence denotes This new coronavirus has been denominated SARS-CoV-2 for its genetic resemblance with SARS-CoV (∼80%), and its related disease has been named COVID-19 (COronaVIrus Disease 2019).
T213 1423-1583 Sentence denotes Owing to its high reproduction number R0 (2–3), SARS-CoV-2 has rapidly diffused in several countries and is currently posing a significant global health threat.
T214 1584-1657 Sentence denotes On March 11, 2020, the WHO has declared the COVID-19 outbreak a pandemic.
T215 1658-1852 Sentence denotes The early discovery that SARS-CoV-2 also engages ACE2 as entry door for cell infection has prompted an intense research effort to elucidate the biochemical determinants of CoV-ACE2 interactions.
T216 1854-1904 Sentence denotes Mechanism of Viral Entry Mediated by the S Protein
T217 1905-2030 Sentence denotes A coronavirus contains four structural proteins, namely spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins.
T218 2031-2157 Sentence denotes These proteins assemble around a lipid bilayer to provide the shell enclosing the viral genome (Figure 4A; Tang et al., 2020).
T219 2158-2349 Sentence denotes Homotrimers of S protrude from the viral surface, and are densely decorated by N-linked glycans, creating the “crown” (“Corona” in Latin) that christens this virus group (Walls et al., 2016).
T220 2350-2504 Sentence denotes S is a ∼180 kDa glycoprotein anchored in the viral membrane, which plays the most important roles in viral attachment, fusion and entry (Ou et al., 2020).
T221 2505-2655 Sentence denotes Sequence analysis has shown that SARS-CoV-2 S protein shares 76% of the primary sequence with the corresponding S of human SARS-CoV (Ou et al., 2020).
T222 2656-2786 Sentence denotes Accordingly, it has been early proposed that SARS-CoV-2 utilizes a similar cell entry mechanism as SARS-CoV, pivoted on S protein.
T223 2787-2857 Sentence denotes This hypothesis has been confirmed from an experimental point of view.
T224 2858-3070 Sentence denotes By using pseudotyped virus bearing SARS-CoV S or SARS-CoV-2 S, it was shown that a large panel of cell lines allows comparable entry of SARS-CoV or SARS-CoV-2 viruses (Hoffmann et al., 2020b; Walls et al., 2020).
T225 3071-3203 Sentence denotes FIGURE 4 (A) Structure of a Coronavirus. (B) Functional motifs in the sequence of the S “spike” protein of SARS-CoV and SARS-CoV-2.
T226 3204-3485 Sentence denotes The S protein consists of ∼1300 aminoacids and it is composed by a N-terminal “S1”subunit (∼700 aa) and a C-terminal “S2”subunit (∼600 aa); binding to the host receptor is mediated by S1, whereas S2 induces fusion of the viral envelope with cellular membranes (Walls et al., 2017).
T227 3486-3612 Sentence denotes S1 and S2 can be further subdivided in functional segments with different roles in viral entry (Figure 4B; Tang et al., 2020).
T228 3613-3713 Sentence denotes The S1 subunit contains two subdomains, the N-terminal domain (NTD) and the C-terminal domain (CTD).
T229 3714-3917 Sentence denotes In SARS-CoV (Li, 2015) and SARS-CoV-2 (Wang et al., 2020) CTD encloses the receptor-binding domain (RBD), and the RBD section that directly contacts the receptor is named as receptor-binding motif (RBM).
T230 3918-4071 Sentence denotes The N-region of S2 contains a fusion peptide (FP), two heptapeptide repeat domains (HR1, HR2), a transmembrane domain (TM), and cytoplasmic peptide (CP).
T231 4072-4239 Sentence denotes FP is a short segment composed of mostly hydrophobic residues, such as glycine (G) or alanine (A), which inserts in the host cell membrane to trigger the fusion event.
T232 4240-4423 Sentence denotes HR1 and HR2 are composed of a repetitive heptapeptide with HPPHCPC sequence, where H represents hydrophobic or bulky residues, P polar or hydrophilic residues, and C charged residues.
T233 4424-4522 Sentence denotes HR regions typically fold into α-helices with a hydrophobic interface that drives membrane fusion.
T234 4523-4720 Sentence denotes On the basis of the strong similarity between the S proteins of SARS-CoV and SARS-CoV-2, many researchers early set-out to demonstrate whether both viruses target the same host cell receptor, ACE2.
T235 4721-4879 Sentence denotes Zhou et al. (2020) highlighted that the virus was able to infect cell lines only when they expressed human, bat, civet, and pig (but not mouse) ACE2 receptor.
T236 4880-5071 Sentence denotes Hoffmann et al. (2020b), Ou et al. (2020), and Walls et al. (2020) elegantly outlined that the BHK cell line could be infected by pseudotyped SARS-CoV-2 or SARS-CoV only upon ACE2 expression.
T237 5072-5277 Sentence denotes Conversely, the expression of different human receptors used by other CoVs (hDPP4 and APN, used by MERS CoV and HCoV-229E, respectively) did not enable pseudovirus access to cells (Hoffmann et al., 2020b).
T238 5278-5372 Sentence denotes Taken together, these findings are solid evidence that SARS-CoV-2 engages ACE2 for cell entry.
T239 5373-5596 Sentence denotes Nonetheless, the two viruses were demonstrated by Xia to share also the membrane fusion mechanism, as strongly suggested by the impressive 89.9% sequence identity of S2 between SARS-CoV and SARS-CoV-2 (Xia et al., 2020a,b).
T240 5597-5822 Sentence denotes To date, the cell entry mechanism of SARS-CoV and SARS-CoV-2 has been understood in its general details and it is based on a concerted action of receptor binding and proteolysis of the S protein (Figure 5; Tang et al., 2020).
T241 5823-6014 Sentence denotes Ultrastructural studies showed a metastable “prefusion” V-shaped trimer composed by three S1 heads sitting on top of a trimeric S2 stalk anchored into the virus membrane (Walls et al., 2016).
T242 6015-6232 Sentence denotes The RBD constantly switches between a standing-up (“open”) position for receptor binding and a lying-down (“closed”) configuration, the latter allowing immune evasion (Figure 6; Song et al., 2018; Wrapp et al., 2020).
T243 6233-6351 Sentence denotes Yet only one of the three RBD in trimeric S can flip up at a time and interact with the receptor (Wrapp et al., 2020).
T244 6352-6514 Sentence denotes The second key feature of the fusion mechanism is “priming” by host proteases, which recognize and cleave a short peptide motif at the S1/S2 boundary (Figure 4B).
T245 6515-6878 Sentence denotes This cleavage does not disassemble S1 from S2 in pre-fusion conditions (Belouzard et al., 2009), but the binding interaction of RBD with its receptor, accompanied by a further cleavage in a second site in S2 (S2’site, upstream of FP, Figure 4B), triggers the possible dissociation of S1 and the irreversible refolding of S2 into a “post-fusion” state (Figure 4B).
T246 6879-7114 Sentence denotes In detail, HR1 undergoes a dramatic “jack-knife” conformational change, converting four helical stretches that run in an antiparallel fashion into a single long (∼130 aa) α-helix (Heald-Sargent and Gallagher, 2012; Walls et al., 2017).
T247 7115-7229 Sentence denotes At first, three of these helices assemble into a homotrimeric bundle and stick the FP into the host cell membrane.
T248 7230-7384 Sentence denotes Then, HR2 (one for each S2 chain) fold backward and bind to HR1, yielding the “six-helix bundle fusion core” (6-HB) of post-fusion S2 (Song et al., 2018).
T249 7385-7617 Sentence denotes This conformational foldback brings the FP (at N-terminus of HR1) and the TM (at the C terminus of HR2) close to each other, so that the viral and host cell membranes approach until their outer leaflets merge (hemifusion, Figure 5).
T250 7618-7828 Sentence denotes Eventually the inner leaflets merge (pore formation), enabling a connection between the interior of the virus and the host cell cytoplasm, that allows the delivery of viral genome (Figure 5; Tang et al., 2020).
T251 7829-7878 Sentence denotes FIGURE 5 Coronavirus viral fusion pathway model.
T252 7879-7942 Sentence denotes Initially, the S protein is in the pre-fusion native state (1).
T253 7943-8241 Sentence denotes Then S undergoes priming of the S1 subunit at S1/S2 by local proteases yielding the pre-fusion metastable state (2); note that priming at S1/S2 could also happen upon virus formation in releasing cell: in such a case the virus attaches to a host cell already in the pre-fusion metastable state (2).
T254 8242-8421 Sentence denotes Subsequent triggering by a protease on S2’ enables the FP to insert in the host membrane upon the “jack-knife” transition of HR1 and HR2 yielding the pre-hairpin intermediate (3).
T255 8422-8536 Sentence denotes The pre-hairpin folds back on itself due to HR1 and HR2 interactions eventually forming the post-fusion (6) state.
T256 8537-8707 Sentence denotes During the S protein foldback, the two membranes approach each other until the outer leaflets merge (hemifusion) and eventually the inner leaflets merge (pore formation).
T257 8708-8829 Sentence denotes Note that cell membrane may refer to plasma membrane (direct fusion) or endosomal membrane (fusion in endocytic vesicle).
T258 8830-8862 Sentence denotes Adapted from Tang et al. (2020).
T259 8863-8939 Sentence denotes FIGURE 6 Trimeric S protein of SARS-CoV-2 in the ”Closed” and “Open” forms.
T260 8940-9028 Sentence denotes Note the single RBD protruding out of the V-shaped conformation of the protein assembly.
T261 9029-9077 Sentence denotes The structures have been drawn from PDB 6X2C (R.
T262 9078-9141 Sentence denotes Henderson, 10.1101/2020.05.18.10208) by Mol on the PDB website.
T263 9142-9311 Sentence denotes Although not directly related to ACE2, the role of S “priming” by host cell proteases deserves particular attention in the context of SARS-CoV-2 virus entry and tropism.
T264 9312-9524 Sentence denotes Possibly, the most notable feature of SARS-CoV-2 genome, as compared to SARS-CoV and some related bat coronaviruses, is a four basic aminoacid insert (PRRA) at the S1/S2 junction (Figure 4B; Jaimes et al., 2020).
T265 9525-9680 Sentence denotes This site is potentially cleavable by the protease furin, a proprotein convertase widely recognized to activate the fusion machinery of viral glycoprotein.
T266 9681-9913 Sentence denotes Indeed, many authors showed that pseudoviruses bearing SARS-CoV-2 S were already “primed” (i.e., cleaved) at the S1/S2 boundary by furin upon assembly in the cell, at odds with pseudoviruses bearing SARS-CoV S (Shang et al., 2020a).
T267 9914-10307 Sentence denotes SARS-COV-2 shows a large flexibility with regard to protease priming, which may independently occur by a) furin and furin-like proteases intracellularly, b) trypsin-like proteases such as TMPRSS2 that are present on the host cell membrane (particularly on airway epithelial cells), and 3) endosomal cathepsins activated by a drop in pH (e.g., cathepsin L) (Figure 7; Hoffmann et al., 2020a,b).
T268 10308-10459 Sentence denotes This flexibility could be the crucial factor that explain SARS-CoV-2 cell tropism and the peculiar features of COVID-19 symptoms (Jaimes et al., 2020).
T269 10460-10645 Sentence denotes Additionally, the kind of protease “priming” may determine whether the membrane fusion process occur directly at the plasma membrane or at endosomal level (Tang et al., 2020; Figure 7).
T270 10646-10731 Sentence denotes FIGURE 7 Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells.
T271 10732-10892 Sentence denotes The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell.
T272 10893-11118 Sentence denotes The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA.
T273 11119-11429 Sentence denotes Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles.
T274 11430-11540 Sentence denotes Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell.
T275 11542-11579 Sentence denotes SARS-CoV-2 RBD and Its Receptor, ACE2
T276 11580-11727 Sentence denotes Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV.
T277 11728-11804 Sentence denotes SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005).
T278 11805-11944 Sentence denotes Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020).
T279 11945-12075 Sentence denotes Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy.
T280 12076-12279 Sentence denotes Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor).
T281 12280-12409 Sentence denotes Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner.
T282 12410-12486 Sentence denotes The SARS-CoV-2 RBD sequence was further investigated by structural analysis.
T283 12487-12884 Sentence denotes X-ray crystallography showed that SARS-CoV-2 RBD folds into two structural domains (Figure 8): (1) the core subdomain with five antiparallel β-strands (β1, β2, β3, β4, β7), (2) the external subdomain, which inserts between β4 and β7, and it is characterized by the two small β5 and β6 strands [β1’ and β2’ in Wang et al. (2020)] connected by a disulfide bond (Lan et al., 2020; Wang et al., 2020).
T284 12885-13152 Sentence denotes In keeping with their high sequence homology, the 3D structure of SARS-COV-2 and SARS-CoV RBD nearly superimpose (RMSD = 0.475 Å for 128 Cα atoms; Wang et al., 2020) with the exception of the β5/β6 loop, which actually entailed the larger primary sequence difference.
T285 13153-13387 Sentence denotes FIGURE 8 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2. (A) Cartoon representation. (B) Gaussian surface representation. hACE2 is in green, the core of SARS-CoV-2 RBD is in red, and the RBM is in blue.
T286 13388-13460 Sentence denotes The β1-β7 typical motifs of RBD (Lan et al., 2020) are indicated in (A).
T287 13461-13551 Sentence denotes The structures have been drawn from PDB 6MOJ (Lan et al., 2020) by Mol on the PDB website.
T288 13552-13629 Sentence denotes Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2.
T289 13630-13716 Sentence denotes Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD.
T290 13717-13877 Sentence denotes To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch.
T291 13878-13992 Sentence denotes In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1).
T292 13993-14141 Sentence denotes Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b).
T293 14142-14333 Sentence denotes In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020).
T294 14334-14551 Sentence denotes The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020).
T295 14552-14729 Sentence denotes Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a).
T296 14730-14973 Sentence denotes This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host.
T297 14974-15300 Sentence denotes Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases.
T298 15301-15418 Sentence denotes Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells.
T299 15419-15512 Sentence denotes TABLE 1 Binding affinity between SARS-CoV-2 spike (S) protein and S subset regions and ACE2.
T300 15513-15550 Sentence denotes Sequence KD (nM) Method References
T301 15551-15590 Sentence denotes SARS-2 S 14.7 SPR Wrapp et al., 2020
T302 15591-15628 Sentence denotes SARS-2 S 11.2 SPR Lei et al., 2020
T303 15629-15678 Sentence denotes SARS-2 S20–685 (S1) 94.6 SPR Wang et al., 2020
T304 15679-15731 Sentence denotes SARS-2 S319–541 (RBD) 133.3 SPR Wang et al., 2020
T305 15732-15781 Sentence denotes SARS-2 S319–541 (RBD) 4.7 SPR Lan et al., 2020
T306 15782-15829 Sentence denotes SARS-2 S319–529 44.2 SPR Shang et al., 2020b
T307 15830-15896 Sentence denotes SARS-2 S319–591 34.6 Biolayer interferometry Wrapp et al., 2020
T308 15897-15962 Sentence denotes SARS-2 S328–533 1.2 Biolayer interferometry Walls et al., 2020
T309 15964-15997 Sentence denotes Structure of the ACE2-RBD Complex
T310 15998-16231 Sentence denotes Previous studies showed that the extracellular Peptidase Domain (PD) of ACE2, which adopts a claw-like morphology, is the interaction site of SARS-CoV RBD (Towler et al., 2004; Li, 2015; Kirchdoerfer et al., 2018; Song et al., 2018).
T311 16232-16406 Sentence denotes More specifically, ACE2 engages SARS-CoV RBD by establishing contacts with the 424–494 residue domain, which is referred to as Receptor Binding Motif (RBM) (Li et al., 2005).
T312 16407-16687 Sentence denotes In spite of the recent emergence of SARS-CoV-2, multiple authors have already highlighted the structure of ACE2/SARS-CoV-2 RBD complex by either X-ray (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020) or cryo-EM (Walls et al., 2020; Wrapp et al., 2020; Yan et al., 2020).
T313 16688-16798 Sentence denotes Pleasantly, all data converged to a consistent tridimensional arrangement of the receptor (Wang et al., 2020).
T314 16799-16916 Sentence denotes In the “closed” conformation of S protein, the RBD is buried at the interface between protomers (Walls et al., 2020).
T315 16917-17099 Sentence denotes Only in the “open” S conformation, RBD engages PD of ACE2 (Wrapp et al., 2020), and the complex may involve a dimeric ACE2 that accommodates two S protein trimers (Yan et al., 2020).
T316 17100-17289 Sentence denotes In keeping with their sequence similarity, strong structural homology was found between ACE2/SARS-CoV RBD and ACE2/SARS-CoV-2 RBD (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020).
T317 17290-17478 Sentence denotes SARS-CoV-2 RBM spans from residue 438–506 of S sequence and, likewise SARS-CoV RBM, it approaches the outer surface of ACE2 by a gently concave surface with a ridge on one side (Figure 8).
T318 17479-17644 Sentence denotes The concave surface is made up by the two short β5 and β6 sheets of the external RBD subdomain, whereas the ridge contains the β5/β6 loop (loop 1: residues 474–489).
T319 17645-17746 Sentence denotes A second smaller loop (loop 2: residues 498–505) is visible on the other side of the concave surface.
T320 17747-18012 Sentence denotes Inspection of the complex structure and molecular dynamics (MD) highlighted that the motifs 453–456 (in β5), 484–489 (in the loop 1), and 500–505 (in the loop 2) are at the basis of the largest differences between SARS-CoV-2 and SARS-CoV RBM interactions with ACE2.
T321 18013-18267 Sentence denotes SARS-CoV RBM ridge contains a Pro-Pro-Ala motif that is replaced by Gly-Val-Glu-Gly in SARS-CoV-2 (residues 482–485), yielding a more compact loop able to engage more interactions with proximal ACE2 residues (e.g., Ser19 and Gln24) (Shang et al., 2020b).
T322 18268-18476 Sentence denotes Additionally, Phe486 of SARS-CoV-2 RBM (which replaces Ile of SARS) inserts into a hydrophobic pocket on the receptor surface, establishing strong aromatic interactions with Tyr83 of ACE2 (Wang et al., 2020).
T323 18477-18572 Sentence denotes Asn501 in loop 2 further engages recognized hotspots on the ACE2 surface (Shang et al., 2020b).
T324 18573-18724 Sentence denotes Consistently, MD studies confirmed that loop 1 and 2 are much more rigid in RBM-ACE2 complex of SARS-CoV-2 with respect to SARS (Brielle et al., 2020).
T325 18725-18845 Sentence denotes These subtle structural differences probably account for the higher affinity of SARS-CoV-2 for ACE2 (Wang et al., 2020).
T326 18846-19055 Sentence denotes Interestingly, MD simulations suggest that the difference in affinity is largely due to the solvation energy, emphasizing the relevant role of hydrophobic patches in RBM/ACE2 binding surface (He et al., 2020).
T327 19056-19323 Sentence denotes It is worth noting that the RBD-receptor engagement is the crucial effector of viral-host interaction, which eventually determines viral host range, and in tandem with the host proteases is responsible for virus tropism and pathogenicity (Millet and Whittaker, 2015).
T328 19324-19558 Sentence denotes Structure-guided sequence analysis has suggested that several mammals, including pets such as cats and dogs, host ACE2 receptors that could bind effectively to SARS-CoV-2 S protein and propagate COVID-19 infection (Luan et al., 2020).
T329 19559-19641 Sentence denotes Yet, no correlation between genetic distance and the S/ACE2 interaction was found.
T330 19642-19853 Sentence denotes In this context, a third human CoV, hCoV-NL63, has been previously found to use ACE2 for cell entry (Hofmann et al., 2005), although its S1 sequence is rather dissimilar from SARS (23.4%) and SARS-CoV-2 (29.2%).
T331 19854-20026 Sentence denotes In spite of this, the structures of hCoV-NL63 (Wu et al., 2009) and SARS-CoV RBD (Li et al., 2005) were found to engage some sterically overlapping sites in ACE (Li, 2015).
T332 20027-20187 Sentence denotes This homology can be transitively extended to SARS-CoV-2, suggesting these three CoVs have evolved to recognize a “hotspot” region in ACE2 for receptor binding.
T333 20188-20381 Sentence denotes This might represent a critical feature for the appearance of novel CoV able to infect humans in the future, as it is known that at least three more bat CoVs bind ACE2 (Hoffmann et al., 2020b).
T334 20382-20605 Sentence denotes Indeed, bat RaTG13 CoV binds ACE2 and contains a similar four-residue motif in the ACE2 binding ridge of RBM, suggesting that SARS-CoV-2 could have evolved from RaTG13 or a yet-unknown related bat CoV (Shang et al., 2020b).
T335 20607-20648 Sentence denotes The Controversial Role of ACE2 Expression
T336 20649-20889 Sentence denotes Epidemiological data consistently show that the COVID-19 patients at highest risk of a poor prognosis are males older than 60 years with chronic underlying diseases, mostly hypertension, cardiovascular diseases and type-2 diabetes mellitus.
T337 20890-21072 Sentence denotes Clinical reports have been rapidly delivered from all over the world, and meta-analyses assessing the prevalence of comorbidities and their impact on prognosis are already available.
T338 21073-21320 Sentence denotes A meta-analysis pooling data from seven studies following a total number of 1,576 infected patients from hospitals in China found that the most prevalent comorbidities were hypertension (21.1%), diabetes (9.7%), and cardiovascular diseases (8.4%).
T339 21321-21529 Sentence denotes These increased the risk of developing a more serious disease (i.e., requiring intensive care treatment), with odds ratios ranging from 2.4 (hypertension) to 3.4 (cardiovascular disease) (Yang et al., 2020b).
T340 21530-21805 Sentence denotes These findings have been confirmed in the analysis performed by the Chinese Center for Disease Control and Prevention in a huge sample of 72314 COVID-19 cases (Epidemiology Working Group for Ncip Epidemic Response and Chinese Center for Disease Control and Prevention, 2020).
T341 21806-21959 Sentence denotes A study with 1591 Italian patients, similarly, reported a significant association between hypertension and mortality in Intensive Care Unit (63 vs. 40%).
T342 21960-22104 Sentence denotes This series reported an even higher prevalence of hypertension (49%), diabetes (17%), and cardiovascular disease (21%) (Grasselli et al., 2020).
T343 22105-22293 Sentence denotes Diabetes has been reported to predict the occurrence of ARDS (HR = 1.44), acute kidney injury (HR = 3.01), septic shock (HR = 1.95), and all-cause mortality (HR = 1.70) (Zhu et al., 2020).
T344 22294-22452 Sentence denotes Notably, poor glycemic control was significantly associated with worse clinical outcomes, namely multi-organ injuries and higher mortality (Zhu et al., 2020).
T345 22453-22534 Sentence denotes Obesity has also emerged as an important factor in determining COVID-19 severity.
T346 22535-22803 Sentence denotes Indeed, obesity was more frequent in patients admitted to critical care for SARS-CoV-2 as compared to the general population; moreover, the BMI was positively related to the need for invasive mechanical ventilation and mortality (Drucker, 2020; Simonnet et al., 2020).
T347 22804-22946 Sentence denotes The RAAS system is the target of widely used anti-hypertensive drugs, such as ACE-inhibitors (ACEI) and Ang-II type 1 receptor blockers (ARB).
T348 22947-23159 Sentence denotes Several experimental studies reported that, although not directly affecting ACE2 activity, these drugs are able to upregulate its expression (Ishiyama et al., 2004; Ferrario et al., 2005; Gallagher et al., 2008).
T349 23160-23392 Sentence denotes Increased expression of ACE2 has also been reported to facilitate SARS-CoV infection in several experimental models and postulated to act in the same way for SARS-CoV-2 (Li et al., 2003; Hofmann et al., 2004; Perrotta et al., 2020).
T350 23393-23563 Sentence denotes Hence, following the SARS-CoV-2 outbreak, it has been speculated that the use of ACEI and ARB could increase viral invasion and should therefore be temporarily suspended.
T351 23564-24032 Sentence denotes This topic has been abundantly debated in the last few months (March–May 2020), with contradictory views (Bavishi et al., 2020; Buckley et al., 2020; Danser et al., 2020; Fang et al., 2020; Huang Z. et al., 2020; Kreutz et al., 2020; Kuster et al., 2020; Mourad and Levy, 2020; Park et al., 2020; Rico-Mesa et al., 2020; Sommerstein et al., 2020; South et al., 2020; Tignanelli et al., 2020; Vaduganathan et al., 2020; Verdecchia et al., 2020b; Zhang P. et al., 2020).
T352 24033-24422 Sentence denotes As a consequence of this debate, several clinical societies have stated that suspension of ACEI and ARB is not justified on the basis of the present scientific evidence, although a recent BMJ editorial (Aronson and Ferner, 2020) suggested to consider stopping ACE inhibitors or angiotensin receptor blockers in patients with mild hypertension who are at high risk of coronavirus infection.
T353 24423-24648 Sentence denotes On the other hand, a different viewpoint is based on the intriguing observation that several conditions increasing the risk of viral infection and disease severity are all characterized by a certain degree of ACE2 deficiency.
T354 24649-24836 Sentence denotes As discussed above (section “Structure of ACE2”) ACE2 deficiency has been suggested to play a significant role in the pathophysiology of hypertension, cardiovascular disease and diabetes.
T355 24837-25034 Sentence denotes The role of ACE2 expression in the panel of comorbidities correlated to SARS-CoV-2 is a matter of intense still unsolved debate, as brilliantly revised by Shyh et al. (2020) in a very recent paper.
T356 25035-25174 Sentence denotes On the whole, there is still uncertainty about the relationship between ACE2 density on cell membrane and the fate of SARS-CoV-2 infection.
T357 25175-25516 Sentence denotes An interesting speculation which could reconcile the two position comes from the hypothesis that while ACE2 is for sure the entry door for the virus, once the infection has evolved, there is the subsequent downregulation of ACE2, responsible for the precipitating of respiratory distress, as showed also in animal models (Kuba et al., 2005).
T358 25517-25689 Sentence denotes It should be pointed out that the great clinical impact of this issue has encouraged discussions that are largely based on indirect speculations rather than objective data.
T359 25690-25983 Sentence denotes Data from appropriate clinical trials are still lacking, although a retrospective multicenter study on more than 1,000 patients with COVID-19 and hypertension treated with ACEI or ARB revealed that the use of these drugs was associated with lower mortality from all cause (Bosso et al., 2020).
T360 25984-26388 Sentence denotes A definite conclusion would require specific prospective clinical trials, which are still running: https://clinicaltrials.gov/ct2/show/NCT04312009 is a multi-centered double blind trial with the aim to test the role of ARB in patients with COVID-19 and https://clinicaltrials.gov/ct2/show/NCT04331574 is another trial evaluating the outcome of patients with COVID-19 in therapy with either ACEI and ARBS.
T361 26389-26944 Sentence denotes In the meanwhile, partial but important information might be obtained by circumscribed experimental and clinical investigations focused some on crucial issues, namely: fate of SARS-CoV-2 infection in human cells manipulated in order to modify ACE2 density; correlation of ACE2 density (in different cell types) and clinical course in human patients; potential role of additional proteins interacting with ACE2, such as the membrane transporter SIT1, which appears to be associated with COVID-19 prognosis and is also affected by anti-hypertensive therapy.
T362 26946-26994 Sentence denotes ACE2 and the Inflammatory Response to SARS-CoV-2
T363 26995-27161 Sentence denotes Differently from other flu-like viral infections, COVID19 showed a relatively high lethality, although the latter was quite different in different geographical areas.
T364 27162-27321 Sentence denotes The appearance of ARDS and acute severe lung injury was initially regarded as the main insult, and patients underwent the typical treatment developed for ARDS.
T365 27322-27637 Sentence denotes However, more recent evidence from autopsy series revealed that COVID-19 is a systemic disease, in which interstitial pneumonia is associated with extensive microvascular damage, which is not limited to the lungs and leads to fibrin deposition, neutrophils trapping in microvasculature, and arteriolar microthrombi.
T366 27638-27792 Sentence denotes Moreover, cardiovascular involvement has been observed, occasionally leading to myocardial injury and sudden death after weeks from the initial infection.
T367 27793-27964 Sentence denotes These findings are crucial to optimize the treatment of COVID-19 patients, hopefully improving the prognosis (Buja et al., 2020; Carsana et al., 2020; Magro et al., 2020).
T368 27965-28113 Sentence denotes Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection.
T369 28114-28252 Sentence denotes Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia.
T370 28253-28351 Sentence denotes In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required.
T371 28352-28477 Sentence denotes These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people.
T372 28478-28793 Sentence denotes Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020).
T373 28794-28912 Sentence denotes The molecular mechanisms involved in the cytokine storm and the role of ACE2 are currently still not fully understood.
T374 28913-29126 Sentence denotes As discussed above, virus binding to the ACE2 is the event that initiates viral replication in susceptible cells, such as alveolar epithelial cells, vascular cells and immune system cells (macrophages, monocytes).
T375 29127-29255 Sentence denotes This has been suggested to trigger the primary inflammatory response, which involves apoptosis and pyroptosis (Fu et al., 2020).
T376 29256-29506 Sentence denotes The apoptosis pattern indices cell death to avoid viral replication in the absence of overt inflammation, whereas, pyroptosis is a violent form of programmed cell death, followed by an inflammatory storm (Cookson and Brennan, 2001; Liu et al., 2016).
T377 29507-29753 Sentence denotes In the standard pyroptosis model, when the pathogen enters the host cell, some specific structures on the pathogen surface (PAMPs–pathogen associated molecular patterns) are identified by pattern recognition receptors (PRRs) on the host membrane.
T378 29754-30199 Sentence denotes One common PRR is NOD-like receptors protein 3 (NLRP3), which forms together with a protein caspase activating protein (ASC or apoptosis-associated speck-like protein containing a caspase recruitment domain) and pro-caspase 1, the inflammasome unit capable of recruiting proinflammatory cytokines and inducing cell lysis with further inflammation signals (Fernandes-Alnemri et al., 2007; Schroder and Tschopp, 2010; Wree et al., 2014; Figure 9).
T379 30200-30307 Sentence denotes FIGURE 9 Possible role of ACE2 in the molecular mechanisms involved in the “cytokine storm” of SARS-CoV-2.
T380 30308-30529 Sentence denotes In the SARS-CoV-2 infection, pyroptosis has been demonstrated to be active in macrophages, being viroporin 3a a trigger for NLRP3 with subsequent production of proinflammatory cytokines, such as IL-1β (Chen et al., 2019).
T381 30530-30668 Sentence denotes In COVID-19 patients, the pyroptosis activation has been indirectly demonstrated by the high serum level of IL-1β (Huang C. et al., 2020).
T382 30669-30856 Sentence denotes Moreover, the severe leucopoenia and lymphopenia, commonly showed in COVID-19 pneumonia and associated with poor prognosis, are likely due to lymphocyte injury by pyroptosis (Yang, 2020).
T383 30857-30982 Sentence denotes Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system.
T384 30983-31279 Sentence denotes It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018).
T385 31280-31624 Sentence denotes The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release.
T386 31625-31864 Sentence denotes Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020).
T387 31865-31961 Sentence denotes The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm.
T388 31962-32158 Sentence denotes The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020).
T389 32159-32247 Sentence denotes ACE2 shedding is an additional mechanism contributing to inflammation (Fu et al., 2020).
T390 32248-32501 Sentence denotes ACE2 shedding consists in proteolytic cleavage of the protein ectodomain and leads to the release of enzymatically active soluble ACE2 (sACE), whose action is not completely understood, but might enhance the pro-inflammatory response (Guy et al., 2005).
T391 32502-32717 Sentence denotes ADAM 17 and disintegrin are able to shed not only TNFα but also a variety of membrane-anchored enzymes, including ACE2 (Black et al., 1997; Palau et al., 2020), as demonstrated by Lambert in 2005 (Guy et al., 2005).
T392 32718-33034 Sentence denotes In their experiment, human embryonic kidney cells (HEK293) expressing human ACE2 (HEK-ACE2) were treated with phorbol myristate acetate stimulation and the production of a polypeptide of 105 kDa was demonstrated by western blot analysis, suggesting the occurrence of a proteolytic shedding in the ectodomain of ACE2.
T393 33035-33255 Sentence denotes Subsequently, they demonstrated that the cleavage was performed by ADAM17, incubating cells with a specific hydroxamic acid-based metalloproteinase inhibitor, namely TAPI-1 (TNFα protease inhibitor 1) (Guy et al., 2005).
T394 33256-33373 Sentence denotes ACE2 shedding seems to be inducible by specific stimuli produced either by a viral infection or by the immune system.
T395 33374-33487 Sentence denotes Jia et al. (2009) confirmed ACE2 shedding in differentiated primary airway epithelial cells and Calu-3-cell line.
T396 33488-33696 Sentence denotes Furthermore, they demonstrated that the incubation with IL-1β at the dosage of 100 ng/ml and TNF α 100 ng/ml induced ACE2 shedding and sACE release, with a maximum after 18 h of incubation (Jia et al., 2009).
T397 33697-33832 Sentence denotes These findings suggest that an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection.
T398 33833-34017 Sentence denotes Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).
T399 34018-34177 Sentence denotes Other conditions have been assumed to be involved in the susceptibility to SARS-CoV-2 and among them vitamin D deficiency was proposed as a credible candidate.
T400 34178-34339 Sentence denotes The interesting candidate could be identified as a modifiable risk factor (hypovitaminosis D) and a potential tool in COVID-19 prevention or ancillary treatment.
T401 34340-34996 Sentence denotes The rationale has been summarized by Grant et al. in a recent review on the evidence supporting a possible correlation between vitamin D and SARS-CoV-2 risk: (i) the seasonal flare of SARS-CoV-2 which coincides with the nadir of vitamin D levels, (ii) the association between hypovitaminosis D and pulmonary infections together with the demonstrated protective role in acute respiratory infections, in adults (iii) the anti-inflammatory role of vitamin D which could be of benefit against the so called “cytokine storm,” which seems to be a major player in SARS-CoV-2 morbidity and mortality (Martineau et al., 2017; Zhou et al., 2019; Grant et al., 2020).
T402 34998-35026 Sentence denotes ACE2 as a Therapeutic Target
T403 35027-35115 Sentence denotes As evidence builds up, ACE2 rapidly emerged as a specific target for COVID-19 treatment.
T404 35116-35420 Sentence denotes Since this enzyme was identified as the SARS-CoV-2 receptor (Zhou et al., 2020), several approaches to address ACE2 mediated infection have been described (Li Y. et al., 2020; Zhang H. et al., 2020), with the aim to prevent host cell entry and subsequent viral replication, as well as severe lung injury.
T405 35421-35474 Sentence denotes Potential therapeutic approaches include (Figure 10):
T406 35475-35586 Sentence denotes FIGURE 10 Schematic representation of the potential therapeutic approaches to address ACE2 mediated infection.
T407 35587-35791 Sentence denotes Exogenous administration of soluble recombinant human ACE 2 sequesters circulating viral particles, while specific ACE2 blockers bind the receptor, impeding the S-protein interaction with the host target.
T408 35792-35794 Sentence denotes 1.
T409 35796-35810 Sentence denotes ACE2 blockers;
T410 35811-35813 Sentence denotes 2.
T411 35815-35848 Sentence denotes Exogenous administration of ACE2.
T412 35850-35863 Sentence denotes ACE2 Blockers
T413 35864-36114 Sentence denotes Blockade of ACE2 receptor could be achieved through specific antibodies (Li et al., 2003), rationally designed small molecules (Dales et al., 2002; Huentelman et al., 2004; Gross et al., 2020; Pillaiyar et al., 2020) or peptides (Huang et al., 2003).
T414 36115-36303 Sentence denotes Although their efficacy needs to be confirmed, some of these agents are currently available on the market and have been show to effectively block SARS-CoV invasion (Li S.-R. et al., 2020).
T415 36304-36631 Sentence denotes For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004).
T416 36632-36830 Sentence denotes Therefore, although ACE2 catalytic site is distinct from the S-protein-binding domain, NAAE exerts dual inhibitory effects on ACE2 catalytic activity and SARS binding (Adedeji and Sarafianos, 2014).
T417 36831-37127 Sentence denotes However, since a protecting role for ACE2 receptor against virus-induced acute lung injury in infections with SARS coronavirus has not been excluded (Imai et al., 2005; Kuba et al., 2005; Li S.-R. et al., 2020), the choice of ACE2 inhibition as therapeutic approach should be carefully evaluated.
T418 37129-37161 Sentence denotes Exogenous Administration of ACE2
T419 37162-37570 Sentence denotes The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a).
T420 37571-37750 Sentence denotes A pilot clinical study is currently investigating the efficiency of a recombinant human angiotensin-converting enzyme 2 (rhACE2) in patients with COVID-19 (Zhang H. et al., 2020).
T421 37751-37955 Sentence denotes Recombinant human ACE 2, rhACE2 (hrsACE2, APN01, GSK2586881), sequesters circulating viral particles interfering with S-protein binding to its host target, beside its role in regulating the systemic RAAS.
T422 37956-38311 Sentence denotes Taken together, these activities may offer therapeutic benefits in COVID-19 patients, although the large molecular weight of the protein may potentially limit its effects on local RAAS (Gheblawi et al., 2020). rhACE2 has already undergone phase 1 and 2 clinical trials in healthy volunteers and in a small cohort of patients with ARDS (Khan et al., 2017).
T423 38312-38518 Sentence denotes Moreover, it has been demonstrated that rhACE2 can significantly block the early stages of SARS-CoV-2 infections in engineered human blood vessel organoids and human kidney organoids (Monteil et al., 2020).
T424 38519-38680 Sentence denotes In this context, Procko (2020) was able to engineer hACE2 sequences to obtain soluble receptors able to sequester SARS-CoV-2 RBD and inhibit its cell attachment.
T425 38681-38887 Sentence denotes Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement.
T426 38888-39117 Sentence denotes Additionally, the availability of ACE2 nanoparticles applied to nose filters, chewing gums, clothes, filters and gloves could be of help in sequestering the virus thus preventing its entry into the host (Aydemir and Ulusu, 2020).
T427 39118-39350 Sentence denotes Prevention virus transmission could represent a more convenient strategy than therapeutic interventions on viral infection, avoiding interference with ACE2 and disturbance of the finely regulated RAAS axis (Aydemir and Ulusu, 2020).
T428 39352-39375 Sentence denotes ACE2 and Other Diseases
T429 39376-39430 Sentence denotes ACE2 is a multiform protein (Feng et al., 2010, 2011).
T430 39431-39621 Sentence denotes As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013).
T431 39622-39734 Sentence denotes Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis.
T432 39735-39852 Sentence denotes Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012).
T433 39853-39950 Sentence denotes Moreover, ACE2 participates in the regulation of metabolism, particularly of glucose homeostasis.
T434 39951-40058 Sentence denotes In the pancreas, activation of the ACE2-Ang1-7-MasR pathway improves insulin secretion (Yuan et al., 2013).
T435 40059-40245 Sentence denotes Obesity and high-fat diets cause a reduction in ACE2 expression in the adipose tissue, which in turn results in increased blood pressure (Gupte et al., 2008, 2012; Carsana et al., 2020).
T436 40246-40391 Sentence denotes A role for ACE2 is emerging in Alzheimer disease, since it has been shown that ACE2 can hydrolyse Beta amyloid peptides (Zou et al., 2007, 2013).
T437 40392-40475 Sentence denotes There is also increasing evidence that the RAAS system may be implicated in cancer.
T438 40476-40676 Sentence denotes ACE2 was found to inhibit cancer cell growth, metastasis, and angiogenesis in breast (Yu et al., 2016; Zhang Q. et al., 2019), pancreatic (Zhou et al., 2011), and colon cancer (Bernardi et al., 2012).
T439 40677-40886 Sentence denotes Another study pointed out that hepatocellular carcinoma patients with higher levels of ACE2 had longer survival times, suggesting a positive link between ACE2 expression and better prognosis (Ye et al., 2015).
T440 40887-41053 Sentence denotes Studies on human xenografts in mice clearly indicated that ACE2 inhibited tumor growth by suppressing invasion and angiogenesis in Non-Small Cell Lung Cancer (NSCLC).
T441 41054-41327 Sentence denotes Remarkably, the same group demonstrated that overexpression of ACE2 promotes the expression of E-cadherin at expenses of mesenchymal markers such as vimentin, and thereby inhibits the epithelial-mesenchymal transition in NSCLC models (Feng et al., 2010; Qian et al., 2013).
T442 41328-41534 Sentence denotes The discovery that lung cancer patients that harbor COVID-19 display more severe symptoms (Liang et al., 2020) set out intensive research on the possible connection between malignancies and ACE2 expression.
T443 41535-41652 Sentence denotes A thorough bioinformatics analysis of the TCGA dataset on several kinds of cancer (Chai et al., 2020) has shown that:
T444 41653-41721 Sentence denotes (1) Mutation and amplification of ACE2 gene are frequent in cancer.
T445 41722-41827 Sentence denotes Yet, hot-spot mutation sites were never observed, as ACE2 mutations were distributed across all 18 exons.
T446 41828-42084 Sentence denotes (2) ACE2 transcription was upregulated in six tumors: colon adenocarcinoma (COAD), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and lung adenocarcinoma (LUAD).
T447 42085-42172 Sentence denotes Interestingly, ACE2 transcription was unchanged in lung squamous cell carcinoma (LUSC).
T448 42173-42317 Sentence denotes (3) ACE2 transcription was downregulated in three tumors: testicular germ cell (TGCT), thyroid carcinoma (THCA), and kidney chromophobe (KICH).
T449 42318-42473 Sentence denotes (4) Changes of ACE2 transcription were epigenetic in nature, as both mutation and copy variation of ACE2 did not correlate with its up- or downregulation.
T450 42474-42578 Sentence denotes (5) In most cases, changes of ACE2 transcription strongly correlated with methylation in ACE2 promoter.
T451 42579-42709 Sentence denotes More specifically, decreased methylation levels correlated with upregulation, whereas increased methylation led to downregulation.
T452 42710-42797 Sentence denotes (6) No prognostic role of ACE2 expression on patient’s survival could be demonstrated.
T453 42798-42918 Sentence denotes These data confirm the remarkable role of methylation in determining the ACE2 expression, as described in paragraph 2.2.
T454 42919-43264 Sentence denotes Interestingly, a second bioinformatics study on Oncomine and TCGA databases gave slightly different results in terms of tumor-associated ACE2 expression changes, but confirmed the role of promoter hypomethylation in KIRP and uterine corpus endometrial carcinoma (UCEC) where ACE2 transcription was significantly upregulated (Yang et al., 2020a).

LitCovid-sample-PD-UBERON

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T153 38952-38956 Body_part denotes nose http://purl.obolibrary.org/obo/UBERON_0000004
T154 39528-39534 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T155 39958-39966 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264
T156 40130-40144 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T157 40181-40186 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T158 40554-40560 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T159 40639-40644 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T160 41033-41037 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T161 41347-41351 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T162 41883-41888 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
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T164 41992-41998 Body_part denotes rectum http://purl.obolibrary.org/obo/UBERON_0001052
T165 42022-42029 Body_part denotes stomach http://purl.obolibrary.org/obo/UBERON_0000945
T166 42057-42061 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T167 42136-42140 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T168 42261-42268 Body_part denotes thyroid http://purl.obolibrary.org/obo/UBERON_0002046
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T170 43152-43158 Body_part denotes corpus http://purl.obolibrary.org/obo/UBERON_3000645

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1992 39376-39380 Gene denotes ACE2 Gene:59272
1993 39472-39476 Gene denotes ACE2 Gene:59272
1994 39514-39524 Gene denotes collectrin Gene:57393
1080 5352-5356 Gene denotes ACE2 Gene:59272
1081 4587-4595 Species denotes SARS-CoV Tax:694009
1014 1961-1966 Gene denotes spike Gene:43740568
1015 1986-1994 Gene denotes membrane Gene:43740571
1016 1972-1980 Gene denotes envelope Gene:43740570
1017 2918-2919 Gene denotes S Gene:43740568
1018 2617-2618 Gene denotes S Gene:43740568
1019 2549-2550 Gene denotes S Gene:43740568
1020 2401-2409 Gene denotes membrane Gene:43740571
1021 1907-1918 Species denotes coronavirus Tax:11118
1022 2538-2548 Species denotes SARS-CoV-2 Tax:2697049
1023 2622-2627 Species denotes human Tax:9606
1024 2628-2636 Species denotes SARS-CoV Tax:694009
1025 2701-2711 Species denotes SARS-CoV-2 Tax:2697049
1026 2755-2763 Species denotes SARS-CoV Tax:694009
1027 2893-2901 Species denotes SARS-CoV Tax:694009
1028 2907-2917 Species denotes SARS-CoV-2 Tax:2697049
1029 2994-3002 Species denotes SARS-CoV Tax:694009
1030 3006-3016 Species denotes SARS-CoV-2 Tax:2697049
1031 2237-2253 Chemical denotes N-linked glycans
1035 3100-3111 Species denotes Coronavirus Tax:11118
1036 3179-3187 Species denotes SARS-CoV Tax:694009
1037 3192-3202 Species denotes SARS-CoV-2 Tax:2697049
1048 3431-3439 Gene denotes envelope Gene:43740570
1049 3208-3209 Gene denotes S Gene:43740568
1050 17049-17056 Gene denotes mmodate Gene:43740571
1051 16704-16714 Gene denotes data conve Gene:43740571
1052 3717-3725 Species denotes SARS-CoV Tax:694009
1053 5563-5573 Species denotes SARS-CoV-2 Tax:2697049
1054 3339-3341 Gene denotes aa Gene:351
1055 3300-3302 Gene denotes aa Gene:351
1056 16581-16604 Chemical denotes g et al., 2020b; Wang e MESH:D005998
1057 16630-16636 Chemical denotes alls e MESH:D000409
1076 4715-4719 Gene denotes ACE2 Gene:59272
1077 4865-4869 Gene denotes ACE2 Gene:70008
1078 5055-5059 Gene denotes ACE2 Gene:59272
1079 5148-5153 Gene denotes hDPP4 Gene:1803
1082 4600-4610 Species denotes SARS-CoV-2 Tax:2697049
1083 4822-4827 Species denotes human Tax:9606
1084 4845-4848 Species denotes pig Tax:9823
1085 4858-4863 Species denotes mouse Tax:10090
1086 5022-5032 Species denotes SARS-CoV-2 Tax:2697049
1087 5036-5044 Species denotes SARS-CoV Tax:694009
1088 5112-5117 Species denotes human Tax:9606
1089 5142-5146 Species denotes CoVs Tax:11118
1090 5171-5179 Species denotes MERS CoV Tax:1335626
1091 5184-5193 Species denotes HCoV-229E Tax:11137
1092 5333-5343 Species denotes SARS-CoV-2 Tax:2697049
1093 4998-5006 Disease denotes infected MESH:D007239
1097 5445-5453 Gene denotes membrane Gene:43740571
1098 5550-5558 Species denotes SARS-CoV Tax:694009
1099 5563-5573 Species denotes SARS-CoV-2 Tax:2697049
1109 6275-6276 Gene denotes S Gene:43740568
1110 5782-5783 Gene denotes S Gene:43740568
1111 7349-7353 Gene denotes post Gene:159371
1112 6847-6851 Gene denotes post Gene:159371
1113 7220-7228 Gene denotes membrane Gene:43740571
1114 5984-5992 Gene denotes membrane Gene:43740571
1115 5634-5642 Species denotes SARS-CoV Tax:694009
1116 5647-5657 Species denotes SARS-CoV-2 Tax:2697049
1117 7046-7048 Gene denotes aa Gene:351
1127 8548-8549 Gene denotes S Gene:43740568
1128 7948-7949 Gene denotes S Gene:43740568
1129 7894-7895 Gene denotes S Gene:43740568
1130 8514-8518 Gene denotes post Gene:159371
1131 8790-8798 Gene denotes membrane Gene:43740571
1132 8752-8760 Gene denotes membrane Gene:43740571
1133 8723-8731 Gene denotes membrane Gene:43740571
1134 8322-8330 Gene denotes membrane Gene:43740571
1135 7839-7850 Species denotes Coronavirus Tax:11118
1139 9129-9132 Gene denotes PDB Gene:5131
1140 8882-8883 Gene denotes S Gene:43740568
1141 8895-8905 Species denotes SARS-CoV-2 Tax:2697049
1163 9175-9179 Gene denotes ACE2 Gene:59272
1164 10020-10025 Gene denotes furin Gene:5045
1165 10102-10109 Gene denotes TMPRSS2 Gene:7113
1166 10257-10268 Gene denotes cathepsin L Gene:1514
1167 9576-9581 Gene denotes furin Gene:5045
1168 9812-9817 Gene denotes furin Gene:5045
1169 9747-9748 Gene denotes S Gene:43740568
1170 9193-9194 Gene denotes S Gene:43740568
1171 10584-10592 Gene denotes membrane Gene:43740571
1172 10531-10539 Gene denotes membrane Gene:43740571
1173 10144-10152 Gene denotes membrane Gene:43740571
1174 9276-9286 Species denotes SARS-CoV-2 Tax:2697049
1175 9350-9360 Species denotes SARS-CoV-2 Tax:2697049
1176 9384-9392 Species denotes SARS-CoV Tax:694009
1177 9414-9427 Species denotes coronaviruses Tax:11118
1178 9736-9746 Species denotes SARS-CoV-2 Tax:2697049
1179 9880-9888 Species denotes SARS-CoV Tax:694009
1180 9914-9924 Species denotes SARS-COV-2 Tax:2697049
1181 10366-10376 Species denotes SARS-CoV-2 Tax:2697049
1182 10030-10035 Gene denotes furin Gene:5045
1183 10419-10427 Disease denotes COVID-19 MESH:C000657245
1192 11014-11021 Gene denotes TMPRSS2 Gene:487770
1193 10816-10821 Gene denotes furin Gene:5045
1194 10669-10670 Gene denotes S Gene:43740568
1195 11289-11293 Gene denotes fuse Gene:2522
1196 11310-11318 Gene denotes membrane Gene:43740571
1197 11229-11237 Gene denotes membrane Gene:43740571
1198 11076-11084 Gene denotes membrane Gene:43740571
1199 10989-10997 Gene denotes membrane Gene:43740571
1201 11542-11552 Species denotes SARS-CoV-2 Tax:2697049
1217 12149-12153 Gene denotes ACE2 Gene:59272
1218 12257-12262 Gene denotes hDPP4 Gene:1803
1219 12302-12306 Gene denotes ACE2 Gene:59272
1220 12360-12364 Gene denotes ACE2 Gene:59272
1221 12238-12246 Gene denotes membrane Gene:43740571
1222 11586-11596 Species denotes SARS-CoV-2 Tax:2697049
1223 11601-11609 Species denotes SARS-CoV Tax:694009
1224 11677-11687 Species denotes SARS-CoV-2 Tax:2697049
1225 11718-11726 Species denotes SARS-CoV Tax:694009
1226 11728-11736 Species denotes SARS-CoV Tax:694009
1227 11854-11864 Species denotes SARS-CoV-2 Tax:2697049
1228 11911-11919 Species denotes SARS-CoV Tax:694009
1229 12027-12037 Species denotes SARS-CoV-2 Tax:2697049
1230 12083-12093 Species denotes SARS-CoV-2 Tax:2697049
1231 12183-12186 CellLine denotes HEK CVCL:M624
1248 12639-12641 Gene denotes β1 Gene:597
1249 12643-12645 Gene denotes β2 Gene:170589
1250 12647-12649 Gene denotes β3 Gene:28883
1251 12651-12653 Gene denotes β4 Gene:28898
1252 12655-12657 Gene denotes β7 Gene:28885
1253 12710-12712 Gene denotes β4 Gene:28898
1254 12789-12792 Gene denotes β2’ Gene:170589
1255 12781-12784 Gene denotes β1’ Gene:597
1256 12769-12771 Gene denotes β6 Gene:28873
1257 12762-12764 Gene denotes β5 Gene:28884
1258 12717-12719 Gene denotes β7 Gene:28885
1259 12414-12424 Species denotes SARS-CoV-2 Tax:2697049
1260 12521-12531 Species denotes SARS-CoV-2 Tax:2697049
1261 12951-12961 Species denotes SARS-COV-2 Tax:2697049
1262 12966-12974 Species denotes SARS-CoV Tax:694009
1263 12831-12840 Chemical denotes disulfide MESH:D004220
1271 13236-13240 Gene denotes ACE2 Gene:59272
1272 13307-13312 Gene denotes hACE2 Gene:59272
1273 13195-13200 Gene denotes spike Gene:43740568
1274 13539-13542 Gene denotes PDB Gene:5131
1275 13497-13500 Gene denotes PDB Gene:5131
1276 12951-12961 Species denotes SARS-COV-2 Tax:2697049
1277 13338-13348 Species denotes SARS-CoV-2 Tax:2697049
1301 13624-13628 Gene denotes ACE2 Gene:59272
1302 13943-13947 Gene denotes ACE2 Gene:59272
1303 14212-14216 Gene denotes ACE2 Gene:59272
1304 14444-14448 Gene denotes ACE2 Gene:59272
1305 14603-14607 Gene denotes ACE2 Gene:59272
1306 15126-15130 Gene denotes ACE2 Gene:59272
1307 14705-14706 Gene denotes S Gene:43740568
1308 14651-14652 Gene denotes S Gene:43740568
1309 13799-13800 Gene denotes S Gene:43740568
1310 13604-13614 Species denotes SARS-CoV-2 Tax:2697049
1311 13701-13711 Species denotes SARS-CoV-2 Tax:2697049
1312 14172-14182 Species denotes SARS-CoV-2 Tax:2697049
1313 14241-14249 Species denotes SARS-CoV Tax:694009
1314 14421-14431 Species denotes SARS-CoV-2 Tax:2697049
1315 14469-14479 Species denotes SARS-CoV-2 Tax:2697049
1316 14503-14511 Species denotes SARS-CoV Tax:694009
1317 14640-14650 Species denotes SARS-CoV-2 Tax:2697049
1318 14767-14777 Species denotes SARS-CoV-2 Tax:2697049
1319 14836-14844 Species denotes SARS-CoV Tax:694009
1320 15014-15024 Species denotes SARS-CoV-2 Tax:2697049
1321 15029-15037 Species denotes SARS-CoV Tax:694009
1322 15073-15083 Species denotes SARS-CoV-2 Tax:2697049
1323 15386-15396 Species denotes SARS-CoV-2 Tax:2697049
1329 15464-15469 Gene denotes spike Gene:43740568
1330 15471-15472 Gene denotes S Gene:43740568
1331 15507-15511 Gene denotes ACE2 Gene:59272
1332 15486-15487 Gene denotes S Gene:43740568
1333 15453-15463 Species denotes SARS-CoV-2 Tax:2697049
1344 15598-15599 Gene denotes S Gene:43740568
1345 15558-15559 Gene denotes S Gene:43740568
1346 15551-15557 Species denotes SARS-2 Tax:2697049
1347 15591-15597 Species denotes SARS-2 Tax:2697049
1348 15629-15635 Species denotes SARS-2 Tax:2697049
1349 15679-15685 Species denotes SARS-2 Tax:2697049
1350 15732-15738 Species denotes SARS-2 Tax:2697049
1351 15830-15836 Species denotes SARS-2 Tax:2697049
1352 15897-15903 Species denotes SARS-2 Tax:2697049
1353 15782-15803 CellLine denotes SARS-2 S319–529 44.2 CVCL:Z232
1355 15981-15985 Gene denotes ACE2 Gene:59272
1360 16070-16074 Gene denotes ACE2 Gene:59272
1361 16251-16255 Gene denotes ACE2 Gene:59272
1362 16140-16148 Species denotes SARS-CoV Tax:694009
1363 16264-16272 Species denotes SARS-CoV Tax:694009
1404 16514-16518 Gene denotes ACE2 Gene:59272
1405 16970-16974 Gene denotes ACE2 Gene:59272
1406 17035-17039 Gene denotes ACE2 Gene:59272
1407 17188-17192 Gene denotes ACE2 Gene:59272
1408 17210-17214 Gene denotes ACE2 Gene:59272
1409 17409-17413 Gene denotes ACE2 Gene:59272
1410 17851-17853 Gene denotes β5 Gene:28884
1411 18007-18011 Gene denotes ACE2 Gene:59272
1412 18207-18211 Gene denotes ACE2 Gene:59272
1413 18451-18455 Gene denotes ACE2 Gene:59272
1414 18537-18541 Gene denotes ACE2 Gene:59272
1415 18653-18657 Gene denotes ACE2 Gene:59272
1416 18820-18824 Gene denotes ACE2 Gene:59272
1417 19016-19020 Gene denotes ACE2 Gene:59272
1418 17335-17336 Gene denotes S Gene:43740568
1419 17062-17063 Gene denotes S Gene:43740568
1420 16936-16937 Gene denotes S Gene:43740568
1421 16831-16832 Gene denotes S Gene:43740568
1422 17534-17536 Gene denotes β6 Gene:28873
1423 17527-17529 Gene denotes β5 Gene:28884
1424 16443-16453 Species denotes SARS-CoV-2 Tax:2697049
1425 16519-16529 Species denotes SARS-CoV-2 Tax:2697049
1426 17193-17201 Species denotes SARS-CoV Tax:694009
1427 17215-17225 Species denotes SARS-CoV-2 Tax:2697049
1428 17290-17300 Species denotes SARS-CoV-2 Tax:2697049
1429 17360-17368 Species denotes SARS-CoV Tax:694009
1430 17961-17971 Species denotes SARS-CoV-2 Tax:2697049
1431 17976-17984 Species denotes SARS-CoV Tax:694009
1432 18013-18021 Species denotes SARS-CoV Tax:694009
1433 18100-18110 Species denotes SARS-CoV-2 Tax:2697049
1434 18292-18302 Species denotes SARS-CoV-2 Tax:2697049
1435 18669-18679 Species denotes SARS-CoV-2 Tax:2697049
1436 18805-18815 Species denotes SARS-CoV-2 Tax:2697049
1437 18043-18054 Chemical denotes Pro-Pro-Ala MESH:C027789
1438 18081-18096 Chemical denotes Gly-Val-Glu-Gly
1439 18228-18233 Chemical denotes Ser19
1440 18238-18243 Chemical denotes Gln24
1441 18282-18288 Chemical denotes Phe486
1442 18442-18447 Chemical denotes Tyr83
1443 18477-18483 Chemical denotes Asn501
1454 19084-19096 Gene denotes RBD-receptor
1455 19438-19442 Gene denotes ACE2 Gene:480847
1456 19614-19618 Gene denotes ACE2 Gene:59272
1457 19612-19613 Gene denotes S Gene:43740568
1458 19495-19496 Gene denotes S Gene:43740568
1459 19418-19422 Species denotes cats Tax:9685
1460 19427-19431 Species denotes dogs Tax:9615
1461 19484-19494 Species denotes SARS-CoV-2 Tax:2697049
1462 19519-19527 Disease denotes COVID-19 MESH:C000657245
1463 19528-19537 Disease denotes infection MESH:D007239
1484 19722-19726 Gene denotes ACE2 Gene:59272
1485 20011-20014 Gene denotes ACE Gene:1636
1486 20161-20165 Gene denotes ACE2 Gene:59272
1487 20351-20355 Gene denotes ACE2 Gene:59272
1488 20411-20415 Gene denotes ACE2 Gene:59272
1489 20465-20469 Gene denotes ACE2 Gene:59272
1490 19667-19672 Species denotes human Tax:9606
1491 19673-19676 Species denotes CoV Tax:11118
1492 19678-19687 Species denotes hCoV-NL63 Tax:277944
1493 19834-19844 Species denotes SARS-CoV-2 Tax:2697049
1494 19890-19899 Species denotes hCoV-NL63 Tax:277944
1496 20073-20083 Species denotes SARS-CoV-2 Tax:2697049
1497 20108-20112 Species denotes CoVs Tax:11118
1498 20250-20259 Species denotes novel CoV Tax:2697049
1499 20275-20281 Species denotes humans Tax:9606
1500 20341-20345 Species denotes CoVs Tax:11118
1501 20401-20404 Species denotes CoV Tax:11118
1502 20508-20518 Species denotes SARS-CoV-2 Tax:2697049
1503 20579-20582 Species denotes CoV Tax:11118
1505 20633-20637 Gene denotes ACE2 Gene:59272
1536 20706-20714 Species denotes patients Tax:9606
1537 21164-21172 Species denotes patients Tax:9606
1538 21832-21840 Species denotes patients Tax:9606
1539 22572-22580 Species denotes patients Tax:9606
1540 22611-22621 Species denotes SARS-CoV-2 Tax:2697049
1541 20697-20705 Disease denotes COVID-19 MESH:C000657245
1542 20822-20834 Disease denotes hypertension MESH:D006973
1543 20836-20859 Disease denotes cardiovascular diseases MESH:D002318
1544 20864-20888 Disease denotes type-2 diabetes mellitus MESH:D003924
1545 21155-21163 Disease denotes infected MESH:D007239
1546 21246-21258 Disease denotes hypertension MESH:D006973
1547 21268-21276 Disease denotes diabetes MESH:D003920
1548 21289-21312 Disease denotes cardiovascular diseases MESH:D002318
1549 21462-21474 Disease denotes hypertension MESH:D006973
1550 21484-21506 Disease denotes cardiovascular disease MESH:D002318
1551 21674-21682 Disease denotes COVID-19 MESH:C000657245
1552 21896-21908 Disease denotes hypertension MESH:D006973
1553 21913-21922 Disease denotes mortality MESH:D003643
1554 22010-22022 Disease denotes hypertension MESH:D006973
1555 22030-22038 Disease denotes diabetes MESH:D003920
1556 22050-22072 Disease denotes cardiovascular disease MESH:D002318
1557 22105-22113 Disease denotes Diabetes MESH:D003920
1558 22161-22165 Disease denotes ARDS MESH:D012128
1559 22179-22198 Disease denotes acute kidney injury MESH:D058186
1560 22212-22224 Disease denotes septic shock MESH:D012772
1561 22252-22261 Disease denotes mortality MESH:D003643
1562 22423-22432 Disease denotes mortality MESH:D003643
1563 22516-22524 Disease denotes COVID-19 MESH:C000657245
1564 22543-22550 Disease denotes obesity MESH:D009765
1565 22754-22763 Disease denotes mortality MESH:D003643
1571 23023-23027 Gene denotes ACE2 Gene:59272
1572 23184-23188 Gene denotes ACE2 Gene:59272
1573 23318-23328 Species denotes SARS-CoV-2 Tax:2697049
1574 22854-22866 Disease denotes hypertensive MESH:D006973
1575 23226-23244 Disease denotes SARS-CoV infection MESH:C000657245
1581 24293-24296 Gene denotes ACE Gene:1636
1582 23414-23424 Species denotes SARS-CoV-2 Tax:2697049
1583 24344-24352 Species denotes patients Tax:9606
1584 24363-24375 Disease denotes hypertension MESH:D006973
1585 24400-24421 Disease denotes coronavirus infection MESH:D018352
1595 24632-24636 Gene denotes ACE2 Gene:59272
1596 24691-24695 Gene denotes ACE2 Gene:59272
1597 24698-24702 Gene denotes ACE2 Gene:59272
1598 24849-24853 Gene denotes ACE2 Gene:59272
1599 24909-24919 Species denotes SARS-CoV-2 Tax:2697049
1600 24550-24565 Disease denotes viral infection MESH:D001102
1601 24786-24798 Disease denotes hypertension MESH:D006973
1602 24800-24822 Disease denotes cardiovascular disease MESH:D002318
1603 24827-24835 Disease denotes diabetes MESH:D003920
1611 25107-25111 Gene denotes ACE2 Gene:59272
1612 25278-25282 Gene denotes ACE2 Gene:59272
1613 25399-25403 Gene denotes ACE2 Gene:59272
1614 25128-25136 Gene denotes membrane Gene:43740571
1615 25153-25173 Disease denotes SARS-CoV-2 infection MESH:C000657245
1616 25334-25343 Disease denotes infection MESH:D007239
1617 25442-25462 Disease denotes respiratory distress MESH:D012128
1622 25809-25817 Species denotes patients Tax:9606
1623 25823-25831 Disease denotes COVID-19 MESH:C000657245
1624 25836-25848 Disease denotes hypertension MESH:D006973
1625 25937-25946 Disease denotes mortality MESH:D003643
1630 26210-26218 Species denotes patients Tax:9606
1631 26328-26336 Species denotes patients Tax:9606
1632 26224-26232 Disease denotes COVID-19 MESH:C000657245
1633 26342-26350 Disease denotes COVID-19 MESH:C000657245
1645 26632-26636 Gene denotes ACE2 Gene:59272
1646 26661-26665 Gene denotes ACE2 Gene:59272
1647 26794-26798 Gene denotes ACE2 Gene:59272
1648 26833-26837 Gene denotes SIT1 Gene:27240
1649 26589-26594 Species denotes human Tax:9606
1650 26723-26728 Species denotes human Tax:9606
1651 26729-26737 Species denotes patients Tax:9606
1652 26812-26820 Gene denotes membrane Gene:43740571
1653 26565-26585 Disease denotes SARS-CoV-2 infection MESH:C000657245
1654 26875-26883 Disease denotes COVID-19 MESH:C000657245
1655 26923-26935 Disease denotes hypertensive MESH:D006973
1657 26946-26950 Gene denotes ACE2 Gene:59272
1673 27261-27269 Species denotes patients Tax:9606
1674 27858-27866 Species denotes patients Tax:9606
1675 27027-27043 Disease denotes viral infections MESH:D001102
1676 27045-27052 Disease denotes COVID19 MESH:C000657245
1677 27180-27184 Disease denotes ARDS MESH:D012128
1678 27202-27213 Disease denotes lung injury MESH:D055370
1679 27316-27320 Disease denotes ARDS MESH:D012128
1680 27386-27394 Disease denotes COVID-19 MESH:C000657245
1681 27440-27449 Disease denotes pneumonia MESH:D011014
1682 27479-27499 Disease denotes microvascular damage MESH:D017566
1683 27648-27674 Disease denotes cardiovascular involvement MESH:D002318
1684 27718-27735 Disease denotes myocardial injury MESH:D009202
1685 27740-27752 Disease denotes sudden death MESH:D003645
1686 27782-27791 Disease denotes infection MESH:D007239
1687 27849-27857 Disease denotes COVID-19 MESH:C000657245
1703 28406-28411 Gene denotes IL-1β Gene:3552
1704 28413-28418 Gene denotes IFN-γ Gene:3458
1705 28420-28425 Gene denotes IP-10 Gene:3627
1706 28427-28432 Gene denotes MCP-1 Gene:6347
1707 28434-28438 Gene denotes IL-4 Gene:3565
1708 28444-28449 Gene denotes IL-10 Gene:3586
1709 28158-28166 Species denotes patients Tax:9606
1710 28272-28280 Species denotes patients Tax:9606
1711 28358-28366 Species denotes patients Tax:9606
1712 28470-28476 Species denotes people Tax:9606
1713 28492-28500 Species denotes patients Tax:9606
1714 28103-28112 Disease denotes infection MESH:D007239
1715 28229-28237 Disease denotes COVID-19 MESH:C000657245
1716 28242-28251 Disease denotes pneumonia MESH:D011014
1717 28281-28285 Disease denotes ARDS MESH:D012128
1725 28866-28870 Gene denotes ACE2 Gene:59272
1726 28954-28958 Gene denotes ACE2 Gene:59272
1727 29802-29807 Gene denotes NLRP3 Gene:114548
1728 29970-29979 Gene denotes caspase 1 Gene:834
1729 29744-29752 Gene denotes membrane Gene:43740571
1730 29348-29360 Disease denotes inflammation MESH:D007249
1731 30088-30100 Disease denotes inflammation MESH:D007249
1734 30227-30231 Gene denotes ACE2 Gene:59272
1735 30296-30306 Species denotes SARS-CoV-2 Tax:2697049
1746 30432-30437 Gene denotes NLRP3 Gene:114548
1747 30503-30519 Gene denotes IL-1β (Chen et a Gene:3552
1748 30638-30658 Gene denotes IL-1β (Huang C. et a Gene:3552
1749 30542-30550 Species denotes patients Tax:9606
1750 30315-30335 Disease denotes SARS-CoV-2 infection MESH:C000657245
1751 30533-30541 Disease denotes COVID-19 MESH:C000657245
1752 30690-30701 Disease denotes leucopoenia
1753 30706-30717 Disease denotes lymphopenia MESH:D008231
1754 30738-30756 Disease denotes COVID-19 pneumonia MESH:C000657245
1755 30811-30842 Disease denotes lymphocyte injury by pyroptosis MESH:D015451
1771 30944-30947 Gene denotes ACE Gene:1636
1772 30948-30952 Gene denotes ACE2 Gene:59272
1773 31016-31020 Gene denotes ACE2 Gene:59272
1774 31291-31295 Gene denotes AT1R Gene:185
1775 31349-31356 Gene denotes ADAM 17 Gene:6868
1776 31372-31376 Gene denotes TNFα Gene:7124
1777 31393-31397 Gene denotes TACE Gene:6868
1778 31479-31483 Gene denotes EGFR Gene:1956
1779 31489-31493 Gene denotes TNFα Gene:7124
1780 31639-31646 Gene denotes ADAM 17 Gene:6868
1781 31704-31710 Gene denotes IL-6Rα Gene:3570
1782 31722-31726 Gene denotes IL-6 Gene:3569
1783 31727-31732 Gene denotes STAT3 Gene:6774
1784 32041-32056 Gene denotes angiotensinogen Gene:183
1785 30930-30940 Species denotes SARS-CoV-2 Tax:2697049
1803 32159-32163 Gene denotes ACE2 Gene:59272
1804 32248-32252 Gene denotes ACE2 Gene:59272
1805 32378-32382 Gene denotes ACE2 Gene:59272
1806 32502-32509 Gene denotes ADAM 17 Gene:6868
1807 32552-32556 Gene denotes TNFα Gene:7124
1808 32616-32620 Gene denotes ACE2 Gene:59272
1809 32794-32798 Gene denotes ACE2 Gene:59272
1810 33029-33033 Gene denotes ACE2 Gene:59272
1811 33102-33108 Gene denotes ADAM17 Gene:6868
1812 32739-32744 Species denotes human Tax:9606
1813 32788-32793 Species denotes human Tax:9606
1814 32579-32587 Gene denotes membrane Gene:43740571
1815 32828-32853 Chemical denotes phorbol myristate acetate MESH:D013755
1816 32216-32228 Disease denotes inflammation MESH:D007249
1817 32745-32761 Disease denotes embryonic kidney MESH:D007674
1818 32769-32775 CellLine denotes HEK293 CVCL:0045
1819 32800-32808 CellLine denotes HEK-ACE2 CVCL:L310
1829 33256-33260 Gene denotes ACE2 Gene:59272
1830 33402-33406 Gene denotes ACE2 Gene:59272
1831 33544-33549 Gene denotes IL-1β Gene:3552
1832 33605-33609 Gene denotes ACE2 Gene:59272
1833 33772-33776 Gene denotes ACE2 Gene:59272
1834 33854-33860 Gene denotes ADAM17 Gene:6868
1835 33925-33935 Species denotes SARS-CoV-2 Tax:2697049
1836 33333-33348 Disease denotes viral infection MESH:D001102
1837 33816-33831 Disease denotes viral infection MESH:D001102
1849 34093-34103 Species denotes SARS-CoV-2 Tax:2697049
1850 34481-34491 Species denotes SARS-CoV-2 Tax:2697049
1851 34524-34534 Species denotes SARS-CoV-2 Tax:2697049
1852 34897-34907 Species denotes SARS-CoV-2 Tax:2697049
1853 34119-34128 Chemical denotes vitamin D MESH:D014807
1854 34253-34268 Disease denotes hypovitaminosis
1855 34296-34304 Disease denotes COVID-19 MESH:C000657245
1856 34616-34631 Disease denotes hypovitaminosis
1857 34638-34658 Disease denotes pulmonary infections MESH:D012141
1858 34715-34737 Disease denotes respiratory infections MESH:D012141
1859 34922-34931 Disease denotes mortality MESH:D003643
1861 34998-35002 Gene denotes ACE2 Gene:59272
1868 35050-35054 Gene denotes ACE2 Gene:59272
1869 35227-35231 Gene denotes ACE2 Gene:59272
1870 35156-35166 Species denotes SARS-CoV-2 Tax:2697049
1871 35096-35104 Disease denotes COVID-19 MESH:C000657245
1872 35241-35250 Disease denotes infection MESH:D007239
1873 35408-35419 Disease denotes lung injury MESH:D055370
1880 35562-35566 Gene denotes ACE2 Gene:59272
1881 35641-35646 Gene denotes ACE 2 Gene:59272
1882 35702-35706 Gene denotes ACE2 Gene:59272
1883 35748-35757 Gene denotes S-protein Gene:43740568
1884 35635-35640 Species denotes human Tax:9606
1885 35576-35585 Disease denotes infection MESH:D007239
1887 35796-35800 Gene denotes ACE2 Gene:59272
1889 35843-35847 Gene denotes ACE2 Gene:59272
1891 35850-35854 Gene denotes ACE2 Gene:59272
1907 35876-35880 Gene denotes ACE2 Gene:59272
1908 36400-36404 Gene denotes ACE2 Gene:59272
1909 36652-36656 Gene denotes ACE2 Gene:59272
1910 36758-36762 Gene denotes ACE2 Gene:59272
1911 36868-36872 Gene denotes ACE2 Gene:59272
1912 37057-37061 Gene denotes ACE2 Gene:59272
1913 36261-36269 Species denotes SARS-CoV Tax:694009
1914 36483-36491 Species denotes SARS-CoV Tax:694009
1915 36941-36957 Species denotes SARS coronavirus Tax:694009
1916 36693-36702 Gene denotes S-protein Gene:43740568
1917 36348-36386 Chemical denotes N-(2-aminoethyl)-1aziridine-ethanamine
1918 36388-36392 Chemical denotes NAAE
1919 36719-36723 Chemical denotes NAAE
1920 36904-36921 Disease denotes acute lung injury MESH:D055371
1921 36925-36935 Disease denotes infections MESH:D007239
1932 37218-37222 Gene denotes ACE2 Gene:59272
1933 37282-37286 Gene denotes ACE2 Gene:59272
1934 37433-37437 Gene denotes ACE2 Gene:59272
1935 37659-37690 Gene denotes angiotensin-converting enzyme 2 Gene:59272
1936 37336-37346 Species denotes SARS-CoV-2 Tax:2697049
1937 37653-37658 Species denotes human Tax:9606
1938 37703-37711 Species denotes patients Tax:9606
1939 37692-37698 Chemical denotes rhACE2
1940 37531-37542 Disease denotes lung injury MESH:D055370
1941 37717-37725 Disease denotes COVID-19 MESH:C000657245
1959 35641-35646 Gene denotes ACE 2 Gene:59272
1960 37869-37878 Gene denotes S-protein Gene:43740568
1961 38571-38576 Gene denotes hACE2 Gene:59272
1962 38724-38728 Gene denotes ACE2 Gene:59272
1963 38838-38842 Gene denotes ACE2 Gene:59272
1964 35635-35640 Species denotes human Tax:9606
1965 38032-38040 Species denotes patients Tax:9606
1966 38272-38280 Species denotes patients Tax:9606
2111 42564-42568 Gene denotes ACE2 Gene:59272
2114 42737-42741 Gene denotes ACE2 Gene:59272
1967 38439-38444 Species denotes human Tax:9606
1968 38472-38477 Species denotes human Tax:9606
1969 38633-38643 Species denotes SARS-CoV-2 Tax:2697049
1970 38740-38750 Species denotes SARS-CoV-2 Tax:2697049
1971 38166-38172 Chemical denotes rhACE2
1972 38352-38358 Chemical denotes rhACE2
1973 38023-38031 Disease denotes COVID-19 MESH:C000657245
1974 38286-38290 Disease denotes ARDS MESH:D012128
1975 38403-38424 Disease denotes SARS-CoV-2 infections MESH:C000657245
1979 38922-38926 Gene denotes ACE2 Gene:59272
1980 39269-39273 Gene denotes ACE2 Gene:59272
1981 39225-39240 Disease denotes viral infection MESH:D001102
1995 39583-39590 Gene denotes insulin Gene:3630
1996 39637-39641 Gene denotes ACE2 Gene:59272
1997 39743-39747 Gene denotes ACE2 Gene:59272
1998 39812-39826 Species denotes gut microbiome Tax:749906
1999 39668-39685 Disease denotes Hartnup’s disease MESH:D006250
2007 39863-39867 Gene denotes ACE2 Gene:59272
2008 39986-39990 Gene denotes ACE2 Gene:59272
2009 39991-39995 Gene denotes Ang1 Gene:284
2010 40020-40027 Gene denotes insulin Gene:3630
2011 40107-40111 Gene denotes ACE2 Gene:59272
2012 39998-40002 Gene denotes MasR Gene:116511
2013 39930-39949 Disease denotes glucose homeostasis MESH:D044882
2017 40257-40261 Gene denotes ACE2 Gene:59272
2018 40325-40329 Gene denotes ACE2 Gene:59272
2019 40277-40294 Disease denotes Alzheimer disease MESH:D000544
2038 40476-40480 Gene denotes ACE2 Gene:59272
2039 40764-40768 Gene denotes ACE2 Gene:59272
2040 40831-40835 Gene denotes ACE2 Gene:59272
2041 40946-40950 Gene denotes ACE2 Gene:70008
2042 41117-41121 Gene denotes ACE2 Gene:70008
2043 41149-41159 Gene denotes E-cadherin Gene:999
2044 41203-41211 Gene denotes vimentin Gene:7431
2045 40733-40741 Species denotes patients Tax:9606
2046 40898-40903 Species denotes human Tax:9606
2047 40918-40922 Species denotes mice Tax:10090
2048 40468-40474 Disease denotes cancer MESH:D009369
2049 40502-40508 Disease denotes cancer MESH:D009369
2051 40708-40732 Disease denotes hepatocellular carcinoma MESH:D006528
2052 40961-40966 Disease denotes tumor MESH:D009369
2053 41018-41044 Disease denotes Non-Small Cell Lung Cancer MESH:D002289
2054 41046-41051 Disease denotes NSCLC MESH:D002289
2055 41275-41280 Disease denotes NSCLC MESH:D002289
2062 41518-41522 Gene denotes ACE2 Gene:59272
2063 41359-41367 Species denotes patients Tax:9606
2064 41347-41358 Disease denotes lung cancer MESH:D008175
2065 41380-41388 Disease denotes COVID-19 MESH:C000657245
2066 41501-41513 Disease denotes malignancies MESH:D009369
2067 41610-41616 Disease denotes cancer MESH:D009369
2071 41688-41692 Gene denotes ACE2 Gene:59272
2072 41775-41779 Gene denotes ACE2 Gene:59272
2073 41714-41720 Disease denotes cancer MESH:D009369
2084 41833-41837 Gene denotes ACE2 Gene:59272
2085 42100-42104 Gene denotes ACE2 Gene:59272
2086 41875-41881 Disease denotes tumors MESH:D009369
2087 41883-41903 Disease denotes colon adenocarcinoma MESH:D003110
2088 41912-41949 Disease denotes kidney renal papillary cell carcinoma MESH:C538614
2089 41958-41983 Disease denotes pancreatic adenocarcinoma MESH:D000230
2090 41992-42013 Disease denotes rectum adenocarcinoma MESH:D012004
2091 42022-42044 Disease denotes stomach adenocarcinoma MESH:D000230
2092 42057-42076 Disease denotes lung adenocarcinoma MESH:D000077192
2093 42136-42164 Disease denotes lung squamous cell carcinoma MESH:D002294
2099 42178-42182 Gene denotes ACE2 Gene:59272
2100 42224-42230 Disease denotes tumors MESH:D009369
2101 42261-42278 Disease denotes thyroid carcinoma MESH:D013964
2102 42291-42309 Disease denotes kidney chromophobe MESH:D000238
2103 42311-42315 Disease denotes KICH
2106 42334-42338 Gene denotes ACE2 Gene:59272
2107 42419-42423 Gene denotes ACE2 Gene:59272
2110 42505-42509 Gene denotes ACE2 Gene:59272
2115 42756-42763 Species denotes patient Tax:9606
2122 42871-42875 Gene denotes ACE2 Gene:59272
2123 43056-43060 Gene denotes ACE2 Gene:59272
2124 43194-43198 Gene denotes ACE2 Gene:59272
2125 42967-42975 Chemical denotes Oncomine
2126 43039-43044 Disease denotes tumor MESH:D009369
2127 43159-43180 Disease denotes endometrial carcinoma MESH:D016889
950 52-56 Gene denotes ACE2 Gene:59272
951 916-920 Gene denotes ACE2 Gene:59272
952 525-526 Gene denotes S Gene:43740568
953 369-380 Species denotes coronavirus Tax:11118
954 398-406 Species denotes SARS-CoV Tax:694009
955 94-123 Disease denotes respiratory infective disease MESH:D012141
956 740-791 Disease denotes SARS-CoV efficiently infected African Monkey kidney MESH:C000657245
957 807-809 CellLine denotes E6 CVCL:4582
976 1707-1711 Gene denotes ACE2 Gene:59272
977 1834-1838 Gene denotes ACE2 Gene:59272
978 940-948 Species denotes SARS-CoV Tax:694009
979 1069-1080 Species denotes coronavirus Tax:11118
980 1094-1099 Species denotes human Tax:9606
981 1249-1264 Species denotes new coronavirus Tax:2697049
982 1286-1296 Species denotes SARS-CoV-2 Tax:2697049
983 1330-1338 Species denotes SARS-CoV Tax:694009
984 1471-1481 Species denotes SARS-CoV-2 Tax:2697049
985 1683-1693 Species denotes SARS-CoV-2 Tax:2697049
986 1830-1833 Species denotes CoV Tax:11118
987 1004-1014 Disease denotes infections MESH:D007239
988 1167-1172 Disease denotes fever MESH:D005334
989 1181-1203 Disease denotes respiratory impairment MESH:D012131
990 1209-1218 Disease denotes pneumonia MESH:D011014
991 1396-1420 Disease denotes COronaVIrus Disease 2019 MESH:C000657245
992 1628-1636 Disease denotes COVID-19 MESH:C000657245
993 1735-1744 Disease denotes infection MESH:D007239

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T2682 14-18 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2683 52-56 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2684 505-523 Protein denotes spike glycoprotein https://www.uniprot.org/uniprot/Q9QAS2|https://www.uniprot.org/uniprot/Q9QAR5|https://www.uniprot.org/uniprot/Q9QAQ8|https://www.uniprot.org/uniprot/Q9IW04|https://www.uniprot.org/uniprot/Q9IKD1|https://www.uniprot.org/uniprot/Q990M4|https://www.uniprot.org/uniprot/Q990M3|https://www.uniprot.org/uniprot/Q990M2|https://www.uniprot.org/uniprot/Q990M1|https://www.uniprot.org/uniprot/Q91AV1|https://www.uniprot.org/uniprot/Q91A26|https://www.uniprot.org/uniprot/Q8V436|https://www.uniprot.org/uniprot/Q8JSP8|https://www.uniprot.org/uniprot/Q8BB25|https://www.uniprot.org/uniprot/Q86623|https://www.uniprot.org/uniprot/Q85088|https://www.uniprot.org/uniprot/Q85087|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q80BV6|https://www.uniprot.org/uniprot/Q7TFB1|https://www.uniprot.org/uniprot/Q7TFA2|https://www.uniprot.org/uniprot/Q7TA19|https://www.uniprot.org/uniprot/Q7T6T3|https://www.uniprot.org/uniprot/Q7T696|https://www.uniprot.org/uniprot/Q77NC4|https://www.uniprot.org/uniprot/Q6TNF9|https://www.uniprot.org/uniprot/Q6R1L7|https://www.uniprot.org/uniprot/Q6QU82|https://www.uniprot.org/uniprot/Q6Q1S2|https://www.uniprot.org/uniprot/Q696Q6|https://www.uniprot.org/uniprot/Q66291|https://www.uniprot.org/uniprot/Q66290|https://www.uniprot.org/uniprot/Q66199|https://www.uniprot.org/uniprot/Q66177|https://www.uniprot.org/uniprot/Q66176|https://www.uniprot.org/uniprot/Q66174|https://www.uniprot.org/uniprot/Q65984|https://www.uniprot.org/uniprot/Q5MQD0|https://www.uniprot.org/uniprot/Q5I5X9|https://www.uniprot.org/uniprot/Q5DIY0|https://www.uniprot.org/uniprot/Q5DIX9|https://www.uniprot.org/uniprot/Q5DIX8|https://www.uniprot.org/uniprot/Q5DIX7|https://www.uniprot.org/uniprot/Q52PA3|https://www.uniprot.org/uniprot/Q4ZJS1|https://www.uniprot.org/uniprot/Q4U5G0|https://www.uniprot.org/uniprot/Q3T8J0|https://www.uniprot.org/uniprot/Q3LZX1|https://www.uniprot.org/uniprot/Q3I5J5|https://www.uniprot.org/uniprot/Q14EB0|https://www.uniprot.org/uniprot/Q0ZME7|https://www.uniprot.org/uniprot/Q0Q4F2|https://www.uniprot.org/uniprot/Q0Q475|https://www.uniprot.org/uniprot/Q0Q466|https://www.uniprot.org/uniprot/Q0GNB8|https://www.uniprot.org/uniprot/Q02385|https://www.uniprot.org/uniprot/Q02167|https://www.uniprot.org/uniprot/Q01977|https://www.uniprot.org/uniprot/Q008X4|https://www.uniprot.org/uniprot/P89344|https://www.uniprot.org/uniprot/P89343|https://www.uniprot.org/uniprot/P89342|https://www.uniprot.org/uniprot/P59594|https://www.uniprot.org/uniprot/P36334|https://www.uniprot.org/uniprot/P36300|https://www.uniprot.org/uniprot/P33470|https://www.uniprot.org/uniprot/P30208|https://www.uniprot.org/uniprot/P30207|https://www.uniprot.org/uniprot/P30206|https://www.uniprot.org/uniprot/P27662|https://www.uniprot.org/uniprot/P27655|https://www.uniprot.org/uniprot/P27277|https://www.uniprot.org/uniprot/P25194|https://www.uniprot.org/uniprot/P25193|https://www.uniprot.org/uniprot/P25192|https://www.uniprot.org/uniprot/P25191|https://www.uniprot.org/uniprot/P25190|https://www.uniprot.org/uniprot/P24413|https://www.uniprot.org/uniprot/P23052|https://www.uniprot.org/uniprot/P22432|https://www.uniprot.org/uniprot/P18450|https://www.uniprot.org/uniprot/P17662|https://www.uniprot.org/uniprot/P15777|https://www.uniprot.org/uniprot/P15423|https://www.uniprot.org/uniprot/P12722|https://www.uniprot.org/uniprot/P12651|https://www.uniprot.org/uniprot/P12650|https://www.uniprot.org/uniprot/P12647|https://www.uniprot.org/uniprot/P11225|https://www.uniprot.org/uniprot/P11224|https://www.uniprot.org/uniprot/P11223|https://www.uniprot.org/uniprot/P10033|https://www.uniprot.org/uniprot/P0DTC2|https://www.uniprot.org/uniprot/P07946|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P05135|https://www.uniprot.org/uniprot/P05134|https://www.uniprot.org/uniprot/O90304|https://www.uniprot.org/uniprot/O39227|https://www.uniprot.org/uniprot/K9N5Q8|https://www.uniprot.org/uniprot/A3EXG6|https://www.uniprot.org/uniprot/A3EXD0|https://www.uniprot.org/uniprot/A3EX94
T2788 838-850 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T2873 916-920 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2874 1707-1711 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2875 1834-1838 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2876 1895-1904 Protein denotes S Protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T2909 1933-1952 Protein denotes structural proteins https://www.uniprot.org/uniprot/Q6LEG6|https://www.uniprot.org/uniprot/Q04766|https://www.uniprot.org/uniprot/Q04765
T2912 2366-2378 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T2997 2549-2558 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3030 2776-2785 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3063 3161-3175 Protein denotes spike” protein https://www.uniprot.org/uniprot/P31340
T3064 3208-3217 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3097 3814-3817 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3106 3828-3831 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3115 4573-4583 Protein denotes S proteins https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3148 4715-4719 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3149 4865-4869 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3150 5055-5059 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3151 5158-5161 Protein denotes APN https://www.uniprot.org/uniprot/Q9UCE0|https://www.uniprot.org/uniprot/Q9JHP4|https://www.uniprot.org/uniprot/Q99K63|https://www.uniprot.org/uniprot/Q91YH8|https://www.uniprot.org/uniprot/Q8IVH3|https://www.uniprot.org/uniprot/Q8IUK3|https://www.uniprot.org/uniprot/Q6GT90|https://www.uniprot.org/uniprot/Q3MHR1|https://www.uniprot.org/uniprot/Q29242|https://www.uniprot.org/uniprot/Q16728|https://www.uniprot.org/uniprot/Q10737|https://www.uniprot.org/uniprot/P97449|https://www.uniprot.org/uniprot/P91887|https://www.uniprot.org/uniprot/P91885|https://www.uniprot.org/uniprot/P81731|https://www.uniprot.org/uniprot/P79171|https://www.uniprot.org/uniprot/P79143|https://www.uniprot.org/uniprot/P79098|https://www.uniprot.org/uniprot/P15684|https://www.uniprot.org/uniprot/P15541|https://www.uniprot.org/uniprot/P15145|https://www.uniprot.org/uniprot/P15144|https://www.uniprot.org/uniprot/O97783|https://www.uniprot.org/uniprot/F1PCB5
T3175 5352-5356 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3176 5782-5791 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3209 6019-6022 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3218 6259-6262 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3227 6643-6646 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3236 7894-7903 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3269 8269-8277 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T3513 8548-8557 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3546 8882-8891 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3579 8956-8959 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3588 9175-9179 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3589 9567-9575 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T3833 9576-9581 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T3841 9667-9679 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T3926 9812-9817 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T3934 9966-9974 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4178 10020-10025 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4186 10030-10035 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4194 10071-10093 Protein denotes trypsin-like proteases https://www.uniprot.org/uniprot/Q9UBX7|https://www.uniprot.org/uniprot/Q9NS65|https://www.uniprot.org/uniprot/Q8IXD7|https://www.uniprot.org/uniprot/Q0WXX5|https://www.uniprot.org/uniprot/O75837
T4199 10257-10268 Protein denotes cathepsin L https://www.uniprot.org/uniprot/Q9QV07|https://www.uniprot.org/uniprot/Q9GL24|https://www.uniprot.org/uniprot/Q9GKL8|https://www.uniprot.org/uniprot/Q96QJ0|https://www.uniprot.org/uniprot/Q95029|https://www.uniprot.org/uniprot/Q91UZ0|https://www.uniprot.org/uniprot/Q6IAV1|https://www.uniprot.org/uniprot/Q5U121|https://www.uniprot.org/uniprot/Q3T0P2|https://www.uniprot.org/uniprot/Q28944|https://www.uniprot.org/uniprot/Q26636|https://www.uniprot.org/uniprot/Q26534|https://www.uniprot.org/uniprot/Q10991|https://www.uniprot.org/uniprot/P25975|https://www.uniprot.org/uniprot/P25773|https://www.uniprot.org/uniprot/P09648|https://www.uniprot.org/uniprot/P07711|https://www.uniprot.org/uniprot/P07154|https://www.uniprot.org/uniprot/P06797|https://www.uniprot.org/uniprot/O97431|https://www.uniprot.org/uniprot/O77502|https://www.uniprot.org/uniprot/M3WXJ1
T4221 10486-10494 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4465 10816-10821 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4473 10998-11006 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4717 11271-11279 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4961 11553-11556 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4970 11575-11579 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T4971 11705-11708 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4980 11737-11740 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4989 11776-11785 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5022 11920-11923 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5031 12038-12041 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5040 12149-12153 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5041 12183-12186 Protein denotes HEK https://www.uniprot.org/uniprot/Q9H2V4|https://www.uniprot.org/uniprot/Q9H2V3|https://www.uniprot.org/uniprot/P29320
T5044 12302-12306 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5045 12360-12364 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5046 12425-12428 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5055 12532-12535 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5064 12975-12978 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5073 13236-13240 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5074 13349-13352 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5083 13416-13419 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5092 13615-13618 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5101 13624-13628 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5102 13712-13715 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5111 13799-13808 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5144 13818-13821 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5153 13943-13947 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5154 13948-13951 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5163 14183-14186 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5172 14212-14216 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5173 14250-14253 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5182 14444-14448 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5183 14603-14607 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5184 14651-14660 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5217 14778-14781 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5226 14845-14848 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5235 15126-15130 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5236 15164-15167 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5245 15227-15236 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5278 15470-15481 Protein denotes (S) protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5311 15507-15511 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5312 15567-15570 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5334 15607-15610 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5356 15656-15659 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5378 15696-15699 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5387 15709-15712 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5409 15749-15752 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5418 15760-15763 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5440 15805-15808 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5462 15981-15985 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5463 15986-15989 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5472 16070-16074 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5473 16149-16152 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5482 16251-16255 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5483 16273-16276 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5492 16514-16518 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5493 16530-16533 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5502 16831-16840 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5535 16846-16849 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5544 16952-16955 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5553 16970-16974 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5554 17035-17039 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5555 17062-17071 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5588 17188-17192 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5589 17202-17205 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5598 17210-17214 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5599 17226-17229 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5608 17409-17413 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5609 17560-17563 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5618 18007-18011 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5619 18207-18211 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5620 18451-18455 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5621 18537-18541 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5622 18653-18657 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5623 18820-18824 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5624 19016-19020 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5625 19084-19087 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5634 19438-19442 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5635 19495-19504 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5668 19614-19618 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5669 19722-19726 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5670 19931-19934 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5679 20011-20014 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5704 20161-20165 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5705 20351-20355 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5706 20411-20415 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5707 20465-20469 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5708 20633-20637 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5709 22882-22885 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5734 23023-23027 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5735 23184-23188 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5736 24293-24296 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5761 24311-24322 Protein denotes angiotensin https://www.uniprot.org/uniprot/Q10757
T5762 24632-24636 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5763 24691-24695 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5764 24698-24702 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5765 24849-24853 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5766 25107-25111 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5767 25278-25282 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5768 25399-25403 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5769 26632-26636 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5770 26661-26665 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5771 26794-26798 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5772 26946-26950 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5773 28420-28425 Protein denotes IP-10 https://www.uniprot.org/uniprot/Q96QJ5|https://www.uniprot.org/uniprot/Q8MIZ1|https://www.uniprot.org/uniprot/Q865F5|https://www.uniprot.org/uniprot/Q6GTC7|https://www.uniprot.org/uniprot/P70538|https://www.uniprot.org/uniprot/P48973|https://www.uniprot.org/uniprot/P17515|https://www.uniprot.org/uniprot/P02778
T5781 28427-28432 Protein denotes MCP-1 https://www.uniprot.org/uniprot/Q9UDF3|https://www.uniprot.org/uniprot/Q9TTQ3|https://www.uniprot.org/uniprot/Q9QYD7|https://www.uniprot.org/uniprot/Q9MYN4|https://www.uniprot.org/uniprot/Q549R5|https://www.uniprot.org/uniprot/Q08782|https://www.uniprot.org/uniprot/P61275|https://www.uniprot.org/uniprot/P61274|https://www.uniprot.org/uniprot/P52203|https://www.uniprot.org/uniprot/P42831|https://www.uniprot.org/uniprot/P28292|https://www.uniprot.org/uniprot/P28291|https://www.uniprot.org/uniprot/P14844|https://www.uniprot.org/uniprot/P13500|https://www.uniprot.org/uniprot/P10148|https://www.uniprot.org/uniprot/B2R4V3|https://www.uniprot.org/uniprot/A9QWP7
T5798 28434-28438 Protein denotes IL-4 https://www.uniprot.org/uniprot/Q9XS58|https://www.uniprot.org/uniprot/Q9MZR8|https://www.uniprot.org/uniprot/Q9GL85|https://www.uniprot.org/uniprot/Q95MZ6|https://www.uniprot.org/uniprot/Q8MKE6|https://www.uniprot.org/uniprot/Q8HYB1|https://www.uniprot.org/uniprot/Q865Y0|https://www.uniprot.org/uniprot/Q865X5|https://www.uniprot.org/uniprot/Q7YS71|https://www.uniprot.org/uniprot/Q6YL20|https://www.uniprot.org/uniprot/Q6NZ77|https://www.uniprot.org/uniprot/Q60440|https://www.uniprot.org/uniprot/Q58M18|https://www.uniprot.org/uniprot/Q3S4V6|https://www.uniprot.org/uniprot/Q2PE74|https://www.uniprot.org/uniprot/Q29054|https://www.uniprot.org/uniprot/Q14630|https://www.uniprot.org/uniprot/Q0MS73|https://www.uniprot.org/uniprot/Q0MS70|https://www.uniprot.org/uniprot/Q04745|https://www.uniprot.org/uniprot/P79339|https://www.uniprot.org/uniprot/P79170|https://www.uniprot.org/uniprot/P79155|https://www.uniprot.org/uniprot/P55030|https://www.uniprot.org/uniprot/P51744|https://www.uniprot.org/uniprot/P51492|https://www.uniprot.org/uniprot/P47966|https://www.uniprot.org/uniprot/P46652|https://www.uniprot.org/uniprot/P42202|https://www.uniprot.org/uniprot/P30368|https://www.uniprot.org/uniprot/P30367|https://www.uniprot.org/uniprot/P20096|https://www.uniprot.org/uniprot/P07750|https://www.uniprot.org/uniprot/P05112|https://www.uniprot.org/uniprot/O77762|https://www.uniprot.org/uniprot/O70330|https://www.uniprot.org/uniprot/O62774|https://www.uniprot.org/uniprot/O46393|https://www.uniprot.org/uniprot/A9QWQ7|https://www.uniprot.org/uniprot/A1E293
T5838 28444-28449 Protein denotes IL-10 https://www.uniprot.org/uniprot/Q9Z1Y5|https://www.uniprot.org/uniprot/Q9TSJ7|https://www.uniprot.org/uniprot/Q9TSJ4|https://www.uniprot.org/uniprot/Q9JHK7|https://www.uniprot.org/uniprot/Q8MKG9|https://www.uniprot.org/uniprot/Q865X4|https://www.uniprot.org/uniprot/Q6A2H5|https://www.uniprot.org/uniprot/Q6A2H4|https://www.uniprot.org/uniprot/Q63263|https://www.uniprot.org/uniprot/Q5Q0V6|https://www.uniprot.org/uniprot/Q2PE73|https://www.uniprot.org/uniprot/Q29408|https://www.uniprot.org/uniprot/Q29055|https://www.uniprot.org/uniprot/Q28374|https://www.uniprot.org/uniprot/Q25BC1|https://www.uniprot.org/uniprot/Q1W5D6|https://www.uniprot.org/uniprot/Q0Z972|https://www.uniprot.org/uniprot/Q0VBJ1|https://www.uniprot.org/uniprot/P79338|https://www.uniprot.org/uniprot/P55029|https://www.uniprot.org/uniprot/P51746|https://www.uniprot.org/uniprot/P51497|https://www.uniprot.org/uniprot/P51496|https://www.uniprot.org/uniprot/P48411|https://www.uniprot.org/uniprot/P47965|https://www.uniprot.org/uniprot/P46651|https://www.uniprot.org/uniprot/P43480|https://www.uniprot.org/uniprot/P29456|https://www.uniprot.org/uniprot/P22301|https://www.uniprot.org/uniprot/P18893|https://www.uniprot.org/uniprot/O97798|https://www.uniprot.org/uniprot/O46673|https://www.uniprot.org/uniprot/A9QWR2|https://www.uniprot.org/uniprot/A2T6Z6
T5872 28866-28870 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5873 28954-28958 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5874 29791-29800 Protein denotes protein 3 https://www.uniprot.org/uniprot/Q9JGT9|https://www.uniprot.org/uniprot/Q98663|https://www.uniprot.org/uniprot/Q8V3T9|https://www.uniprot.org/uniprot/Q6UBL8|https://www.uniprot.org/uniprot/Q6Q1S1|https://www.uniprot.org/uniprot/Q6E0W9|https://www.uniprot.org/uniprot/Q68Y30|https://www.uniprot.org/uniprot/Q5GA88|https://www.uniprot.org/uniprot/Q3LZX0|https://www.uniprot.org/uniprot/Q3I5J4|https://www.uniprot.org/uniprot/Q12988|https://www.uniprot.org/uniprot/Q0Q474|https://www.uniprot.org/uniprot/Q02967|https://www.uniprot.org/uniprot/Q00967|https://www.uniprot.org/uniprot/P09522|https://www.uniprot.org/uniprot/P05398|https://www.uniprot.org/uniprot/P03553|https://www.uniprot.org/uniprot/P03552|https://www.uniprot.org/uniprot/P03551
T5893 29836-29845 Protein denotes a protein https://www.uniprot.org/uniprot/Q38365|https://www.uniprot.org/uniprot/P25244|https://www.uniprot.org/uniprot/P25243|https://www.uniprot.org/uniprot/P15966|https://www.uniprot.org/uniprot/P09676|https://www.uniprot.org/uniprot/P07394|https://www.uniprot.org/uniprot/P03632|https://www.uniprot.org/uniprot/P03610|https://www.uniprot.org/uniprot/O64306
T5902 29846-29853 Protein denotes caspase https://www.uniprot.org/uniprot/Q9VAH1|https://www.uniprot.org/uniprot/O01382
T5904 29874-29877 Protein denotes ASC https://www.uniprot.org/uniprot/P50427|https://www.uniprot.org/uniprot/P15589|https://www.uniprot.org/uniprot/P08842|https://www.uniprot.org/uniprot/B2RA47
T5908 29934-29941 Protein denotes caspase https://www.uniprot.org/uniprot/Q9VAH1|https://www.uniprot.org/uniprot/O01382
T5910 29970-29979 Protein denotes caspase 1 https://www.uniprot.org/uniprot/Q9W1N0|https://www.uniprot.org/uniprot/Q9UCN3|https://www.uniprot.org/uniprot/Q9TV13|https://www.uniprot.org/uniprot/Q9N2I1|https://www.uniprot.org/uniprot/Q9MZV7|https://www.uniprot.org/uniprot/Q9MZV6|https://www.uniprot.org/uniprot/Q6PI75|https://www.uniprot.org/uniprot/Q6GSS3|https://www.uniprot.org/uniprot/Q6DMQ1|https://www.uniprot.org/uniprot/Q53EY6|https://www.uniprot.org/uniprot/P89116|https://www.uniprot.org/uniprot/P43527|https://www.uniprot.org/uniprot/P29466|https://www.uniprot.org/uniprot/P29452|https://www.uniprot.org/uniprot/O02002|https://www.uniprot.org/uniprot/B5MDZ1
T5926 30227-30231 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5927 30944-30947 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5952 30948-30952 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5953 31016-31020 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5954 31313-31324 Protein denotes disintegrin https://www.uniprot.org/uniprot/Q9YI19|https://www.uniprot.org/uniprot/Q9PVK9|https://www.uniprot.org/uniprot/Q9IAX6|https://www.uniprot.org/uniprot/Q7SZE0|https://www.uniprot.org/uniprot/Q7SZD7|https://www.uniprot.org/uniprot/Q7SZD6|https://www.uniprot.org/uniprot/Q5EE07|https://www.uniprot.org/uniprot/P0DMH4|https://www.uniprot.org/uniprot/P0C6E3|https://www.uniprot.org/uniprot/O73795|https://www.uniprot.org/uniprot/E9NW26
T5965 31349-31356 Protein denotes ADAM 17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T5974 31446-31469 Protein denotes epidermal growth factor https://www.uniprot.org/uniprot/Q9GU69|https://www.uniprot.org/uniprot/Q9BEA0|https://www.uniprot.org/uniprot/Q9BDQ0|https://www.uniprot.org/uniprot/Q95ND4|https://www.uniprot.org/uniprot/Q6P9J2|https://www.uniprot.org/uniprot/Q63183|https://www.uniprot.org/uniprot/Q569W5|https://www.uniprot.org/uniprot/Q52LZ6|https://www.uniprot.org/uniprot/Q00968|https://www.uniprot.org/uniprot/P07522|https://www.uniprot.org/uniprot/P01133|https://www.uniprot.org/uniprot/P01132|https://www.uniprot.org/uniprot/O62759|https://www.uniprot.org/uniprot/E9QNX6|https://www.uniprot.org/uniprot/E9PBF0|https://www.uniprot.org/uniprot/E7EVD2|https://www.uniprot.org/uniprot/B4DRK7
T5991 31639-31646 Protein denotes ADAM 17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6000 31722-31726 Protein denotes IL-6 https://www.uniprot.org/uniprot/Q9XT80|https://www.uniprot.org/uniprot/Q9UCU4|https://www.uniprot.org/uniprot/Q9UCU3|https://www.uniprot.org/uniprot/Q9UCU2|https://www.uniprot.org/uniprot/Q9MZR1|https://www.uniprot.org/uniprot/Q9MYZ7|https://www.uniprot.org/uniprot/Q95KN6|https://www.uniprot.org/uniprot/Q95181|https://www.uniprot.org/uniprot/Q90YI0|https://www.uniprot.org/uniprot/Q8MKH0|https://www.uniprot.org/uniprot/Q8BN26|https://www.uniprot.org/uniprot/Q865X6|https://www.uniprot.org/uniprot/Q865W7|https://www.uniprot.org/uniprot/Q6V919|https://www.uniprot.org/uniprot/Q6L6X6|https://www.uniprot.org/uniprot/Q5I6E3|https://www.uniprot.org/uniprot/Q3UCQ0|https://www.uniprot.org/uniprot/Q2MH06|https://www.uniprot.org/uniprot/Q28819|https://www.uniprot.org/uniprot/Q28747|https://www.uniprot.org/uniprot/Q28319|https://www.uniprot.org/uniprot/Q25BC2|https://www.uniprot.org/uniprot/Q0PW36|https://www.uniprot.org/uniprot/Q0GGL7|https://www.uniprot.org/uniprot/Q08DT2|https://www.uniprot.org/uniprot/P79341|https://www.uniprot.org/uniprot/P51494|https://www.uniprot.org/uniprot/P46650|https://www.uniprot.org/uniprot/P41693|https://www.uniprot.org/uniprot/P41683|https://www.uniprot.org/uniprot/P41323|https://www.uniprot.org/uniprot/P29455|https://www.uniprot.org/uniprot/P26893|https://www.uniprot.org/uniprot/P26892|https://www.uniprot.org/uniprot/P20607|https://www.uniprot.org/uniprot/P08505|https://www.uniprot.org/uniprot/P05231|https://www.uniprot.org/uniprot/O46568|https://www.uniprot.org/uniprot/O35736|https://www.uniprot.org/uniprot/O19007|https://www.uniprot.org/uniprot/B6CKP4|https://www.uniprot.org/uniprot/A9QWQ9|https://www.uniprot.org/uniprot/A3FBE9|https://www.uniprot.org/uniprot/A0S0B0
T6044 32041-32056 Protein denotes angiotensinogen https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T6061 32159-32163 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6062 32248-32252 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6063 32378-32382 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6064 32502-32509 Protein denotes ADAM 17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6073 32514-32525 Protein denotes disintegrin https://www.uniprot.org/uniprot/Q9YI19|https://www.uniprot.org/uniprot/Q9PVK9|https://www.uniprot.org/uniprot/Q9IAX6|https://www.uniprot.org/uniprot/Q7SZE0|https://www.uniprot.org/uniprot/Q7SZD7|https://www.uniprot.org/uniprot/Q7SZD6|https://www.uniprot.org/uniprot/Q5EE07|https://www.uniprot.org/uniprot/P0DMH4|https://www.uniprot.org/uniprot/P0C6E3|https://www.uniprot.org/uniprot/O73795|https://www.uniprot.org/uniprot/E9NW26
T6084 32616-32620 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6085 32745-32754 Protein denotes embryonic https://www.uniprot.org/uniprot/P02301
T6086 32794-32798 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6087 32800-32803 Protein denotes HEK https://www.uniprot.org/uniprot/Q9H2V4|https://www.uniprot.org/uniprot/Q9H2V3|https://www.uniprot.org/uniprot/P29320
T6090 32804-32808 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6091 33029-33033 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6092 33102-33108 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6101 33165-33192 Protein denotes metalloproteinase inhibitor https://www.uniprot.org/uniprot/Q9DGI0|https://www.uniprot.org/uniprot/Q98TC1|https://www.uniprot.org/uniprot/P29695
T6104 33214-33234 Protein denotes protease inhibitor 1 https://www.uniprot.org/uniprot/C1IC50
T6105 33256-33260 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6106 33402-33406 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6107 33605-33609 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6108 33772-33776 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6109 33854-33860 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6118 34998-35002 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6119 35050-35054 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6120 35227-35231 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6121 35562-35566 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6122 35641-35644 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6147 35702-35706 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6148 35748-35757 Protein denotes S-protein https://www.uniprot.org/uniprot/Q9D080|https://www.uniprot.org/uniprot/Q9BSH7|https://www.uniprot.org/uniprot/Q91X32|https://www.uniprot.org/uniprot/Q8VII4|https://www.uniprot.org/uniprot/Q5SYG4|https://www.uniprot.org/uniprot/P48819|https://www.uniprot.org/uniprot/P29788|https://www.uniprot.org/uniprot/P22458|https://www.uniprot.org/uniprot/P04004|https://www.uniprot.org/uniprot/P01141|https://www.uniprot.org/uniprot/B2R7G0
T6159 35796-35800 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6160 35843-35847 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6161 35850-35854 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6162 35876-35880 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6163 36400-36404 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6164 36652-36656 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6165 36693-36702 Protein denotes S-protein https://www.uniprot.org/uniprot/Q9D080|https://www.uniprot.org/uniprot/Q9BSH7|https://www.uniprot.org/uniprot/Q91X32|https://www.uniprot.org/uniprot/Q8VII4|https://www.uniprot.org/uniprot/Q5SYG4|https://www.uniprot.org/uniprot/P48819|https://www.uniprot.org/uniprot/P29788|https://www.uniprot.org/uniprot/P22458|https://www.uniprot.org/uniprot/P04004|https://www.uniprot.org/uniprot/P01141|https://www.uniprot.org/uniprot/B2R7G0
T6176 36758-36762 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6177 36868-36872 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6178 37057-37061 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6179 37157-37161 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6180 37218-37222 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6181 37282-37286 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6182 37433-37437 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6183 37659-37690 Protein denotes angiotensin-converting enzyme 2 https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1
T6198 37769-37772 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6223 37869-37878 Protein denotes S-protein https://www.uniprot.org/uniprot/Q9D080|https://www.uniprot.org/uniprot/Q9BSH7|https://www.uniprot.org/uniprot/Q91X32|https://www.uniprot.org/uniprot/Q8VII4|https://www.uniprot.org/uniprot/Q5SYG4|https://www.uniprot.org/uniprot/P48819|https://www.uniprot.org/uniprot/P29788|https://www.uniprot.org/uniprot/P22458|https://www.uniprot.org/uniprot/P04004|https://www.uniprot.org/uniprot/P01141|https://www.uniprot.org/uniprot/B2R7G0
T6234 38644-38647 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T6243 38724-38728 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6244 38751-38754 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T6253 38838-38842 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6254 38922-38926 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6255 39269-39273 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6256 39352-39356 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6257 39376-39380 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6258 39472-39476 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6259 39514-39524 Protein denotes collectrin https://www.uniprot.org/uniprot/Q9HBJ8|https://www.uniprot.org/uniprot/Q9ESG4|https://www.uniprot.org/uniprot/Q9ESG3|https://www.uniprot.org/uniprot/Q6UW07|https://www.uniprot.org/uniprot/Q6AYY2|https://www.uniprot.org/uniprot/Q3UFF6|https://www.uniprot.org/uniprot/Q0VCT4|https://www.uniprot.org/uniprot/B2R9M1
T6267 39583-39590 Protein denotes insulin https://www.uniprot.org/uniprot/Q9W7R2|https://www.uniprot.org/uniprot/Q9W653|https://www.uniprot.org/uniprot/Q9TSJ5|https://www.uniprot.org/uniprot/Q9TQY8|https://www.uniprot.org/uniprot/Q9TQY7|https://www.uniprot.org/uniprot/Q9PRR2|https://www.uniprot.org/uniprot/Q9PRR1|https://www.uniprot.org/uniprot/Q9NDE7|https://www.uniprot.org/uniprot/Q98TA8|https://www.uniprot.org/uniprot/Q91XI3|https://www.uniprot.org/uniprot/Q91479|https://www.uniprot.org/uniprot/Q91478|https://www.uniprot.org/uniprot/Q91477|https://www.uniprot.org/uniprot/Q8WNW6|https://www.uniprot.org/uniprot/Q8HXV2|https://www.uniprot.org/uniprot/Q6YK33|https://www.uniprot.org/uniprot/Q62587|https://www.uniprot.org/uniprot/Q5EEX2|https://www.uniprot.org/uniprot/Q53YX4|https://www.uniprot.org/uniprot/Q504H9|https://www.uniprot.org/uniprot/Q10995|https://www.uniprot.org/uniprot/P81881|https://www.uniprot.org/uniprot/P81423|https://www.uniprot.org/uniprot/P81025|https://www.uniprot.org/uniprot/P69048|https://www.uniprot.org/uniprot/P69047|https://www.uniprot.org/uniprot/P69046|https://www.uniprot.org/uniprot/P69045|https://www.uniprot.org/uniprot/P68992|https://www.uniprot.org/uniprot/P68991|https://www.uniprot.org/uniprot/P68990|https://www.uniprot.org/uniprot/P68989|https://www.uniprot.org/uniprot/P68988|https://www.uniprot.org/uniprot/P68987|https://www.uniprot.org/uniprot/P68245|https://www.uniprot.org/uniprot/P68243|https://www.uniprot.org/uniprot/P67974|https://www.uniprot.org/uniprot/P67973|https://www.uniprot.org/uniprot/P67972|https://www.uniprot.org/uniprot/P67971|https://www.uniprot.org/uniprot/P67970|https://www.uniprot.org/uniprot/P67969|https://www.uniprot.org/uniprot/P67968|https://www.uniprot.org/uniprot/P51463|https://www.uniprot.org/uniprot/P42633|https://www.uniprot.org/uniprot/P41522|https://www.uniprot.org/uniprot/P31887|https://www.uniprot.org/uniprot/P30410|https://www.uniprot.org/uniprot/P30407|https://www.uniprot.org/uniprot/P30406|https://www.uniprot.org/uniprot/P29335|https://www.uniprot.org/uniprot/P23187|https://www.uniprot.org/uniprot/P21563|https://www.uniprot.org/uniprot/P18109|https://www.uniprot.org/uniprot/P17715|https://www.uniprot.org/uniprot/P14806|https://www.uniprot.org/uniprot/P13190|https://www.uniprot.org/uniprot/P12708|https://www.uniprot.org/uniprot/P12705|https://www.uniprot.org/uniprot/P12704|https://www.uniprot.org/uniprot/P12703|https://www.uniprot.org/uniprot/P10604|https://www.uniprot.org/uniprot/P0C236|https://www.uniprot.org/uniprot/P09536|https://www.uniprot.org/uniprot/P09477|https://www.uniprot.org/uniprot/P09476|https://www.uniprot.org/uniprot/P07454|https://www.uniprot.org/uniprot/P07453|https://www.uniprot.org/uniprot/P06306|https://www.uniprot.org/uniprot/P04667|https://www.uniprot.org/uniprot/P01342|https://www.uniprot.org/uniprot/P01341|https://www.uniprot.org/uniprot/P01340|https://www.uniprot.org/uniprot/P01339|https://www.uniprot.org/uniprot/P01336|https://www.uniprot.org/uniprot/P01335|https://www.uniprot.org/uniprot/P01334|https://www.uniprot.org/uniprot/P01333|https://www.uniprot.org/uniprot/P01332|https://www.uniprot.org/uniprot/P01331|https://www.uniprot.org/uniprot/P01330|https://www.uniprot.org/uniprot/P01329|https://www.uniprot.org/uniprot/P01328|https://www.uniprot.org/uniprot/P01327|https://www.uniprot.org/uniprot/P01324|https://www.uniprot.org/uniprot/P01321|https://www.uniprot.org/uniprot/P01320|https://www.uniprot.org/uniprot/P01319|https://www.uniprot.org/uniprot/P01318|https://www.uniprot.org/uniprot/P01317|https://www.uniprot.org/uniprot/P01316|https://www.uniprot.org/uniprot/P01315|https://www.uniprot.org/uniprot/P01314|https://www.uniprot.org/uniprot/P01313|https://www.uniprot.org/uniprot/P01312|https://www.uniprot.org/uniprot/P01311|https://www.uniprot.org/uniprot/P01310|https://www.uniprot.org/uniprot/P01309|https://www.uniprot.org/uniprot/P01308|https://www.uniprot.org/uniprot/O73727|https://www.uniprot.org/uniprot/O42485|https://www.uniprot.org/uniprot/C0HJU0|https://www.uniprot.org/uniprot/C0HJT9|https://www.uniprot.org/uniprot/C0HJI4|https://www.uniprot.org/uniprot/C0HJI1
T6372 39637-39641 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6373 39743-39747 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6374 39863-39867 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6375 39986-39990 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6376 40020-40027 Protein denotes insulin https://www.uniprot.org/uniprot/Q9W7R2|https://www.uniprot.org/uniprot/Q9W653|https://www.uniprot.org/uniprot/Q9TSJ5|https://www.uniprot.org/uniprot/Q9TQY8|https://www.uniprot.org/uniprot/Q9TQY7|https://www.uniprot.org/uniprot/Q9PRR2|https://www.uniprot.org/uniprot/Q9PRR1|https://www.uniprot.org/uniprot/Q9NDE7|https://www.uniprot.org/uniprot/Q98TA8|https://www.uniprot.org/uniprot/Q91XI3|https://www.uniprot.org/uniprot/Q91479|https://www.uniprot.org/uniprot/Q91478|https://www.uniprot.org/uniprot/Q91477|https://www.uniprot.org/uniprot/Q8WNW6|https://www.uniprot.org/uniprot/Q8HXV2|https://www.uniprot.org/uniprot/Q6YK33|https://www.uniprot.org/uniprot/Q62587|https://www.uniprot.org/uniprot/Q5EEX2|https://www.uniprot.org/uniprot/Q53YX4|https://www.uniprot.org/uniprot/Q504H9|https://www.uniprot.org/uniprot/Q10995|https://www.uniprot.org/uniprot/P81881|https://www.uniprot.org/uniprot/P81423|https://www.uniprot.org/uniprot/P81025|https://www.uniprot.org/uniprot/P69048|https://www.uniprot.org/uniprot/P69047|https://www.uniprot.org/uniprot/P69046|https://www.uniprot.org/uniprot/P69045|https://www.uniprot.org/uniprot/P68992|https://www.uniprot.org/uniprot/P68991|https://www.uniprot.org/uniprot/P68990|https://www.uniprot.org/uniprot/P68989|https://www.uniprot.org/uniprot/P68988|https://www.uniprot.org/uniprot/P68987|https://www.uniprot.org/uniprot/P68245|https://www.uniprot.org/uniprot/P68243|https://www.uniprot.org/uniprot/P67974|https://www.uniprot.org/uniprot/P67973|https://www.uniprot.org/uniprot/P67972|https://www.uniprot.org/uniprot/P67971|https://www.uniprot.org/uniprot/P67970|https://www.uniprot.org/uniprot/P67969|https://www.uniprot.org/uniprot/P67968|https://www.uniprot.org/uniprot/P51463|https://www.uniprot.org/uniprot/P42633|https://www.uniprot.org/uniprot/P41522|https://www.uniprot.org/uniprot/P31887|https://www.uniprot.org/uniprot/P30410|https://www.uniprot.org/uniprot/P30407|https://www.uniprot.org/uniprot/P30406|https://www.uniprot.org/uniprot/P29335|https://www.uniprot.org/uniprot/P23187|https://www.uniprot.org/uniprot/P21563|https://www.uniprot.org/uniprot/P18109|https://www.uniprot.org/uniprot/P17715|https://www.uniprot.org/uniprot/P14806|https://www.uniprot.org/uniprot/P13190|https://www.uniprot.org/uniprot/P12708|https://www.uniprot.org/uniprot/P12705|https://www.uniprot.org/uniprot/P12704|https://www.uniprot.org/uniprot/P12703|https://www.uniprot.org/uniprot/P10604|https://www.uniprot.org/uniprot/P0C236|https://www.uniprot.org/uniprot/P09536|https://www.uniprot.org/uniprot/P09477|https://www.uniprot.org/uniprot/P09476|https://www.uniprot.org/uniprot/P07454|https://www.uniprot.org/uniprot/P07453|https://www.uniprot.org/uniprot/P06306|https://www.uniprot.org/uniprot/P04667|https://www.uniprot.org/uniprot/P01342|https://www.uniprot.org/uniprot/P01341|https://www.uniprot.org/uniprot/P01340|https://www.uniprot.org/uniprot/P01339|https://www.uniprot.org/uniprot/P01336|https://www.uniprot.org/uniprot/P01335|https://www.uniprot.org/uniprot/P01334|https://www.uniprot.org/uniprot/P01333|https://www.uniprot.org/uniprot/P01332|https://www.uniprot.org/uniprot/P01331|https://www.uniprot.org/uniprot/P01330|https://www.uniprot.org/uniprot/P01329|https://www.uniprot.org/uniprot/P01328|https://www.uniprot.org/uniprot/P01327|https://www.uniprot.org/uniprot/P01324|https://www.uniprot.org/uniprot/P01321|https://www.uniprot.org/uniprot/P01320|https://www.uniprot.org/uniprot/P01319|https://www.uniprot.org/uniprot/P01318|https://www.uniprot.org/uniprot/P01317|https://www.uniprot.org/uniprot/P01316|https://www.uniprot.org/uniprot/P01315|https://www.uniprot.org/uniprot/P01314|https://www.uniprot.org/uniprot/P01313|https://www.uniprot.org/uniprot/P01312|https://www.uniprot.org/uniprot/P01311|https://www.uniprot.org/uniprot/P01310|https://www.uniprot.org/uniprot/P01309|https://www.uniprot.org/uniprot/P01308|https://www.uniprot.org/uniprot/O73727|https://www.uniprot.org/uniprot/O42485|https://www.uniprot.org/uniprot/C0HJU0|https://www.uniprot.org/uniprot/C0HJT9|https://www.uniprot.org/uniprot/C0HJI4|https://www.uniprot.org/uniprot/C0HJI1
T6481 40107-40111 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6482 40257-40261 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6483 40325-40329 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6484 40344-40348 Protein denotes Beta https://www.uniprot.org/uniprot/Q66765|https://www.uniprot.org/uniprot/Q66764|https://www.uniprot.org/uniprot/Q2V6G9|https://www.uniprot.org/uniprot/Q155Z9|https://www.uniprot.org/uniprot/P32540|https://www.uniprot.org/uniprot/P17594|https://www.uniprot.org/uniprot/P17593|https://www.uniprot.org/uniprot/P12296|https://www.uniprot.org/uniprot/P03304|https://www.uniprot.org/uniprot/C0MHL9|https://www.uniprot.org/uniprot/B8XTP8
T6495 40476-40480 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6496 40764-40768 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6497 40831-40835 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6498 40946-40950 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6499 41117-41121 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6500 41149-41159 Protein denotes E-cadherin https://www.uniprot.org/uniprot/Q9UII8|https://www.uniprot.org/uniprot/Q9R0T4|https://www.uniprot.org/uniprot/Q9JIV9|https://www.uniprot.org/uniprot/Q91709|https://www.uniprot.org/uniprot/Q6R8F2|https://www.uniprot.org/uniprot/Q61377|https://www.uniprot.org/uniprot/Q5RAX1|https://www.uniprot.org/uniprot/Q4PJ14|https://www.uniprot.org/uniprot/Q16194|https://www.uniprot.org/uniprot/Q15855|https://www.uniprot.org/uniprot/Q14216|https://www.uniprot.org/uniprot/Q13799|https://www.uniprot.org/uniprot/P30944|https://www.uniprot.org/uniprot/P12830|https://www.uniprot.org/uniprot/P09803|https://www.uniprot.org/uniprot/P08641|https://www.uniprot.org/uniprot/O35794|https://www.uniprot.org/uniprot/F1PAA9|https://www.uniprot.org/uniprot/A8K1U7
T6519 41203-41211 Protein denotes vimentin https://www.uniprot.org/uniprot/Q9NTM3|https://www.uniprot.org/uniprot/Q9MZA9|https://www.uniprot.org/uniprot/Q96ML2|https://www.uniprot.org/uniprot/Q92155|https://www.uniprot.org/uniprot/Q91023|https://www.uniprot.org/uniprot/Q8N850|https://www.uniprot.org/uniprot/Q8CCH1|https://www.uniprot.org/uniprot/Q6LER9|https://www.uniprot.org/uniprot/Q5R1W8|https://www.uniprot.org/uniprot/Q548L2|https://www.uniprot.org/uniprot/Q4R4X4|https://www.uniprot.org/uniprot/Q3HWE4|https://www.uniprot.org/uniprot/Q17QM7|https://www.uniprot.org/uniprot/Q15869|https://www.uniprot.org/uniprot/Q15868|https://www.uniprot.org/uniprot/Q15867|https://www.uniprot.org/uniprot/P84198|https://www.uniprot.org/uniprot/P48674|https://www.uniprot.org/uniprot/P48670|https://www.uniprot.org/uniprot/P48616|https://www.uniprot.org/uniprot/P31000|https://www.uniprot.org/uniprot/P20152|https://www.uniprot.org/uniprot/P09654|https://www.uniprot.org/uniprot/P08670|https://www.uniprot.org/uniprot/P02544|https://www.uniprot.org/uniprot/P02543|https://www.uniprot.org/uniprot/O08704|https://www.uniprot.org/uniprot/F1RWC0|https://www.uniprot.org/uniprot/F1RWB8|https://www.uniprot.org/uniprot/D3DRU4|https://www.uniprot.org/uniprot/B0YJC2|https://www.uniprot.org/uniprot/A5A6N8
T6551 41518-41522 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6552 41688-41692 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6553 41775-41779 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6554 41833-41837 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6555 42100-42104 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6556 42178-42182 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6557 42334-42338 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6558 42419-42423 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6559 42505-42509 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6560 42564-42568 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6561 42737-42741 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6562 42871-42875 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6563 43056-43060 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6564 43194-43198 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T100 106-115 http://purl.obolibrary.org/obo/IDO_0000464 denotes infective
T101 116-123 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T102 297-305 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T103 346-351 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T104 435-440 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T105 619-623 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T106 624-629 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T107 708-712 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T108 761-769 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T109 792-796 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T110 867-872 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T111 1004-1014 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T112 1100-1108 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T113 1150-1158 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T114 1363-1370 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T115 1408-1415 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T116 1441-1453 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T117 1730-1734 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T118 1735-1744 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T119 2316-2321 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T120 2731-2735 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T121 2879-2884 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T122 2956-2960 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T123 3017-3024 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T124 3117-3127 http://purl.obolibrary.org/obo/BFO_0000034 denotes Functional
T125 3359-3363 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T126 3525-3535 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional
T127 4192-4196 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T128 4197-4201 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T129 4671-4678 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T130 4695-4699 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T131 4700-4704 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T132 4761-4766 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T133 4779-4785 http://purl.obolibrary.org/obo/IDO_0000586 denotes infect
T134 4786-4790 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T135 4979-4983 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T136 4998-5009 http://purl.obolibrary.org/obo/IDO_0000464 denotes infected by
T137 4998-5006 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T138 5246-5251 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T139 5361-5365 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T140 5394-5401 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T141 5610-5614 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T142 5978-5983 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T143 6415-6419 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T144 6712-6716 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T145 6727-6731 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T146 7210-7214 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T147 7215-7219 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T148 7532-7536 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T149 7537-7541 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T150 7722-7727 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T151 7736-7740 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T152 7741-7745 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T153 8110-8115 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T154 8139-8143 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T155 8164-8169 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T156 8184-8188 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T157 8189-8193 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T158 8317-8321 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T159 8718-8722 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T160 9208-9212 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T161 9213-9217 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T162 9287-9292 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T163 9530-9534 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T164 9839-9843 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T165 10134-10138 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T166 10139-10143 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T167 10188-10193 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T168 10377-10381 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T169 10428-10436 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T170 10690-10694 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T171 10725-10730 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T172 10741-10746 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T173 10755-10762 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T174 10845-10852 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T175 10887-10891 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T176 10904-10911 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T177 10963-10967 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T178 11042-11046 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T179 11130-11137 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T180 11188-11193 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T181 11206-11210 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T182 11344-11349 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T183 11454-11461 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T184 11535-11539 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T185 11625-11629 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T186 11630-11634 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T187 12167-12171 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T188 12187-12192 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T189 12376-12381 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T190 14462-14467 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T191 14968-14972 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T192 15285-15289 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T193 15407-15411 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T194 15412-15417 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T195 15488-15494 http://www.geneontology.org/formats/oboInOwl#Subset denotes subset
T196 16132-16136 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T197 19141-19145 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T198 19193-19197 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T199 19228-19232 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T200 19262-19267 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T201 19280-19293 http://purl.obolibrary.org/obo/IDO_0000450 denotes pathogenicity
T202 19433-19437 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T203 19528-19537 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T204 19731-19735 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T205 20002-20007 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T206 20268-20274 http://purl.obolibrary.org/obo/IDO_0000586 denotes infect
T207 20805-20813 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T208 20851-20859 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T209 21155-21163 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T210 21304-21312 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T211 21375-21382 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T212 21499-21506 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T213 21617-21624 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T214 21767-21774 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T215 22065-22072 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T216 22397-22402 http://purl.obolibrary.org/obo/OBI_0100026 denotes organ
T217 23235-23244 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T218 24412-24421 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T219 24556-24565 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T220 24570-24577 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T221 24815-24822 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T222 25123-25127 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T223 25164-25173 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T224 25318-25323 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T225 25334-25343 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T226 25640-25648 http://purl.obolibrary.org/obo/TRANS_0000002 denotes indirect
T227 25674-25683 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T228 26576-26585 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T229 26595-26600 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T230 26688-26692 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T231 27033-27043 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T232 27409-27416 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T233 27782-27791 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T234 28091-28095 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T235 28103-28112 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T236 28392-28402 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T237 28761-28768 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T238 28933-28938 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T239 28993-29004 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T240 29008-29019 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptible
T241 29020-29025 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T242 29055-29060 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T243 29071-29076 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T244 29095-29100 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T245 29286-29290 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T246 29312-29323 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T247 29414-29418 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T248 29550-29558 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T249 29570-29574 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T250 29575-29579 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T251 29613-29621 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T252 29637-29645 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T253 29739-29743 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T254 30064-30068 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T255 30326-30335 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T256 30454-30464 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T257 30587-30597 http://purl.obolibrary.org/obo/TRANS_0000002 denotes indirectly
T258 31040-31045 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T259 31432-31442 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T260 31456-31462 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T261 31494-31504 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T262 31670-31680 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T263 32762-32767 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T264 32874-32884 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T265 33121-33126 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T266 33339-33348 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T267 33460-33465 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T268 33477-33481 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T269 33822-33831 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T270 34075-34089 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T271 34648-34658 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T272 34727-34737 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T273 35241-35250 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T274 35340-35344 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T275 35345-35349 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T276 35377-35388 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T277 35576-35585 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T278 35779-35783 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T279 36412-36416 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T280 36588-36592 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T281 36593-36597 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T282 36667-36671 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T283 36890-36895 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T284 36925-36935 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T285 37302-37311 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T286 37365-37370 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T287 37389-37406 http://purl.obolibrary.org/obo/GO_0044409 denotes entry in the host
T288 37402-37406 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T289 37407-37411 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T290 37894-37898 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T291 38414-38427 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections in
T292 38445-38450 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T293 38664-38668 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T294 39045-39050 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T295 39071-39090 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T296 39086-39090 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T297 39129-39134 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T298 39231-39240 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T299 39367-39375 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Diseases
T300 39678-39685 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T301 40181-40186 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T302 40287-40294 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T303 40509-40513 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T304 40514-40520 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T305 40967-40973 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T306 41028-41032 http://purl.obolibrary.org/obo/CL_0000000 denotes Cell
T307 41409-41417 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T308 41745-41750 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T309 41935-41939 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T310 42150-42154 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T311 42248-42252 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T294 342-345 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T295 441-447 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T296 511-523 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T297 624-629 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T298 708-712 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T299 785-791 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T300 792-796 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T301 838-850 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T302 1730-1734 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T303 1897-1904 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T304 1944-1952 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T305 2021-2029 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T306 2037-2045 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T307 2064-2069 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T308 2119-2125 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T309 2366-2378 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T310 2551-2558 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T311 2731-2735 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T312 2778-2785 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T313 2956-2960 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T314 3168-3175 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T315 3210-3217 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T316 3236-3246 Body_part denotes aminoacids http://purl.org/sig/ont/fma/fma82739
T317 3445-3463 Body_part denotes cellular membranes http://purl.org/sig/ont/fma/fma63841
T318 3854-3875 Body_part denotes contacts the receptor http://purl.org/sig/ont/fma/fma85595
T319 4046-4057 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T320 4143-4150 Body_part denotes glycine http://purl.org/sig/ont/fma/fma82753
T321 4158-4165 Body_part denotes alanine http://purl.org/sig/ont/fma/fma82749
T322 4197-4210 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T323 4197-4201 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T324 4575-4583 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T325 4700-4704 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T326 4786-4790 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T327 4979-4983 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T328 5246-5251 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T329 5361-5365 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T330 5610-5614 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T331 5784-5791 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T332 7052-7057 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T333 7215-7228 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T334 7215-7219 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T335 7313-7318 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T336 7537-7551 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T337 7537-7541 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T338 7741-7745 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T339 7746-7755 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T340 7791-7797 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T341 7896-7903 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T342 8139-8143 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T343 8189-8193 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T344 8550-8557 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T345 8718-8731 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T346 8718-8722 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T347 8745-8760 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T348 8780-8789 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T349 8810-8827 Body_part denotes endocytic vesicle http://purl.org/sig/ont/fma/fma67463
T350 8884-8891 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T351 9011-9018 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T352 9213-9217 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T353 9361-9367 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T354 9445-9454 Body_part denotes aminoacid http://purl.org/sig/ont/fma/fma82739
T355 9667-9679 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T356 9839-9843 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T357 10139-10152 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T358 10139-10143 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T359 10177-10193 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T360 10188-10193 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T361 10203-10212 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T362 10377-10381 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T363 10577-10592 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T364 10599-10608 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T365 10725-10730 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T366 10741-10746 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T367 10887-10891 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T368 10963-10967 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T369 11114-11117 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T370 11156-11162 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T371 11206-11210 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T372 11303-11318 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T373 11410-11428 Body_part denotes endocytic vesicles http://purl.org/sig/ont/fma/fma67463
T374 11535-11539 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T375 11630-11634 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T376 11778-11785 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T377 12167-12179 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T378 12167-12171 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T379 12187-12192 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T380 12347-12355 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T381 12376-12381 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T382 13801-13808 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T383 14462-14467 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T384 14653-14660 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T385 14947-14960 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T386 15229-15236 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T387 15412-15417 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T388 15474-15481 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T389 16833-16840 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T390 17064-17071 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T391 17449-17454 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T392 17587-17592 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T393 18026-18031 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T394 19497-19504 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T395 19731-19735 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T396 20478-20483 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T397 22185-22191 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T398 22397-22402 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T399 24436-24440 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T400 25123-25136 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T401 25123-25127 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T402 26595-26600 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T403 26688-26692 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T404 26768-26776 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T405 27202-27206 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T406 27529-27534 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T407 27567-27578 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T408 28406-28410 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T409 28599-28608 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T410 28685-28693 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T411 28835-28843 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T412 29020-29025 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T413 29035-29060 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T414 29055-29060 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T415 29071-29076 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T416 29081-29094 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T417 29095-29100 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T418 29102-29113 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T419 29115-29124 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T420 29286-29290 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T421 29414-29418 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T422 29575-29579 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T423 29791-29798 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T424 29838-29845 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T425 29865-29872 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T426 29913-29920 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T427 30041-30050 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T428 30064-30068 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T429 30277-30285 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T430 30386-30397 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T431 30484-30493 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T432 30503-30507 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T433 30623-30628 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T434 30638-30642 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T435 30811-30821 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T436 31606-31615 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T437 31946-31954 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T438 32057-32061 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T439 32302-32309 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T440 32755-32761 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T441 32762-32767 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T442 33121-33126 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T443 33359-33372 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T444 33449-33465 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T445 33460-33465 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T446 33477-33481 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T447 33544-33548 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T448 34844-34852 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T449 35345-35349 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T450 35408-35412 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T451 35750-35757 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T452 36588-36592 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T453 36593-36597 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T454 36695-36702 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T455 36910-36914 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T456 37407-37411 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T457 37531-37535 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T458 37871-37878 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T459 38085-38092 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T460 38445-38457 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T461 38478-38484 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T462 38664-38668 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T463 38952-38956 Body_part denotes nose http://purl.org/sig/ont/fma/fma46472
T464 39319-39323 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T465 39396-39403 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T466 39528-39534 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T467 39535-39542 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T468 39555-39566 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T469 39583-39590 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T470 39710-39721 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T471 39778-39788 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T472 39802-39807 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T473 39812-39815 Body_part denotes gut http://purl.org/sig/ont/fma/fma7199
T474 39930-39937 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T475 39958-39966 Body_part denotes pancreas http://purl.org/sig/ont/fma/fma7198
T476 40020-40027 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T477 40130-40144 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T478 40181-40186 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T479 40509-40513 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T480 40554-40560 Body_part denotes breast http://purl.org/sig/ont/fma/fma9601
T481 40639-40644 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T482 41028-41032 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T483 41033-41037 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T484 41149-41159 Body_part denotes E-cadherin http://purl.org/sig/ont/fma/fma61792
T485 41203-41211 Body_part denotes vimentin http://purl.org/sig/ont/fma/fma67330
T486 41347-41351 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T487 41693-41697 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T488 41883-41888 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T489 41912-41918 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T490 41935-41939 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T491 41992-41998 Body_part denotes rectum http://purl.org/sig/ont/fma/fma14544
T492 42022-42029 Body_part denotes stomach http://purl.org/sig/ont/fma/fma7148
T493 42057-42061 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T494 42136-42140 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T495 42150-42154 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T496 42248-42252 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T497 42261-42268 Body_part denotes thyroid http://purl.org/sig/ont/fma/fma9603
T498 42291-42297 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T499 43144-43158 Body_part denotes uterine corpus http://purl.org/sig/ont/fma/fma17739

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T95 23-31 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 94-115 Disease denotes respiratory infective http://purl.obolibrary.org/obo/MONDO_0024355
T97 134-167 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T98 169-173 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T99 398-406 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 398-402 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 740-748 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 740-744 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 940-948 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T104 940-944 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T105 960-964 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T106 1004-1014 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T107 1209-1218 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T108 1286-1296 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T109 1286-1290 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T110 1330-1338 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T111 1330-1334 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T112 1386-1394 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T113 1396-1420 Disease denotes COronaVIrus Disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T114 1471-1481 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T115 1471-1475 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T116 1628-1636 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 1683-1693 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T118 1683-1687 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T119 1735-1744 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T120 2538-2548 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T121 2538-2542 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T122 2628-2636 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T123 2628-2632 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T124 2701-2711 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T125 2701-2705 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T126 2755-2763 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T127 2755-2759 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T128 2893-2901 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T129 2893-2897 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T130 2907-2917 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T131 2907-2911 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T132 2994-3002 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T133 2994-2998 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T134 3006-3016 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T135 3006-3010 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T136 3179-3187 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T137 3179-3183 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T138 3192-3202 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T139 3192-3196 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T140 3717-3725 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T141 3717-3721 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T142 3741-3751 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T143 3741-3745 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T144 4587-4595 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T145 4587-4591 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T146 4600-4610 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T147 4600-4604 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T148 5022-5032 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T149 5022-5026 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T150 5036-5044 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T151 5036-5040 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T152 5333-5343 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T153 5333-5337 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T154 5550-5558 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 5550-5554 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T156 5563-5573 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T157 5563-5567 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T158 5634-5642 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T159 5634-5638 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T160 5647-5657 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T161 5647-5651 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T162 8895-8905 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T163 8895-8899 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T164 9276-9286 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T165 9276-9280 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T166 9350-9360 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T167 9350-9354 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T168 9384-9392 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T169 9384-9388 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T170 9736-9746 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T171 9736-9740 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T172 9880-9888 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T173 9880-9884 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T174 9914-9924 Disease denotes SARS-COV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T175 9914-9918 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T176 10366-10376 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T177 10366-10370 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T178 10419-10427 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T179 11542-11552 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T180 11542-11546 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T181 11586-11596 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T182 11586-11590 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T183 11601-11609 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T184 11601-11605 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T185 11677-11687 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T186 11677-11681 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T187 11718-11726 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T188 11718-11722 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T189 11728-11736 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T190 11728-11732 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T191 11854-11864 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T192 11854-11858 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T193 11911-11919 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T194 11911-11915 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T195 12027-12037 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T196 12027-12031 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T197 12083-12093 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T198 12083-12087 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T199 12414-12424 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T200 12414-12418 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T201 12521-12531 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T202 12521-12525 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T203 12951-12961 Disease denotes SARS-COV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T204 12951-12955 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T205 12966-12974 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T206 12966-12970 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T207 13184-13194 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T208 13184-13188 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T209 13338-13348 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T210 13338-13342 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T211 13604-13614 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T212 13604-13608 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T213 13701-13711 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T214 13701-13705 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T215 14172-14182 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T216 14172-14176 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T217 14241-14249 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T218 14241-14245 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T219 14421-14431 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T220 14421-14425 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T221 14469-14479 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T222 14469-14473 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T223 14503-14511 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T224 14503-14507 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T225 14640-14650 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T226 14640-14644 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T227 14700-14704 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T228 14767-14777 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T229 14767-14771 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T230 14836-14844 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T231 14836-14840 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T232 15014-15024 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T233 15014-15018 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T234 15029-15037 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T235 15029-15033 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T236 15073-15083 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T237 15073-15077 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T238 15386-15396 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T239 15386-15390 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T240 15453-15463 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T241 15453-15457 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T242 15551-15555 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T243 15591-15595 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T244 15629-15633 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T245 15679-15683 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T246 15732-15736 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T247 15782-15786 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T248 15830-15834 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T249 15897-15901 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T250 16140-16148 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T251 16140-16144 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T252 16264-16272 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T253 16264-16268 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T254 16443-16453 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T255 16443-16447 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T256 16519-16529 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T257 16519-16523 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T258 17193-17201 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T259 17193-17197 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T260 17215-17225 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T261 17215-17219 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T262 17290-17300 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T263 17290-17294 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T264 17335-17345 Disease denotes S sequence http://purl.obolibrary.org/obo/MONDO_0007821
T265 17360-17368 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T266 17360-17364 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T267 17961-17971 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T268 17961-17965 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T269 17976-17984 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T270 17976-17980 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T271 18013-18021 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T272 18013-18017 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T273 18100-18110 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T274 18100-18104 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T275 18292-18302 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T276 18292-18296 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T277 18330-18334 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T278 18669-18679 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T279 18669-18673 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T280 18696-18700 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T281 18805-18815 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T282 18805-18809 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T283 19484-19494 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T284 19484-19488 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T285 19519-19527 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T286 19528-19537 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T287 19817-19821 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T288 19834-19844 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T289 19834-19838 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T290 19922-19930 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T291 19922-19926 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T292 20073-20083 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T293 20073-20077 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T294 20508-20518 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T295 20508-20512 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T296 20697-20705 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T297 20822-20859 Disease denotes hypertension, cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0001302
T298 20864-20888 Disease denotes type-2 diabetes mellitus http://purl.obolibrary.org/obo/MONDO_0005148
T299 21246-21258 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T300 21268-21276 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T301 21289-21312 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T302 21462-21474 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T303 21484-21506 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T304 21674-21682 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T305 21896-21908 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T306 22010-22022 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T307 22030-22038 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T308 22050-22072 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T309 22105-22113 Disease denotes Diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T310 22161-22165 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T311 22179-22198 Disease denotes acute kidney injury http://purl.obolibrary.org/obo/MONDO_0002492
T312 22453-22460 Disease denotes Obesity http://purl.obolibrary.org/obo/MONDO_0011122
T313 22516-22524 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T314 22543-22550 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T315 22611-22621 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T316 22611-22615 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T317 22941-22944 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T318 23226-23244 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T319 23226-23230 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T320 23318-23328 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T321 23318-23322 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T322 23414-23424 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T323 23414-23418 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T324 23483-23486 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T325 23842-23846 Disease denotes Park http://purl.obolibrary.org/obo/MONDO_0008199
T326 24133-24136 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T327 24363-24375 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T328 24412-24421 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T329 24550-24565 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T330 24786-24822 Disease denotes hypertension, cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0001302
T331 24827-24835 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T332 24909-24919 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T333 24909-24913 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T334 25153-25163 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T335 25153-25157 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T336 25164-25173 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T337 25334-25343 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T338 25823-25831 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T339 25836-25848 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T340 25870-25873 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T341 26203-26206 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T342 26224-26232 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T343 26342-26350 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T344 26565-26575 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T345 26565-26569 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T346 26576-26585 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T347 26875-26883 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T348 26984-26994 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T349 26984-26988 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T350 27018-27021 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T351 27027-27043 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T352 27045-27052 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T353 27180-27184 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T354 27207-27213 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T355 27316-27320 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T356 27386-27394 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T357 27400-27416 Disease denotes systemic disease http://purl.obolibrary.org/obo/MONDO_0015938
T358 27440-27449 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T359 27729-27735 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T360 27782-27791 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T361 27849-27857 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T362 28103-28112 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T363 28229-28237 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T364 28242-28251 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T365 28281-28285 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T366 29348-29360 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T367 29726-29730 Disease denotes PRRs http://purl.obolibrary.org/obo/MONDO_0025494
T368 29772-29775 Disease denotes NOD http://purl.obolibrary.org/obo/MONDO_0007435
T369 29874-29877 Disease denotes ASC http://purl.obolibrary.org/obo/MONDO_0019018
T370 30088-30100 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T371 30296-30306 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T372 30296-30300 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T373 30315-30325 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T374 30315-30319 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T375 30326-30335 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T376 30533-30541 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T377 30706-30717 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T378 30738-30746 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T379 30747-30756 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T380 30822-30828 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T381 30930-30940 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T382 30930-30934 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T383 32216-32228 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T384 33333-33348 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T385 33816-33831 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T386 33925-33935 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T387 33925-33929 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T388 34093-34103 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T389 34093-34097 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T390 34253-34270 Disease denotes hypovitaminosis D http://purl.obolibrary.org/obo/MONDO_0005520
T391 34296-34304 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T392 34481-34491 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T393 34481-34485 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T394 34524-34534 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T395 34524-34528 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T396 34616-34633 Disease denotes hypovitaminosis D http://purl.obolibrary.org/obo/MONDO_0005520
T397 34648-34658 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T398 34715-34737 Disease denotes respiratory infections http://purl.obolibrary.org/obo/MONDO_0024355
T399 34897-34907 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T400 34897-34901 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T401 35096-35104 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T402 35156-35166 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T403 35156-35160 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T404 35241-35250 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T405 35413-35419 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T406 35576-35585 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T407 36261-36269 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T408 36261-36265 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T409 36483-36491 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T410 36483-36487 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T411 36786-36790 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T412 36904-36921 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T414 36925-36935 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T415 36941-36945 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T416 37336-37346 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T417 37336-37340 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T418 37536-37542 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T419 37717-37725 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T420 38023-38031 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T421 38286-38290 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T422 38403-38413 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T423 38403-38407 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T424 38414-38427 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T425 38633-38643 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T426 38633-38637 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T427 38740-38750 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T428 38740-38744 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T429 39225-39240 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T430 39668-39685 Disease denotes Hartnup’s disease http://purl.obolibrary.org/obo/MONDO_0009324
T431 39958-39966 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040
T432 40059-40066 Disease denotes Obesity http://purl.obolibrary.org/obo/MONDO_0011122
T433 40171-40195 Disease denotes increased blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T434 40277-40294 Disease denotes Alzheimer disease http://purl.obolibrary.org/obo/MONDO_0004975
T435 40349-40356 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T436 40468-40474 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T437 40502-40508 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T438 40639-40651 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T439 40708-40732 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T440 40961-40966 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T441 41018-41044 Disease denotes Non-Small Cell Lung Cancer http://purl.obolibrary.org/obo/MONDO_0005233
T442 41046-41051 Disease denotes NSCLC http://purl.obolibrary.org/obo/MONDO_0005233
T443 41275-41280 Disease denotes NSCLC http://purl.obolibrary.org/obo/MONDO_0005233
T444 41347-41358 Disease denotes lung cancer http://purl.obolibrary.org/obo/MONDO_0008903
T445 41380-41388 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T446 41610-41616 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T447 41618-41622 Disease denotes Chai http://purl.obolibrary.org/obo/MONDO_0014493
T448 41714-41720 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T449 41875-41881 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T450 41883-41903 Disease denotes colon adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0002271
T451 41905-41909 Disease denotes COAD http://purl.obolibrary.org/obo/MONDO_0002271
T452 41940-41949 Disease denotes carcinoma http://purl.obolibrary.org/obo/MONDO_0004993
T453 41958-41983 Disease denotes pancreatic adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0006047
T454 41985-41989 Disease denotes PAAD http://purl.obolibrary.org/obo/MONDO_0006047
T455 41992-42013 Disease denotes rectum adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0002169
T456 42015-42019 Disease denotes READ http://purl.obolibrary.org/obo/MONDO_0002169
T457 42022-42044 Disease denotes stomach adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0005036
T458 42046-42050 Disease denotes STAD http://purl.obolibrary.org/obo/MONDO_0005036
T459 42057-42076 Disease denotes lung adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0005061
T460 42078-42082 Disease denotes LUAD http://purl.obolibrary.org/obo/MONDO_0005061
T461 42136-42164 Disease denotes lung squamous cell carcinoma http://purl.obolibrary.org/obo/MONDO_0005097
T462 42166-42170 Disease denotes LUSC http://purl.obolibrary.org/obo/MONDO_0005097
T463 42224-42230 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T464 42254-42258 Disease denotes TGCT http://purl.obolibrary.org/obo/MONDO_0006906|http://purl.obolibrary.org/obo/MONDO_0010108
T466 42261-42278 Disease denotes thyroid carcinoma http://purl.obolibrary.org/obo/MONDO_0015075
T467 42280-42284 Disease denotes THCA http://purl.obolibrary.org/obo/MONDO_0015075
T468 42291-42309 Disease denotes kidney chromophobe http://purl.obolibrary.org/obo/MONDO_0017885
T469 42311-42315 Disease denotes KICH http://purl.obolibrary.org/obo/MONDO_0017885
T470 43039-43044 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T471 43144-43180 Disease denotes uterine corpus endometrial carcinoma http://purl.obolibrary.org/obo/MONDO_0000553
T472 43182-43186 Disease denotes UCEC http://purl.obolibrary.org/obo/MONDO_0000553

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T124 785-791 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T125 5916-5921 http://purl.obolibrary.org/obo/MAT_0000294 denotes heads
T126 16091-16095 http://purl.obolibrary.org/obo/MAT_0000158 denotes claw
T127 18198-18206 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T128 20755-20760 http://purl.obolibrary.org/obo/MAT_0000029 denotes males
T129 22185-22191 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T130 24436-24440 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand
T131 27202-27206 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T132 27529-27534 http://purl.obolibrary.org/obo/MAT_0000135 denotes lungs
T133 32755-32761 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T134 35408-35412 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T135 36910-36914 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T136 37531-37535 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T137 38445-38457 http://purl.obolibrary.org/obo/MAT_0000393 denotes blood vessel
T138 38445-38450 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T139 38445-38450 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T140 38478-38484 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T141 38952-38956 http://purl.obolibrary.org/obo/MAT_0000139 denotes nose
T142 39528-39534 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T143 39812-39815 http://purl.obolibrary.org/obo/MAT_0000043 denotes gut
T144 39958-39966 http://purl.obolibrary.org/obo/MAT_0000075 denotes pancreas
T145 40130-40144 http://purl.obolibrary.org/obo/MAT_0000015 denotes adipose tissue
T146 40181-40186 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T147 40181-40186 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T148 40639-40644 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T149 41033-41037 http://purl.obolibrary.org/obo/MAT_0000135 denotes Lung
T150 41347-41351 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T151 41883-41888 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T152 41912-41918 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T153 41992-41998 http://purl.obolibrary.org/obo/MAT_0000050 denotes rectum
T154 42022-42029 http://purl.obolibrary.org/obo/MAT_0000051 denotes stomach
T155 42057-42061 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T156 42136-42140 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T157 42243-42252 http://purl.obolibrary.org/obo/MAT_0000334 denotes germ cell
T158 42261-42268 http://purl.obolibrary.org/obo/MAT_0000081 denotes thyroid
T159 42291-42297 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T88 1441-1453 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T89 4506-4521 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T90 5445-5460 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T91 5763-5774 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T92 6167-6181 http://purl.obolibrary.org/obo/GO_0020012 denotes immune evasion
T93 6167-6181 http://purl.obolibrary.org/obo/GO_0051805 denotes immune evasion
T94 7655-7669 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T95 7660-7669 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T96 8116-8125 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T97 8691-8705 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T98 8696-8705 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T99 9303-9310 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T100 10382-10389 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T101 10531-10546 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T102 11076-11091 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T103 11369-11380 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T104 19268-19275 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T105 24550-24565 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T106 26812-26832 http://purl.obolibrary.org/obo/GO_0055085 denotes membrane transporter
T107 26959-26980 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T108 27027-27043 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T109 27747-27752 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T110 28427-28430 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T111 28987-29004 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T112 28987-29004 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T113 29174-29195 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T114 29212-29221 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T115 29212-29221 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T116 29260-29269 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T117 29260-29269 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T118 29286-29296 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T119 29291-29296 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T120 29306-29323 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T121 29306-29323 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T122 29348-29360 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T123 29403-29424 http://purl.obolibrary.org/obo/GO_0012501 denotes programmed cell death
T124 29414-29424 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T125 29419-29424 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T126 29846-29864 http://purl.obolibrary.org/obo/GO_0006919 denotes caspase activating
T127 29881-29890 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T128 29881-29890 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T129 30069-30074 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T130 30088-30100 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T131 30405-30414 http://purl.obolibrary.org/obo/GO_0039707 denotes viroporin
T132 31456-31462 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T133 31479-31483 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T134 31541-31554 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T135 31704-31709 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T136 31773-31782 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T137 32085-32106 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T138 32216-32228 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T139 32460-32481 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T140 33165-33192 http://purl.obolibrary.org/obo/GO_0008191 denotes metalloproteinase inhibitor
T141 33333-33348 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T142 33728-33749 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T143 33816-33831 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T144 35371-35388 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T145 35371-35388 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T146 35758-35783 http://purl.obolibrary.org/obo/GO_0051701 denotes interaction with the host
T147 36588-36604 http://purl.obolibrary.org/obo/GO_0000768 denotes cell-cell fusion
T148 36588-36604 http://purl.obolibrary.org/obo/GO_0045026 denotes cell-cell fusion
T149 36593-36604 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T150 36763-36781 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T151 37383-37411 http://purl.obolibrary.org/obo/GO_0046718 denotes viral entry in the host cell
T152 38966-38973 http://purl.obolibrary.org/obo/GO_0071626 denotes chewing
T153 39028-39040 http://purl.obolibrary.org/obo/GO_0051235 denotes sequestering
T154 39071-39090 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T155 39225-39240 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T156 39583-39600 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T157 39591-39600 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T158 39710-39733 http://purl.obolibrary.org/obo/GO_0080144 denotes amino acids homeostasis
T159 39722-39733 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T160 39778-39798 http://purl.obolibrary.org/obo/GO_0006865 denotes amino acid transport
T161 39789-39798 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T162 39888-39912 http://purl.obolibrary.org/obo/GO_0019222 denotes regulation of metabolism
T163 39888-39898 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T164 39902-39912 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T165 39938-39949 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T166 40020-40037 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T167 40028-40037 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T168 40509-40520 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T169 40514-40520 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T170 40538-40550 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T171 40967-40973 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T172 41002-41014 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T173 41238-41271 http://purl.obolibrary.org/obo/GO_0001837 denotes epithelial-mesenchymal transition
T174 41838-41851 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T175 42105-42118 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T176 42183-42196 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T177 42339-42352 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T178 42510-42523 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T179 42549-42560 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T180 42608-42619 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T181 42675-42686 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T182 42840-42851 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T183 43199-43212 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T38 94-115 Phenotype denotes respiratory infective http://purl.obolibrary.org/obo/HP_0011947
T39 1167-1172 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T40 1181-1203 Phenotype denotes respiratory impairment http://purl.obolibrary.org/obo/HP_0002093
T41 1209-1218 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T42 20822-20834 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T43 20836-20859 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T44 20871-20888 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T45 21246-21258 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T46 21289-21312 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T47 21462-21474 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T48 21484-21506 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T49 21896-21908 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T50 22010-22022 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T51 22050-22072 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T52 22179-22198 Phenotype denotes acute kidney injury http://purl.obolibrary.org/obo/HP_0001919
T53 22219-22224 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T54 22453-22460 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T55 22543-22550 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T56 24363-24375 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T57 24786-24798 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T58 24800-24822 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T59 25442-25462 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T60 25836-25848 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T61 27440-27449 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T62 27740-27752 Phenotype denotes sudden death http://purl.obolibrary.org/obo/HP_0001699
T63 28242-28251 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T64 28685-28699 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T65 28835-28849 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T66 30277-30291 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T67 30706-30717 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T68 30747-30756 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T69 31946-31960 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T70 34119-34139 Phenotype denotes vitamin D deficiency http://purl.obolibrary.org/obo/HP_0100512
T71 34638-34658 Phenotype denotes pulmonary infections http://purl.obolibrary.org/obo/HP_0006532
T72 34715-34737 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T73 34844-34858 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T74 40059-40066 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T75 40171-40195 Phenotype denotes increased blood pressure http://purl.obolibrary.org/obo/HP_0032263
T76 40277-40294 Phenotype denotes Alzheimer disease http://purl.obolibrary.org/obo/HP_0002511
T77 40468-40474 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T78 40502-40508 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T79 40639-40651 Phenotype denotes colon cancer http://purl.obolibrary.org/obo/HP_0003003
T80 40708-40732 Phenotype denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/HP_0001402
T81 40961-40966 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T82 41018-41044 Phenotype denotes Non-Small Cell Lung Cancer http://purl.obolibrary.org/obo/HP_0030358
T83 41347-41358 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526
T84 41610-41616 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T85 41714-41720 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T86 41940-41949 Phenotype denotes carcinoma http://purl.obolibrary.org/obo/HP_0030731
T87 41958-41983 Phenotype denotes pancreatic adenocarcinoma http://purl.obolibrary.org/obo/HP_0006725
T88 42057-42076 Phenotype denotes lung adenocarcinoma http://purl.obolibrary.org/obo/HP_0030078
T89 42141-42164 Phenotype denotes squamous cell carcinoma http://purl.obolibrary.org/obo/HP_0002860
T90 42261-42278 Phenotype denotes thyroid carcinoma http://purl.obolibrary.org/obo/HP_0002890
T91 42280-42284 Phenotype denotes THCA http://purl.obolibrary.org/obo/HP_0002890
T92 43039-43044 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T93 43159-43180 Phenotype denotes endometrial carcinoma http://purl.obolibrary.org/obo/HP_0012114

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T91 1441-1453 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T92 4506-4521 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T93 5445-5460 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T94 5763-5774 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T95 6167-6181 http://purl.obolibrary.org/obo/GO_0042783 denotes immune evasion
T96 7655-7669 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T97 7660-7669 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T98 8116-8125 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T99 8691-8705 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T100 8696-8705 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T101 9303-9310 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T102 10382-10389 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T103 10531-10546 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T104 11076-11091 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T105 11369-11380 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T106 19268-19275 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T107 24550-24565 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T108 26812-26832 http://purl.obolibrary.org/obo/GO_0055085 denotes membrane transporter
T109 26959-26980 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T110 27027-27043 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T111 28987-29004 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T112 28987-29004 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T113 29174-29195 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T114 29212-29221 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T115 29212-29221 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T116 29226-29236 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T117 29260-29269 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T118 29260-29269 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T119 29286-29296 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T120 29306-29323 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T121 29306-29323 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T122 29348-29360 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T123 29371-29381 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T124 29403-29424 http://purl.obolibrary.org/obo/GO_0012501 denotes programmed cell death
T125 29414-29424 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T126 29523-29533 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T127 29846-29864 http://purl.obolibrary.org/obo/GO_0006919 denotes caspase activating
T128 29881-29890 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T129 29881-29890 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T130 30069-30074 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T131 30088-30100 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T132 30337-30347 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T133 30405-30414 http://purl.obolibrary.org/obo/GO_0039707 denotes viroporin
T134 30556-30566 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T135 30832-30842 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T136 31456-31462 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T137 31479-31483 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T138 31541-31561 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T139 31541-31554 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T140 31704-31709 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T141 31773-31782 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T142 32085-32106 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T143 32216-32228 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T144 32460-32481 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T145 33165-33192 http://purl.obolibrary.org/obo/GO_0008191 denotes metalloproteinase inhibitor
T146 33333-33348 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T147 33728-33749 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T148 33816-33831 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T149 35371-35388 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T150 35371-35388 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T151 35758-35783 http://purl.obolibrary.org/obo/GO_0051701 denotes interaction with the host
T152 36588-36604 http://purl.obolibrary.org/obo/GO_0140253 denotes cell-cell fusion
T153 36588-36604 http://purl.obolibrary.org/obo/GO_0045026 denotes cell-cell fusion
T154 36593-36604 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T155 36593-36604 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T156 37383-37411 http://purl.obolibrary.org/obo/GO_0046718 denotes viral entry in the host cell
T157 38966-38973 http://purl.obolibrary.org/obo/GO_0071626 denotes chewing
T158 39028-39040 http://purl.obolibrary.org/obo/GO_0051235 denotes sequestering
T159 39071-39090 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T160 39225-39240 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T161 39583-39600 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T162 39591-39600 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T163 39710-39733 http://purl.obolibrary.org/obo/GO_0080144 denotes amino acids homeostasis
T164 39722-39733 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T165 39778-39798 http://purl.obolibrary.org/obo/GO_0006865 denotes amino acid transport
T166 39789-39798 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T167 39888-39912 http://purl.obolibrary.org/obo/GO_0019222 denotes regulation of metabolism
T168 39888-39898 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T169 39902-39912 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T170 39930-39949 http://purl.obolibrary.org/obo/GO_0042593 denotes glucose homeostasis
T171 39938-39949 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T172 40020-40037 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T173 40028-40037 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T174 40509-40520 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T175 40514-40520 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T176 40538-40550 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T177 40967-40973 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T178 41002-41014 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T179 41238-41271 http://purl.obolibrary.org/obo/GO_0001837 denotes epithelial-mesenchymal transition
T180 41838-41851 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T181 42105-42118 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T182 42183-42196 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T183 42339-42352 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T184 42510-42523 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T185 42549-42560 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T186 42608-42619 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T187 42675-42686 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T188 42840-42851 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T189 43199-43212 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T41 94-115 Phenotype denotes respiratory infective http://purl.obolibrary.org/obo/HP_0011947
T42 1167-1172 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T43 1181-1203 Phenotype denotes respiratory impairment http://purl.obolibrary.org/obo/HP_0002093
T44 1209-1218 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T45 20822-20834 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T46 20836-20859 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T47 20871-20888 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T48 21246-21258 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T49 21289-21312 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T50 21462-21474 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T51 21484-21506 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T52 21896-21908 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T53 22010-22022 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T54 22050-22072 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T55 22179-22198 Phenotype denotes acute kidney injury http://purl.obolibrary.org/obo/HP_0001919
T56 22219-22224 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T57 22453-22460 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T58 22543-22550 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T59 24363-24375 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T60 24786-24798 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T61 24800-24822 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T62 25442-25462 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T63 25836-25848 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T64 27440-27449 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T65 27740-27752 Phenotype denotes sudden death http://purl.obolibrary.org/obo/HP_0001699
T66 28242-28251 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T67 28685-28699 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T68 28835-28849 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T69 30277-30291 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T70 30706-30717 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T71 30747-30756 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T72 31946-31960 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T73 34119-34139 Phenotype denotes vitamin D deficiency http://purl.obolibrary.org/obo/HP_0100512
T74 34638-34658 Phenotype denotes pulmonary infections http://purl.obolibrary.org/obo/HP_0006532
T75 34715-34737 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T76 34844-34858 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T77 36904-36921 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T78 40059-40066 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T79 40171-40195 Phenotype denotes increased blood pressure http://purl.obolibrary.org/obo/HP_0032263
T80 40277-40294 Phenotype denotes Alzheimer disease http://purl.obolibrary.org/obo/HP_0002511
T81 40468-40474 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T82 40502-40508 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T83 40639-40651 Phenotype denotes colon cancer http://purl.obolibrary.org/obo/HP_0003003
T84 40708-40732 Phenotype denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/HP_0001402
T85 40961-40966 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T86 41018-41044 Phenotype denotes Non-Small Cell Lung Cancer http://purl.obolibrary.org/obo/HP_0030358
T87 41046-41051 Phenotype denotes NSCLC http://purl.obolibrary.org/obo/HP_0030358
T88 41275-41280 Phenotype denotes NSCLC http://purl.obolibrary.org/obo/HP_0030358
T89 41347-41358 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526
T90 41610-41616 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T91 41714-41720 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T92 41940-41949 Phenotype denotes carcinoma http://purl.obolibrary.org/obo/HP_0030731
T93 41958-41983 Phenotype denotes pancreatic adenocarcinoma http://purl.obolibrary.org/obo/HP_0006725
T94 42057-42076 Phenotype denotes lung adenocarcinoma http://purl.obolibrary.org/obo/HP_0030078
T95 42141-42164 Phenotype denotes squamous cell carcinoma http://purl.obolibrary.org/obo/HP_0002860
T96 42261-42278 Phenotype denotes thyroid carcinoma http://purl.obolibrary.org/obo/HP_0002890
T97 42280-42284 Phenotype denotes THCA http://purl.obolibrary.org/obo/HP_0002890
T98 43039-43044 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T99 43159-43180 Phenotype denotes endometrial carcinoma http://purl.obolibrary.org/obo/HP_0012114

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T4 11119-11122 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T5 11119-11122 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T6 11119-11122 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T7 11119-11122 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T8 11119-11122 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T9 11119-11122 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T10 11119-11122 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T11 11119-11122 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T12 11119-11122 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T13 11119-11122 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non
T14 13993-13996 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T15 13993-13996 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T16 13993-13996 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T17 13993-13996 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T18 13993-13996 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T19 13993-13996 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T20 13993-13996 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T21 13993-13996 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T22 13993-13996 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T23 13993-13996 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non
T24 39930-39937 http://rdf.glyconavi.org/CarTNa/CarTNa210/trivialname denotes glucose
T25 41018-41021 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T26 41018-41021 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T27 41018-41021 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T28 41018-41021 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T29 41018-41021 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T30 41018-41021 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T31 41018-41021 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T32 41018-41021 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T33 41018-41021 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T34 41018-41021 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
328 13539-13542 Gene denotes PDB Gene:5131
940 14-18 Gene denotes ACE2 Gene:59272
941 23-31 Disease denotes COVID-19 MESH:C000657245
950 52-56 Gene denotes ACE2 Gene:59272
951 916-920 Gene denotes ACE2 Gene:59272
952 525-526 Gene denotes S Gene:43740568
953 369-380 Species denotes coronavirus Tax:11118
954 398-406 Species denotes SARS-CoV Tax:694009
955 94-123 Disease denotes respiratory infective disease MESH:D012141
956 740-791 Disease denotes SARS-CoV efficiently infected African Monkey kidney MESH:C000657245
957 807-809 CellLine denotes E6 CVCL:4582
976 1707-1711 Gene denotes ACE2 Gene:59272
977 1834-1838 Gene denotes ACE2 Gene:59272
978 940-948 Species denotes SARS-CoV Tax:694009
979 1069-1080 Species denotes coronavirus Tax:11118
980 1094-1099 Species denotes human Tax:9606
981 1249-1264 Species denotes new coronavirus Tax:2697049
982 1286-1296 Species denotes SARS-CoV-2 Tax:2697049
983 1330-1338 Species denotes SARS-CoV Tax:694009
984 1471-1481 Species denotes SARS-CoV-2 Tax:2697049
985 1683-1693 Species denotes SARS-CoV-2 Tax:2697049
986 1830-1833 Species denotes CoV Tax:11118
987 1004-1014 Disease denotes infections MESH:D007239
988 1167-1172 Disease denotes fever MESH:D005334
989 1181-1203 Disease denotes respiratory impairment MESH:D012131
990 1209-1218 Disease denotes pneumonia MESH:D011014
991 1396-1420 Disease denotes COronaVIrus Disease 2019 MESH:C000657245
992 1628-1636 Disease denotes COVID-19 MESH:C000657245
993 1735-1744 Disease denotes infection MESH:D007239
995 1895-1896 Gene denotes S Gene:43740568
1014 1961-1966 Gene denotes spike Gene:43740568
1015 1986-1994 Gene denotes membrane Gene:43740571
1016 1972-1980 Gene denotes envelope Gene:43740570
1017 2918-2919 Gene denotes S Gene:43740568
1018 2617-2618 Gene denotes S Gene:43740568
1019 2549-2550 Gene denotes S Gene:43740568
1020 2401-2409 Gene denotes membrane Gene:43740571
1021 1907-1918 Species denotes coronavirus Tax:11118
1022 2538-2548 Species denotes SARS-CoV-2 Tax:2697049
1023 2622-2627 Species denotes human Tax:9606
1024 2628-2636 Species denotes SARS-CoV Tax:694009
1025 2701-2711 Species denotes SARS-CoV-2 Tax:2697049
1026 2755-2763 Species denotes SARS-CoV Tax:694009
1027 2893-2901 Species denotes SARS-CoV Tax:694009
1028 2907-2917 Species denotes SARS-CoV-2 Tax:2697049
1029 2994-3002 Species denotes SARS-CoV Tax:694009
1030 3006-3016 Species denotes SARS-CoV-2 Tax:2697049
1031 2237-2253 Chemical denotes N-linked glycans
1035 3100-3111 Species denotes Coronavirus Tax:11118
1036 3179-3187 Species denotes SARS-CoV Tax:694009
1037 3192-3202 Species denotes SARS-CoV-2 Tax:2697049
1048 3431-3439 Gene denotes envelope Gene:43740570
1049 3208-3209 Gene denotes S Gene:43740568
1050 4506-4514 Gene denotes membrane Gene:43740571
1051 4202-4210 Gene denotes membrane Gene:43740571
1052 3717-3725 Species denotes SARS-CoV Tax:694009
1053 3741-3751 Species denotes SARS-CoV-2 Tax:2697049
1054 3339-3341 Gene denotes aa Gene:351
1055 3300-3302 Gene denotes aa Gene:351
1056 4143-4150 Chemical denotes glycine MESH:D005998
1057 4158-4165 Chemical denotes alanine MESH:D000409
1076 4715-4719 Gene denotes ACE2 Gene:59272
1077 4865-4869 Gene denotes ACE2 Gene:70008
1078 5055-5059 Gene denotes ACE2 Gene:59272
1079 5148-5153 Gene denotes hDPP4 Gene:1803
1080 5352-5356 Gene denotes ACE2 Gene:59272
1081 4587-4595 Species denotes SARS-CoV Tax:694009
1082 4600-4610 Species denotes SARS-CoV-2 Tax:2697049
1083 4822-4827 Species denotes human Tax:9606
1084 4845-4848 Species denotes pig Tax:9823
1085 4858-4863 Species denotes mouse Tax:10090
1086 5022-5032 Species denotes SARS-CoV-2 Tax:2697049
1087 5036-5044 Species denotes SARS-CoV Tax:694009
1088 5112-5117 Species denotes human Tax:9606
1089 5142-5146 Species denotes CoVs Tax:11118
1090 5171-5179 Species denotes MERS CoV Tax:1335626
1091 5184-5193 Species denotes HCoV-229E Tax:11137
1092 5333-5343 Species denotes SARS-CoV-2 Tax:2697049
1093 4998-5006 Disease denotes infected MESH:D007239
1097 5445-5453 Gene denotes membrane Gene:43740571
1098 5550-5558 Species denotes SARS-CoV Tax:694009
1099 5563-5573 Species denotes SARS-CoV-2 Tax:2697049
1109 6275-6276 Gene denotes S Gene:43740568
1110 5782-5783 Gene denotes S Gene:43740568
1111 7349-7353 Gene denotes post Gene:159371
1112 6847-6851 Gene denotes post Gene:159371
1113 7220-7228 Gene denotes membrane Gene:43740571
1114 5984-5992 Gene denotes membrane Gene:43740571
1115 5634-5642 Species denotes SARS-CoV Tax:694009
1116 5647-5657 Species denotes SARS-CoV-2 Tax:2697049
1117 7046-7048 Gene denotes aa Gene:351
1127 8548-8549 Gene denotes S Gene:43740568
1128 7948-7949 Gene denotes S Gene:43740568
1129 7894-7895 Gene denotes S Gene:43740568
1130 8514-8518 Gene denotes post Gene:159371
1131 8790-8798 Gene denotes membrane Gene:43740571
1132 8752-8760 Gene denotes membrane Gene:43740571
1133 8723-8731 Gene denotes membrane Gene:43740571
1134 8322-8330 Gene denotes membrane Gene:43740571
1135 7839-7850 Species denotes Coronavirus Tax:11118
1139 9129-9132 Gene denotes PDB Gene:5131
1140 8882-8883 Gene denotes S Gene:43740568
1141 8895-8905 Species denotes SARS-CoV-2 Tax:2697049
1163 9175-9179 Gene denotes ACE2 Gene:59272
1164 10020-10025 Gene denotes furin Gene:5045
1165 10102-10109 Gene denotes TMPRSS2 Gene:7113
1166 10257-10268 Gene denotes cathepsin L Gene:1514
1167 9576-9581 Gene denotes furin Gene:5045
1168 9812-9817 Gene denotes furin Gene:5045
1169 9747-9748 Gene denotes S Gene:43740568
1170 9193-9194 Gene denotes S Gene:43740568
1171 10584-10592 Gene denotes membrane Gene:43740571
1172 10531-10539 Gene denotes membrane Gene:43740571
1173 10144-10152 Gene denotes membrane Gene:43740571
1174 9276-9286 Species denotes SARS-CoV-2 Tax:2697049
1175 9350-9360 Species denotes SARS-CoV-2 Tax:2697049
1176 9384-9392 Species denotes SARS-CoV Tax:694009
1177 9414-9427 Species denotes coronaviruses Tax:11118
1178 9736-9746 Species denotes SARS-CoV-2 Tax:2697049
1179 9880-9888 Species denotes SARS-CoV Tax:694009
1180 9914-9924 Species denotes SARS-COV-2 Tax:2697049
1181 10366-10376 Species denotes SARS-CoV-2 Tax:2697049
1182 10030-10035 Gene denotes furin Gene:5045
1183 10419-10427 Disease denotes COVID-19 MESH:C000657245
1192 11014-11021 Gene denotes TMPRSS2 Gene:487770
1193 10816-10821 Gene denotes furin Gene:5045
1194 10669-10670 Gene denotes S Gene:43740568
1195 11289-11293 Gene denotes fuse Gene:2522
1196 11310-11318 Gene denotes membrane Gene:43740571
1197 11229-11237 Gene denotes membrane Gene:43740571
1198 11076-11084 Gene denotes membrane Gene:43740571
1199 10989-10997 Gene denotes membrane Gene:43740571
1201 11542-11552 Species denotes SARS-CoV-2 Tax:2697049
1217 12149-12153 Gene denotes ACE2 Gene:59272
1218 12257-12262 Gene denotes hDPP4 Gene:1803
1219 12302-12306 Gene denotes ACE2 Gene:59272
1220 12360-12364 Gene denotes ACE2 Gene:59272
1221 12238-12246 Gene denotes membrane Gene:43740571
1222 11586-11596 Species denotes SARS-CoV-2 Tax:2697049
1223 11601-11609 Species denotes SARS-CoV Tax:694009
1224 11677-11687 Species denotes SARS-CoV-2 Tax:2697049
1225 11718-11726 Species denotes SARS-CoV Tax:694009
1226 11728-11736 Species denotes SARS-CoV Tax:694009
1227 11854-11864 Species denotes SARS-CoV-2 Tax:2697049
1228 11911-11919 Species denotes SARS-CoV Tax:694009
1229 12027-12037 Species denotes SARS-CoV-2 Tax:2697049
1230 12083-12093 Species denotes SARS-CoV-2 Tax:2697049
1231 12183-12186 CellLine denotes HEK CVCL:M624
1248 12639-12641 Gene denotes β1 Gene:597
1249 12643-12645 Gene denotes β2 Gene:170589
1250 12647-12649 Gene denotes β3 Gene:28883
1251 12651-12653 Gene denotes β4 Gene:28898
1252 12655-12657 Gene denotes β7 Gene:28885
1253 12710-12712 Gene denotes β4 Gene:28898
1254 12789-12792 Gene denotes β2’ Gene:170589
1255 12781-12784 Gene denotes β1’ Gene:597
1256 12769-12771 Gene denotes β6 Gene:28873
1257 12762-12764 Gene denotes β5 Gene:28884
1258 12717-12719 Gene denotes β7 Gene:28885
1259 12414-12424 Species denotes SARS-CoV-2 Tax:2697049
1260 12521-12531 Species denotes SARS-CoV-2 Tax:2697049
1261 12951-12961 Species denotes SARS-COV-2 Tax:2697049
1262 12966-12974 Species denotes SARS-CoV Tax:694009
1263 12831-12840 Chemical denotes disulfide MESH:D004220
1271 13236-13240 Gene denotes ACE2 Gene:59272
1272 13307-13312 Gene denotes hACE2 Gene:59272
1273 13195-13200 Gene denotes spike Gene:43740568
1275 13497-13500 Gene denotes PDB Gene:5131
1276 13184-13194 Species denotes SARS-CoV-2 Tax:2697049
1277 13338-13348 Species denotes SARS-CoV-2 Tax:2697049
1301 13624-13628 Gene denotes ACE2 Gene:59272
1302 13943-13947 Gene denotes ACE2 Gene:59272
1303 14212-14216 Gene denotes ACE2 Gene:59272
1304 14444-14448 Gene denotes ACE2 Gene:59272
1305 14603-14607 Gene denotes ACE2 Gene:59272
1306 15126-15130 Gene denotes ACE2 Gene:59272
1307 14705-14706 Gene denotes S Gene:43740568
1308 14651-14652 Gene denotes S Gene:43740568
1309 13799-13800 Gene denotes S Gene:43740568
1310 13604-13614 Species denotes SARS-CoV-2 Tax:2697049
1311 13701-13711 Species denotes SARS-CoV-2 Tax:2697049
1312 14172-14182 Species denotes SARS-CoV-2 Tax:2697049
1313 14241-14249 Species denotes SARS-CoV Tax:694009
1314 14421-14431 Species denotes SARS-CoV-2 Tax:2697049
1315 14469-14479 Species denotes SARS-CoV-2 Tax:2697049
1316 14503-14511 Species denotes SARS-CoV Tax:694009
1317 14640-14650 Species denotes SARS-CoV-2 Tax:2697049
1318 14767-14777 Species denotes SARS-CoV-2 Tax:2697049
1319 14836-14844 Species denotes SARS-CoV Tax:694009
1320 15014-15024 Species denotes SARS-CoV-2 Tax:2697049
1321 15029-15037 Species denotes SARS-CoV Tax:694009
1322 15073-15083 Species denotes SARS-CoV-2 Tax:2697049
1323 15386-15396 Species denotes SARS-CoV-2 Tax:2697049
1329 15464-15469 Gene denotes spike Gene:43740568
1330 15471-15472 Gene denotes S Gene:43740568
1331 15507-15511 Gene denotes ACE2 Gene:59272
1332 15486-15487 Gene denotes S Gene:43740568
1333 15453-15463 Species denotes SARS-CoV-2 Tax:2697049
1344 15598-15599 Gene denotes S Gene:43740568
1345 15558-15559 Gene denotes S Gene:43740568
1346 15551-15557 Species denotes SARS-2 Tax:2697049
1347 15591-15597 Species denotes SARS-2 Tax:2697049
1348 15629-15635 Species denotes SARS-2 Tax:2697049
1349 15679-15685 Species denotes SARS-2 Tax:2697049
1350 15732-15738 Species denotes SARS-2 Tax:2697049
1351 15810-15836 Species denotes Shang et al., 2020b SARS-2 Tax:2697049
1352 15897-15903 Species denotes SARS-2 Tax:2697049
1353 15782-15803 CellLine denotes SARS-2 S319–529 44.2 CVCL:Z232
1355 15981-15985 Gene denotes ACE2 Gene:59272
1360 16070-16074 Gene denotes ACE2 Gene:59272
1361 16251-16255 Gene denotes ACE2 Gene:59272
1362 16140-16148 Species denotes SARS-CoV Tax:694009
1363 16264-16272 Species denotes SARS-CoV Tax:694009
1404 16514-16518 Gene denotes ACE2 Gene:59272
1405 16970-16974 Gene denotes ACE2 Gene:59272
1406 17035-17039 Gene denotes ACE2 Gene:59272
1407 17188-17192 Gene denotes ACE2 Gene:59272
1408 17210-17214 Gene denotes ACE2 Gene:59272
1409 17409-17413 Gene denotes ACE2 Gene:59272
1410 17851-17853 Gene denotes β5 Gene:28884
1411 18007-18011 Gene denotes ACE2 Gene:59272
1412 18207-18211 Gene denotes ACE2 Gene:59272
1413 18451-18455 Gene denotes ACE2 Gene:59272
1414 18537-18541 Gene denotes ACE2 Gene:59272
1415 18653-18657 Gene denotes ACE2 Gene:59272
1416 18820-18824 Gene denotes ACE2 Gene:59272
1417 19016-19020 Gene denotes ACE2 Gene:59272
1418 17335-17336 Gene denotes S Gene:43740568
1419 17062-17063 Gene denotes S Gene:43740568
1420 16936-16937 Gene denotes S Gene:43740568
1421 16831-16832 Gene denotes S Gene:43740568
1422 17534-17536 Gene denotes β6 Gene:28873
1423 17527-17529 Gene denotes β5 Gene:28884
1424 16443-16453 Species denotes SARS-CoV-2 Tax:2697049
1425 16519-16529 Species denotes SARS-CoV-2 Tax:2697049
1426 17193-17201 Species denotes SARS-CoV Tax:694009
1427 17215-17225 Species denotes SARS-CoV-2 Tax:2697049
1428 17290-17300 Species denotes SARS-CoV-2 Tax:2697049
1429 17360-17368 Species denotes SARS-CoV Tax:694009
1430 17961-17971 Species denotes SARS-CoV-2 Tax:2697049
1431 17976-17984 Species denotes SARS-CoV Tax:694009
1432 18013-18021 Species denotes SARS-CoV Tax:694009
1433 18100-18110 Species denotes SARS-CoV-2 Tax:2697049
1434 18292-18302 Species denotes SARS-CoV-2 Tax:2697049
1435 18669-18679 Species denotes SARS-CoV-2 Tax:2697049
1436 18805-18815 Species denotes SARS-CoV-2 Tax:2697049
1437 18043-18054 Chemical denotes Pro-Pro-Ala MESH:C027789
1438 18081-18096 Chemical denotes Gly-Val-Glu-Gly
1439 18228-18233 Chemical denotes Ser19
1440 18238-18243 Chemical denotes Gln24
1441 18282-18288 Chemical denotes Phe486
1442 18442-18447 Chemical denotes Tyr83
1443 18477-18483 Chemical denotes Asn501
1454 19084-19096 Gene denotes RBD-receptor
1455 19438-19442 Gene denotes ACE2 Gene:480847
1456 19614-19618 Gene denotes ACE2 Gene:59272
1457 19612-19613 Gene denotes S Gene:43740568
1458 19495-19496 Gene denotes S Gene:43740568
1459 19418-19422 Species denotes cats Tax:9685
1460 19427-19431 Species denotes dogs Tax:9615
1461 19484-19494 Species denotes SARS-CoV-2 Tax:2697049
1462 19519-19527 Disease denotes COVID-19 MESH:C000657245
1463 19528-19537 Disease denotes infection MESH:D007239
1484 19722-19726 Gene denotes ACE2 Gene:59272
1485 20011-20014 Gene denotes ACE Gene:1636
1486 20161-20165 Gene denotes ACE2 Gene:59272
1487 20351-20355 Gene denotes ACE2 Gene:59272
1488 20411-20415 Gene denotes ACE2 Gene:59272
1489 20465-20469 Gene denotes ACE2 Gene:59272
1490 19667-19672 Species denotes human Tax:9606
1491 19673-19676 Species denotes CoV Tax:11118
1492 19678-19687 Species denotes hCoV-NL63 Tax:277944
1493 19834-19844 Species denotes SARS-CoV-2 Tax:2697049
1494 19890-19899 Species denotes hCoV-NL63 Tax:277944
1495 19922-19930 Species denotes SARS-CoV Tax:694009
1496 20073-20083 Species denotes SARS-CoV-2 Tax:2697049
1497 20108-20112 Species denotes CoVs Tax:11118
1498 20250-20259 Species denotes novel CoV Tax:2697049
1499 20275-20281 Species denotes humans Tax:9606
1500 20341-20345 Species denotes CoVs Tax:11118
1501 20401-20404 Species denotes CoV Tax:11118
1502 20508-20518 Species denotes SARS-CoV-2 Tax:2697049
1503 20579-20582 Species denotes CoV Tax:11118
1505 20633-20637 Gene denotes ACE2 Gene:59272
1536 20706-20714 Species denotes patients Tax:9606
1537 21164-21172 Species denotes patients Tax:9606
1538 21832-21840 Species denotes patients Tax:9606
1539 22572-22580 Species denotes patients Tax:9606
1540 22611-22621 Species denotes SARS-CoV-2 Tax:2697049
1541 20697-20705 Disease denotes COVID-19 MESH:C000657245
1542 20822-20834 Disease denotes hypertension MESH:D006973
1543 20836-20859 Disease denotes cardiovascular diseases MESH:D002318
1544 20864-20888 Disease denotes type-2 diabetes mellitus MESH:D003924
1545 21155-21163 Disease denotes infected MESH:D007239
1546 21246-21258 Disease denotes hypertension MESH:D006973
1547 21268-21276 Disease denotes diabetes MESH:D003920
1548 21289-21312 Disease denotes cardiovascular diseases MESH:D002318
1549 21462-21474 Disease denotes hypertension MESH:D006973
1550 21484-21506 Disease denotes cardiovascular disease MESH:D002318
1551 21674-21682 Disease denotes COVID-19 MESH:C000657245
1552 21896-21908 Disease denotes hypertension MESH:D006973
1553 21913-21922 Disease denotes mortality MESH:D003643
1554 22010-22022 Disease denotes hypertension MESH:D006973
1555 22030-22038 Disease denotes diabetes MESH:D003920
1556 22050-22072 Disease denotes cardiovascular disease MESH:D002318
1557 22105-22113 Disease denotes Diabetes MESH:D003920
1558 22161-22165 Disease denotes ARDS MESH:D012128
1559 22179-22198 Disease denotes acute kidney injury MESH:D058186
1560 22212-22224 Disease denotes septic shock MESH:D012772
1561 22252-22261 Disease denotes mortality MESH:D003643
1562 22423-22432 Disease denotes mortality MESH:D003643
1563 22516-22524 Disease denotes COVID-19 MESH:C000657245
1564 22543-22550 Disease denotes obesity MESH:D009765
1565 22754-22763 Disease denotes mortality MESH:D003643
1571 23023-23027 Gene denotes ACE2 Gene:59272
1572 23184-23188 Gene denotes ACE2 Gene:59272
1573 23318-23328 Species denotes SARS-CoV-2 Tax:2697049
1574 22854-22866 Disease denotes hypertensive MESH:D006973
1575 23226-23244 Disease denotes SARS-CoV infection MESH:C000657245
1581 24293-24296 Gene denotes ACE Gene:1636
1582 23414-23424 Species denotes SARS-CoV-2 Tax:2697049
1583 24344-24352 Species denotes patients Tax:9606
1584 24363-24375 Disease denotes hypertension MESH:D006973
1585 24400-24421 Disease denotes coronavirus infection MESH:D018352
1595 24632-24636 Gene denotes ACE2 Gene:59272
1596 24691-24695 Gene denotes ACE2 Gene:59272
1597 24698-24702 Gene denotes ACE2 Gene:59272
1598 24849-24853 Gene denotes ACE2 Gene:59272
1599 24909-24919 Species denotes SARS-CoV-2 Tax:2697049
1600 24550-24565 Disease denotes viral infection MESH:D001102
1601 24786-24798 Disease denotes hypertension MESH:D006973
1602 24800-24822 Disease denotes cardiovascular disease MESH:D002318
1603 24827-24835 Disease denotes diabetes MESH:D003920
1611 25107-25111 Gene denotes ACE2 Gene:59272
1612 25278-25282 Gene denotes ACE2 Gene:59272
1613 25399-25403 Gene denotes ACE2 Gene:59272
1614 25128-25136 Gene denotes membrane Gene:43740571
1615 25153-25173 Disease denotes SARS-CoV-2 infection MESH:C000657245
1616 25334-25343 Disease denotes infection MESH:D007239
1617 25442-25462 Disease denotes respiratory distress MESH:D012128
1622 25809-25817 Species denotes patients Tax:9606
1623 25823-25831 Disease denotes COVID-19 MESH:C000657245
1624 25836-25848 Disease denotes hypertension MESH:D006973
1625 25937-25946 Disease denotes mortality MESH:D003643
1630 26210-26218 Species denotes patients Tax:9606
1631 26328-26336 Species denotes patients Tax:9606
1632 26224-26232 Disease denotes COVID-19 MESH:C000657245
1633 26342-26350 Disease denotes COVID-19 MESH:C000657245
1645 26632-26636 Gene denotes ACE2 Gene:59272
1646 26661-26665 Gene denotes ACE2 Gene:59272
1647 26794-26798 Gene denotes ACE2 Gene:59272
1648 26833-26837 Gene denotes SIT1 Gene:27240
1649 26589-26594 Species denotes human Tax:9606
1650 26723-26728 Species denotes human Tax:9606
1651 26729-26737 Species denotes patients Tax:9606
1652 26812-26820 Gene denotes membrane Gene:43740571
1653 26565-26585 Disease denotes SARS-CoV-2 infection MESH:C000657245
1654 26875-26883 Disease denotes COVID-19 MESH:C000657245
1655 26923-26935 Disease denotes hypertensive MESH:D006973
1657 26946-26950 Gene denotes ACE2 Gene:59272
1673 27261-27269 Species denotes patients Tax:9606
1674 27858-27866 Species denotes patients Tax:9606
1675 27027-27043 Disease denotes viral infections MESH:D001102
1676 27045-27052 Disease denotes COVID19 MESH:C000657245
1677 27180-27184 Disease denotes ARDS MESH:D012128
1678 27202-27213 Disease denotes lung injury MESH:D055370
1679 27316-27320 Disease denotes ARDS MESH:D012128
1680 27386-27394 Disease denotes COVID-19 MESH:C000657245
1681 27440-27449 Disease denotes pneumonia MESH:D011014
1682 27479-27499 Disease denotes microvascular damage MESH:D017566
1683 27648-27674 Disease denotes cardiovascular involvement MESH:D002318
1684 27718-27735 Disease denotes myocardial injury MESH:D009202
1685 27740-27752 Disease denotes sudden death MESH:D003645
1686 27782-27791 Disease denotes infection MESH:D007239
1687 27849-27857 Disease denotes COVID-19 MESH:C000657245
1703 28406-28411 Gene denotes IL-1β Gene:3552
1704 28413-28418 Gene denotes IFN-γ Gene:3458
1705 28420-28425 Gene denotes IP-10 Gene:3627
1706 28427-28432 Gene denotes MCP-1 Gene:6347
1707 28434-28438 Gene denotes IL-4 Gene:3565
1708 28444-28449 Gene denotes IL-10 Gene:3586
1709 28158-28166 Species denotes patients Tax:9606
1710 28272-28280 Species denotes patients Tax:9606
1711 28358-28366 Species denotes patients Tax:9606
1712 28470-28476 Species denotes people Tax:9606
1713 28492-28500 Species denotes patients Tax:9606
1714 28103-28112 Disease denotes infection MESH:D007239
1715 28229-28237 Disease denotes COVID-19 MESH:C000657245
1716 28242-28251 Disease denotes pneumonia MESH:D011014
1717 28281-28285 Disease denotes ARDS MESH:D012128
1725 28866-28870 Gene denotes ACE2 Gene:59272
1726 28954-28958 Gene denotes ACE2 Gene:59272
1727 29802-29807 Gene denotes NLRP3 Gene:114548
1728 29970-29979 Gene denotes caspase 1 Gene:834
1729 29744-29752 Gene denotes membrane Gene:43740571
1730 29348-29360 Disease denotes inflammation MESH:D007249
1731 30088-30100 Disease denotes inflammation MESH:D007249
1734 30227-30231 Gene denotes ACE2 Gene:59272
1735 30296-30306 Species denotes SARS-CoV-2 Tax:2697049
1746 30432-30437 Gene denotes NLRP3 Gene:114548
1747 30503-30508 Gene denotes IL-1β Gene:3552
1748 30638-30643 Gene denotes IL-1β Gene:3552
1749 30542-30550 Species denotes patients Tax:9606
1750 30315-30335 Disease denotes SARS-CoV-2 infection MESH:C000657245
1751 30533-30541 Disease denotes COVID-19 MESH:C000657245
1752 30690-30701 Disease denotes leucopoenia
1753 30706-30717 Disease denotes lymphopenia MESH:D008231
1754 30738-30756 Disease denotes COVID-19 pneumonia MESH:C000657245
1755 30811-30842 Disease denotes lymphocyte injury by pyroptosis MESH:D015451
1771 30944-30947 Gene denotes ACE Gene:1636
1772 30948-30952 Gene denotes ACE2 Gene:59272
1773 31016-31020 Gene denotes ACE2 Gene:59272
1774 31291-31295 Gene denotes AT1R Gene:185
1775 31349-31356 Gene denotes ADAM 17 Gene:6868
1776 31372-31376 Gene denotes TNFα Gene:7124
1777 31393-31397 Gene denotes TACE Gene:6868
1778 31479-31483 Gene denotes EGFR Gene:1956
1779 31489-31493 Gene denotes TNFα Gene:7124
1780 31639-31646 Gene denotes ADAM 17 Gene:6868
1781 31704-31710 Gene denotes IL-6Rα Gene:3570
1782 31722-31726 Gene denotes IL-6 Gene:3569
1783 31727-31732 Gene denotes STAT3 Gene:6774
1784 32041-32056 Gene denotes angiotensinogen Gene:183
1785 30930-30940 Species denotes SARS-CoV-2 Tax:2697049
1803 32159-32163 Gene denotes ACE2 Gene:59272
1804 32248-32252 Gene denotes ACE2 Gene:59272
1805 32378-32382 Gene denotes ACE2 Gene:59272
1806 32502-32509 Gene denotes ADAM 17 Gene:6868
1807 32552-32556 Gene denotes TNFα Gene:7124
1808 32616-32620 Gene denotes ACE2 Gene:59272
1809 32794-32798 Gene denotes ACE2 Gene:59272
1810 33029-33033 Gene denotes ACE2 Gene:59272
1811 33102-33108 Gene denotes ADAM17 Gene:6868
1812 32739-32744 Species denotes human Tax:9606
1813 32788-32793 Species denotes human Tax:9606
1814 32579-32587 Gene denotes membrane Gene:43740571
1815 32828-32853 Chemical denotes phorbol myristate acetate MESH:D013755
1816 32216-32228 Disease denotes inflammation MESH:D007249
1817 32745-32761 Disease denotes embryonic kidney MESH:D007674
1818 32769-32775 CellLine denotes HEK293 CVCL:0045
1819 32800-32808 CellLine denotes HEK-ACE2 CVCL:L310
1829 33256-33260 Gene denotes ACE2 Gene:59272
1830 33402-33406 Gene denotes ACE2 Gene:59272
1831 33544-33549 Gene denotes IL-1β Gene:3552
1832 33605-33609 Gene denotes ACE2 Gene:59272
1833 33772-33776 Gene denotes ACE2 Gene:59272
1834 33854-33860 Gene denotes ADAM17 Gene:6868
1835 33925-33935 Species denotes SARS-CoV-2 Tax:2697049
1836 33333-33348 Disease denotes viral infection MESH:D001102
1837 33816-33831 Disease denotes viral infection MESH:D001102
1849 34093-34103 Species denotes SARS-CoV-2 Tax:2697049
1850 34481-34491 Species denotes SARS-CoV-2 Tax:2697049
1851 34524-34534 Species denotes SARS-CoV-2 Tax:2697049
1852 34897-34907 Species denotes SARS-CoV-2 Tax:2697049
1853 34119-34128 Chemical denotes vitamin D MESH:D014807
1854 34253-34268 Disease denotes hypovitaminosis
1855 34296-34304 Disease denotes COVID-19 MESH:C000657245
1856 34616-34631 Disease denotes hypovitaminosis
1857 34638-34658 Disease denotes pulmonary infections MESH:D012141
1858 34715-34737 Disease denotes respiratory infections MESH:D012141
1859 34922-34931 Disease denotes mortality MESH:D003643
1861 34998-35002 Gene denotes ACE2 Gene:59272
1868 35050-35054 Gene denotes ACE2 Gene:59272
1869 35227-35231 Gene denotes ACE2 Gene:59272
1870 35156-35166 Species denotes SARS-CoV-2 Tax:2697049
1871 35096-35104 Disease denotes COVID-19 MESH:C000657245
1872 35241-35250 Disease denotes infection MESH:D007239
1873 35408-35419 Disease denotes lung injury MESH:D055370
1880 35562-35566 Gene denotes ACE2 Gene:59272
1881 35641-35646 Gene denotes ACE 2 Gene:59272
1882 35702-35706 Gene denotes ACE2 Gene:59272
1883 35748-35757 Gene denotes S-protein Gene:43740568
1884 35635-35640 Species denotes human Tax:9606
1885 35576-35585 Disease denotes infection MESH:D007239
1887 35796-35800 Gene denotes ACE2 Gene:59272
1889 35843-35847 Gene denotes ACE2 Gene:59272
1891 35850-35854 Gene denotes ACE2 Gene:59272
1907 35876-35880 Gene denotes ACE2 Gene:59272
1908 36400-36404 Gene denotes ACE2 Gene:59272
1909 36652-36656 Gene denotes ACE2 Gene:59272
1910 36758-36762 Gene denotes ACE2 Gene:59272
1911 36868-36872 Gene denotes ACE2 Gene:59272
1912 37057-37061 Gene denotes ACE2 Gene:59272
1913 36261-36269 Species denotes SARS-CoV Tax:694009
1914 36483-36491 Species denotes SARS-CoV Tax:694009
1915 36941-36957 Species denotes SARS coronavirus Tax:694009
1916 36693-36702 Gene denotes S-protein Gene:43740568
1917 36348-36386 Chemical denotes N-(2-aminoethyl)-1aziridine-ethanamine
1918 36388-36392 Chemical denotes NAAE
1919 36719-36723 Chemical denotes NAAE
1920 36904-36921 Disease denotes acute lung injury MESH:D055371
1921 36925-36935 Disease denotes infections MESH:D007239
1932 37218-37222 Gene denotes ACE2 Gene:59272
1933 37282-37286 Gene denotes ACE2 Gene:59272
1934 37433-37437 Gene denotes ACE2 Gene:59272
1935 37659-37690 Gene denotes angiotensin-converting enzyme 2 Gene:59272
1936 37336-37346 Species denotes SARS-CoV-2 Tax:2697049
1937 37653-37658 Species denotes human Tax:9606
1938 37703-37711 Species denotes patients Tax:9606
1939 37692-37698 Chemical denotes rhACE2
1940 37531-37542 Disease denotes lung injury MESH:D055370
1941 37717-37725 Disease denotes COVID-19 MESH:C000657245
1959 37769-37774 Gene denotes ACE 2 Gene:59272
1960 37869-37878 Gene denotes S-protein Gene:43740568
1961 38571-38576 Gene denotes hACE2 Gene:59272
1962 38724-38728 Gene denotes ACE2 Gene:59272
1963 38838-38842 Gene denotes ACE2 Gene:59272
1964 37763-37768 Species denotes human Tax:9606
1965 38032-38040 Species denotes patients Tax:9606
1966 38272-38280 Species denotes patients Tax:9606
1967 38439-38444 Species denotes human Tax:9606
1968 38472-38477 Species denotes human Tax:9606
1969 38633-38643 Species denotes SARS-CoV-2 Tax:2697049
1970 38740-38750 Species denotes SARS-CoV-2 Tax:2697049
1971 38166-38172 Chemical denotes rhACE2
1972 38352-38358 Chemical denotes rhACE2
1973 38023-38031 Disease denotes COVID-19 MESH:C000657245
1974 38286-38290 Disease denotes ARDS MESH:D012128
1975 38403-38424 Disease denotes SARS-CoV-2 infections MESH:C000657245
1979 38922-38926 Gene denotes ACE2 Gene:59272
1980 39269-39273 Gene denotes ACE2 Gene:59272
1981 39225-39240 Disease denotes viral infection MESH:D001102
1983 39352-39356 Gene denotes ACE2 Gene:59272
1992 39376-39380 Gene denotes ACE2 Gene:59272
1993 39472-39476 Gene denotes ACE2 Gene:59272
1994 39514-39524 Gene denotes collectrin Gene:57393
1995 39583-39590 Gene denotes insulin Gene:3630
1996 39637-39641 Gene denotes ACE2 Gene:59272
1997 39743-39747 Gene denotes ACE2 Gene:59272
1998 39812-39826 Species denotes gut microbiome Tax:749906
1999 39668-39685 Disease denotes Hartnup’s disease MESH:D006250
2007 39863-39867 Gene denotes ACE2 Gene:59272
2008 39986-39990 Gene denotes ACE2 Gene:59272
2009 39991-39995 Gene denotes Ang1 Gene:284
2010 40020-40027 Gene denotes insulin Gene:3630
2011 40107-40111 Gene denotes ACE2 Gene:59272
2012 39998-40002 Gene denotes MasR Gene:116511
2013 39930-39949 Disease denotes glucose homeostasis MESH:D044882
2017 40257-40261 Gene denotes ACE2 Gene:59272
2018 40325-40329 Gene denotes ACE2 Gene:59272
2019 40277-40294 Disease denotes Alzheimer disease MESH:D000544
2038 40476-40480 Gene denotes ACE2 Gene:59272
2039 40764-40768 Gene denotes ACE2 Gene:59272
2040 40831-40835 Gene denotes ACE2 Gene:59272
2041 40946-40950 Gene denotes ACE2 Gene:70008
2042 41117-41121 Gene denotes ACE2 Gene:70008
2043 41149-41159 Gene denotes E-cadherin Gene:999
2044 41203-41211 Gene denotes vimentin Gene:7431
2045 40733-40741 Species denotes patients Tax:9606
2046 40898-40903 Species denotes human Tax:9606
2047 40918-40922 Species denotes mice Tax:10090
2048 40468-40474 Disease denotes cancer MESH:D009369
2049 40502-40508 Disease denotes cancer MESH:D009369
2051 40708-40732 Disease denotes hepatocellular carcinoma MESH:D006528
2052 40961-40966 Disease denotes tumor MESH:D009369
2053 41018-41044 Disease denotes Non-Small Cell Lung Cancer MESH:D002289
2054 41046-41051 Disease denotes NSCLC MESH:D002289
2055 41275-41280 Disease denotes NSCLC MESH:D002289
2062 41518-41522 Gene denotes ACE2 Gene:59272
2063 41359-41367 Species denotes patients Tax:9606
2064 41347-41358 Disease denotes lung cancer MESH:D008175
2065 41380-41388 Disease denotes COVID-19 MESH:C000657245
2066 41501-41513 Disease denotes malignancies MESH:D009369
2067 41610-41616 Disease denotes cancer MESH:D009369
2071 41688-41692 Gene denotes ACE2 Gene:59272
2072 41775-41779 Gene denotes ACE2 Gene:59272
2073 41714-41720 Disease denotes cancer MESH:D009369
2084 41833-41837 Gene denotes ACE2 Gene:59272
2085 42100-42104 Gene denotes ACE2 Gene:59272
2086 41875-41881 Disease denotes tumors MESH:D009369
2087 41883-41903 Disease denotes colon adenocarcinoma MESH:D003110
2088 41912-41949 Disease denotes kidney renal papillary cell carcinoma MESH:C538614
2089 41958-41983 Disease denotes pancreatic adenocarcinoma MESH:D000230
2090 41992-42013 Disease denotes rectum adenocarcinoma MESH:D012004
2091 42022-42044 Disease denotes stomach adenocarcinoma MESH:D000230
2092 42057-42076 Disease denotes lung adenocarcinoma MESH:D000077192
2093 42136-42164 Disease denotes lung squamous cell carcinoma MESH:D002294
2099 42178-42182 Gene denotes ACE2 Gene:59272
2100 42224-42230 Disease denotes tumors MESH:D009369
2101 42261-42278 Disease denotes thyroid carcinoma MESH:D013964
2102 42291-42309 Disease denotes kidney chromophobe MESH:D000238
2103 42311-42315 Disease denotes KICH
2106 42334-42338 Gene denotes ACE2 Gene:59272
2107 42419-42423 Gene denotes ACE2 Gene:59272
2110 42505-42509 Gene denotes ACE2 Gene:59272
2111 42564-42568 Gene denotes ACE2 Gene:59272
2114 42737-42741 Gene denotes ACE2 Gene:59272
2115 42756-42763 Species denotes patient Tax:9606
2122 42871-42875 Gene denotes ACE2 Gene:59272
2123 43056-43060 Gene denotes ACE2 Gene:59272
2124 43194-43198 Gene denotes ACE2 Gene:59272
2125 42967-42975 Chemical denotes Oncomine
2126 43039-43044 Disease denotes tumor MESH:D009369
2127 43159-43180 Disease denotes endometrial carcinoma MESH:D016889

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T205 0-31 Sentence denotes Links Between ACE2 and COVID-19
T206 32-280 Sentence denotes A “second life” for ACE2 was discovered in 2003, when a novel respiratory infective disease, known as severe acute respiratory syndrome (SARS), appeared in China and spread all over Asia and Canada, with a lethality rate of 10% (Rota et al., 2003).
T207 281-430 Sentence denotes The responsible pathogen was identified in a positive strand RNA virus belonging to the coronavirus family and named SARS-CoV (Ksiazek et al., 2003).
T208 431-651 Sentence denotes The virus genome was sequenced and this allowed the identification of the spike glycoprotein (S), whose N-terminal portion, or S1-domain, was found to mediate the high affinity binding to host cells (Marra et al., 2003).
T209 652-939 Sentence denotes The group of Farzan et al. succeeded in identifying the cell receptor: they showed that SARS-CoV efficiently infected African Monkey kidney cell line Vero E6 and co-immunoprecipitated a glycoprotein responsible for virus binding and entry, which was identified as ACE2 (Li et al., 2003).
T210 940-1046 Sentence denotes SARS-CoV caused the SARS epidemic in 2002–2003, with over 8,000 infections and a fatality rate around 10%.
T211 1047-1243 Sentence denotes In late 2019, another coronavirus emerged as a human pathogen in the city of Wuhan in China, producing symptoms such as fever, severe respiratory impairment, and pneumonia (Petersen et al., 2020).
T212 1244-1422 Sentence denotes This new coronavirus has been denominated SARS-CoV-2 for its genetic resemblance with SARS-CoV (∼80%), and its related disease has been named COVID-19 (COronaVIrus Disease 2019).
T213 1423-1583 Sentence denotes Owing to its high reproduction number R0 (2–3), SARS-CoV-2 has rapidly diffused in several countries and is currently posing a significant global health threat.
T214 1584-1657 Sentence denotes On March 11, 2020, the WHO has declared the COVID-19 outbreak a pandemic.
T215 1658-1852 Sentence denotes The early discovery that SARS-CoV-2 also engages ACE2 as entry door for cell infection has prompted an intense research effort to elucidate the biochemical determinants of CoV-ACE2 interactions.
T216 1854-1904 Sentence denotes Mechanism of Viral Entry Mediated by the S Protein
T217 1905-2030 Sentence denotes A coronavirus contains four structural proteins, namely spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins.
T218 2031-2157 Sentence denotes These proteins assemble around a lipid bilayer to provide the shell enclosing the viral genome (Figure 4A; Tang et al., 2020).
T219 2158-2349 Sentence denotes Homotrimers of S protrude from the viral surface, and are densely decorated by N-linked glycans, creating the “crown” (“Corona” in Latin) that christens this virus group (Walls et al., 2016).
T220 2350-2504 Sentence denotes S is a ∼180 kDa glycoprotein anchored in the viral membrane, which plays the most important roles in viral attachment, fusion and entry (Ou et al., 2020).
T221 2505-2655 Sentence denotes Sequence analysis has shown that SARS-CoV-2 S protein shares 76% of the primary sequence with the corresponding S of human SARS-CoV (Ou et al., 2020).
T222 2656-2786 Sentence denotes Accordingly, it has been early proposed that SARS-CoV-2 utilizes a similar cell entry mechanism as SARS-CoV, pivoted on S protein.
T223 2787-2857 Sentence denotes This hypothesis has been confirmed from an experimental point of view.
T224 2858-3070 Sentence denotes By using pseudotyped virus bearing SARS-CoV S or SARS-CoV-2 S, it was shown that a large panel of cell lines allows comparable entry of SARS-CoV or SARS-CoV-2 viruses (Hoffmann et al., 2020b; Walls et al., 2020).
T225 3071-3203 Sentence denotes FIGURE 4 (A) Structure of a Coronavirus. (B) Functional motifs in the sequence of the S “spike” protein of SARS-CoV and SARS-CoV-2.
T226 3204-3485 Sentence denotes The S protein consists of ∼1300 aminoacids and it is composed by a N-terminal “S1”subunit (∼700 aa) and a C-terminal “S2”subunit (∼600 aa); binding to the host receptor is mediated by S1, whereas S2 induces fusion of the viral envelope with cellular membranes (Walls et al., 2017).
T227 3486-3612 Sentence denotes S1 and S2 can be further subdivided in functional segments with different roles in viral entry (Figure 4B; Tang et al., 2020).
T228 3613-3713 Sentence denotes The S1 subunit contains two subdomains, the N-terminal domain (NTD) and the C-terminal domain (CTD).
T229 3714-3917 Sentence denotes In SARS-CoV (Li, 2015) and SARS-CoV-2 (Wang et al., 2020) CTD encloses the receptor-binding domain (RBD), and the RBD section that directly contacts the receptor is named as receptor-binding motif (RBM).
T230 3918-4071 Sentence denotes The N-region of S2 contains a fusion peptide (FP), two heptapeptide repeat domains (HR1, HR2), a transmembrane domain (TM), and cytoplasmic peptide (CP).
T231 4072-4239 Sentence denotes FP is a short segment composed of mostly hydrophobic residues, such as glycine (G) or alanine (A), which inserts in the host cell membrane to trigger the fusion event.
T232 4240-4423 Sentence denotes HR1 and HR2 are composed of a repetitive heptapeptide with HPPHCPC sequence, where H represents hydrophobic or bulky residues, P polar or hydrophilic residues, and C charged residues.
T233 4424-4522 Sentence denotes HR regions typically fold into α-helices with a hydrophobic interface that drives membrane fusion.
T234 4523-4720 Sentence denotes On the basis of the strong similarity between the S proteins of SARS-CoV and SARS-CoV-2, many researchers early set-out to demonstrate whether both viruses target the same host cell receptor, ACE2.
T235 4721-4879 Sentence denotes Zhou et al. (2020) highlighted that the virus was able to infect cell lines only when they expressed human, bat, civet, and pig (but not mouse) ACE2 receptor.
T236 4880-5071 Sentence denotes Hoffmann et al. (2020b), Ou et al. (2020), and Walls et al. (2020) elegantly outlined that the BHK cell line could be infected by pseudotyped SARS-CoV-2 or SARS-CoV only upon ACE2 expression.
T237 5072-5277 Sentence denotes Conversely, the expression of different human receptors used by other CoVs (hDPP4 and APN, used by MERS CoV and HCoV-229E, respectively) did not enable pseudovirus access to cells (Hoffmann et al., 2020b).
T238 5278-5372 Sentence denotes Taken together, these findings are solid evidence that SARS-CoV-2 engages ACE2 for cell entry.
T239 5373-5596 Sentence denotes Nonetheless, the two viruses were demonstrated by Xia to share also the membrane fusion mechanism, as strongly suggested by the impressive 89.9% sequence identity of S2 between SARS-CoV and SARS-CoV-2 (Xia et al., 2020a,b).
T240 5597-5822 Sentence denotes To date, the cell entry mechanism of SARS-CoV and SARS-CoV-2 has been understood in its general details and it is based on a concerted action of receptor binding and proteolysis of the S protein (Figure 5; Tang et al., 2020).
T241 5823-6014 Sentence denotes Ultrastructural studies showed a metastable “prefusion” V-shaped trimer composed by three S1 heads sitting on top of a trimeric S2 stalk anchored into the virus membrane (Walls et al., 2016).
T242 6015-6232 Sentence denotes The RBD constantly switches between a standing-up (“open”) position for receptor binding and a lying-down (“closed”) configuration, the latter allowing immune evasion (Figure 6; Song et al., 2018; Wrapp et al., 2020).
T243 6233-6351 Sentence denotes Yet only one of the three RBD in trimeric S can flip up at a time and interact with the receptor (Wrapp et al., 2020).
T244 6352-6514 Sentence denotes The second key feature of the fusion mechanism is “priming” by host proteases, which recognize and cleave a short peptide motif at the S1/S2 boundary (Figure 4B).
T245 6515-6878 Sentence denotes This cleavage does not disassemble S1 from S2 in pre-fusion conditions (Belouzard et al., 2009), but the binding interaction of RBD with its receptor, accompanied by a further cleavage in a second site in S2 (S2’site, upstream of FP, Figure 4B), triggers the possible dissociation of S1 and the irreversible refolding of S2 into a “post-fusion” state (Figure 4B).
T246 6879-7114 Sentence denotes In detail, HR1 undergoes a dramatic “jack-knife” conformational change, converting four helical stretches that run in an antiparallel fashion into a single long (∼130 aa) α-helix (Heald-Sargent and Gallagher, 2012; Walls et al., 2017).
T247 7115-7229 Sentence denotes At first, three of these helices assemble into a homotrimeric bundle and stick the FP into the host cell membrane.
T248 7230-7384 Sentence denotes Then, HR2 (one for each S2 chain) fold backward and bind to HR1, yielding the “six-helix bundle fusion core” (6-HB) of post-fusion S2 (Song et al., 2018).
T249 7385-7617 Sentence denotes This conformational foldback brings the FP (at N-terminus of HR1) and the TM (at the C terminus of HR2) close to each other, so that the viral and host cell membranes approach until their outer leaflets merge (hemifusion, Figure 5).
T250 7618-7828 Sentence denotes Eventually the inner leaflets merge (pore formation), enabling a connection between the interior of the virus and the host cell cytoplasm, that allows the delivery of viral genome (Figure 5; Tang et al., 2020).
T251 7829-7878 Sentence denotes FIGURE 5 Coronavirus viral fusion pathway model.
T252 7879-7942 Sentence denotes Initially, the S protein is in the pre-fusion native state (1).
T253 7943-8241 Sentence denotes Then S undergoes priming of the S1 subunit at S1/S2 by local proteases yielding the pre-fusion metastable state (2); note that priming at S1/S2 could also happen upon virus formation in releasing cell: in such a case the virus attaches to a host cell already in the pre-fusion metastable state (2).
T254 8242-8421 Sentence denotes Subsequent triggering by a protease on S2’ enables the FP to insert in the host membrane upon the “jack-knife” transition of HR1 and HR2 yielding the pre-hairpin intermediate (3).
T255 8422-8536 Sentence denotes The pre-hairpin folds back on itself due to HR1 and HR2 interactions eventually forming the post-fusion (6) state.
T256 8537-8707 Sentence denotes During the S protein foldback, the two membranes approach each other until the outer leaflets merge (hemifusion) and eventually the inner leaflets merge (pore formation).
T257 8708-8829 Sentence denotes Note that cell membrane may refer to plasma membrane (direct fusion) or endosomal membrane (fusion in endocytic vesicle).
T258 8830-8862 Sentence denotes Adapted from Tang et al. (2020).
T259 8863-8939 Sentence denotes FIGURE 6 Trimeric S protein of SARS-CoV-2 in the ”Closed” and “Open” forms.
T260 8940-9028 Sentence denotes Note the single RBD protruding out of the V-shaped conformation of the protein assembly.
T261 9029-9077 Sentence denotes The structures have been drawn from PDB 6X2C (R.
T262 9078-9141 Sentence denotes Henderson, 10.1101/2020.05.18.10208) by Mol on the PDB website.
T263 9142-9311 Sentence denotes Although not directly related to ACE2, the role of S “priming” by host cell proteases deserves particular attention in the context of SARS-CoV-2 virus entry and tropism.
T264 9312-9524 Sentence denotes Possibly, the most notable feature of SARS-CoV-2 genome, as compared to SARS-CoV and some related bat coronaviruses, is a four basic aminoacid insert (PRRA) at the S1/S2 junction (Figure 4B; Jaimes et al., 2020).
T265 9525-9680 Sentence denotes This site is potentially cleavable by the protease furin, a proprotein convertase widely recognized to activate the fusion machinery of viral glycoprotein.
T266 9681-9913 Sentence denotes Indeed, many authors showed that pseudoviruses bearing SARS-CoV-2 S were already “primed” (i.e., cleaved) at the S1/S2 boundary by furin upon assembly in the cell, at odds with pseudoviruses bearing SARS-CoV S (Shang et al., 2020a).
T267 9914-10307 Sentence denotes SARS-COV-2 shows a large flexibility with regard to protease priming, which may independently occur by a) furin and furin-like proteases intracellularly, b) trypsin-like proteases such as TMPRSS2 that are present on the host cell membrane (particularly on airway epithelial cells), and 3) endosomal cathepsins activated by a drop in pH (e.g., cathepsin L) (Figure 7; Hoffmann et al., 2020a,b).
T268 10308-10459 Sentence denotes This flexibility could be the crucial factor that explain SARS-CoV-2 cell tropism and the peculiar features of COVID-19 symptoms (Jaimes et al., 2020).
T269 10460-10645 Sentence denotes Additionally, the kind of protease “priming” may determine whether the membrane fusion process occur directly at the plasma membrane or at endosomal level (Tang et al., 2020; Figure 7).
T270 10646-10731 Sentence denotes FIGURE 7 Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells.
T271 10732-10892 Sentence denotes The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell.
T272 10893-11118 Sentence denotes The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA.
T273 11119-11429 Sentence denotes Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles.
T274 11430-11540 Sentence denotes Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell.
T275 11542-11579 Sentence denotes SARS-CoV-2 RBD and Its Receptor, ACE2
T276 11580-11727 Sentence denotes Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV.
T277 11728-11804 Sentence denotes SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005).
T278 11805-11944 Sentence denotes Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020).
T279 11945-12075 Sentence denotes Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy.
T280 12076-12279 Sentence denotes Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor).
T281 12280-12409 Sentence denotes Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner.
T282 12410-12486 Sentence denotes The SARS-CoV-2 RBD sequence was further investigated by structural analysis.
T283 12487-12884 Sentence denotes X-ray crystallography showed that SARS-CoV-2 RBD folds into two structural domains (Figure 8): (1) the core subdomain with five antiparallel β-strands (β1, β2, β3, β4, β7), (2) the external subdomain, which inserts between β4 and β7, and it is characterized by the two small β5 and β6 strands [β1’ and β2’ in Wang et al. (2020)] connected by a disulfide bond (Lan et al., 2020; Wang et al., 2020).
T284 12885-13152 Sentence denotes In keeping with their high sequence homology, the 3D structure of SARS-COV-2 and SARS-CoV RBD nearly superimpose (RMSD = 0.475 Å for 128 Cα atoms; Wang et al., 2020) with the exception of the β5/β6 loop, which actually entailed the larger primary sequence difference.
T285 13153-13387 Sentence denotes FIGURE 8 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2. (A) Cartoon representation. (B) Gaussian surface representation. hACE2 is in green, the core of SARS-CoV-2 RBD is in red, and the RBM is in blue.
T286 13388-13460 Sentence denotes The β1-β7 typical motifs of RBD (Lan et al., 2020) are indicated in (A).
T287 13461-13551 Sentence denotes The structures have been drawn from PDB 6MOJ (Lan et al., 2020) by Mol on the PDB website.
T288 13552-13629 Sentence denotes Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2.
T289 13630-13716 Sentence denotes Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD.
T290 13717-13877 Sentence denotes To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch.
T291 13878-13992 Sentence denotes In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1).
T292 13993-14141 Sentence denotes Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b).
T293 14142-14333 Sentence denotes In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020).
T294 14334-14551 Sentence denotes The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020).
T295 14552-14729 Sentence denotes Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a).
T296 14730-14973 Sentence denotes This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host.
T297 14974-15300 Sentence denotes Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases.
T298 15301-15418 Sentence denotes Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells.
T299 15419-15512 Sentence denotes TABLE 1 Binding affinity between SARS-CoV-2 spike (S) protein and S subset regions and ACE2.
T300 15513-15550 Sentence denotes Sequence KD (nM) Method References
T301 15551-15590 Sentence denotes SARS-2 S 14.7 SPR Wrapp et al., 2020
T302 15591-15628 Sentence denotes SARS-2 S 11.2 SPR Lei et al., 2020
T303 15629-15678 Sentence denotes SARS-2 S20–685 (S1) 94.6 SPR Wang et al., 2020
T304 15679-15731 Sentence denotes SARS-2 S319–541 (RBD) 133.3 SPR Wang et al., 2020
T305 15732-15781 Sentence denotes SARS-2 S319–541 (RBD) 4.7 SPR Lan et al., 2020
T306 15782-15829 Sentence denotes SARS-2 S319–529 44.2 SPR Shang et al., 2020b
T307 15830-15896 Sentence denotes SARS-2 S319–591 34.6 Biolayer interferometry Wrapp et al., 2020
T308 15897-15962 Sentence denotes SARS-2 S328–533 1.2 Biolayer interferometry Walls et al., 2020
T309 15964-15997 Sentence denotes Structure of the ACE2-RBD Complex
T310 15998-16231 Sentence denotes Previous studies showed that the extracellular Peptidase Domain (PD) of ACE2, which adopts a claw-like morphology, is the interaction site of SARS-CoV RBD (Towler et al., 2004; Li, 2015; Kirchdoerfer et al., 2018; Song et al., 2018).
T311 16232-16406 Sentence denotes More specifically, ACE2 engages SARS-CoV RBD by establishing contacts with the 424–494 residue domain, which is referred to as Receptor Binding Motif (RBM) (Li et al., 2005).
T312 16407-16687 Sentence denotes In spite of the recent emergence of SARS-CoV-2, multiple authors have already highlighted the structure of ACE2/SARS-CoV-2 RBD complex by either X-ray (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020) or cryo-EM (Walls et al., 2020; Wrapp et al., 2020; Yan et al., 2020).
T313 16688-16798 Sentence denotes Pleasantly, all data converged to a consistent tridimensional arrangement of the receptor (Wang et al., 2020).
T314 16799-16916 Sentence denotes In the “closed” conformation of S protein, the RBD is buried at the interface between protomers (Walls et al., 2020).
T315 16917-17099 Sentence denotes Only in the “open” S conformation, RBD engages PD of ACE2 (Wrapp et al., 2020), and the complex may involve a dimeric ACE2 that accommodates two S protein trimers (Yan et al., 2020).
T316 17100-17289 Sentence denotes In keeping with their sequence similarity, strong structural homology was found between ACE2/SARS-CoV RBD and ACE2/SARS-CoV-2 RBD (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020).
T317 17290-17478 Sentence denotes SARS-CoV-2 RBM spans from residue 438–506 of S sequence and, likewise SARS-CoV RBM, it approaches the outer surface of ACE2 by a gently concave surface with a ridge on one side (Figure 8).
T318 17479-17644 Sentence denotes The concave surface is made up by the two short β5 and β6 sheets of the external RBD subdomain, whereas the ridge contains the β5/β6 loop (loop 1: residues 474–489).
T319 17645-17746 Sentence denotes A second smaller loop (loop 2: residues 498–505) is visible on the other side of the concave surface.
T320 17747-18012 Sentence denotes Inspection of the complex structure and molecular dynamics (MD) highlighted that the motifs 453–456 (in β5), 484–489 (in the loop 1), and 500–505 (in the loop 2) are at the basis of the largest differences between SARS-CoV-2 and SARS-CoV RBM interactions with ACE2.
T321 18013-18267 Sentence denotes SARS-CoV RBM ridge contains a Pro-Pro-Ala motif that is replaced by Gly-Val-Glu-Gly in SARS-CoV-2 (residues 482–485), yielding a more compact loop able to engage more interactions with proximal ACE2 residues (e.g., Ser19 and Gln24) (Shang et al., 2020b).
T322 18268-18476 Sentence denotes Additionally, Phe486 of SARS-CoV-2 RBM (which replaces Ile of SARS) inserts into a hydrophobic pocket on the receptor surface, establishing strong aromatic interactions with Tyr83 of ACE2 (Wang et al., 2020).
T323 18477-18572 Sentence denotes Asn501 in loop 2 further engages recognized hotspots on the ACE2 surface (Shang et al., 2020b).
T324 18573-18724 Sentence denotes Consistently, MD studies confirmed that loop 1 and 2 are much more rigid in RBM-ACE2 complex of SARS-CoV-2 with respect to SARS (Brielle et al., 2020).
T325 18725-18845 Sentence denotes These subtle structural differences probably account for the higher affinity of SARS-CoV-2 for ACE2 (Wang et al., 2020).
T326 18846-19055 Sentence denotes Interestingly, MD simulations suggest that the difference in affinity is largely due to the solvation energy, emphasizing the relevant role of hydrophobic patches in RBM/ACE2 binding surface (He et al., 2020).
T327 19056-19323 Sentence denotes It is worth noting that the RBD-receptor engagement is the crucial effector of viral-host interaction, which eventually determines viral host range, and in tandem with the host proteases is responsible for virus tropism and pathogenicity (Millet and Whittaker, 2015).
T328 19324-19558 Sentence denotes Structure-guided sequence analysis has suggested that several mammals, including pets such as cats and dogs, host ACE2 receptors that could bind effectively to SARS-CoV-2 S protein and propagate COVID-19 infection (Luan et al., 2020).
T329 19559-19641 Sentence denotes Yet, no correlation between genetic distance and the S/ACE2 interaction was found.
T330 19642-19853 Sentence denotes In this context, a third human CoV, hCoV-NL63, has been previously found to use ACE2 for cell entry (Hofmann et al., 2005), although its S1 sequence is rather dissimilar from SARS (23.4%) and SARS-CoV-2 (29.2%).
T331 19854-20026 Sentence denotes In spite of this, the structures of hCoV-NL63 (Wu et al., 2009) and SARS-CoV RBD (Li et al., 2005) were found to engage some sterically overlapping sites in ACE (Li, 2015).
T332 20027-20187 Sentence denotes This homology can be transitively extended to SARS-CoV-2, suggesting these three CoVs have evolved to recognize a “hotspot” region in ACE2 for receptor binding.
T333 20188-20381 Sentence denotes This might represent a critical feature for the appearance of novel CoV able to infect humans in the future, as it is known that at least three more bat CoVs bind ACE2 (Hoffmann et al., 2020b).
T334 20382-20605 Sentence denotes Indeed, bat RaTG13 CoV binds ACE2 and contains a similar four-residue motif in the ACE2 binding ridge of RBM, suggesting that SARS-CoV-2 could have evolved from RaTG13 or a yet-unknown related bat CoV (Shang et al., 2020b).
T335 20607-20648 Sentence denotes The Controversial Role of ACE2 Expression
T336 20649-20889 Sentence denotes Epidemiological data consistently show that the COVID-19 patients at highest risk of a poor prognosis are males older than 60 years with chronic underlying diseases, mostly hypertension, cardiovascular diseases and type-2 diabetes mellitus.
T337 20890-21072 Sentence denotes Clinical reports have been rapidly delivered from all over the world, and meta-analyses assessing the prevalence of comorbidities and their impact on prognosis are already available.
T338 21073-21320 Sentence denotes A meta-analysis pooling data from seven studies following a total number of 1,576 infected patients from hospitals in China found that the most prevalent comorbidities were hypertension (21.1%), diabetes (9.7%), and cardiovascular diseases (8.4%).
T339 21321-21529 Sentence denotes These increased the risk of developing a more serious disease (i.e., requiring intensive care treatment), with odds ratios ranging from 2.4 (hypertension) to 3.4 (cardiovascular disease) (Yang et al., 2020b).
T340 21530-21805 Sentence denotes These findings have been confirmed in the analysis performed by the Chinese Center for Disease Control and Prevention in a huge sample of 72314 COVID-19 cases (Epidemiology Working Group for Ncip Epidemic Response and Chinese Center for Disease Control and Prevention, 2020).
T341 21806-21959 Sentence denotes A study with 1591 Italian patients, similarly, reported a significant association between hypertension and mortality in Intensive Care Unit (63 vs. 40%).
T342 21960-22104 Sentence denotes This series reported an even higher prevalence of hypertension (49%), diabetes (17%), and cardiovascular disease (21%) (Grasselli et al., 2020).
T343 22105-22293 Sentence denotes Diabetes has been reported to predict the occurrence of ARDS (HR = 1.44), acute kidney injury (HR = 3.01), septic shock (HR = 1.95), and all-cause mortality (HR = 1.70) (Zhu et al., 2020).
T344 22294-22452 Sentence denotes Notably, poor glycemic control was significantly associated with worse clinical outcomes, namely multi-organ injuries and higher mortality (Zhu et al., 2020).
T345 22453-22534 Sentence denotes Obesity has also emerged as an important factor in determining COVID-19 severity.
T346 22535-22803 Sentence denotes Indeed, obesity was more frequent in patients admitted to critical care for SARS-CoV-2 as compared to the general population; moreover, the BMI was positively related to the need for invasive mechanical ventilation and mortality (Drucker, 2020; Simonnet et al., 2020).
T347 22804-22946 Sentence denotes The RAAS system is the target of widely used anti-hypertensive drugs, such as ACE-inhibitors (ACEI) and Ang-II type 1 receptor blockers (ARB).
T348 22947-23159 Sentence denotes Several experimental studies reported that, although not directly affecting ACE2 activity, these drugs are able to upregulate its expression (Ishiyama et al., 2004; Ferrario et al., 2005; Gallagher et al., 2008).
T349 23160-23392 Sentence denotes Increased expression of ACE2 has also been reported to facilitate SARS-CoV infection in several experimental models and postulated to act in the same way for SARS-CoV-2 (Li et al., 2003; Hofmann et al., 2004; Perrotta et al., 2020).
T350 23393-23563 Sentence denotes Hence, following the SARS-CoV-2 outbreak, it has been speculated that the use of ACEI and ARB could increase viral invasion and should therefore be temporarily suspended.
T351 23564-24032 Sentence denotes This topic has been abundantly debated in the last few months (March–May 2020), with contradictory views (Bavishi et al., 2020; Buckley et al., 2020; Danser et al., 2020; Fang et al., 2020; Huang Z. et al., 2020; Kreutz et al., 2020; Kuster et al., 2020; Mourad and Levy, 2020; Park et al., 2020; Rico-Mesa et al., 2020; Sommerstein et al., 2020; South et al., 2020; Tignanelli et al., 2020; Vaduganathan et al., 2020; Verdecchia et al., 2020b; Zhang P. et al., 2020).
T352 24033-24422 Sentence denotes As a consequence of this debate, several clinical societies have stated that suspension of ACEI and ARB is not justified on the basis of the present scientific evidence, although a recent BMJ editorial (Aronson and Ferner, 2020) suggested to consider stopping ACE inhibitors or angiotensin receptor blockers in patients with mild hypertension who are at high risk of coronavirus infection.
T353 24423-24648 Sentence denotes On the other hand, a different viewpoint is based on the intriguing observation that several conditions increasing the risk of viral infection and disease severity are all characterized by a certain degree of ACE2 deficiency.
T354 24649-24836 Sentence denotes As discussed above (section “Structure of ACE2”) ACE2 deficiency has been suggested to play a significant role in the pathophysiology of hypertension, cardiovascular disease and diabetes.
T355 24837-25034 Sentence denotes The role of ACE2 expression in the panel of comorbidities correlated to SARS-CoV-2 is a matter of intense still unsolved debate, as brilliantly revised by Shyh et al. (2020) in a very recent paper.
T356 25035-25174 Sentence denotes On the whole, there is still uncertainty about the relationship between ACE2 density on cell membrane and the fate of SARS-CoV-2 infection.
T357 25175-25516 Sentence denotes An interesting speculation which could reconcile the two position comes from the hypothesis that while ACE2 is for sure the entry door for the virus, once the infection has evolved, there is the subsequent downregulation of ACE2, responsible for the precipitating of respiratory distress, as showed also in animal models (Kuba et al., 2005).
T358 25517-25689 Sentence denotes It should be pointed out that the great clinical impact of this issue has encouraged discussions that are largely based on indirect speculations rather than objective data.
T359 25690-25983 Sentence denotes Data from appropriate clinical trials are still lacking, although a retrospective multicenter study on more than 1,000 patients with COVID-19 and hypertension treated with ACEI or ARB revealed that the use of these drugs was associated with lower mortality from all cause (Bosso et al., 2020).
T360 25984-26388 Sentence denotes A definite conclusion would require specific prospective clinical trials, which are still running: https://clinicaltrials.gov/ct2/show/NCT04312009 is a multi-centered double blind trial with the aim to test the role of ARB in patients with COVID-19 and https://clinicaltrials.gov/ct2/show/NCT04331574 is another trial evaluating the outcome of patients with COVID-19 in therapy with either ACEI and ARBS.
T361 26389-26944 Sentence denotes In the meanwhile, partial but important information might be obtained by circumscribed experimental and clinical investigations focused some on crucial issues, namely: fate of SARS-CoV-2 infection in human cells manipulated in order to modify ACE2 density; correlation of ACE2 density (in different cell types) and clinical course in human patients; potential role of additional proteins interacting with ACE2, such as the membrane transporter SIT1, which appears to be associated with COVID-19 prognosis and is also affected by anti-hypertensive therapy.
T362 26946-26994 Sentence denotes ACE2 and the Inflammatory Response to SARS-CoV-2
T363 26995-27161 Sentence denotes Differently from other flu-like viral infections, COVID19 showed a relatively high lethality, although the latter was quite different in different geographical areas.
T364 27162-27321 Sentence denotes The appearance of ARDS and acute severe lung injury was initially regarded as the main insult, and patients underwent the typical treatment developed for ARDS.
T365 27322-27637 Sentence denotes However, more recent evidence from autopsy series revealed that COVID-19 is a systemic disease, in which interstitial pneumonia is associated with extensive microvascular damage, which is not limited to the lungs and leads to fibrin deposition, neutrophils trapping in microvasculature, and arteriolar microthrombi.
T366 27638-27792 Sentence denotes Moreover, cardiovascular involvement has been observed, occasionally leading to myocardial injury and sudden death after weeks from the initial infection.
T367 27793-27964 Sentence denotes These findings are crucial to optimize the treatment of COVID-19 patients, hopefully improving the prognosis (Buja et al., 2020; Carsana et al., 2020; Magro et al., 2020).
T368 27965-28113 Sentence denotes Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection.
T369 28114-28252 Sentence denotes Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia.
T370 28253-28351 Sentence denotes In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required.
T371 28352-28477 Sentence denotes These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people.
T372 28478-28793 Sentence denotes Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020).
T373 28794-28912 Sentence denotes The molecular mechanisms involved in the cytokine storm and the role of ACE2 are currently still not fully understood.
T374 28913-29126 Sentence denotes As discussed above, virus binding to the ACE2 is the event that initiates viral replication in susceptible cells, such as alveolar epithelial cells, vascular cells and immune system cells (macrophages, monocytes).
T375 29127-29255 Sentence denotes This has been suggested to trigger the primary inflammatory response, which involves apoptosis and pyroptosis (Fu et al., 2020).
T376 29256-29506 Sentence denotes The apoptosis pattern indices cell death to avoid viral replication in the absence of overt inflammation, whereas, pyroptosis is a violent form of programmed cell death, followed by an inflammatory storm (Cookson and Brennan, 2001; Liu et al., 2016).
T377 29507-29753 Sentence denotes In the standard pyroptosis model, when the pathogen enters the host cell, some specific structures on the pathogen surface (PAMPs–pathogen associated molecular patterns) are identified by pattern recognition receptors (PRRs) on the host membrane.
T378 29754-30199 Sentence denotes One common PRR is NOD-like receptors protein 3 (NLRP3), which forms together with a protein caspase activating protein (ASC or apoptosis-associated speck-like protein containing a caspase recruitment domain) and pro-caspase 1, the inflammasome unit capable of recruiting proinflammatory cytokines and inducing cell lysis with further inflammation signals (Fernandes-Alnemri et al., 2007; Schroder and Tschopp, 2010; Wree et al., 2014; Figure 9).
T379 30200-30307 Sentence denotes FIGURE 9 Possible role of ACE2 in the molecular mechanisms involved in the “cytokine storm” of SARS-CoV-2.
T380 30308-30529 Sentence denotes In the SARS-CoV-2 infection, pyroptosis has been demonstrated to be active in macrophages, being viroporin 3a a trigger for NLRP3 with subsequent production of proinflammatory cytokines, such as IL-1β (Chen et al., 2019).
T381 30530-30668 Sentence denotes In COVID-19 patients, the pyroptosis activation has been indirectly demonstrated by the high serum level of IL-1β (Huang C. et al., 2020).
T382 30669-30856 Sentence denotes Moreover, the severe leucopoenia and lymphopenia, commonly showed in COVID-19 pneumonia and associated with poor prognosis, are likely due to lymphocyte injury by pyroptosis (Yang, 2020).
T383 30857-30982 Sentence denotes Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system.
T384 30983-31279 Sentence denotes It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018).
T385 31280-31624 Sentence denotes The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release.
T386 31625-31864 Sentence denotes Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020).
T387 31865-31961 Sentence denotes The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm.
T388 31962-32158 Sentence denotes The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020).
T389 32159-32247 Sentence denotes ACE2 shedding is an additional mechanism contributing to inflammation (Fu et al., 2020).
T390 32248-32501 Sentence denotes ACE2 shedding consists in proteolytic cleavage of the protein ectodomain and leads to the release of enzymatically active soluble ACE2 (sACE), whose action is not completely understood, but might enhance the pro-inflammatory response (Guy et al., 2005).
T391 32502-32717 Sentence denotes ADAM 17 and disintegrin are able to shed not only TNFα but also a variety of membrane-anchored enzymes, including ACE2 (Black et al., 1997; Palau et al., 2020), as demonstrated by Lambert in 2005 (Guy et al., 2005).
T392 32718-33034 Sentence denotes In their experiment, human embryonic kidney cells (HEK293) expressing human ACE2 (HEK-ACE2) were treated with phorbol myristate acetate stimulation and the production of a polypeptide of 105 kDa was demonstrated by western blot analysis, suggesting the occurrence of a proteolytic shedding in the ectodomain of ACE2.
T393 33035-33255 Sentence denotes Subsequently, they demonstrated that the cleavage was performed by ADAM17, incubating cells with a specific hydroxamic acid-based metalloproteinase inhibitor, namely TAPI-1 (TNFα protease inhibitor 1) (Guy et al., 2005).
T394 33256-33373 Sentence denotes ACE2 shedding seems to be inducible by specific stimuli produced either by a viral infection or by the immune system.
T395 33374-33487 Sentence denotes Jia et al. (2009) confirmed ACE2 shedding in differentiated primary airway epithelial cells and Calu-3-cell line.
T396 33488-33696 Sentence denotes Furthermore, they demonstrated that the incubation with IL-1β at the dosage of 100 ng/ml and TNF α 100 ng/ml induced ACE2 shedding and sACE release, with a maximum after 18 h of incubation (Jia et al., 2009).
T397 33697-33832 Sentence denotes These findings suggest that an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection.
T398 33833-34017 Sentence denotes Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).
T399 34018-34177 Sentence denotes Other conditions have been assumed to be involved in the susceptibility to SARS-CoV-2 and among them vitamin D deficiency was proposed as a credible candidate.
T400 34178-34339 Sentence denotes The interesting candidate could be identified as a modifiable risk factor (hypovitaminosis D) and a potential tool in COVID-19 prevention or ancillary treatment.
T401 34340-34996 Sentence denotes The rationale has been summarized by Grant et al. in a recent review on the evidence supporting a possible correlation between vitamin D and SARS-CoV-2 risk: (i) the seasonal flare of SARS-CoV-2 which coincides with the nadir of vitamin D levels, (ii) the association between hypovitaminosis D and pulmonary infections together with the demonstrated protective role in acute respiratory infections, in adults (iii) the anti-inflammatory role of vitamin D which could be of benefit against the so called “cytokine storm,” which seems to be a major player in SARS-CoV-2 morbidity and mortality (Martineau et al., 2017; Zhou et al., 2019; Grant et al., 2020).
T402 34998-35026 Sentence denotes ACE2 as a Therapeutic Target
T403 35027-35115 Sentence denotes As evidence builds up, ACE2 rapidly emerged as a specific target for COVID-19 treatment.
T404 35116-35420 Sentence denotes Since this enzyme was identified as the SARS-CoV-2 receptor (Zhou et al., 2020), several approaches to address ACE2 mediated infection have been described (Li Y. et al., 2020; Zhang H. et al., 2020), with the aim to prevent host cell entry and subsequent viral replication, as well as severe lung injury.
T405 35421-35474 Sentence denotes Potential therapeutic approaches include (Figure 10):
T406 35475-35586 Sentence denotes FIGURE 10 Schematic representation of the potential therapeutic approaches to address ACE2 mediated infection.
T407 35587-35791 Sentence denotes Exogenous administration of soluble recombinant human ACE 2 sequesters circulating viral particles, while specific ACE2 blockers bind the receptor, impeding the S-protein interaction with the host target.
T408 35792-35794 Sentence denotes 1.
T409 35796-35810 Sentence denotes ACE2 blockers;
T410 35811-35813 Sentence denotes 2.
T411 35815-35848 Sentence denotes Exogenous administration of ACE2.
T412 35850-35863 Sentence denotes ACE2 Blockers
T413 35864-36114 Sentence denotes Blockade of ACE2 receptor could be achieved through specific antibodies (Li et al., 2003), rationally designed small molecules (Dales et al., 2002; Huentelman et al., 2004; Gross et al., 2020; Pillaiyar et al., 2020) or peptides (Huang et al., 2003).
T414 36115-36303 Sentence denotes Although their efficacy needs to be confirmed, some of these agents are currently available on the market and have been show to effectively block SARS-CoV invasion (Li S.-R. et al., 2020).
T415 36304-36631 Sentence denotes For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004).
T416 36632-36830 Sentence denotes Therefore, although ACE2 catalytic site is distinct from the S-protein-binding domain, NAAE exerts dual inhibitory effects on ACE2 catalytic activity and SARS binding (Adedeji and Sarafianos, 2014).
T417 36831-37127 Sentence denotes However, since a protecting role for ACE2 receptor against virus-induced acute lung injury in infections with SARS coronavirus has not been excluded (Imai et al., 2005; Kuba et al., 2005; Li S.-R. et al., 2020), the choice of ACE2 inhibition as therapeutic approach should be carefully evaluated.
T418 37129-37161 Sentence denotes Exogenous Administration of ACE2
T419 37162-37570 Sentence denotes The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a).
T420 37571-37750 Sentence denotes A pilot clinical study is currently investigating the efficiency of a recombinant human angiotensin-converting enzyme 2 (rhACE2) in patients with COVID-19 (Zhang H. et al., 2020).
T421 37751-37955 Sentence denotes Recombinant human ACE 2, rhACE2 (hrsACE2, APN01, GSK2586881), sequesters circulating viral particles interfering with S-protein binding to its host target, beside its role in regulating the systemic RAAS.
T422 37956-38311 Sentence denotes Taken together, these activities may offer therapeutic benefits in COVID-19 patients, although the large molecular weight of the protein may potentially limit its effects on local RAAS (Gheblawi et al., 2020). rhACE2 has already undergone phase 1 and 2 clinical trials in healthy volunteers and in a small cohort of patients with ARDS (Khan et al., 2017).
T423 38312-38518 Sentence denotes Moreover, it has been demonstrated that rhACE2 can significantly block the early stages of SARS-CoV-2 infections in engineered human blood vessel organoids and human kidney organoids (Monteil et al., 2020).
T424 38519-38680 Sentence denotes In this context, Procko (2020) was able to engineer hACE2 sequences to obtain soluble receptors able to sequester SARS-CoV-2 RBD and inhibit its cell attachment.
T425 38681-38887 Sentence denotes Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement.
T426 38888-39117 Sentence denotes Additionally, the availability of ACE2 nanoparticles applied to nose filters, chewing gums, clothes, filters and gloves could be of help in sequestering the virus thus preventing its entry into the host (Aydemir and Ulusu, 2020).
T427 39118-39350 Sentence denotes Prevention virus transmission could represent a more convenient strategy than therapeutic interventions on viral infection, avoiding interference with ACE2 and disturbance of the finely regulated RAAS axis (Aydemir and Ulusu, 2020).
T428 39352-39375 Sentence denotes ACE2 and Other Diseases
T429 39376-39430 Sentence denotes ACE2 is a multiform protein (Feng et al., 2010, 2011).
T430 39431-39621 Sentence denotes As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013).
T431 39622-39734 Sentence denotes Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis.
T432 39735-39852 Sentence denotes Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012).
T433 39853-39950 Sentence denotes Moreover, ACE2 participates in the regulation of metabolism, particularly of glucose homeostasis.
T434 39951-40058 Sentence denotes In the pancreas, activation of the ACE2-Ang1-7-MasR pathway improves insulin secretion (Yuan et al., 2013).
T435 40059-40245 Sentence denotes Obesity and high-fat diets cause a reduction in ACE2 expression in the adipose tissue, which in turn results in increased blood pressure (Gupte et al., 2008, 2012; Carsana et al., 2020).
T436 40246-40391 Sentence denotes A role for ACE2 is emerging in Alzheimer disease, since it has been shown that ACE2 can hydrolyse Beta amyloid peptides (Zou et al., 2007, 2013).
T437 40392-40475 Sentence denotes There is also increasing evidence that the RAAS system may be implicated in cancer.
T438 40476-40676 Sentence denotes ACE2 was found to inhibit cancer cell growth, metastasis, and angiogenesis in breast (Yu et al., 2016; Zhang Q. et al., 2019), pancreatic (Zhou et al., 2011), and colon cancer (Bernardi et al., 2012).
T439 40677-40886 Sentence denotes Another study pointed out that hepatocellular carcinoma patients with higher levels of ACE2 had longer survival times, suggesting a positive link between ACE2 expression and better prognosis (Ye et al., 2015).
T440 40887-41053 Sentence denotes Studies on human xenografts in mice clearly indicated that ACE2 inhibited tumor growth by suppressing invasion and angiogenesis in Non-Small Cell Lung Cancer (NSCLC).
T441 41054-41327 Sentence denotes Remarkably, the same group demonstrated that overexpression of ACE2 promotes the expression of E-cadherin at expenses of mesenchymal markers such as vimentin, and thereby inhibits the epithelial-mesenchymal transition in NSCLC models (Feng et al., 2010; Qian et al., 2013).
T442 41328-41534 Sentence denotes The discovery that lung cancer patients that harbor COVID-19 display more severe symptoms (Liang et al., 2020) set out intensive research on the possible connection between malignancies and ACE2 expression.
T443 41535-41652 Sentence denotes A thorough bioinformatics analysis of the TCGA dataset on several kinds of cancer (Chai et al., 2020) has shown that:
T444 41653-41721 Sentence denotes (1) Mutation and amplification of ACE2 gene are frequent in cancer.
T445 41722-41827 Sentence denotes Yet, hot-spot mutation sites were never observed, as ACE2 mutations were distributed across all 18 exons.
T446 41828-42084 Sentence denotes (2) ACE2 transcription was upregulated in six tumors: colon adenocarcinoma (COAD), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and lung adenocarcinoma (LUAD).
T447 42085-42172 Sentence denotes Interestingly, ACE2 transcription was unchanged in lung squamous cell carcinoma (LUSC).
T448 42173-42317 Sentence denotes (3) ACE2 transcription was downregulated in three tumors: testicular germ cell (TGCT), thyroid carcinoma (THCA), and kidney chromophobe (KICH).
T449 42318-42473 Sentence denotes (4) Changes of ACE2 transcription were epigenetic in nature, as both mutation and copy variation of ACE2 did not correlate with its up- or downregulation.
T450 42474-42578 Sentence denotes (5) In most cases, changes of ACE2 transcription strongly correlated with methylation in ACE2 promoter.
T451 42579-42709 Sentence denotes More specifically, decreased methylation levels correlated with upregulation, whereas increased methylation led to downregulation.
T452 42710-42797 Sentence denotes (6) No prognostic role of ACE2 expression on patient’s survival could be demonstrated.
T453 42798-42918 Sentence denotes These data confirm the remarkable role of methylation in determining the ACE2 expression, as described in paragraph 2.2.
T454 42919-43264 Sentence denotes Interestingly, a second bioinformatics study on Oncomine and TCGA databases gave slightly different results in terms of tumor-associated ACE2 expression changes, but confirmed the role of promoter hypomethylation in KIRP and uterine corpus endometrial carcinoma (UCEC) where ACE2 transcription was significantly upregulated (Yang et al., 2020a).